Detalles de la búsqueda
1.
PredMS: a random forest model for predicting metabolic stability of drug candidates in human liver microsomes.
Bioinformatics
; 38(2): 364-368, 2022 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34515778
2.
Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice.
BMC Neurosci
; 24(1): 39, 2023 07 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37525115
3.
LightBBB: computational prediction model of blood-brain-barrier penetration based on LightGBM.
Bioinformatics
; 37(8): 1135-1139, 2021 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33112379
4.
Anti-neuroinflammatory Effects and Brain Pharmacokinetic Properties of Selonsertib, an Apoptosis signal-regulating Kinase 1 Inhibitor, in mice.
Neurochem Res
; 47(12): 3829-3837, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36309631
5.
Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease.
Molecules
; 27(11)2022 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35684355
6.
IVIVC of Octreotide in PLGA-Glucose Microsphere Formulation, Sandostatin® LAR.
AAPS PharmSciTech
; 23(7): 258, 2022 Sep 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-36123513
7.
VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.
Mol Cell
; 52(3): 459-67, 2013 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24140421
8.
Optimization of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.
Bioorg Med Chem Lett
; 30(2): 126787, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31759849
9.
A Novel Way of Preventing Postoperative Pancreatic Fistula by Directly Injecting Profibrogenic Materials into the Pancreatic Parenchyma.
Int J Mol Sci
; 21(5)2020 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32143463
10.
Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine.
J Transl Med
; 17(1): 195, 2019 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31182117
11.
Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse.
Xenobiotica
; 49(7): 823-832, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29972081
12.
Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents.
Bioorg Med Chem Lett
; 28(3): 529-532, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29295794
13.
Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 27(23): 5213-5220, 2017 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29103971
14.
Determination of a novel phosphodiesterase4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass spectrometry.
Biomed Chromatogr
; 29(3): 321-4, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25065367
15.
Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 24(17): 4281-5, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25082125
16.
Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor.
Xenobiotica
; 44(5): 465-71, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24152122
17.
Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2-[4-(4-{5-[2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido]-1H-benzo[d]imidazol-2-yl} phenyl) cyclohexyl] acetic acid (KR-69232) in rat plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Biomed Chromatogr
; 28(3): 324-6, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24122805
18.
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.
Bioorg Med Chem Lett
; 23(16): 4713-8, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23810496
19.
Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans.
Xenobiotica
; 43(2): 193-200, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22856387
20.
Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies.
Biomed Chromatogr
; 27(7): 846-52, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23420715