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INTRODUCTION: Early cognitive decline may manifest in subtle differences in speech. METHODS: We examined 238 cognitively unimpaired adults from the Framingham Heart Study (32-75 years) who completed amyloid and tau PET imaging. Speech patterns during delayed recall of a story memory task were quantified via five speech markers, and their associations with global amyloid status and regional tau signal were examined. RESULTS: Total utterance time, number of between-utterance pauses, speech rate, and percentage of unique words significantly correlated with delayed recall score although the shared variance was low (2%-15%). Delayed recall score was not significantly different between ß-amyoid-positive (Aß+) and -negative (Aß-) groups and was not associated with regional tau signal. However, longer and more between-utterance pauses, and slower speech rate were associated with increased tau signal across medial temporal and early neocortical regions. DISCUSSION: Subtle speech changes during memory recall may reflect cognitive impairment associated with early Alzheimer's disease pathology. HIGHLIGHTS: Speech during delayed memory recall relates to tau PET signal across adulthood. Delayed memory recall score was not associated with tau PET signal. Speech shows greater sensitivity to detecting subtle cognitive changes associated with early tau accumulation. Our cohort spans adulthood, while most PET imaging studies focus on older adults.
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Enfermedad de Alzheimer , Disfunción Cognitiva , Adulto , Anciano , Humanos , Enfermedad de Alzheimer/patología , Amiloide/metabolismo , Péptidos beta-Amiloides/metabolismo , Encéfalo/patología , Disfunción Cognitiva/patología , Memoria , Tomografía de Emisión de Positrones/métodos , Habla , Proteínas tau/metabolismoRESUMEN
This study employs an auditory-visual associative priming paradigm to test whether non-emotional words uttered in emotional prosody (e.g., pineapple spoken in angry prosody or happy prosody) facilitate recognition of semantically emotional words (e.g., mad, upset or smile, joy). The results show an affective priming effect between emotional prosody and emotional words independent of lexical carriers of the prosody. Learned acoustic patterns in speech (e.g., emotional prosody) map directly to social concepts and representations, and this social information influences the spoken word recognition process.
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The discovery that listeners more accurately identify words repeated in the same voice than in a different voice has had an enormous influence on models of representation and speech perception. Widely replicated in English, we understand little about whether and how this effect generalizes across languages. In a continuous recognition memory study with Hindi speakers and listeners (N = 178), we replicated the talker-specificity effect for accuracy-based measures (hit rate and D'), and found the latency advantage to be marginal (p = 0.06). These data help us better understand talker-specificity effects cross-linguistically and highlight the importance of expanding work to less studied languages.
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Percepción del Habla , Voz , Humanos , Lenguaje , Reconocimiento en PsicologíaRESUMEN
Effects of word-level phonetic variation on the recognition of words with different pronunciation variants (e.g., center produced with/(out) [t]) are investigated via the semantic- and pseudoword-priming paradigms. A bias favoring clearly articulated words with canonical variants ([nt]) is found. By reducing the bias, words with different variants show robust and equivalent lexical activation. The equivalence of different word forms highlights a snag for frequency-based theories of lexical access: How are words and word productions with vastly different frequencies recognized equally well by listeners? A process-based account is proposed, suggesting that careful speech induces bottom-up processing and casual speech induces top-down processing.
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Aprendizaje por Asociación de Pares , Fonética , Reconocimiento en Psicología , Semántica , Acústica del Lenguaje , Percepción del Habla , Adulto , Atención , Señales (Psicología) , Femenino , Humanos , Masculino , Reconocimiento Visual de Modelos , Tiempo de Reacción , Espectrografía del SonidoRESUMEN
This study reports equivalence in recognition for variable productions of spoken words that differ greatly in frequency. General American (GA) listeners participated in either a semantic priming or a false-memory task, each with three talkers with different accents: GA, New York City (NYC), and Southern Standard British English (BE). GA/BE induced strong semantic priming and low false recall rates. NYC induced no semantic priming but high false recall rates. These results challenge current theory and illuminate encoding-based differences sensitive to phonetically-cued talker variation. The findings highlight the central role of phonetic variation in the spoken word recognition process.
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Señales (Psicología) , Fonética , Semántica , Acústica del Lenguaje , Percepción del Habla , Calidad de la Voz , Estimulación Acústica , Audiometría del Habla , Humanos , Reconocimiento en Psicología , Inteligibilidad del HablaRESUMEN
Given any feasible amount of time, a talker would never be able to produce the same word twice in an identical manner. Yet recognition memory experiments have consistently used identical tokens to demonstrate that listeners recognize a word more quickly and accurately when it is repeated by the same talker than by a different talker. These talker-specificity effects have served as the foundation of decades of research in speech perception, but the use of identical tokens introduces a confound: Is it the talker or the physical stimulus that drives these effects? And consequently, to what extent do listeners encode the high-level acoustic characteristics of a talker's voice? We investigate the roles of token and talker repetition in two continuous recognition memory experiments. In Exp. 1, listeners heard the voice of one talker, with either Identical or Novel repeated tokens. In Exp. 2, listeners heard two demographically matched talkers, with same-voice repetitions being either Identical or Novel. Classic talker-specificity effects were replicated in both Identical and Novel tokens, but recognition of Identical tokens was in some cases stronger than recognition of Novel tokens. In addition, recognition memory varied across demographically matched talkers, suggesting stronger episodic encoding for one talker than for the other. We argue that novel tokens should serve as the default design for similar studies and that consideration of talker variation can advance our understanding of encoding and memory differences more broadly.
