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1.
Efficacy and safety of the glucagon receptor antagonist PF-06291874: A 12-week, randomized, dose-response study in patients with type 2 diabetes mellitus on background metformin therapy.
Diabetes Obes Metab
; 20(11): 2608-2616, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29923286
2.
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Diabetes Obes Metab
; 19(12): 1762-1772, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28573777
3.
Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study.
Br J Clin Pharmacol
; 80(5): 1051-63, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25940675
4.
Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology.
Clin Ther
; 45(1): 55-70, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36690550
5.
Effect of a Ketohexokinase Inhibitor (PF-06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug.
Clin Pharmacol Ther
; 112(3): 605-614, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35355249
6.
Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial.
Med
; 2(7): 800-813.e3, 2021 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35590219
7.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34635855
8.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Mol Metab
; 48: 101196, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33667726
9.
A 4-week study assessing the pharmacokinetics, pharmacodynamics, safety, and tolerability of the glucagon receptor antagonist PF-06291874 administered as monotherapy in subjects with type 2 diabetes mellitus.
Diabetes Res Clin Pract
; 126: 95-104, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28237861
10.
Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene.
Menopause
; 13(3): 377-86, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16735934
11.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Cell Metab
; 23(3): 427-40, 2016 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26959184
12.
Effects of multiple doses of the DPP-IV inhibitor PF-734200 on the relationship between GLP-1 and glucose in subjects with type 2 diabetes mellitus.
Diabetes Res Clin Pract
; 91(2): e45-9, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21130513
13.
A methodology study to validate a structured diagnostic method used to diagnose female sexual dysfunction and its subtypes in postmenopausal women.
J Sex Marital Ther
; 31(4): 271-83, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16020146
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