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1.
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Bioorg Med Chem Lett
; 21(11): 3452-6, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21515047
2.
Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.
J Med Chem
; 54(7): 2255-65, 2011 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21375264
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