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1.
J Hand Surg Am ; 48(3): 217-225, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-36658050

RESUMEN

PURPOSE: The purpose of this study was to examine the true monetary implications, at the health system level, of moving simple hand procedures, performed with wide-awake local anesthesia no tourniquet surgery, from the ambulatory surgery center (ASC) to office setting. METHODS: We analyzed the costs, revenues, case times, and patient demographics for 2 cohorts of patients who underwent hand and non-hand surgical procedures over a 2-year period. We calculated the mean margin per minute for the top 5 procedures in non-hand orthopedic surgery subgroups, complex plastics hand, and non-hand plastic surgery. We then calculated the following: (1) hours operating room or ASC time gained by moving hand procedures to the office, (2) additional subgroup patients theoretically treated by using the ASC hours gained, and (3) net margin (in dollars) because of additional procedures. RESULTS: Six board-certified hand surgeons performed 623 simple ASC and 808 in-office procedures, consisting of 795 carpal tunnel releases, 84 first dorsal compartment releases, and 446 trigger finger releases. The net margin per minute for simple ASC and in-office hand procedures was $25.01/min and $5.63/min, respectively. In the office setting, hand surgery freed up 821 hours of ASC time, which could be theoretically used to treat over 300 additional patients awaiting outpatient orthopedic hand or plastic surgery. Depending on the subspecialty and type of substituted cases, the theoretical net margin varied from -$150,413 to $3.9 million. CONCLUSIONS: Transitioning simple hand operations out of ASCs realized a mean cost savings of 82% per case ($1,137 vs $206) and effectively opened 821 additional hours of operating room time over a 2-year period. CLINICAL RELEVANCE: Transitioning simple hand operations out of the operating room setting and into the office setting reduces the cost of hand surgical care, improves operating room access for alternate procedures or patients, and validates the sustainability of safe and effective wide-awake local anesthesia no tourniquet surgery from a hospital system's financial standpoint.


Asunto(s)
Síndrome del Túnel Carpiano , Procedimientos Ortopédicos , Humanos , Quirófanos , Anestesia Local/métodos , Mano/cirugía , Síndrome del Túnel Carpiano/cirugía , Procedimientos Ortopédicos/métodos , Procedimientos Quirúrgicos Ambulatorios
2.
J Hand Surg Am ; 45(4): 360.e1-360.e4, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31653469

RESUMEN

PURPOSE: To describe the branching pattern of the posterior antebrachial cutaneous nerve (PABCN) and to corroborate measurements and observations reported by previous authors. METHODS: Using 28 fresh-frozen cadaver specimens, we dissected the PABCN from its origin from the radial nerve to its terminal arborization in the distal forearm. Measurements relative to the lateral humeral epicondyle were recorded. The course of the nerve over the muscles of the mobile wad and its branching pattern in the proximal forearm were noted. RESULTS: The PABCN originated from the radial nerve at a mean of 14.2 cm proximal to the lateral epicondyle. The fascial hiatus through which the PABCN emerged to become superficial was a mean of 8.2 cm proximal to the lateral epicondyle. All specimens had at least 1 longitudinal branch that passed a mean of 2.8 cm anterior to the lateral epicondyle. Thirty-two percent of specimens had a lesser proximal branch in the distal third of the lateral arm; 86% had an epicondylar branch to the lateral epicondyle; and 21% had a second longitudinal branch. Ninety-three percent had a longitudinal branch coursing over the interval between the brachioradialis and the extensor carpi radialis longus in the proximal forearm. CONCLUSIONS: After becoming superficial in the distal brachium, the PABCN typically gives off a discrete epicondylar branch and then continues distally in the forearm as 1 or 2 longitudinal branches. In addition, in the proximal third of the forearm, a consistent longitudinal branch of the PABCN courses over the interval between the brachioradialis and the extensor carpi radialis longus. This review confirms previous observations of the PABCN. CLINICAL RELEVANCE: Knowledge of the course of the PABCN will assist surgeons in identifying and avoiding injury in clinical situations such as plating the proximal radius or releasing the radial tunnel.


