Epidemiological and clinical risk factors related to severe COVID-19 in Iran: a multi-center study.

BACKGROUND: Iran was one of the first countries to be affected by COVID-19. Identifying factors associated with the severity of COVID-19 is effective in disease management. This study investigated the epidemiological and clinical features and factors related to the severity of COVID-19 in one of the less privileged areas in Iran. METHODS: In a multi-center study, all patients admitted to Zahedan University of Medical Sciences hospitals in southeastern Iran were investigated from February 29 to April 31, 2020. Demographic, epidemiological, and clinical data of patients were extracted from medical records. Bivariate and multivariate logistic regression models were used to explore the risk factors associated with the severity of COVID-19. RESULTS: Among the 413 patients, 55.5% were male, and 145 (35.10%) were in a severe condition at admission time. Multivariate analysis showed that the adjusted odds of the disease severity increased in patients with older age (OR 2.27; 95% CI 1.41-3.65), substance abuse (OR 2.49; 95% CI 1.14-5.43), having one underlying disease (OR 1.52; 95% CI 0.90-2.55), having two underlying disease (OR 2.31; 95% CI 1.19-4.50), and having three or more underlying disease (OR 2.60; 95% CI 1.19-5.66). CONCLUSIONS: COVID-19 was more severe in older patients, patients with a history of substance abuse, and patients with the underlying disease. Understanding the factors affecting the disease severity can help the clinical management of COVID-19, especially in less privileged areas where fewer resources are available.

Investigating medical student's attitudes about road accident risks: A cross-sectional study.

Background and Aims: Given that unsafe human actions are the main cause of accidents, it is essential to comprehend the attitudes of medical students toward the risks of road accidents, particularly given their potential influence as future healthcare professionals. Therefore, this study was carried out to investigate the attitudes of medical students towards road accidents. Methods: This cross-sectional study was conducted on 300 Zahedan University of Medical Sciences students in 2021 as available sampling. The required information was collected using a researcher-made questionnaire with a content validity ratio of 0.9, a content validity index of 0.9-0.8, and a reliability (α) of 0.79, which was presented online in the university systems. Statistical analysis was done using SPSS 23 software, data description was done as frequency and percentage, and analytical analysis was done with the χ 2 test. Results: The average age of the participants was 21.7 (4.2) years; 45.7% of the participants were male and 11.3% were married; 79.7% had less than 300 km of driving experience; 76% had less than 3 years since receiving their license; 14% stated that they drive faster than others; 18.3% reported a history of fines; and 28.3% reported an accident history. The most incorrect attitudes of students regarding low-risk using mobile phones (86%), text sending (84.3%), eating and drinking while driving (74.6%), driving after consuming alcohol or drugs (73%), and driving when tired and sleepy (85.4%) were reported. Conclusion: Based on the results, it is suggested to plan to correct wrong attitudes, especially among young and educated drivers, through education and culture, so that we can move in the direction of reducing accidents.

The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients.

BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity. MATERIAL AND METHOD: Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean ± SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. RESULTS: Among 80 type A hemophilia patients, 66 (82.5%) were male. The mean age was 15 ± 3.51 years. 12 (15%) of them were suffering from mild disease and 68 (85%) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 ± 0.78. The correlation between this ration and disease severity was 0.019. CONCLUSION: The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender.