RESUMEN
Anionic nucleotides adenosine monophosphate or guanosine monophosphate interact with cationic vesicles, exchange with the counteranions of the amphiphiles in situ, and organize themselves at the membrane surfaces. Such organized nucleotides reciprocally transfer their chirality to membranes of nonchiral amphiphiles to induce the formation of right-handed micrometric helices on the time scale of hours. The kinetics of the nucleotide molecular organization and the formation of supramolecular helices was followed. We have shown that helix formation is a kinetic-dependent process that does not primarily result from ion exchange but from conformational reorganization and formation of weak interactions between confined nucleotides.
Asunto(s)
Conformación de Ácido Nucleico , Nucleótidos/química , Aniones , Carbono/química , Cationes , Enlace de Hidrógeno , Cinética , Espectroscopía de Resonancia Magnética , Microscopía de Contraste de Fase/métodos , Conformación Molecular , Nanopartículas/química , Nanotecnología/métodos , Polímeros/química , Espectrofotometría Infrarroja/métodos , Propiedades de Superficie , Tensoactivos/química , Factores de TiempoRESUMEN
The handedness of nanometrical helices based on surfactant assemblies was inverted when these helices were in contact with an excess solution of chiral anions with opposite enantiomers. An important difference in the kinetics of chirality inversion at the molecular level and mesoscopic level was observed.