RESUMEN
The Fabry-Perot (F-P) interference model was used to make a 6-layer metasurface with cross-polarization that can be changed by heat. The fundamental concept behind the metasurface is to utilize the selectivity of linearly polarized waves by a metal grating to achieve broadband and efficient polarized conversion (PC). It also uses the thermal conversion properties of vanadium dioxide (VO2) to control the amplitude of terahertz (THz) waves in a dynamic way. While achromatic metalenses have been extensively studied, altering the entire spatial incidence angle remains relatively uncommon. Enter modulated orbital angular momentum (MOAM), a promising approach for applications such as holographic encryption, optical communication, and imaging. However, achieving MOAM multidimensional multiplexing has proven to be a significant challenge. In response to this challenge, we have integrated the transmission phase into the metasurface design. This new idea makes it possible to make a full spatially achromatic metalenses with angular multiplexing and makes MOAM multidimensional multiplexing easier by letting you switch between frequency, angle, and MOAM modes. This pioneering approach unveils new prospects for enhancing the capacity, rate, and quality of information exchange in domains such as optical encryption, optical imaging, optical communication, and other related technological fields.
RESUMEN
BACKGROUND: Precancerous lesions of cervical cancer exhibit characteristics indicative of natural progression. To prevent overtreatment of patients whose cervical intraepithelial neoplasia (CIN) in regression and to predict the onset of invasive cervical cancer at an early stage, we've identified the vaginal microbiome as a potential key factor, which is associated with both HPV infection and the various cervical intraepithelial neoplasia. This study aims to investigate the microbiome characteristics of patients with various cervical intraepithelial neoplasia. METHODS: Utilizing high-throughput 16S ribosomal RNA (16S rRNA) sequencing technology, a description of the characteristics and community composition of Vaginal Microbiota (VMB) was conducted among 692 Chinese women infected with the High-risk Human Papillomavirus (HR-HPV). RESULTS: As the grade of the lesions increased, the proportions of Lactobacillus and Pseudomonas demonstrated a significant declining trend, while the proportions of Gardnerella, Dialister, and Prevotella significantly increased. The diversity of the VMB was more significant in high-grade CIN. Furthermore, KEGG pathway enrichment analysis indicates that high-grade cervical intraepithelial neoplasia can inhibit various pathways, including those of phosphotransferase system, transcription factors, Fructose and mannose metabolism, amino sugar and nucleotide sugar metabolism, and galactose metabolism, which may contribute to the development of early cervical cancer symptoms. CONCLUSION: Patients with CIN exhibit a distinct vaginal microbial profile characterized by a decrease in Lactobacillus and Pseudomonas, and an increase in Gardnerella, Prevotella, and Dialister. The proliferation and diminution of these two types of microbial communities are interrelated, suggesting a mutual restraint and balance among them. Disruption of this regulatory balance could potentially lead to the onset of cervical lesions and carcinogenesis. Retrospectively registered: This study was approved by the Ethics Committee of the Beijing Chaoyang Hospital affiliated with the Capital Medical University (NO.2023-S-415).