RESUMEN
BACKGROUND: Moderate-to-large residual shunts following percutaneous patent foramen ovale (PFO) closure are clinically important and associated with recurrent neuroembolic events. However, their management has not been clearly established in clinical practice. We report our experience in patients of these patients with a prior history of cryptogenic stroke and/or transient ischemic attack (TIA). METHODS: All patients undergoing percutaneous PFO closure were routinely screened at six-months for residual shunts using transthoracic 2D echocardiography with antecubital administration of agitated saline contrast and color flow Doppler. Patients with evidence of moderate-to-large residual shunts were selected to undergo reintervention with shunt closure. Post-reintervention follow-up was performed at 24-hr, 30 days, and every six months thereafter. Clinical predictors of the moderate-to-large residual shunts, and the feasibility, safety and long-term efficacy of percutaneous residual shunt closure using a second device implant were examined. RESULTS: Between 1995 and 2007, a total of 424 patients underwent PFO closure. Of these, 5% (21/424) had moderate-to-large residual shunts. Baseline characteristics among patients with moderate-to-large residual shunts and those with only none or small defects (n = 403) were similar. Multivariate analysis identified the 24-hr postprocedure shunt as the only independent predictor of residual shunting at six months. Of the 21 study patients with moderate-to-large residual shunt (mean age, 47 +/- 14), one underwent successful elective surgical repair, while the remaining 20 underwent transcatheter closure using a second device. The technique was successful in 95% (19/20), and all but one patient had complete shunt closure at six months of their percutaneous reintervention. We report no deaths, recurrent strokes or TIAs during the long-term mean follow-up period of 2.9 years. CONCLUSIONS: Our study suggests that in patients with moderate-to-large residual PFO shunts, percutaneous reintervention using a second device implant is safe and effective.
Asunto(s)
Cateterismo Cardíaco , Foramen Oval Permeable/terapia , Hemodinámica , Adulto , Anciano , Boston , Cateterismo Cardíaco/efectos adversos , Cateterismo Cardíaco/instrumentación , Cateterismo , Distribución de Chi-Cuadrado , Ecocardiografía Doppler en Color , Femenino , Foramen Oval Permeable/complicaciones , Foramen Oval Permeable/diagnóstico por imagen , Foramen Oval Permeable/fisiopatología , Humanos , Ataque Isquémico Transitorio/etiología , Ataque Isquémico Transitorio/fisiopatología , Ataque Isquémico Transitorio/prevención & control , Modelos Logísticos , Masculino , Persona de Mediana Edad , Medición de Riesgo , Factores de Riesgo , Dispositivo Oclusor Septal , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/fisiopatología , Accidente Cerebrovascular/prevención & control , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenAsunto(s)
Cardiopatías Congénitas , Pericardio , Corazón , Humanos , Pericardio/diagnóstico por imagenAsunto(s)
Fibroma/diagnóstico , Neoplasias Cardíacas/diagnóstico , Recurrencia Local de Neoplasia/diagnóstico , Adulto , Biopsia , Procedimientos Quirúrgicos Cardíacos , Ecocardiografía Tridimensional , Ecocardiografía Transesofágica , Fibroma/cirugía , Neoplasias Cardíacas/cirugía , Ventrículos Cardíacos , Humanos , MasculinoRESUMEN
No disponible
Asunto(s)
Humanos , Masculino , Adulto , Fibroelastosis Endocárdica/diagnóstico , Accidente Cerebrovascular/complicaciones , Implantación de Prótesis de Válvulas Cardíacas , Neoplasias Cardíacas/cirugía , Ecocardiografía/métodos , Insuficiencia de la Válvula Mitral/cirugía , Recurrencia Local de NeoplasiaRESUMEN
No disponible