Asunto(s)
Antebrazo , Nervio Radial , Brazo , Cadáver , Codo , Humanos , Nervio Radial/anatomía & histología , Cúbito
3.
J Ultrasound Med ; 33(6): 1057-63, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24866613

RESUMEN

OBJECTIVES: Ultrasound guidance may decrease the procedural time for many peripheral nerve blocks compared to nerve stimulation, but these studies have generally excluded obese patients. This single-blinded randomized clinical trial was designed to compare procedural times and related outcomes for ultrasound- versus nerve stimulation-guided lateral popliteal-sciatic nerve blockade specifically in obese patients. METHODS: With Institutional Review Board approval and informed consent, patients with a body mass index greater than 30 kg/m(2) who were scheduled for foot/ankle surgery and desiring a peripheral nerve block were offered enrollment. Study patients were randomly assigned to receive a lateral popliteal-sciatic nerve block under either ultrasound or nerve stimulation guidance. The patient and assessor were blinded to group assignment. The primary outcome was procedural time in seconds. Secondary outcomes included number of needle redirections, procedure-related pain, patient satisfaction with the block, success rate, sensory and motor onset times, block duration, and complication rates. RESULTS: Twenty-four patients were enrolled and completed the study. All patients had successful nerve blocks. The mean procedural times (SD) were 577 (57) seconds under nerve stimulation and 206 (40) seconds with ultrasound guidance (P< .001; 95% confidence interval for difference, 329-412 seconds). Patients in the ultrasound group had fewer needle redirections and less procedure-related pain, required less opioids, and were more satisfied with their block procedures. There were no statistically significant differences in other outcomes. CONCLUSIONS: The results of this study show that, for obese patients undergoing lateral popliteal-sciatic nerve blocks, ultrasound guidance reduces the procedural time and procedure-related pain and increases patient satisfaction compared to nerve stimulation while providing similar block characteristics.


Asunto(s)
Bloqueo Nervioso/métodos , Obesidad/complicaciones , Dimensión del Dolor , Dolor Postoperatorio/prevención & control , Nervio Ciático/diagnóstico por imagen , Ciática/terapia , Estimulación Eléctrica Transcutánea del Nervio/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Obesidad/diagnóstico por imagen , Dolor Postoperatorio/diagnóstico , Dolor Postoperatorio/etiología , Ciática/complicaciones , Método Simple Ciego , Resultado del Tratamiento , Ultrasonografía Intervencional/métodos
4.
Clin Plast Surg ; 51(4): 575-582, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39216943

RESUMEN

Functional impairment, absence, or traumatic loss of the thumb is associated with considerable morbidity. A fully functioning thumb is estimated to account for 40% of hand function. An array of options exists for thumb reconstruction, and the intervention selected must be tailored to each individual patient. Pollicization is a powerful and elegant operation that can dramatically improve function for many patients. However, the surgeon and patient must be keenly aware that pollicization does not construct a "normal" thumb. Herein, we present a stepwise approach to treatment, including surgical nuances, alternatives to pollicization, complications, and outcomes.


Asunto(s)
Procedimientos de Cirugía Plástica , Pulgar , Humanos , Pulgar/cirugía , Pulgar/anomalías , Pulgar/lesiones , Procedimientos de Cirugía Plástica/métodos , Niño , Amputación Traumática/cirugía , Colgajos Quirúrgicos
5.
Hand Clin ; 39(3): 379-388, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-37453765

RESUMEN

Scapholunate and lunotriquetral instability are common causes of chronic, debilitating wrist pain and functional impairment. In the setting of subacute or chronic injuries with predynamic or dynamic instability, the ideal surgical approach remains unclear. In January 2020 the authors started enrolling patients with predynamic and dynamic instability in an Institutional Review Board-approved prospective study, aimed at meticulously studying outcomes using the all-dorsal InternalBrace reconstruction technique. The all-dorsal technique described herein is straightforward, efficient, and easy to learn, with early outcomes equivalent or superior to those of other techniques.


