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Recently, synthesized Chevron graphene nanoribbons (CGNRs) and its laterally extended counterpart known as extended CGNRs (ECGNR) are constructed by making alternated regular cuts in pristine graphene nanoribbons (GNRs). First-principles calculations demonstrate that these GNRs are super-ductile and possess width-dependent mechanical properties. The Young's modulus is calculated to be 389.4 GPa and 414.6 GPa for CGNR and ECGNR, respectively. The bandgap of these nanoribbons decreases on the application of tensile strain. The carrier effective masses are found to be highly sensitive towards mechanical strains. The holes (electrons) mobility of ECGNR is calculated to be 7.68 × 104 cm2 V-1 s-1 (1.69 × 104 cm2 V-1 s-1), which is higher than that of CGNR can be further enhanced by elongation. The prominent peaks of the imaginary part of dielectric function and electron energy loss spectra show redshift on increasing the tensile strain. The electron energy loss spectra show intense plasmonic structure in low energy spectrum indicating GNRs to be more sensitive to the visible region than ultra violet spectrum. Our results provide insight about the possible applications of GNRs in the fields of high-speed transistors, sensors, photonics, and optoelectronics.
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Introduction: Unilateral intertrochanteric fractures are common injuries in elderly population. Simultaneous bilateral intertrochanteric fractures do occur but are very rare and only a few cases have been reported in the literature. Case Report: We report two cases with different modes of injury. Both cases were fixed in a single stage by proximal femoral nailing (PFN). The first case had multiple comorbidities and after 6 weeks of follow up, she suddenly expired at home due to medical issue. The second case is the only case reported with associated bilateral superior and inferior pubic rami fracture. PFN was done in a single stage and at 1-year follow-up, the patient was having a good functional outcome. Conclusion: Simultaneous bilateral intertrochanteric fractures are very rare injuries but these are potentially life-threatening with high morbidity. Quick assessment and early single-stage stabilization with proximal femoral nail give stable fixation and good functional outcome.
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AIM: This article investigates the oral health preferences of parents residing in rural areas for their children, including dental maintenance and treatment. MATERIALS AND METHODS: Data were collected through a cross-sectional survey of 500 parents who sought dental consultation for their children between two and seven years old, excluding those with systemic or neurological disorders. Demographic characteristics, including child and parent age and gender, family structure, and parental education levels, were collected using self-administered questionnaires. RESULTS: The study on oral health preferences of rural parents reveals the following key trends: peak dental treatment interest at six years old (104 children), slight gender disparity favoring males (54.8%), prevalent joint family structures (58%), and families with two children (48%). Most mothers marry before age 21 (62.8%), with varied education levels. Toothpaste and toothbrushes are preferred by the majority (65.2%) for oral hygiene. Common treatments include oral prophylaxis (164), pulpectomy/pulpotomy (114), and extractions (86). However, significant gaps exist: 62.8% do not grasp the importance of primary teeth, and 72% lack knowledge about specific treatments and drug-induced tooth problems, urging targeted educational strategies. CONCLUSION: The study's outcome focuses on parental preferences for oral hygiene maintenance and their choices for dental treatment in primary dentition. The results highlight the influence of various factors on parental preferences and underscore the importance of improving parental knowledge for better oral health outcomes in rural populations.
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Background Presently, modern regenerative and surgical techniques for immediate implant placement in prepared sockets with soft tissue grafts and bone substitutes have helped eliminate concerns about bone deficiency. This also allowed the placement of dental implants based on prosthodontic needs. Aim The present study aimed to comparatively assess dental implant healing following immediate implant placement with or without bone graft and dental implant healing after delayed implant placement with or without bone graft. Methods The study included 120 study subjects that were divided into two groups. Group I for immediate implant placement with or without bone graft (n=60) and Group II for delayed implant placement with or without bone graft (n=60). These two groups were further divided into subgroups. Group I subjects were further divided into two subgroups, where Group A (n=30) subjects underwent immediate implant placement with bone graft and Group B (n=30) subjects were given immediate implant placement without bone graft. Group II participants were further divided into two subgroups, where Group C (n=30) subjects underwent delayed implant placement with bone graft and Group D (n=30) subjects underwent delayed implant placement without bone graft. In the two groups, crestal bone levels were compared radiographically preoperatively and postoperatively at the immediate postoperative time, three months, and six months. Results More reduction in the crestal bone level was seen in the immediate implant placement group at three and six months postoperatively compared to the delayed implant placement group. A non-significant reduction in crestal bone levels was seen in the immediate implant placement with bone graft group with p>0.05 at three and six months compared to immediate implant placement without bone graft. Similar, non-significant crestal bone loss was seen in the delayed implant placement with bone graft group at three and six months compared to delayed implant placement with bone graft. Conclusions This study concluded that healing of crestal bone in the delayed implant placement group with or without bone graft is better in comparison to the immediate implant placement group with or without bone graft.