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Percepción del Habla , Voz , Humanos , Reconocimiento en Psicología , AudiciónRESUMEN
When a listener hears a word (beef), current theories of spoken word recognition posit the activation of both lexical (beef) and sublexical (/b/, /i/, /f/) representations. No lexical representation can be settled on for an unfamiliar utterance (peef). The authors examined the perception of nonwords (peef) as a function of words or nonwords heard 10-20 min earlier. In lexical decision, nonword recognition responses were delayed if a similar word had been heard earlier. In contrast, nonword processing was facilitated by the earlier presentation of a similar nonword (baff-paff). This pattern was observed for both word-initial (beef-peef), and word-final (job-jop) deviation. With the word-in-noise task, real word primes (beef) increased real word intrusions for the target nonword (peef), but only consonant-vowel (CV) or vowel-consonant (VC) intrusions were increased with similar pseudoword primes (baff-paff). The results across tasks and experiments support both a lexical neighborhood view of activation and sublexical representations based on chunks larger than individual phonemes (CV or VC sequences).
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Inhibición Psicológica , Lingüística/métodos , Vocabulario , Humanos , Tiempo de Reacción , Percepción del Habla , Factores de TiempoRESUMEN
Speech serves a linguistic function, cueing sounds and words, and a social function, cueing talkers and their social attributes. Listeners readily map sound patterns in speech to social representations. This mapping introduces social biases on the recognition and encoding of sound patterns produced by different groups and individuals.
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Percepción Social , Percepción del Habla/fisiología , Habla , Vocabulario , HumanosRESUMEN
Spoken words are highly variable. A single word may never be uttered the same way twice. As listeners, we regularly encounter speakers of different ages, genders, and accents, increasing the amount of variation we face. How listeners understand spoken words as quickly and adeptly as they do despite this variation remains an issue central to linguistic theory. We propose that learned acoustic patterns are mapped simultaneously to linguistic representations and to social representations. In doing so, we illuminate a paradox that results in the literature from, we argue, the focus on representations and the peripheral treatment of word-level phonetic variation. We consider phonetic variation more fully and highlight a growing body of work that is problematic for current theory: words with different pronunciation variants are recognized equally well in immediate processing tasks, while an atypical, infrequent, but socially idealized form is remembered better in the long-term. We suggest that the perception of spoken words is socially weighted, resulting in sparse, but high-resolution clusters of socially idealized episodes that are robust in immediate processing and are more strongly encoded, predicting memory inequality. Our proposal includes a dual-route approach to speech perception in which listeners map acoustic patterns in speech to linguistic and social representations in tandem. This approach makes novel predictions about the extraction of information from the speech signal, and provides a framework with which we can ask new questions. We propose that language comprehension, broadly, results from the integration of both linguistic and social information.
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Microfluidic flow assays (MFA) that measure shear dependent platelet function have potential clinical applications in the diagnosis and treatment of bleeding and thrombotic disorders. As a step towards clinical application, the objective of this study was to measure how phenotypic and genetic factors, as well as experimental conditions, affect the variability of platelet accumulation on type 1 collagen within a MFA. Whole blood was perfused over type 1 fibrillar collagen at wall shear rates of 150, 300, 750 and 1500 s⻹ through four independent channels with a height of 50 µm and a width of 500 µm. The accumulation of platelets was characterized by the lag time to 1% platelet surface coverage (Lag(T)), the rate of platelet accumulation (V(PLT)), and platelet surface coverage (SC). A cohort of normal donors was tested and the results were correlated to plasma von Willebrand factor (VWF) levels, platelet count, hematocrit, sex, and collagen receptors genotypes. VWF levels were the strongest determinant of platelet accumulation. VWF levels were positively correlated to V(PLT) and SC at all wall shear rates. A longer Lag(T) for platelet accumulation at arterial shear rates compared to venous shear rates was attributed to the time required for plasma proteins to adsorb to collagen. There was no association between platelet accumulation and hematocrit or platelet count. Individuals with the AG genotype of the GP6 gene had lower platelet accumulation than individuals with the AA genotype at 150 s⻹ and 300 s⻹. Recalcified blood collected into sodium citrate and corn trypsin inhibitor (CTI) resulted in diminished platelet accumulation compared to CTI alone, suggesting that citrate irreversibly diminishes platelet function. This study the largest association study of MFA in healthy donors (nâ=â104) and will likely set up the basis for the determination of the normal range of platelet responses in this type of assay.
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Plaquetas/citología , Plaquetas/metabolismo , Colágeno Tipo I/química , Técnicas Analíticas Microfluídicas/métodos , Técnicas Analíticas Microfluídicas/normas , Adulto , Animales , Femenino , Caballos , Humanos , Masculino , Ratones , Variaciones Dependientes del Observador , Pruebas de Función Plaquetaria/métodos , Reproducibilidad de los ResultadosRESUMEN
Phonetic variation has been considered a barrier that listeners must overcome in speech perception, but has been proved beneficial in category learning. In this paper, I show that listeners use within-speaker variation to accommodate gross categorical variation. Within the perceptual learning paradigm, listeners are exposed to p-initial words in English produced by a native speaker of French. Critically, listeners are trained on these words with either invariant or highly-variable VOTs. While a gross boundary shift is made for participants exposed to the variable VOTs, no such shift is observed after exposure to the invariant stimuli. These data suggest that increasing variation improves the mapping of perceptually mismatched stimuli.