Asunto(s)
Inestabilidad de la Articulación , Hueso Semilunar , Humanos , Hueso Semilunar/cirugía , Hueso Semilunar/lesiones , Estudios Prospectivos , Articulación de la Muñeca/cirugía , Ligamentos Articulares/lesiones
6.
Hand Clin ; 39(2): 227-233, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-37080654

RESUMEN

The diagnosis and management of pediatric flexor tendon injuries present unique challenges to the hand surgeon. Examination of young children is not always straightforward, and tendon lacerations are frequently diagnosed late--sometimes weeks or months after the inciting injury. Four- and six-strand repair techniques are supported by recent literature, though the surgeon must remain diligent to ensure gliding of a bulky repair in a narrow tendon sheath. Beyond the operating room, postoperative management must be tailored to accommodate nuances specific to patient age and behavioral development. A fluid, patient-specific approach to every stage of management is critical for the successful treatment of pediatric flexor tendon injuries.


Asunto(s)
Traumatismos de los Dedos , Deportes , Traumatismos de los Tendones , Niño , Humanos , Preescolar , Traumatismos de los Dedos/diagnóstico , Traumatismos de los Dedos/cirugía , Traumatismos de los Tendones/diagnóstico , Traumatismos de los Tendones/cirugía , Tendones/cirugía , Técnicas de Sutura
7.
Plast Reconstr Surg ; 151(1): 143-147, 2023 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-36219862

RESUMEN

SUMMARY: Intercarpal ligament injuries such as scapholunate and lunotriquetral tears are common causes of wrist pain. There is no shortage of surgical techniques to address these injuries, nor is there a lack of literature exploring this topic. However, research progress has not led to a consensus regarding the optimal management of subacute and chronic injuries without articular wear. The senior author (K.C.C.) has performed the spectrum of reconstructive techniques, including dorsal and volar approaches, tendon weaves, ligament tenodesis procedures, reduction and association procedures, and bone-ligament-bone techniques. In the absence of convincing, consistent outcomes, the authors began investigating a novel all-dorsal reconstructive technique using the Arthrex InternalBrace system. The complexity and unpredictable outcomes associated with traditional ligament tenodesis procedures led them to adopt the all-dorsal InternalBrace technique as their primary reconstructive approach. The authors have performed more than 20 procedures with this technique since 2019. In an average tourniquet time of under 60 minutes, they are able to achieve predictable carpal stabilization, pain relief, and restoration of motion. This is the preferred reconstructive approach of the senior author.


Asunto(s)
Huesos del Carpo , Inestabilidad de la Articulación , Hueso Semilunar , Hueso Escafoides , Tenodesis , Humanos , Articulación de la Muñeca/cirugía , Huesos del Carpo/cirugía , Tenodesis/métodos , Ligamentos Articulares/cirugía , Ligamentos Articulares/lesiones , Artralgia/cirugía , Hueso Semilunar/cirugía , Inestabilidad de la Articulación/etiología , Inestabilidad de la Articulación/cirugía , Hueso Escafoides/cirugía , Hueso Escafoides/lesiones
8.
Hand (N Y) ; 18(2): 307-313, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-34109852

RESUMEN

BACKGROUND: A paucity of literature exists specifically examining self-inflicted (SI) gunshot wounds (GSWs) to the hand and wrist, which impart greater energy and have a higher risk of adverse events than non-self-inflicted (NSI) GSWs. METHODS: We retrospectively reviewed records of patients who presented to our plastic surgery service after sustaining acute GSWs involving the hand and wrist between 2016 and 2018. RESULTS: We identified 60 patients who sustained GSWs involving the hand and wrist; 17 (28%) were SI, and 43 (72%) were NSI. Within the SI group, 100% of patients were Caucasian, with an average age of 54 years. Within the NSI cohort, 77% of patients were Black, 19% were Caucasian, and 4% identified as other. While not statistically significant, we noted a substantial increase in patients requiring operative intervention in the SI cohort (65% SI vs 37% NSI, P = .08). There was a statistically significant increase in patients requiring more than 1 operation in SI patients (24% SI vs 5% NSI, P = .04). Patients who sustained SI injuries were also more likely to present with acute carpal tunnel syndrome requiring urgent surgical release and to develop wound infections (12% vs 0%, P = .08). CONCLUSIONS: Self-inflicted GSWs involving the hand and wrist are associated with greater morbidity than their low-energy NSI counterparts. Individuals presenting with SI GSWs are more likely to be older, to require multiple operations, to develop infections, and to present with acute carpal tunnel syndrome requiring urgent surgical decompression.


