Infiltration therapy in the context of cartilage surgery.

Guideline-based surgical cartilage therapy for focal cartilage damage offers highly effective possibilities to sustainably reduce patients' complaints and to prevent or at least delay the development of early osteoarthritis. In the knee joint, it has the potential to reduce almost a quarter of the arthroses requiring joint replacement caused by cartilage damage. Biologically effective injection therapies could further improve these results. Based on the currently available literature and preclinical studies, intra- and postoperative injectables may have a positive effect of platelet-rich plasma/fibrin (PRP/PRF) and hyaluronic acid (HA) on cartilage regeneration and, in the case of HA injections, also on the clinical outcome can be assumed. The role of a combination therapy with use of intra-articular corticosteroids is lacking in the absence of adequate study data and cannot be defined yet. With regard to adipose tissue-based cell therapy, the current scientific data do not yet justify any recommendation for its use. Further studies also regarding application intervals, timing and differences in different joints are required.

[The meaning of cartilage therapy in the treatment of FAIS : Is a specific cartilage therapy necessary or is deformity correction sufficient?] / Bedeutung der Knorpeltherapie in der Behandlung des FAIS : Ist eine spezifische Knorpeltherapie erforderlich oder reicht die Deformitätenkorrektur?

Femoroacetabular impingement syndrome (FAIS) surgery aims to restore the natural anatomical relationships between bones and the soft tissues comprising the hip joint. Most cartilage repair methods for the hip are based on basic science and strategies that were developed for the knee. Currently, there is a lack of information in the literature regarding systematic reviews on evidence-based options in treating cartilage injuries of the hip joint. The aim of this article is to assess treatment options and their related outcomes for chondral injuries in the hip based on the available evidence whilst highlighting new and innovative techniques.

[Intra-articular injury patterns as evidence of mechanical hip disorders]. / Intraartikuläre Schädigungsmuster als Hinweise auf mechanische Hüfterkrankungen.

FAIS is a well-defined clinical entity with morphological alterations, whether constitutional or acquired, that can lead to damage of the labrum and acetabular cartilage following distinct injury patterns with subsequent osteoarthritis. The combination pathology of cam and pincer deformity is the most common variant. The characteristic changes of the chondrolabral complex that are caused by the dysplasia differ from these FAIS changes. Furthermore, femoral torsion also has an impact on the clinical appearance of Cam- or Pincer-FAIS.

Primary stability of total hip stems: does surgical technique matter?

BACKGROUND: With this preliminary study we hypothesized a modified implantation technique may lead to higher primary stability than the conventional one. METHODS: In the conventional technique we used a sharp spoon to open the femoral cavity. Subsequently the opening was extended by increasing sizes of a sensing device to approve the final size. Finally, a bone compactor of the corresponding size was inserted in the cavity preparing it for implantation while compressing the surrounding cancellous bone. After initial opening of the femoral canal with a sharp spoon, the modified implantation technique was characterized by direct use of increasing sizes of bone compactors. A standardized procedure was implemented for micromotion analysis using LVDT's. Each specimen was positioned in a servo-hydraulic testing machine following a standardized test regime. A total of 1500 load cycles with a maximum hip reaction force of 1000 N were applied on each sample in three series of 500 cycles. The force was applied as a cyclic sinusoidal with a frequency of 1 Hz and a load ratio of R = 0.1. RESULTS: No significant differences of micromotion between implant and surrounding bone stock could be detected regarding conventional vs. modified implantation technique. However, independent of the surgical technique used, significant differences were observed for the operated side, i.e. backhand driving of right-handed surgeon resulted in higher interfacial micromotions at the left side. CONCLUSION: The results did not support our hypothesis. However, the correlation found between operated side and surgeon's backhand driving as a potential risk for reduced primary stability should encourage further investigations.

Bone mineral density after implantation of a femoral neck hip prosthesis--a prospective 5 year follow-up.