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Context: The link between oral infections and systemic disease is a well-proven hypothesis in the current literature. This relationship is the result of interaction between periodontal microbe that triggers inflammatory processes leading to the secretion of cytokines and other mediators of inflammation resulting in the systemic effects of pathogenesis. Materials and Methods: In this study, erythrocyte sedimentation rate (ESR), probing pocket depth, plaque index, gingival index, and the parameters were assessed initially and 1 month after scaling and root planing (SRP). Statistical Analysis Used: The paired t-test and the Pearson correlation were needed to examine and compare measured data. Results: The data from the study reveal that all the clinical parameters like the plaque index, the gingival index, and the probing pocket depth were statistically significantly reduced after 1 month of SRP with respect to baseline. While ESR mean value was also reduced, that is, 3.27 ± 1.24 mm/hr which was also considered statistically significant. Conclusions: The findings from the study showed a positive correlation between periodontal inflammation and ESR.
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For tissue engineering applications, cell adhesion and proliferation are crucial factors, and blending polymers is one of the most effective ways to create a biocompatible scaffold with desired properties. In order to create new potential porous, biodegradable scaffolds using salt leaching technique, poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) were blended in different ratios. SEM, BET, FTIR, and water contact angle measurements were used to analyze the scaffolds' porous surface, surface area, and roughness, chemical interaction, and hydrophilicity. Additionally, a hemolysis assay revealed that the mixtures were hemocompatible and had no impact on red blood cells. Different cells- Vero, Hela and MDBK cell lines cultured on the porous mats of these biopolymeric scaffolds exhibited significant increase in cell viability and attachment over time. The overall finding was that blended scaffolds exhibited reduced crystallinity, diverse porosity, higher surface area and hydrophilicity, and better cell viability, proliferation and adhesion. Our findings imply that a blended scaffold could be more suitable for use in tissue engineering applications.
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Polihidroxialcanoatos , Andamios del Tejido , Andamios del Tejido/química , Poliésteres/farmacología , Poliésteres/química , Supervivencia Celular , Ingeniería de Tejidos/métodos , Proliferación Celular , Materiales Biocompatibles/químicaRESUMEN
Anti-inflammatory therapies currently in use mainly include steroidal and non-steroidal drugs. Contrary to their side effects, the steroid hormones glucocorticoids, which are synthetic versions of natural cortisol, are nevertheless often employed to treat a variety of inflammatory disorders. Other drug class of choice is non-steroidal drugs which mainly target COX-2 and hence the synthesis of prostaglandins, particularly PGE2. To cure both the short-term effects of chronic inflammatory disorders and the long-term symptoms of acute inflammation, pharmaceutical chemists are in continuous search for more potent and less toxic agents. Apart from these two drug classes, phytochemicals are gaining the attention of researchers as source of alternative antiinflammatory agents. However, every drug class has its own advantages or disadvantages thus requiring intervention of newer approaches. Currently, drugs used for anti-inflammatory therapies are costly with low efficacy, high health risk, and socio-economic impact due to the concern issue of their toxicity. Recently, nano-drug delivery system has been experiencing main interest as a new approach for targeting therapeutic agents to the target sites in a controlled, sustained manner and has various advantages as compared to the conventional drug delivery system like, increased solubility, bioavailability, improved pharmacokinetic profile of drugs, surface area and rate of dissolution and additionally, overcomes the problems related to hydrophobicity, toxicity. Present review summarized the intervention of nanotechnology to overcome the limitations/ risk associated with current anti-inflammatory drugs of different classes.
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Antiinflamatorios no Esteroideos , Antiinflamatorios , Humanos , Antiinflamatorios no Esteroideos/uso terapéutico , Antiinflamatorios/uso terapéutico , Nanotecnología , Sistemas de Liberación de Medicamentos , Enfermedad CrónicaRESUMEN
Polyhydroxyalkanoates (PHAs) are natural polyesters produced by microorganisms as a source of intracellular energy reserves. Due to their desirable material characteristics, these polymers have been thoroughly investigated for tissue engineering and drug delivery applications. A tissue engineering scaffold serves as a substitute of the native extracellular matrix (ECM) and plays a crucial role in tissue regeneration by providing temporary support for cells during natural ECM formation. In this study, porous, biodegradable scaffolds were prepared using native polyhydroxybutyrate (PHB) and PHB in nanoparticulate form using salt leaching method, to investigate the differences in the physicochemical properties such as crystallinity, hydrophobicity, surface morphology, roughness, and surface area and biological properties of the prepared scaffolds. As per the BET analysis, PHB nanoparticles-based (PHBN) scaffolds presented a significant difference in the surface area as compare to PHB scaffolds. PHBN scaffolds showed decreased crystallinity and improved mechanical strength as compared to PHB scaffolds. Thermogravimetry analysis shows delayed degradation of PHBN scaffolds. An examination of Vero cell lines' cell viability and adhesion over time revealed enhanced performance of PHBN scaffolds. Our research suggests that scaffold made of PHB nanoparticles could serve as a superior material for tissue engineering applications than its native form.
