The influence of iris -ciliary angle (ICA) on the vault after implantation of V4c implantable collamer lens: a chain mediation model of ICL haptic related factors.

BACKGROUND: This study aims to identify the relationship between iris -ciliary angle (ICA) and the vault. Additionally, we also seek to investigate the chain mediating effects of the ICL haptic related factors on this relationship. METHODS: The participants were categorized into three groups according to the ICA value as follows: low ICA group (< 35°); moderate ICA group (35°-70°); high ICA group (> 70°). We compared the preoperative ocular characteristics and postoperative examinations among the three groups. Multiple variable stepwise regression was performed to establish the vault prediction formula. The Process V4.0 in SPSS and Hayes's PROCESS model 6 was conducted to further elucidate the mediating effects of the final tip point of ICL haptic and the ICL arc-lens arc on the relationship between the ICA and vault. RESULTS: There was a significant difference in the positions of the ICL haptic among three ICA groups. The regression vault equation was Vault = 679.42-7.26*TCA + 192.30*ACD-196.37*CLR + 73.21* STS(horizontal).A significant negative correlation was found between the ICA and vault (P < 0.01).The chain mediation model revealed that the final tip point of ICL haptic and the ICL arc-Lens arc were sequential mediators between ICA and vault (effect = -1.63, 95% CI = -2.72--0.73). CONCLUSION: The ICA was associated with vault via the mediation effect of the final tip point of the ICL haptic and the ICL arc -lens arc. Assessment of ICL haptic related parameters adds significant information to interpret the vault after surgery.

Spontaneous rotation of a toric implantable collamer lens related to abnormal ciliary body morphology: a case report.

BACKGROUND: This is a case of spontaneous toric implantable collamer lens (TICL) rotation that occurred twice in the left eye of a patient. CASE PRESENTATION: A 24-year-old gentleman received TICL implantation for treatment of myopic astigmatism encountered with spontaneous rotation of approximately 90° from its original position. TICL reposition procedure was performed with visual outcome of 20/16. Surprisingly, a re-rotation of TICL occurred. The patient underwent a replacement of non-toric ICL with a larger size after careful re-evaluation with final visual outcome of 20/20. A short and small ciliary process with shallow ciliary sulcus and posteriorly positioned ciliary body was found by Ultrasound Biomicroscopy (UBM). CONCLUSIONS: The unique morphology of the ciliary body may have a potential association with the vault and instability of implanted ICL. Careful examination of the ciliary body morphology is essential in preoperative evaluation.

Corneal power measurement with a new aberrometer/corneal topographer in eyes after small incision lenticule extraction for myopia.

PURPOSE: To assess corneal power measurements obtained by the OPD SCAN III Topographer in eyes with prior myopic small incision lenticule extraction (SMILE) surgery. METHODS: Sixty untreated myopic eyes of sixty subjects and forty previous myopic SMILE surgery eyes of forty subjects were consecutively enrolled in the present study. Manifest refraction, OPD SCAN III and Pentacam HR were performed. Keratometric measurements assessed by OPD SCAN III-simulated keratometry, average pupil power and effective central corneal power (ECCP) were compared with mean keratometry (Km) obtained by Pentacam HR in the untreated group and the clinical history method (CHM) in the treated group. RESULTS: In the untreated group, no statistically significant differences were revealed between all corneal power measurements obtained with OPD SCAN III and Km. In the treated group, all the corneal power measurements were statistically different from the CHM except for the Haigis method and the Shammas method, while ECCP had a statistically but not clinically significant overestimation of 0.42 D with 95% limit of agreement (LOA) of - 0.81 D to 1.64 D. The three modified ECCP had better prediction performance with narrower 95% of LOA lying in (- 1.20, 1.20 D) (- 1.22, 1.23 D) and (- 0.90, 1.00 D), respectively. CONCLUSIONS: The ECCP provided with OPD SCAN III could be used as an alternative option for the CHM after specific modifications in eyes with previous myopic SMILE surgery when the preoperative data are unavailable considering the narrowest agreement between the modified ECCP and the CHM. Otherwise, caution must be raised considering the wide LOA.