BACKGROUND: Bone resorption in the proximal femur due to stress shielding has been observed in a number of conventional cementless implants used in total hip arthroplasty. Short femoral-neck implants are claiming less interference with the biomechanics of the proximal femur. The goal of this study was to prospectively investigate the in vivo changes of bone-mineral density as a parameter of bone remodeling around a short, femoral neck prosthesis over the first 5 years following implantation. The secondary goal was to report on its clinical outcome. METHODS: We are reporting on the changes of bone mineral density of the proximal femur and the clinical outcome up to five years after implantation of a short femoral neck prosthesis. Bone mineral density was determined using dual energy x-ray absorptiometry, performed 10 days, three, 12 and 60 months after surgery. 20 patients with a mean age of 47 years (range 17 to 65) were clinically assessed using the Harris Hip Score. The WOMAC was used as a patient-relevant outcome-measure. RESULTS: In contrast to conventional implants DEXA-scans overall revealed a slight increase of bone mineral density in the proximal femur in the 12 months following the implantation. The Harris Hip Score improved from an average preoperative score of 46 to a postoperative score at 12 months of 91 points and 95 points at 60 months, the global WOMAC index from 5.3 preoperatively to 0.8 at 12 months and 0.6 at 60 months postoperatively. CONCLUSION: At 60 months after implantation of a short femoral neck prosthesis, all regions except one (region of interest #5) showed no significant changes in BMD compared to baseline measurements at 10 days which is less to the changes in bone mineral density seen in conventional implants.

Comparison of the subjective elbow value and the Mayo elbow performance score.

BACKGROUND: The aim of this study was to evaluate the subjective elbow value (SEV) and compare it with the Mayo Elbow Performance Score (MEPS). The SEV is defined as the patient's subjective estimation of the elbow as a percentage of a normal elbow, which would correspond to 100%. METHODS: The MEPS and the SEV were prospectively assessed in all patients treated for any elbow pathology. Two groups in this consecutive series were analyzed: (1) all first consultations (n = 241) and (2) all patients who had a preoperative consultation, a surgical procedure, and a postoperative consultation (n = 41). Statistical analysis included calculation of correlation and responsiveness of the scores. RESULTS: For the first consultations, the mean MEPS and SEV were 65 points and 60%, respectively. Both scores correlated (r = 0.671). The strongest correlation was found for female patients (r = 0.733) and for the diagnosis group of joint damage (r = 0.747). The standardized response means were 1.26 for the MEPS and 1.01 for the SEV, indicating that both scores detected an obvious change in the outcome. CONCLUSIONS: The SEV is an easily administered, responsive, valid tool to assess the condition of the elbow. It should be considered an adjunct to currently used scores because it only detects the subjective condition of the elbow.

Reverse total shoulder arthroplasty after failed deltoid flap reconstruction.

HYPOTHESIS: Reverse shoulder arthroplasty (RSA) yields unsatisfactory results after deltoid flap reconstruction due to defect of the deltoid muscle. METHODS: We retrospectively reviewed the outcome of 19 patients after failed deltoid flap reconstruction treated with RSA. Follow-up was after a mean of 4.5 years. RESULTS: Seven patients (37 %) had nine postoperative complications requiring totally 16 revision surgeries. Nonetheless, at latest follow-up, 17 patients had no or mild, two had moderate, and none had severe pain. Before RSA; 13 patients had a pseudoparesis. At latest follow-up, none of the patients had a pseudoparesis. Mean flexion was 121° (90°-160°). Abduction strength averaged 2.3 kg (range 0-5.4 kg). The mean constant score was 70 % (range 28-98 %). Of the 19 patients, 15 were very satisfied with the outcome, four were satisfied, and none was dissatisfied. The mean overall subjective shoulder value was 73 % (30-95 %) of the value of a normal shoulder. CONCLUSIONS: Despite of a localized defect of the deltoid muscle after deltoid flap repair, RSA can reliably be associated with a satisfactory outcome.

Injection-induced low-grade infection of the shoulder joint: preliminary results.

BACKGROUND: Purulent arthritis of the shoulder has been widely reported. Low-grade post-operative infections of the shoulder have also been observed. Low-grade infections of the shoulder without prior surgery have not been reported in the literature. The purpose of this study is to present our experience of seven patients with low-grade infections of the shoulder without a history of prior surgery. METHODS: We retrospectively reviewed seven patients, mean age of 45 years that originally presented with diffuse shoulder pain, with or without stiffness. None had prior surgery but all had prior injections, average 5.6, into the shoulder. All patients were treated with various arthroscopic procedures. All had harvesting of four tissue probes identifying low-grade infection. Pre/post-operative pain score, pre/post-operative range of motion, intraoperative findings, post-operative Constant score, Subjective Shoulder Value and pre/post operative radiographs were analyzed. Post-operative antibiotic therapy was recorded. RESULTS: All patients showed synovitis without pus or any other sign of infection. Propionibacterium acnes were identified in five, coagulase-negative Staphylococcus in two, and Staphylococcus saccharolyticus in one shoulder. One patient had a mixed infection (Propionibacterium acnes and coagulase-negative Staphylococcus). Therapy consisted of oral antibiotics for 1-6 months. Four patients had a satisfactory and three an unsatisfactory outcome. CONCLUSIONS: Diffuse shoulder pain with or without stiffness in patients without prior surgical history can be caused by low-grade infection. Treatment using oral antibiotics has unpredictable outcomes. Further studies are necessary to analyze this pathology. LEVEL OF EVIDENCE: Level IV, retrospective case series, treatment study.

Is there a need of custom-made prostheses for total hip arthroplasty? Gait analysis, clinical and radiographic analysis of customized femoral components.

INTRODUCTION: Custom-made prosthesis in primary hip arthroplasty based on the concept of a better press-fitting to reach superior clinical results in comparison to conventional implants. Mid-term results provide a more complete picture with respect to gait and electromyographic analyses. MATERIALS AND METHODS: The custom-made femoral component (Adaptiva) was implanted in 24 hips and compared to 23 hips with a conventional implant (Alloclassic-SL). The mean retrospective follow-up times were 3.9 (3-4.9) years and 4.8 (3.1-5.1) years. Clinically, the Harris Hip Score (HHS) and the SF 36 were recorded. Motion analysis data (body kinematics, kinetics and muscle activities) were recorded with 3D gait analysis. RESULTS: Neither the HHS nor the SF-36 revealed any statistical differences between the two groups (P > 0.05). The radiographic parameters did not show the intended physiologic load transfer. Periprosthetic changes indicated a more distal load transfer of the customized stem. Gait analysis revealed in comparison to the controls (45.03 degrees ), a reduced mean hip range of motion in the sagittal plane by 11.4% (39.9 degrees ) in the customized stem group versus 17.4% (37.2 degrees ) in the conventional stem group. In keeping with the limited range of hip motion kinematic impairments of the ipsilateral knee and ankle joints were detected. The electromyographic amplitudes of the tensor fasciae latae and gluteus medius muscles both for stabilizing the hip joint in the stance phase were significantly higher in both groups. CONCLUSION: Compared to a conventional cementless hip prosthesis the custom-made device did not improve the mid-term clinical and radiographic outcome. Despite the individualized reconstruction of the biomechanical hip geometry objective gait analysis failed to show a benefit.

Surgically Relevant Morphological Parameters of Proximal Human Femur: A Statistical Analysis Based on 3D Reconstruction of CT Data.

OBJECTIVES: Recently, more accurate description of the femoral geometry has become of interest to engineers and orthopedic surgeons. However, an appropriate database is lacking. Therefore, the aim of this study is to present morphological parameters and their correlations, which are relevant for medical issues such as impingement after total hip replacement, as well as for implant design and the etiology of hip fractures. METHODS: We investigated 12 well-known morphological parameters of the femur in 169 healthy human subjects through evaluation of 3D-reconstructed CT scans. Pearson's coefficients of correlations were calculated using a statistical t-test method for each pair of parameters. RESULTS: The mean, maximum, minimum, median, and standard deviation values are reported for all parameters. Histograms showing the distribution of each morphological parameter are also presented. It is shown that absolute and horizontal offsets, total femur length, and NCVD parameters are normally distributed, but NCDF and NCDS are not. Furthermore, an inter-correlation matrix was reported to reveal statistical correlations between these parameters. The strongest positive correlation existed between absolute offset (OSA) and horizontal offset (OSH), while the least positive correlation was found between NCDF and total femur length (TFL), and also between NCDS and NCDF. Anteversion angle (ATA) and OSA showed the least negative correlation. However, the strongest negative correlation was found between neck-shaft angle (NSA) and greater trochanter height (GTH), as well as between OSA and NCVD. CONCLUSIONS: Comprehending patients' native bone morphology, including the variations and correlations, is essential for orthopedic surgeons to undertake preoperative planning and surgery as well as to appropriately design medical devices. Thus, more population-based detailed databases are necessary. We investigated an extensive set of proximal femoral morphology parameters using a statistically standardized method to expand the existing knowledge. The results of our study can be used for diverse medical and biomechanical purposes.

Malpositioning of radial head prostheses: an in vitro study.

Nonanatomic insertion of radial head prostheses may result in maltracking and capitellar erosion. The purpose of this study was to analyze the ability to perform anatomic radial head replacement and to study radiocapitellar prosthetic subluxation under unstable conditions. In vitro measurements were performed in 10 intact elbows and after insertion of radial head prostheses (rigid uncemented, rigid cemented, bipolar). The diameter and length of the proximal radius were approximately restored. However, prosthesis-shaft malalignment, up to 21 degrees , was observed frequently. A posterolateral rotatory stress after resection of 50% of the coronoid caused a mean radiocapitellar subluxation of more than 30% for the rigid prostheses, whereas bipolar devices self-aligned with a mean subluxation similar to intact elbows. In conclusion, it was not possible to consistently insert radial head prostheses anatomically. Marked radiocapitellar subluxation occurred for the rigid but not for the bipolar implants. Clinical trials are needed to analyze these findings.

Morselized bone grafting in revision arthroplasty of the knee: a retrospective analysis of 34 reconstructions after 2-9 years.

BACKGROUND AND PURPOSE: Loosening of a total knee replacement may lead to loss of bone, requiring biological reconstruction at revision arthroplasty. Good results have been reported from revision arthroplasty of the hip using impaction bone grafting. We report our results of revision total knee arthroplasty using the same technique. PATIENTS AND METHODS: We retrospectively analyzed 30 patients (involving 34 knees) with a mean age of 63 (34-81) years who, between 1994 and 2002, underwent revision arthroplasty of the knee using hinge or rotational knee prostheses (Link) and impaction bone grafting. The average follow-up was 4 (2-9) years and included a questionnaire, a clinical examination, and standardized radiographs. RESULTS: 25 patients were satisfied with their results. 10 patients reported no impairment in their activities of daily living attributed to their operation and did not need any walking support. In 5 patients, there were no clear radiographic signs of incorporation of the graft but that did not compromise the outcome. 5 other patients had complications due to aseptic loosening of their prostheses with radiographic failure of the graft, leading to a periprosthetic fracture in 2 cases. INTERPRETATION: Our results with impaction bone grafting in knee revision arthroplasty appear to be similar to those obtained by the same technique in revision hip surgery.

Primary stability in cementless femoral stems: custom-made versus conventional femoral prosthesis.

