RESUMEN
OBJECTIVE: To assess the economic impact of introducing biosimilars of bevacizumab for the management of cancer patients receiving systemic bevacizumab in the National Health System (SNHS) of Spain. METHODS: A 3-year budget impact analysis model was adapted to estimate the cost of introducing biosimilars of bevacizumab in the SNHS for the adult population who were candidates to receive treatment with bevacizumab. Values for the estimation of the population were obtained from the literature and were validated by an expert panel. In this analysis only pharmaceutical costs (, year 2021) obtained from official databases were considered. A sensitivity analysis was performed to examine the robustness of the model. RESULTS: The introduction of bevacizumab biosimilars would generate an annual cost saving of 11 558 268 (-5.1%) for the first year with a penetration share of biosimilars from 30.0%, 29 126 373 (-8.5%) for the second year with a share of 50.0% and 52 361 778 (-13.6%) for the third year with a share of 80.0%. The total pharmaceutical costs of the scenario without biosimilars are 227 033 352 for the first year, 342 663 209 for the second year and 385 013 076 for the third year. In contrast, the pharmaceutical costs of the scenario with bevacizumab biosimilars are 215 475 084, 313 536 836 and 332 651 297 for years 1, 2 and 3, respectively. CONCLUSIONS: The introduction of biosimilars in the Spanish Health System would generate saving costs in the pharmacological budget to boost biological drugs from the first year.
Asunto(s)
Biosimilares Farmacéuticos , Neoplasias , Humanos , Adulto , Bevacizumab/uso terapéutico , Biosimilares Farmacéuticos/uso terapéutico , España/epidemiología , Preparaciones Farmacéuticas , Neoplasias/tratamiento farmacológico , Neoplasias/epidemiologíaRESUMEN
Objectives: The study aimed to estimate the burden of metastatic breast cancer (mBC) in Spain over 5 years. Methods: An incidence-based cost-of-illness model was developed in which a cohort of patients with mBC was followed from the diagnosis of metastatic disease over 5 years or death. Resource use data were collected through a physician survey conducted with 10 clinical experts in Spain. The model distinguished patients according to HER2 and hormonal receptor (HR) status, and followed the patient cohort in monthly cycles. Results: The incident cohort was estimated to be 2,923 patients with mBC, consisting of 1,575 HER2-/HR+, 520 HER2+/HR+, 324 HER2+/HR-, and 503 triple negative patients. The estimated mean survival over the 5-year time period was 2.51 years, on average, with longer survival of 3.36 years for HER2+/HR+, 2.41 years for HER2-/HR+, 2.82 years for HER2+/HR- and shortest mean survival of 1.74 years for triple negative patients. The total costs were 469,92,731 for the overall population, 190,079,787 for the HER2-/HR+, 151,045,260 for the HER2+/HR+, 80,827,171 for the HER2+/HR- and 47,540,512 for the triple negative subgroups over 5 years. Per patient total costs were 160,642 on average, 120,664 for HER2-/HR+, 290,346 for HER2+/HR+, 249,152 for HER2+/HR-and 94,572 for triple negative patients over 5 years. Conclusions: The economic burden of mBC in Spain is significant, but differs by HER2 and HR status. HER2-/HR +patients account for the highest burden due to the prevalence of this category, but HER2+/HR +patients have the highest per patient costs.
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Neoplasias de la Mama/economía , Neoplasias de la Mama/epidemiología , Costo de Enfermedad , Costos de la Atención en Salud/tendencias , Protocolos de Quimioterapia Combinada Antineoplásica/economía , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama/terapia , Estudios de Cohortes , Femenino , Estudios de Seguimiento , Humanos , Metástasis de la Neoplasia , Receptor ErbB-2 , España/epidemiología , Tasa de Supervivencia/tendencias , Neoplasias de la Mama Triple Negativas/economía , Neoplasias de la Mama Triple Negativas/epidemiología , Neoplasias de la Mama Triple Negativas/terapiaRESUMEN
Future costs are not usually included in economic evaluations. The aim of this study was to assess the extent of published economic analyses that incorporate future costs. A systematic review was conducted of economic analyses published from 2008 to 2013 in three general health economics journals: PharmacoEconomics, Value in Health and the European Journal of Health Economics. A total of 192 articles met the inclusion criteria, 94 of them (49.0%) incorporated future related medical costs, 9 (4.2%) also included future unrelated medical costs and none of them included future nonmedical costs. The percentage of articles including future costs increased from 2008 (30.8%) to 2013 (70.8%), and no differences were detected between the three journals. All relevant costs for the perspective considered should be included in economic evaluations, including related or unrelated, direct or indirect future costs. It is also advisable that pharmacoEconomic guidelines are adapted in this sense.
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Economía Farmacéutica/tendencias , Costos de la Atención en Salud/tendencias , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Costos y Análisis de Costo/métodos , Atención a la Salud/economía , HumanosAsunto(s)
Costos de los Medicamentos , Gastos en Salud , Programas Nacionales de Salud/economía , Atención Primaria de Salud/economía , Resultado del Tratamiento , Control de Costos , Análisis Costo-Beneficio , Utilización de Medicamentos/economía , Utilización de Medicamentos/estadística & datos numéricos , Humanos , EspañaRESUMEN
No disponible
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Femenino , Humanos , Masculino , /organización & administración , /estadística & datos numéricos , /normas , Sistemas Nacionales de Salud , Preparaciones Farmacéuticas/normas , Conocimiento , Gestión del Conocimiento para la Investigación en Salud , Gestión del Conocimiento/estadística & datos numéricosRESUMEN
No disponible
No disponible
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Humanos , Drogas en Investigación , Evaluación de Medicamentos/métodos , Medicamentos de Referencia , Industria Farmacéutica/tendenciasRESUMEN
No disponible
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Humanos , Control de Medicamentos y Narcóticos , Legislación de Medicamentos , Política de Salud , Política Pública , EspañaRESUMEN
No disponible