Asunto(s)
Síndrome del Túnel Carpiano , Heridas por Arma de Fuego , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Heridas por Arma de Fuego/epidemiología , Heridas por Arma de Fuego/cirugía , Heridas por Arma de Fuego/complicaciones , Síndrome del Túnel Carpiano/complicaciones
9.
Hand Clin ; 38(3): 313-319, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-35985755

RESUMEN

The theoretic disadvantage of dynamic tendon transfers is the perception that they are "more complex" than static procedures. The latter may provide a simple solution to claw deformity in a subset of patients; however, they completely disregard the disability associated with loss of the intrinsic musculature. Dynamic procedures reconstruct in part the deficient intrinsic forces and are thus capable of correcting the deformity and some disabilities associated with ulnar nerve palsy. In our practice, we have consistently achieved reasonable correction of claw deformity and improvement in tendon synchrony and grip strength with a modified Stiles-Bunnell, flexor digitorum superficialis tendon transfer.


Asunto(s)
Deformidades Adquiridas de la Mano , Neuropatías Cubitales , Deformidades Adquiridas de la Mano/etiología , Deformidades Adquiridas de la Mano/cirugía , Fuerza de la Mano , Humanos , Transferencia Tendinosa/métodos , Tendones/cirugía , Nervio Cubital/cirugía , Neuropatías Cubitales/cirugía
10.
Artículo en Inglés | MEDLINE | ID: mdl-35141358

RESUMEN

Pindborg tumor is a benign expansile and slow growing odontogenic tumor that occurs mainly in adulthood. Limited management data exist for its treatment in young patients. We report the case of a 5-year-old patient and provide recommendations for the care of pediatric patients diagnosed with this rare odontogenic tumor.

11.
Hand Clin ; 37(3): 335-344, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-34253307

RESUMEN

With the development of newer techniques for symptomatic neuroma treatment, such as regenerative peripheral nerve interface and targeted muscle reinnervation, transposition and coverage techniques often have been referred to as "passive techniques." In spite of its negative connotation, these passive techniques yield positive results in a majority of patients treated. The experienced surgeon has more options than ever before in the prevention and management of problematic neuromas. Critical appraisal of the current literature reveals no single, optimal standard of care. Instead, surgeons have a plethora of useful techniques that can be implemented on a case-by-case basis to optimize outcomes.


Asunto(s)
Muñones de Amputación , Neuroma , Amputación Quirúrgica , Humanos , Neuroma/cirugía , Procedimientos Neuroquirúrgicos , Nervios Periféricos
12.
J Child Adolesc Psychopharmacol ; 30(6): 376-380, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-32423240

RESUMEN

Objectives: The objective of this research was to understand physician, patient, and parent perspectives on barriers to second-generation antipsychotic (SGA) medication adherence in youth with bipolar spectrum disorders, and attitudes toward treatment of SGA-related weight gain. Methods: Patients diagnosed with bipolar disorder before age 18, parents of children diagnosed before 18, and clinicians with experience prescribing SGAs for these patients completed surveys regarding SGA-related side effects, adherence barriers, and acceptability of weight management strategies. Results: Patients (n = 225), parents (n = 128), and clinicians (n = 54) reported weight gain as the most concerning SGA-related side effect (45.6%, 38.9%, and 70.4%, respectively). Weight gain was also the top adherence barrier for patients (35.9%), but was ranked fourth (41.8%) by parents. Patients (61.5%) were more likely "definitely" willing to co-initiate another medication to manage weight gain upon SGA initiation than parents (20.1%) or clinicians (1.9%). Conversely, parents (54.9%) and clinicians (84.9%) were "definitely" willing to accept/prescribe a second medication aiming to reverse weight gain of ≥10 lbs., and patients (61.1%) were willing to add another medication to reverse any weight gain. Conclusion: SGA-related weight gain impairs medication adherence in young patients with bipolar disorder. Many young patients would start pharmacologic treatment to mitigate SGA-related weight gain at treatment initiation, parents and clinicians are more hesitant. This research informs patient-centered perspectives on SGA adherence barriers and strategies to minimize potential side effects, which may improve adherence in this vulnerable patient population.