Characteristics and factors associated with the position of the haptic after ICL V4C implantation.

PURPOSE: To assess the position of implantable collamer lens (ICL) haptic after ICL V4C implantation using standardized panoramic ultrasound bimicroscopy (UBM), to analyze its characteristics, associated factors, and the relationship with the clinical vault quantitatively. SETTING: Hankou Aier Eye Hospital, Wuhan, Hubei, China. DESIGN: Cross-sectional study. METHODS: 167 subjects (323 eyes) implanted with ICL V4C who had a 3-month follow-up with UBM examination were included in this study. The relative position of ICL to the adjacent structure and ICL haptic-related parameters (the final tip point of ICL haptic [ftICL haptic], measured from the scleral spur to the final tip of the ICL haptic, the posterior of the ICL to ICL haptic [ICL arc], measured from the posterior surface of the ICL to the ICL haptic plane, and the height of the crystalline lens from the ICL haptic (lens arc), measured from the anterior surface of the crystalline lens to the ICL haptic plane and other parameters), were estimated on the UBM image. Eyes were divided into 3 subgroups according to the ftICL haptic (Group 1: ≤0.5 mm; Group 2: 0.5 to 1.0 mm; and Group 3:≥1.0 mm, respectively), and the factors associated with the ICL haptic-related parameters and their impact on the clinical vault were evaluated. RESULTS: The haptics could be imaged in the ciliary sulcus, on the ciliary body, and under the ciliary body in 629 (48.7%), 525 (40.6%), and 138 (10.7%) eyes, respectively. The ftICL haptic and the summation of ICL arc and lens arc showed a correlation with the clinical vault ( r = -0.34, P = .00; r = 0.87, P = .00). When the ftICL haptic results were divided into 3 groups, the percentage of eyes that exhibited clinical vault >750 µm were lowest in Group 3. Multivariate regression analysis showed spherical equivalent, white-to-white (WTW), anterior chamber volume (ACV) and iris-ciliary angle (ICA); the difference between the implanted ICL size and horizontal sulcus-to-sulcus (ICL size-STS) were associated with the ftICL haptic. The IOP, WTW, ACV, and the ICL size-STS were significantly associated with ICL arc, while the ICA and lens rise were associated with lens arc. CONCLUSIONS: The position of ICL haptic was associated with the clinical vault. Its quantitative evaluation may provide valuable information to help clinicians to select the best ICL size before surgery and understand the formation of clinical vault after surgery.

Cadmium distribution in rice plants grown in three different soils after application of pig manure with added cadmium.

A glasshouse pot experiment was conducted to investigate Cd concentrations in the aboveground parts of two consecutive crops of rice and Cd availability in three different soils (loam, silt loam, and sandy loam) after application of pig manure with added Cd. Soil pH tended to increase with increasing application rate of pig manure from 1 to 3% (w/w, oven dry basis). Soil diethylene triamine pentaacetic acid (DTPA) extractable Cd showed a clear positive correlation with soil total Cd content and increased with increasing Cd amendment of the manure but showed no difference between the two manure application rates. Cd concentrations in the grain, husk, and straw were significantly and positively correlated with soil DTPA-extractable Cd (p < 0.001). Within each level of manure Cd, the higher rate (3%) of manure produced lower Cd concentrations in the grain, husk, and straw on all three soils than did the lower rate (1%) after the first crop, but this no longer occurred after the growth of the second crop. Grain Cd concentrations exceeded the Chinese National Food Quality Standard (0.2 mg kg(-1)) most often on the loam, with intermediate frequency on the silt loam, and least often on the sandy loam, the soil with the highest pH and lowest organic carbon content and cation exchange capacity.

A novel analysis of Scheimpflug total corneal refractive power following corneal cross-linking in mild to moderate keratoconus.

AIM: To detect an earlier improvement in mild to moderate keratoconus following corneal cross-linking (CXL) with total corneal refractive power (TCRP) using ray tracing method. METHODS: A total of 40 eyes of 30 consecutive patients who underwent CXL for progressive keratoconus were retrospectively enrolled. The following keratometric parameters provided by Pentacam HR, including maximum keratometry (Kmax), steepest keratometry (Ksteep), 3 mm zonal TCRP centered over corneal apex (TCRPapex,zone 3 mm), zonal mean keratometry and TCRP centered over corneal cone (Kmcone,zone and TCRPcone,zone 1, 2, 3 mm) were evaluated preoperatively and 1, 3, 6, and 12mo postoperatively. Groups 1 and 2 were defined based on Kmax at postoperative 1mo as improved (the initial improvement group) or worsen (the initial deterioration group) compared to the preoperative level. RESULTS: In the overall group, only keratometric parameters based on ray tracing method displayed significant improvement early at 3mo postoperatively, in which TCRPcone,zone 1 mm and 2 mm exhibited the largest flattening (0.57 D and 0.53 D, respectively). In Group 1, only Kmax, Kmcone,zone 2 mm and TCRPcone,zone 2 mm showed significant improvement initially at 1mo postoperatively, in which Kmax exhibited the largest improvement (1.05 D), followed by TCRPcone,zone 2 mm (0.82 D). In Group 2, only keratometric parameters based on ray tracing method and Kmcone,zone 3 mm showed slight but not significant improvement early at 3mo, in which TCRPcone,zone 3 mm displayed the most improvement (0.19 D), followed by TCRPcone,zone 2 mm (0.15 D). CONCLUSION: The findings indicate that a 2 mm zonal TCRP centered over Kmax could earlier detect keratometric improvement by CXL compared to other commonly used parameters in mild to moderate keratoconic eyes.

Clinical Prediction of Excessive Vault After Implantable Collamer Lens Implantation Using Ciliary Body Morphology.

PURPOSE: To determine the factors related to the ciliary body that are predictive of outcomes of excessive vault (> 1,000 µm) after Implantable Collamer Lens (ICL V4c; STAAR Surgical) implantation. METHODS: In this retrospective case-control study, 27 eyes of 27 patients who presented with excessive vault (> 1,000 µm) following implantation of an ICL V4c were matched in a 1:2 ratio with those who presented with a normal vault (250 to 1,000 µm) on white-to-white distance, anterior chamber depth, and ICL size. The preoperative biometric parameters and clinical outcomes were compared between the two groups. The relationship between the postoperative vault and various variables was assessed by multiple linear regression analysis. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% CIs for excessive vault. RESULTS: The vault value 1 month postoperatively was associated with preoperative anterior chamber volume, iris-ciliary angle, and crystalline lens rise (P < .05). In the conditional regression logistic analysis, every 1° reduction in iris-ciliary angle was associated with 4% increased odds of vault greater than 1,000 µm (OR = 0.96; 95% CI = 0.93 to 0.99; P < .001) and the anteriorly positioned ciliary body was associated with an increased risk of excessive vault after ICL implantation (OR = 3.57; 95% CI = 1.67 to 7.63; P < .001). In the excessive vault group, 1 eye underwent the ICL extraction and 3 eyes had an ICL exchange for a smaller ICL. After the ICL exchange, the mean value of postoperative vault decreased from 1,525.67 ± 468.22 to 810.33 ± 254.92 µm. CONCLUSIONS: Eyes with an anteriorly positioned ciliary body were associated with a higher rate of excessive vault after ICL implantation, so the size of the ICL may need to be adjusted in these patients. Assessment of ciliary body characteristics adds significant information to the prediction of excessive vault after surgery. [J Refract Surg. 2020;36(6):380-387.].

A Comparative Study of Total Corneal Power Using a Ray Tracing Method Obtained from 3 Different Scheimpflug Camera Devices.

PURPOSE: We sought to assess the agreement of ray-traced corneal power values by 3 Scheimpflug tomographers tp construct the corresponding arithmetic adjustment factor in comparison with an automated keratometer (IOLMaster) and a conventional Placido-based topographer (Allegro Topolyzer). DESIGN: Prospective reliability analysis. METHODS: A total of 74 eyes from 74 healthy subjects who underwent corneal power measurements using Pentacam, Sirius, Galilei, IOLMaster, and Allegro Topolyzer were included. Ray-traced corneal power values, such as total corneal refractive power (TCRP), mean pupil power (MPP), total corneal power (TCP), mean keratometry (Km), and simulated keratometry (SimK) were recorded respectively and analyzed using one-way analysis of variance (ANOVA) and Bland-Altman plots. RESULTS: Among the 3 ray-traced corneal power values, TCRP and MPP did not differ significantly (P = 0.81), whereas TCP presented a slightly significant larger value (P < 0.001). Compared to Km or SimK, corneal power measurements by the ray tracing method exhibited significantly lower values (P < 0.001). Bland-Altman plots disclosed that the 3 Scheimpflug tomographers showed similar 95% limits of agreement after arithmetic adjustment compared with Km (-0.40 to 0.40 D, -0.39 to 0.39 D, and -0.35 to 0.34 D) or SimK (-0.50 to 0.51 D, -0.43 to 0.42 D, and -0.46 to 0.46 D). CONCLUSIONS: Ray-traced corneal power values obtained using 3 Scheimpflug tomographers with default diameter settings were similar, indicating that they could be used interchangeably in daily clinical practice. The 3 Scheimpflug tomographers were satisfactory in agreement after arithmetical adjustment compared with conventional automated keratometer or Placido-based topographer.

Comprehensive evaluation of total corneal refractive power by ray tracing in predicting corneal power in eyes after small incision lenticule extraction.

PURPOSE: To assess the prediction accuracy of four variations of total corneal refractive power (TCRP) by the ray tracing method in determining corneal power in eyes after myopic small incision lenticule extraction (SMILE). METHODS: Forty eyes of forty patients who had undergone myopic SMILE were enrolled in this prospective study. Manifest refraction and Pentacam HR were performed preoperatively and three months or more postoperatively. Mean keratometry (Km), true net power (TNP), equivalent keratometry readings (EKR) and 4 subtypes of TCRP (pupil centered or apex centered within a ring or a zone)-TCRPpupil,ring, TCRPpupil,zone, TCRPapex,ring and TCRPapex,zone-were recorded and compared to the theoretical postoperative keratometry value using the clinical history method (CHM). RESULTS: The only keratometric values that showed no statistically significant differences from the CHM were 4.0 mm and 4.5 mm EKR, 6.0 mm TCRPpupil,zone and TCRPapex,zone. Pearson's correlation test revealed that 4.0 mm TCRPpupil,zone exhibited the highest correlation coefficient (r = 0.974) followed by TCRPapex,zone 4.0 mm (0.972) and EKR 4.5 mm (0.970). The 95% limits of agreement (LOA) of the 4.0 mm EKR and CHM, the 4.5 mm EKR and CHM, the 6.0 mm TCRPpupil,zone and CHM, the 6.0 mm TCRPapex,zone and CHM were (-1.27 to 1.22 D), (-1.04 to 0.98 D), (-1.39 to 1.08 D) and (-1.38 to 0.96 D), respectively, while the modified 4.0 mm TCRPpupil,zone (TCRPpuil,zone + 0.70 D) and TCRPapex,zone (TCRPapex,zone+0.70 D) yielded the narrowest 95% LOA of (-0.96 to 0.95 D) and (-0.96D, 1.05 D). CONCLUSIONS: Total corneal refractive power using the ray tracing method could predict corrected corneal power derived from the CHM in eyes following SMILE surgery after simple modification.

Corneal Power Measurement With the Dual Scheimpflug-Placido Topographer After Myopic Excimer Laser Surgery.

PURPOSE: To evaluate the ability of the Sirius Scheimpflug-Placido Topographer (Costruzione Strumenti Oftalmici, Florence, Italy) in predicting corneal power in eyes with previous myopic corneal refractive surgery. METHODS: The following corneal refractive power measurements were obtained with Sirius in 38 eyes with prior myopic excimer laser surgery: simulated keratometry (SimK), true net power based on the Gaussian optical formula (TNP), and the mean pupil power (MPP) calculated by ray tracing within the diameter of the entrance pupil range from 2.5 to 6 mm. These values, along with the corresponding keratometric value, which was based on the equation that converted the MPP within 4.5-mm entrance pupil diameter to a keratometric reading in 75 myopic eyes, were compared using the clinical history method. RESULTS: SimK significantly overestimated corneal power by 0.67 ± 0.52 diopters (D), whereas TNP significantly underestimated corneal power by -1.05 ± 0.48 D. The only measurements that showed no statistically significant difference by the clinical history method were the 5 mm MPP, 5.5 mm MPP, and KMPP4.5POST, and the 95% limits of agreement (LOA) were -1.10 to 0.62, -0.91 to 0.89, and -0.67 to 1.05 D, respectively. CONCLUSIONS: The Sirius Scheimpflug-Placido Topographer is an alternative method of measuring corneal power in eyes with previous corneal refractive surgery for myopia when preoperative data are not available. The best options seem to be the 5 mm MPP, 5.5 mm MPP, and the keratometric reading calculated from the regression formula.

Evaluation of Equivalent Keratometry Readings Obtained by Pentacam HR (High Resolution).

PURPOSE: To assess the repeatability of Equivalent Keratometry Readings (EKRs) obtained by the Pentacam HR (high resolution) in untreated and post-LASIK eyes, and to compare them with the keratometry (K) values obtained by other algorithms. METHODS: In this prospective study, 100 untreated eyes and 71 post-LASIK eyes were included. In the untreated group, each eye received 3 consecutive scans using the Pentacam HR, and EKR values in all central corneal zone, the true net power (Knet) and the simulated K (SimK) were obtained for each scan. In the post-LASIK group, each eye received subjective refraction and 3 consecutive scans with the Pentacam HR preoperatively. During the 3-month post-surgery exam, the same examinations and the use of an IOLMaster were conducted for each eye. The EKRs in all zone, the Knet, the mean K (Km) by IOLMaster and the K values by clinical history method (KCHM) were obtained. The repeatability of the EKRs was assessed by the within-subject standard deviation (Sw), 2.77Sw, coefficient of variation (CVw) and intraclass correlation coefficient (ICC). The bonferroni corrected multiple comparisons were performed to analyze the differences among the EKRs and K values calculated by other algorithms within the 2 groups. The 95% limits of agreement (LoA) were calculated. RESULTS: The EKR values in all central corneal zone were repeatable in both the untreated group (Sw≦0.19 D, 2.77Sw≦0.52 D, CVw≦1%, ICC≧0.978) and the post-LASIK group (Sw≦0.22 D, 2.77Sw≦0.62 D, CVw≦1%, ICC≧0.980). In the untreated group, the EKR in 4mm zone was close to SimK (P = 1.000), and the 95% LoA was (-0.13 to 0.15 D). The difference between Knet and SimK was -1.30±0.13 D (95% LoA -1.55 to -1.55 D, P<0.001). In the post-LASIK group, all the EKRs were significantly higher than KCHM (all P<0.001). The differences between the EKR in 4mm zone and KCHM, the EKR in 7mm zone and KCHM, Knet and KCHM, Km and KCHM, SimK and Knet were 0.64±0.50 D (95% LoA, -0.33 to 1.62 D), 1.77±0.88 D (95% LoA, 0.04 to 3.51 D), -0.98±0.48 D (95% LoA, -1.92 to -0.04 D), 0.64±0.53 D (95% LoA, -0.40 to 1.68 D), and 1.73±0.20 D (95% LoA, 1.33 to 2.13 D), respectively. CONCLUSIONS: The EKRs obtained by the Pentacam HR were repeatable in both untreated eyes and post-LASIK eyes. Compared to the total corneal power obtained by the clinical history method, the EKR values generally overestimated the total corneal power in post-LASIK eyes. So, further calibrations for the EKR values should be conducted, before they were used for the total corneal power assessment in post-LASIK eyes.

Evaluation of corneal thickness using a Scheimpflug-Placido disk corneal analyzer and comparison with ultrasound pachymetry in eyes after laser in situ keratomileusis.

PURPOSE: To evaluate the repeatability and reproducibility of corneal thickness measurements in post-laser in situ keratomileusis (LASIK) eyes using a rotating Scheimpflug camera combined with a Placido disk corneal topographer (Sirius) and compare the results with those of ultrasound (US) pachymetry. SETTING: Eye Hospital of Wenzhou Medical College, Wenzhou, China. DESIGN: Comparative evaluation of a diagnostic test or technology. METHODS: Patients were examined 3 times with the Scheimpflug-Placido topographer by 2 examiners. The central pupil corneal thickness (CTpupil), apical corneal thickness (CTapex), and thinnest corneal thickness (CTthinnest) were recorded. After noncontact examinations, US pachymetry was used to obtain the central corneal thickness (CCT). RESULTS: The Scheimpflug-Placido topographer showed high intraoperator repeatability as indicated by a test-retest repeatability of less than 8.5 µm for CTpupil, CTapex, and CTthinnest, The coefficients of variation (CoV) were less than 0.7%, and the intraclass correlation coefficient was higher than 0.99. Excellent results were also obtained for interoperator reproducibility. All CoVs were less than 0.5%. The 95% limits of agreement between the Scheimpflug-Placido measurement and the US pachymetry measurements were narrow (-16.62 to 12.44 µm for CTpupil versus US pachymetry CCT; -17.49 to 12.16 µm for CTapex versus US pachymetry CCT; -18.59 to 10.90 µm for CTthinnest versus US pachymetry CCT). CONCLUSIONS: The Scheimpflug-Placido topographer showed excellent intraoperator repeatability and interoperator reproducibility of CTpupil, CTapex, and CTthinnest measurements in post-LASIK eyes. The CCT measurements obtained using the device were in high agreement with those obtained by US pachymetry, suggesting that the 2 devices are interchangeable. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

[Effects of Sedum plumbizincicola--Oryza sativa rotation and phosphate amendment on Cd and Zn uptake by O. sativa].

In a pot experiment, hyperaccumulator Sedum plumbizincicola and low-cadmium accumulating Oryza sativa cultivar "Zhongxiang No. 1" were planted in rotation on a heavy metals-polluted soil, and calcium magnesium phosphate (Ca-P) and rock phosphate (P-R) were amended, aimed to study the effects of the rotation and phosphate amendment on the growth of the two plants and the zinc- and cadmium accumulation in their shoots. After the amendment of 50 g P-R x kg(-1), the Zn and Cd uptake by S. plumbizincicola was 11.5 mg x pot(-1) and 0 x 79 mg x pot(-1), respectively, being significantly higher than that after the amendment of 4 g Ca-P x kg(-1). After the planting of S. plumbizincicola, the Zn and Cd concentrations in "Zhongxiang No. 1" increased, but the amendment of Ca-P decreased the accumulation of Zn and Cd in rice shoot significantly. The rotation with S. plumbizincicola and the amendment of Ca-P and P-R could immobilize the Zn and Cd in the contaminated soil as indicated by the quantitative change of NH4OAc-extractable Cd and Zn, and the efficiency of amendment with Ca-P was better than that of amendment with P-R. Field trial showed that amendment with Ca-P could not only increase the rice yield, but also reduce the Zn and Cd accumulation in rice shoot to a certain extent.