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1.
Ann Oncol ; 25(12): 2363-2372, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25223482

RESUMEN

BACKGROUND: The GeparQuinto study showed that adding bevacizumab to 24 weeks of anthracycline-taxane-based neoadjuvant chemotherapy increases pathological complete response (pCR) rates overall and specifically in patients with triple-negative breast cancer (TNBC). No difference in pCR rate was observed for adding everolimus to paclitaxel in nonearly responding patients. Here, we present disease-free (DFS) and overall survival (OS) analyses. PATIENTS AND METHODS: Patients (n = 1948) with HER2-negative tumors of a median tumor size of 4 cm were randomly assigned to neoadjuvant treatment with epirubicin/cyclophosphamide followed by docetaxel (EC-T) with or without eight infusions of bevacizumab every 3 weeks before surgery. Patients without clinical response to EC ± Bevacizumab were randomized to 12 weekly cycles paclitaxel with or without everolimus 5 mg/day. To detect a hazard ratio (HR) of 0.75 (α = 0.05, ß = 0.8) 379 events had to be observed in the bevacizumab arms. RESULTS: With a median follow-up of 3.8 years, 3-year DFS was 80.8% and 3-year OS was 89.7%. Outcome was not different for patients receiving bevacizumab (HR 1.03; P = 0.784 for DFS and HR 0.974; P = 0.842 for OS) compared with patients receiving chemotherapy alone. Patients with TNBC similarly showed no improvement in DFS (HR = 0.99; P = 0.941) and OS (HR = 1.02; P = 0.891) when treated with bevacizumab. No other predefined subgroup (HR+/HER2-; locally advanced (cT4 or cN3) or not; cT1-3 or cT4; pCR or not) showed a significant benefit. No difference in DFS (HR 0.997; P = 0.987) and OS (HR 1.11; P = 0.658) was observed for nonearly responding patients receiving paclitaxel with or without everolimus overall as well as in subgroups. CONCLUSIONS: Long-term results, in opposite to the results of pCR, do not support the neoadjuvant use of bevacizumab in addition to an anthracycline-taxane-based chemotherapy or everolimus in addition to paclitaxel for nonearly responding patients. CLINICAL TRIAL NUMBER: NCT 00567554, www.clinicaltrials.gov.


Asunto(s)
Inhibidores de la Angiogénesis/uso terapéutico , Anticuerpos Monoclonales Humanizados/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Sirolimus/análogos & derivados , Adulto , Inhibidores de la Angiogénesis/administración & dosificación , Anticuerpos Monoclonales Humanizados/administración & dosificación , Bevacizumab , Neoplasias de la Mama/metabolismo , Quimioterapia Adyuvante , Quimioterapia Combinada , Everolimus , Femenino , Humanos , Persona de Mediana Edad , Receptor ErbB-2/metabolismo , Sirolimus/administración & dosificación , Sirolimus/uso terapéutico , Análisis de Supervivencia
2.
Can J Ophthalmol ; 12(3): 223-5, 1977 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-890594

RESUMEN

In the investigation of a patient with choroidal melanoma in one eye and repaired rhegmatogenous retinal detachment in the other, a C.T. scan demonstrated the tumour in the right globe and the encircling silastic sponge around the left globe. These radiologic findings were confirmed on histological examination of the right eye. We believe C.T. scanning may be a valuable technique for investigating bulbar and para-bulbar soft tissue abnormalities.


Asunto(s)
Neoplasias de la Coroides/diagnóstico , Melanoma/diagnóstico por imagen , Curvatura de la Esclerótica , Tomografía Computarizada por Rayos X , Adulto , Neoplasias de la Coroides/complicaciones , Neoplasias de la Coroides/diagnóstico por imagen , Femenino , Humanos , Melanoma/complicaciones , Desprendimiento de Retina/cirugía
3.
Can J Ophthalmol ; 24(7): 327-30, 1989 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-2696577

RESUMEN

In a consanguineous family of two siblings, both with nanophthalmos, one was found to also have bilateral exfoliation syndrome. This combination of conditions has not, to our knowledge, previously been reported and has not had any apparent negative consequences. Her sister has manifested typical complications of nanophthalmos, including angle-closure glaucoma initially and, eventually, severe uveal effusion after cataract surgery.


Asunto(s)
Enfermedades del Cristalino/complicaciones , Microftalmía/complicaciones , Anciano , Extracción de Catarata/efectos adversos , Femenino , Glaucoma de Ángulo Cerrado/etiología , Humanos , Enfermedades del Cristalino/diagnóstico , Microftalmía/diagnóstico , Persona de Mediana Edad , Síndrome , Tonometría Ocular , Ultrasonografía , Enfermedades de la Úvea/etiología , Agudeza Visual
4.
Can J Ophthalmol ; 26(6): 328-33, 1991 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-1751917

RESUMEN

A 56-year-old man presented with a left ciliary body mass, anterior vitreous hemorrhage and a subluxed, cataractous lens. The clinical course included rapid enlargement of the mass, anterior uveitis, cataract progression and secondary glaucoma. Investigation included fluorescein angiography, ultrasonography and computed tomography. The eye was enucleated because of progressive enlargement with poor vision and uncontrolled secondary glaucoma. Histopathological examination showed an adenoma of the nonpigmented ciliary epithelium with cystic areas of hyaluronidase-sensitive acid mucopolysaccharide. The mass distorted the iris, occluded the angle structures and produced a complete cataract. The basement membrane of the adjacent ciliary processes was extensively thickened. The authors discuss the clinical association with vitreous hemorrhage and the local damage caused by this benign tumour.


