Detalles de la búsqueda
1.
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Biochemistry
; 62(6): 1145-1159, 2023 03 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36854124
2.
Insights into Nitrosoalkane Binding to Myoglobin Provided by Crystallography of Wild-Type and Distal Pocket Mutant Derivatives.
Biochemistry
; 62(8): 1406-1419, 2023 04 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37011611
3.
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
Biochem J
; 477(16): 2999-3018, 2020 08 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32729927
4.
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
Biochemistry
; 59(4): 479-490, 2020 02 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31869219
5.
A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity.
Biochem Biophys Res Commun
; 509(4): 898-902, 2019 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30638931
6.
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.
Biochem J
; 475(20): 3221-3238, 2018 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30249606
7.
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
J Biol Chem
; 292(19): 7971-7983, 2017 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28330869
8.
Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30061280
9.
Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ.
Proc Natl Acad Sci U S A
; 112(28): 8596-601, 2015 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26124101
10.
Fluorescence resonance energy transfer studies of DNA polymerase ß: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.
J Biol Chem
; 289(23): 16541-50, 2014 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24764311
11.
Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.
Hum Mol Genet
; 22(6): 1074-85, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23208208
12.
Catalytically distinct IDH1 mutants tune phenotype severity in tumor models.
bioRxiv
; 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712107
13.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Nat Commun
; 15(1): 3785, 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38710674
14.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Res Sq
; 2024 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38464189
15.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
bioRxiv
; 2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38260668
16.
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
J Biol Chem
; 287(35): 29554-67, 2012 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22773874
17.
Pools and Pols: Mechanism of a mutator phenotype.
Proc Natl Acad Sci U S A
; 112(19): 5864-5, 2015 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25931524
18.
Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
Mol Pharmacol
; 82(1): 125-33, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22513406
19.
Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.
Antimicrob Agents Chemother
; 56(3): 1630-4, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22155823
20.
Probing altered enzyme activity in the biochemical characterization of cancer.
Biosci Rep
; 42(2)2022 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35048115