OBJECTIVE: To compare a custom-made femoral stem with a conventional cementless stem for initial stability in human femurs. DESIGN: The bone-femoral prosthesis interface motion was measured in vitro using displacement transducers. Combined axial and torsional loads simulating single-leg stance, loading were applied. BACKGROUND: The custom-made prosthesis is a cementless femoral stem fabricated from the patient's CT-reconstruction. To justify its clinical use its design has to be tested regarding his primary stability. METHODS: Seven pairs of human cadaveric femurs were used for testing the custom-made prosthesis versus a conventional cementless stem. Subsidence, rotation and interface motion were measured with load cycles up to 2000 N. RESULTS: The critical interface motion of 150 microm for the cementless prosthesis was not exceed for both types of prosthesis. The custom-made prosthesis enlarged in its metaphyseal part showed a decrease of dynamic micromotions and rotation behavior in the proximal region compared to the Alloclassic prosthesis stem. CONCLUSIONS: The initial stability of the custom-made femoral stem was comparable to that of a conventional femoral stem. RELEVANCE: The data set for initial stability justifies the clinical use of a custom-made femoral stem in primary hip replacement. An individualized stem fit into the endosteal cortical bone decrease micromotion.

Postoperative development of bone mineral density and muscle strength in the lower limb after cemented and uncemented total hip replacement.

BACKGROUND: Numerous studies have shown reduction of periprosthetic bone mineral density (BMD) after hip replacement. The effect on the whole limb, however, is still unexplored. This study's objective was to analyse the postoperative development of BMD and muscle strength of the limb after total hip replacement (THR) and to determine links between these parameters. METHODS: 55 patients, who underwent THR, were included. Depending on therapeutic indication, either an uncemented stem (Group A, n=30) or a cemented stem (Group B, n=25) has been implanted. In the limbs, the measurement of BMD using DEXA and the maximum isometric muscle strength, detected by a leg press, were undertaken preoperatively and after 3, 6 and 12 months. RESULTS: A total of 12 patients (Group A: n = 6, Group B: n = 6) were excluded due to reasons which were not relevant to the study. So, the results refer to the data of 43 patients. In Group A (uncemented, n = 24), a significant decrease of BMD on the operated extremity was seen after 3, 6 and 12 months compared with preoperative values. Isometric muscle strength on the affected extremity increased significantly after 6 and 12 months. In Group B (cemented, n = 19), with a lower baseline compared to group A, an increase in BMD of the affected limb was seen postoperatively. This rise was significant after 12 months. With regard to the isometric muscle strength, a significant increase could be observed in this group after 6 and 12 months. CONCLUSION: Analogous to postoperative reduction of periprosthetic bone density, a decrease of the entire limb BMD on the operated leg occurred after implantation of uncemented hip stems. In contrast, an increase in BMD was recorded for cemented stems. Regardless of the type of anchoring, a substantial increase in muscular strength could be observed postoperatively in both groups.

The influence of arthroscopic subscapularis tendon and anterior capsular release on glenohumeral translation: a biomechanical model.

The effect of an arthroscopic release of the intraarticular portion of the subscapularis tendon and the anterior capsule on glenohumeral translation was investigated in a cadaveric model. Ten human cadaveric shoulders with a mean age of 63.5 years (range, 52-79 years) were tested in a robot-assisted shoulder simulator. Joint translation was measured before and after an arthroscopic release of the intraarticular portion of the subscapularis tendon and a subsequent release of the anterior capsule at 0 degrees , 30 degrees , 60 degrees , and 90 degrees of glenohumeral elevation. Translation was measured in the anterior, anterior-inferior, and inferior directions under 20 N of applied load. Testing of the specimen revealed that the release of the intraarticular portion of the subscapularis tendon and the anterior capsule increased translation in all directions. Significant increases in translation were observed after release of the intraarticular portion of the subscapularis tendon in the midrange of motion. The influence of the arthroscopic capsular release, in conjunction with the release of the subscapularis tendon, was very high above 60 degrees of elevation. The study indicates that the intraarticular component of the subscapularis tendon functions as a restraint to anterior-inferior translation primarily in the midrange of glenohumeral motion, whereas the anterior capsule adds anterior-inferior stability to the glenohumeral joint mainly above 60 degrees of elevation.