Asunto(s)
Adenoma/patología , Cuerpo Ciliar/patología , Epitelio Pigmentado Ocular/patología , Neoplasias de la Úvea/patología , Adenoma/diagnóstico por imagen , Catarata/etiología , Cuerpo Ciliar/diagnóstico por imagen , Enucleación del Ojo , Humanos , Subluxación del Cristalino/etiología , Masculino , Persona de Mediana Edad , Epitelio Pigmentado Ocular/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Ultrasonografía , Neoplasias de la Úvea/complicaciones , Neoplasias de la Úvea/diagnóstico por imagen , Hemorragia Vítrea/etiología
5.
Arch Pharm (Weinheim) ; 324(11): 841-6, 1991 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-1804060

RESUMEN

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no correlation between the "minimum structure" of Krebs and Schaltegger concerning antipsoriatic activity and the inhibitory effects against 5-lipoxygenase.


Asunto(s)
Antralina/análogos & derivados , Inhibidores de la Lipooxigenasa/síntesis química , Psoriasis/tratamiento farmacológico , Animales , Antralina/síntesis química , Antralina/farmacología , Bovinos , Cromatografía Líquida de Alta Presión , Humanos , Técnicas In Vitro , Inhibidores de la Lipooxigenasa/farmacología , Inhibidores de la Lipooxigenasa/uso terapéutico , Masoprocol/farmacología , Neutrófilos/efectos de los fármacos , Neutrófilos/enzimología , Relación Estructura-Actividad
6.
Artículo en Alemán | MEDLINE | ID: mdl-9340034

RESUMEN

Introduction of air into the arterial circulation can cause cerebral air embolism, leading to severe neurological deficits. A case is reported on a patient suffering from fatal cerebral air embolism after a subclavian vein catheter had been inserted. The risks associated with inserting and removing central venous catheters are described. Apart from the pathogenesis of a paradoxical air embolism in a patient with a right-to-left shunt due to a patent foramen ovale, air embolism can occur if a large amount of air traverses the pulmonary circulation. The ability of the pulmonary vasculature to filter air may be exceeded by a bolus injection of more than 30 ml air. Air embolism is suspected if acute neurological symptoms occur after inserting a central venous catheter. Echocardiography, especially transoesophageal echocardiography. Is highly sensitive in detecting air emboli in the ventricles. Treatment is effected with hyperbaric oxygen and standard measures of intensive-care medicine.


Asunto(s)
Cateterismo Venoso Central/instrumentación , Catéteres de Permanencia , Embolia Aérea/etiología , Embolia y Trombosis Intracraneal/etiología , Anciano , Embolia Aérea/diagnóstico por imagen , Resultado Fatal , Humanos , Embolia y Trombosis Intracraneal/diagnóstico por imagen , Masculino , Radiografía , Factores de Riesgo , Vena Subclavia
7.
Ultraschall Med ; 25(6): 448-9, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15597240

RESUMEN

We present a patient with Hodgkin's disease in whom computed tomography suggested focal lesions in the liver. As no lesions were detected by diagnostic ultrasound, magnetic resonance imaging (MRI) with iron oxide as contrast medium was performed for verification. MRI confirmed at least 3 small lesions. The ultrasound study performed immediately after this MRI scan easily detected these lesions. A biopsy was taken and histology showed infiltrates of Hodgkin's disease. The change in echogenicity of the liver and/or the lymphomatous tissue may be an effect of iron oxide. This observation has not been reported before.


Asunto(s)
Medios de Contraste , Compuestos Férricos , Enfermedad de Hodgkin/diagnóstico por imagen , Adulto , Biopsia , Femenino , Enfermedad de Hodgkin/patología , Humanos , Hígado/patología , Estadificación de Neoplasias , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos X , Ultrasonografía
8.
Arch Pharm (Weinheim) ; 324(11): 899-906, 1991 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-1804068

RESUMEN

HaCaT keratinocyte cultures were exposed to twelve hydrophilic anthralin derivatives 1 to 12 with substituents at C-1 and C-8 of the anthrone skeleton, of one H at C-10 and of both H's at C-10 by lacton rings. After 3 microM treatment growth was determined by cellular protein content, 3H-thymidine- and 14C-amino-acid-uptake and cytotoxicity by the release of cytoplasmic LDH into the culture medium. In comparison to acetone control (100%) anthralin suppressed mean protein content, as well as DNA- and protein-synthesis to 33, 28, and 21%, respectively, and the drug revealed an enzyme release of 660%. In relation to the parent drug we found similar cell growth inhibitory effects of compounds 4, 6, 8, 9, 10, and 12. Deriv. 4, 8, and 10 were, however, to some extent less cytotoxic than anthralin, whereas deriv. 6, 9, and 12 were in the same range. An extreme suppression of growth parameters which differed from the anthralin effect by a factor 0.5-0.8 was caused by deriv. 11, showing the same cytotoxicity. Deriv. 1, 2, 3, 5, and 7 did not demonstrate any cytotoxicity. Concerning growth parameters, deriv. 2 induced a slight stimulation, deriv. 3 and 7 were completely ineffective, deriv. 1 and 5 induced slightly to moderately inhibited proliferation but both being much less effective than anthralin. These data indicate that the "minimum structure" concept by Krebs and Schaltegger--claiming 1-hydroxy-9-anthrone as a precondition for clinical antipsoriatic potency--is not valid at least in cell-biological tests and point toward possible usefulness of some experimental model compounds as alternative antipsoriatics.


Asunto(s)
Antralina/análogos & derivados , Antralina/farmacología , Supervivencia Celular/efectos de los fármacos , Queratinocitos/efectos de los fármacos , Células Cultivadas , Humanos , L-Lactato Deshidrogenasa/metabolismo , Relación Estructura-Actividad
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