Detalles de la búsqueda
1.
Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg Med Chem
; 26(3): 647-660, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29291937
2.
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.
Bioorg Med Chem
; 25(14): 3719-3735, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28522264
3.
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.
Bioorg Med Chem
; 25(17): 4876-4886, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28760529
4.
Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs).
Bioorg Med Chem Lett
; 25(10): 2037-40, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891103
5.
Molecular modeling, design, synthesis, and biological activity of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives as potassium-competitive acid blockers.
Chem Pharm Bull (Tokyo)
; 62(4): 336-42, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24695343
6.
High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.
EBioMedicine
; 102: 105073, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38520916
7.
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
Bioorg Med Chem
; 21(8): 2333-2345, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23498918
8.
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.
Bioorg Med Chem
; 20(24): 7051-8, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23123015
9.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22763369
10.
Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.
Bioorg Med Chem
; 20(12): 3925-38, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22579619
11.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22883026
12.
Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.
Bioorg Med Chem
; 18(20): 7260-73, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833055
13.
N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
Bioorg Med Chem
; 18(20): 7150-63, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833551
14.
Prediction of Compound Bioactivities Using Heat-Diffusion Equation.
Patterns (N Y)
; 1(9): 100140, 2020 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33336198
15.
Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one.
Bioorg Med Chem
; 17(23): 7993-8002, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19861238
16.
Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.
ChemMedChem
; 14(10): 1022-1030, 2019 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-30945818
17.
Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Partâ 2.
ChemMedChem
; 14(24): 2093-2101, 2019 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31697454
18.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30652849
19.
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.
ACS Med Chem Lett
; 10(10): 1498-1503, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620240
20.
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
PLoS One
; 12(10): e0186587, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29065190