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1.
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J Am Chem Soc
; 145(44): 24035-24051, 2023 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37874670
2.
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice.
J Pharmacol Exp Ther
; 387(2): 135-149, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37142442
3.
Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.
Pharm Res
; 38(6): 1031-1039, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-34009624
4.
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering.
J Immunol
; 195(7): 3198-205, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26320252
5.
Predicting pharmacokinetic profile of therapeutic antibodies after iv injection from only the data after sc injection in cynomolgus monkey.
Xenobiotica
; 47(3): 194-201, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-27151820
6.
Application of human FcRn transgenic mice as a pharmacokinetic screening tool of monoclonal antibody.
Xenobiotica
; 44(12): 1127-34, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25030041
7.
Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver chimeric mice.
Br J Pharmacol
; 181(7): 1091-1106, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-37872109
8.
Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations.
BioDrugs
; 37(1): 99-108, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36449140
9.
Physiologically based pharmacokinetic (PBPK) model that describes enhanced FcRn-dependent distribution of monoclonal antibodies (mAbs) by pI-engineering in mice.
Drug Metab Pharmacokinet
; 53: 100506, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38029470
10.
Prediction of nonlinear intestinal absorption of CYP3A4 and P-glycoprotein substrates from their in vitro Km values.
Pharm Res
; 29(3): 651-68, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913031
11.
Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation.
Pharmaceuticals (Basel)
; 15(5)2022 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631335
12.
Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering.
MAbs
; 14(1): 2068213, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35482905
13.
Simple Approach to Accurately Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies after Subcutaneous Injection in Humans.
Clin Pharmacokinet
; 60(1): 111-120, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32779124
14.
Estimation of Clearance and Bioavailability of Therapeutic Monoclonal Antibodies from Only Subcutaneous Injection Data in Humans Based on Comprehensive Analysis of Clinical Data.
Clin Pharmacokinet
; 60(10): 1325-1334, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33954956
15.
A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target.
AAPS J
; 23(1): 21, 2021 01 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33415498
16.
Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.
Br J Pharmacol
; 178(21): 4335-4351, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34232502
17.
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.
Cancer Discov
; 11(1): 158-175, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32847940
18.
Model analysis of the concentration-dependent permeability of P-gp substrates.
Pharm Res
; 27(3): 442-6, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20135207
19.
Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering.
Drug Metab Pharmacokinet
; 34(1): 25-41, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30472066
20.
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
PLoS One
; 13(12): e0209509, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30592762