RESUMEN
OBJECTIVE: To observe the antitussive and antiasthmatic effects of Radix Fici Hirtae (RFH). METHODS: Antitussive effects were observed by ammonia water steaming test in mice and by citric acid test in guinea pigs. Antiasthmatic actions in guinea pigs were observed by histamine and acetylcholine ultrasonic atomization test, involved isolated guinea pig tracheal smoth muscle experiment and anaphylactic shock of guinea pigs. RESULTS: RFH decreased the frequency of cough induced by ammonia in mice and by citric acid in guinea pig, prolonged the latent period of cough and inhibited the experimental asthma by histamine and acetylcholine solution in conscious guinea pigs, antagonisted the contraction of tracheal smooth muscle by histamine phosphate in guinea pigs and could compete anaphylactic shock in guinea pigs. CONCLUSION: RFH has obvious antitussive and antiasthmatic effects.
Asunto(s)
Antitusígenos/uso terapéutico , Tos/tratamiento farmacológico , Medicamentos Herbarios Chinos/uso terapéutico , Expectorantes/uso terapéutico , Moraceae , Acetilcolina/administración & dosificación , Anafilaxia/inducido químicamente , Anafilaxia/tratamiento farmacológico , Animales , Antitusígenos/administración & dosificación , Antitusígenos/farmacología , Asma/inducido químicamente , Asma/tratamiento farmacológico , Astragalus propinquus/química , Ácido Cítrico/administración & dosificación , Tos/inducido químicamente , Medicamentos Herbarios Chinos/administración & dosificación , Medicamentos Herbarios Chinos/farmacología , Expectorantes/administración & dosificación , Expectorantes/farmacología , Femenino , Cobayas , Histamina , Masculino , Ratones , Moraceae/química , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Fitoterapia , Raíces de Plantas/química , Distribución Aleatoria , Tráquea/efectos de los fármacosRESUMEN
Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model. After administration of RRF (141, 282, and 564 mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH). But no significant impact on serum lutenizing hormone (LH) level was observed. As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated. And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate. Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment. Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration. The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome.