1.
Biochim Biophys Acta Mol Basis Dis
; 1870(1): 166848, 2024 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37586438
RESUMEN
N-propargylglycine prevents 4-hydroxyproline catabolism in mouse liver and kidney. N-propargylglycine is a novel suicide inhibitor of PRODH2 and induces mitochondrial degradation of PRODH2. PRODH2 is selectively expressed in liver and kidney and contributes to primary hyperoxaluria (PH). Preclinical evaluation of N-propargylglycine efficacy as a new PH therapeutic is warranted.