Asunto(s)
Antipsicóticos/uso terapéutico , Trastorno Bipolar/tratamiento farmacológico , Personal de Salud , Cumplimiento de la Medicación , Padres/psicología , Pacientes , Aumento de Peso/efectos de los fármacos , Adolescente , Actitud Frente a la Salud , Niño , Femenino , Personal de Salud/psicología , Personal de Salud/estadística & datos numéricos , Humanos , Internet , Masculino , Pacientes/psicología , Pacientes/estadística & datos numéricos , Encuestas y Cuestionarios
14.
Plast Reconstr Surg ; 153(4): 773-776, 2024 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-38546356
15.
Burns ; 45(5): 1066-1074, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-30824160

RESUMEN

TITLE: Prevalence and Risk Factors for Hypertrophic Scarring of Split Thickness Autograft Donor Sites in a Pediatric Burn Population. OBJECTIVE: The split-thickness autograft remains a fundamental treatment for burn injuries; however, donor sites may remain hypersensitive, hyperemic, less pliable, and develop hypertrophic scarring. This study sought to assess the long-term scarring of donor sites after pediatric burns. METHODS: A retrospective review of pediatric burn patients treated at a single institution (2010-2016) was performed. Primary outcomes were prevalence of donor site hypertrophic scarring, scarring time course, and risk factor assessment. RESULTS: 237 pediatric burn patients were identified. Mean age at burn was 7 yrs., mean %TBSA was 26% with 17% being Full Thickness. Mean follow-up was 2.4 yrs. Hypertrophic scarring was observed in 152 (64%) patients with 81 (34%) patients having persistent hypertrophic scarring through long-term follow-up. Patient-specific risk factors for hypertrophic scarring were Hispanic ethnicity (P=0.03), increased %TBSA (P=0.03), %Full Thickness burn (P=0.02) and total autograft amount (P=0.03). Donor site factors for hypertrophic scarring were longer time to epithelialization (P<0.0001), increased donor site harvest depth (P<0.0001), autografts harvested in the acute burn setting (P=0.008), and thigh donor site location (vs. all other sites; P<0.0001). The scalp, arm, foot, and lower leg donor sites (vs. all other sites) were less likely to develop HTS (P<0.0001, 0.02, 0.005, 0.002, respectively), along with a history of previous donor site harvest (P=0.04). CONCLUSIONS: Hypertrophic scarring is a prominent burden in donor site wounds of pediatric burn patients. Knowledge of pertinent risk factors can assist with guiding management and expectations.


Asunto(s)
Quemaduras/cirugía , Cicatriz Hipertrófica/epidemiología , Trasplante de Piel , Piel/patología , Sitio Donante de Trasplante/patología , Negro o Afroamericano , Superficie Corporal , Quemaduras/patología , Niño , Preescolar , Cicatriz Hipertrófica/etnología , Cicatriz Hipertrófica/patología , Femenino , Hispánicos o Latinos , Humanos , Masculino , Prevalencia , Repitelización , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Recolección de Tejidos y Órganos/métodos , Trasplante Autólogo , Población Blanca
16.
J Investig Med ; 53(5): 264-6, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-16042960

RESUMEN

BACKGROUND: Over the last two decades, pharmaceutical intervention for the treatment of type 2 diabetes has expanded. Studies over this same time demonstrated the benefits of tight glycemic control. Unfortunately, despite the availability of novel therapies, glycemic control remains problematic. Nonpharmacologic interventions need to be explored, including patient empowerment. Improving patient knowledge of diabetes may ultimately improve glycemic control. To test this hypothesis, we compared patients' diabetes knowledge with their glycemic control. METHODS: The Michigan Diabetes Knowledge Test, designed by the University of Michigan, was administered to patients with type 2 diabetes at three University of New Mexico primary care clinics. Patient records were reviewed. The most recent hemoglobin A1c (HbA1c) value was recorded. The data were analyzed using linear regression analysis. RESULTS: Seventy-seven patients completed surveys and had HbA1c values available. Only questions 1 to 14 of the 23-question survey were used because they pertained specifically to type 2 diabetes. HbA1c was inversely correlated with the number of questions answered correctly on the test (r = -.337, p < .003). Using "all subsets" regression, a correct response to questions 1, 3, and 9 specifically correlated with a lower HbA1c (p < .0001). CONCLUSIONS: These results demonstrate that an inverse linear relationship exists between performance on this diabetes test and HbA1c values. Improvement in patient knowledge of diabetes and the importance of treatment may indeed improve glycemic control and ultimately decrease complications. Studies aimed at empowering patients with disease knowledge may help control the ramifications of the growing diabetes epidemic.


