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Burns ; 50(6): 1578-1585, 2024 08.
Artículo en Inglés | MEDLINE | ID: mdl-38582695

RESUMEN

BACKGROUND: This study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence of concomitant bacterial inoculation. METHODS: Eight equal burn wounds were created on six Yorkshire swine. Half the wounds were randomized to post-burn bacterial inoculation. Wounds were subsequently randomized to three treatments groups: no intervention, CI-PRJ012, or silver sulfadiazine cream. At study end, a blinded pathologist evaluated wounds for necrosis and bacterial colonization. RESULTS: When comparing CI-PRJ012 and silver sulfadiazine cream to no treatment, both agents significantly reduced the amount of necrosis and bacteria at 7 days after wound creation (p < 0.01, independently for both). Further, CI-PRJ012 was found to be significantly better than silver sulfadiazine (p < 0.02) in reducing bacterial colonization. For wound necrosis, no significant difference was found between silver sulfadiazine cream and CI-PRJ012 (p = 0.33). CONCLUSIONS: CI-PRJ012 decreases necrosis and bacterial colonization compared to no treatment in a swine model. CI-PRJ012 appeared to perform comparably to silver sulfadiazine. CI-PRJ012, which is easily removed with the application of room-temperature water, may provide clinical advantages over silver sulfadiazine.


Asunto(s)
Antibacterianos , Quemaduras , Modelos Animales de Enfermedad , Necrosis , Sulfadiazina de Plata , Cicatrización de Heridas , Animales , Quemaduras/tratamiento farmacológico , Quemaduras/microbiología , Quemaduras/patología , Sulfadiazina de Plata/uso terapéutico , Proyectos Piloto , Porcinos , Cicatrización de Heridas/efectos de los fármacos , Antibacterianos/uso terapéutico , Antiinfecciosos Locales/uso terapéutico , Hidrogeles/uso terapéutico , Vendajes , Infección de Heridas/tratamiento farmacológico , Infección de Heridas/prevención & control , Distribución Aleatoria
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