Asunto(s)
Automonitorización de la Glucosa Sanguínea , Diabetes Mellitus Tipo 2/sangre , Manejo de la Enfermedad , Hiperglucemia/sangre , Educación del Paciente como Asunto , Diabetes Mellitus Tipo 2/terapia , Hemoglobina Glucada/análisis , Humanos , New Mexico , Atención Primaria de Salud , Universidades
18.
J Clin Mov Disord ; 1: 2, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-26788328

RESUMEN

BACKGROUND: Hydrocephalus is an under-recognized presentation of progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). METHODS: We describe four normal pressure hydrocephalus (NPH)-like presentations of pathology-proven PSP (n = 3) and DLB (n = 1) and review the literature on the hydrocephalic presentation of these atypical parkinsonisms. RESULTS: Despite the presence of ventriculomegaly disproportionate to the extent of parenchymal atrophy, all patients demonstrated early postural impairment and/or oculomotor abnormalities that encouraged a diagnostic revision. Hallucinations were the only early atypical manifestation of the hydrocephalic DLB presentation. CONCLUSIONS: Early postural impairment, falls, oculomotor impairment, and/or hallucinations are inconsistent with the diagnosis of NPH and suggest PSP or DLB as the underlying NPH mimic. We postulate that previously reported cases of "dual" pathology (e.g., NPH and PSP) actually represent the hydrocephalic presentation of selected neurodegenerative disorders.

20.
Clin Chem Lab Med ; 46(6): 791-803, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18601600

RESUMEN

BACKGROUND: The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the general population are too stringent for use in relatives, given the higher prior probability of a first-degree relative being FH (50% vs. 1/500). Our objective was therefore to develop more appropriate LDL-C cutoffs to identify "affected" first-degree relatives found by cascade testing, to test their accuracy and utility in case identification, and to compare them with the published "Make early diagnosis to prevent disease" (MEDPED) cutoffs from the US. METHODS: Using a large, anonymised sample of genetically tested first-degree relatives of Netherlands FH probands (mutation carriers/non-carriers, n=825/2,469), age- and gender-specific LDL-C diagnostic cutoffs for first-degree relatives were constructed. These were used to test similar data from Denmark (n=160/161) and Norway (n=374/742). RESULTS: Gender-specific LDL-C diagnostic cutoffs were established for six different age groups, which achieved an overall accuracy (measured as Youden's index) of 0.53 in the Netherlands data, and performed significantly better amongst younger (<25 years) compared to older first-degree relatives (0.68 vs. 0.42 Youden's index, p<0.001). Compared with the Netherlands data, age- and gender-adjusted mean LDL-C levels were significantly higher (approximately 0.5 mmol/L) in the Denmark and Norway subjects for both mutation carriers and non-carriers. After adjusting for this difference, the LDL-C cut-offs showed a similar accuracy in identifying mutation carriers from Denmark (81%, range 78%-86%) and Norway (84%, range 82%-86%). Although the MEDPED cutoffs performed significantly worse than these for the Netherlands data (p<0.001), they performed equally well in overall accuracy for the Norwegian and Danish data, although the LDL-C cutoffs had a significantly higher sensitivity but lower specificity for all three countries. CONCLUSIONS: The cutoffs developed here are designed to give the greatest overall accuracy when testing relatives of FH patients in the absence of a genetic diagnosis. They have a more balanced specificity and sensitivity than the MEDPED cutoffs that are designed to achieve higher specificity, which is more appropriate for cascade testing purposes. The data suggest that country-specific LDL-C cutoffs may lead to greater accuracy for identifying FH patients, but should be used with caution and only when a genetic diagnosis (DNA) is not available.


Asunto(s)
LDL-Colesterol/sangre , Hipercolesterolemia/diagnóstico , Adolescente , Adulto , Factores de Edad , Niño , Dinamarca , Reacciones Falso Negativas , Reacciones Falso Positivas , Familia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Países Bajos , Noruega , Sensibilidad y Especificidad , Factores Sexuales
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