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Huesos , Polihidroxialcanoatos , Andamios del Tejido/química , Ingeniería de Tejidos/métodos , Poliésteres/química , Hidroxibutiratos/químicaRESUMEN
Objective: The objective of this article is to study the impact of coronavirus disease 2019 (COVID-19) pandemic first wave on the in-hospital length of stay of operated proximal femur fractures. Materials and Methods: A retrospective analysis of data collected through the electronic record system of the hospital, after applying inclusion and exclusion criteria, was done. The data were collected from the pre-pandemic, early part first wave and later part first wave of COVID-19 pandemic to calculate the average preoperative stay (POS) and total length of stay (LOS) of operated proximal femur fracture patients. Also, a sub-analysis of POS and LOS was done as per age (male/female), sex (<60/≥60 years) and fracture subtype (intertrochanteric, neck of femur and subtrochanteric fracture) of the patients to study if any of these had a significant direct impact on the POS and LOS. Results: The LOS and POS were found to be significantly increased during early part of first wave of COVID-19 pandemic in comparison to the pre-pandemic era (13.6 ± 7.7 days vs. 11.1 ± 5.7 days). The later part of the first wave of the pandemic however saw the LOS and POS to return to near pre-pandemic values, although still remaining higher. Conclusion: The study highlights that unpreparedness during the early part of the unprecedented pandemic event leads to a significant increase in LOS of operated patients with its associated implications; however, prompt action by the government, hospital administration and hospital staff the LOS could be reduced to near pre-pandemic values in the later part of the first wave of the pandemic. Analysis of the causes that lead to a significant increase in LOS can help for better future management of similar events in future.
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Background: Despite various complications and failure factors, newer implants are designed that allow placement in sub-optimal conditions to allow the operator to place implants at sites with low bone quality. These newer designs also allow improved stability with higher survival rates in the short term. Aims: The present study was undertaken to evaluate long-term efficacy and risk factors associated with dental implant placement for full mouth rehabilitation. Materials and Methods: In 24 subjects, 438 implants were placed. The data collected were surgical and were retrospectively analyzed. The data collected included medical history, local, patient satisfaction, marginal bone loss, and systemic risk factors affecting implant survival. Outcome variables assessed were peri-implantitis, implant success, and survival at the follow-up visit. The data were expressed in terms of percentage and number, and the results were derived. Results: Peri-implantitis was seen in 31.05% (n = 136) of implants. 76.02% (n = 333) of implants were considered successful at recall. Concerning survival, compromised and satisfactory survival was shown by 10.04% (n = 44) and 2.96% (n = 13) of implants, respectively. 10.95% (n = 48) of implants were considered as failures. Conclusion: The present study concludes that good, long-term survival rates are associated with full mouth rehabilitation using dental implants.
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Background: Less residual alveolar bone at extraction site at esthetic and functional tooth position is the main limitation in placing a dental implant, especially at long-span edentulous ridges. This needs ridge augmentation. Aims: To assess bone width gain and implant stability following narrow ridge augmentation using the vertical ridge split technique. Materials and Methods: In 22 subjects within the age group of 20-60 years and the mean age of 38.46 years. The vertical ridge split technique was done in all subjects for horizontal ridge augmentation. Paraesthesia, pain/discomfort, mobility, and radiographic crestal bone width were assessed 6 months postoperatively. The data were described as mean and standard deviation along with number and percentage. Paired t-test was also used keeping the level of significance at P < 0.05. Results: Implant stability was seen in 86.36% (n = 19) study subjects and were not stable in 13.63% (n = 3) subjects. Bone width preoperatively was in the range of 3.1-4.4 mm with the mean value of 3.64 ± 0.41. Postoperatively, the bone width increased and was in the range of 5.2-6.3 mm with the mean value of 5.62 ± 0.45 mm. This increase postoperatively was statistically significant with a P value of <0.001. Conclusion: The present study concludes that acceptable success results are seen using the ridge split technique with simultaneous dental implants placement in both atrophic maxilla and mandible.
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Our body is built to heal from inside out naturally but wide-ranging medical conditions necessitate the need for artificial assistance, and therefore, something that can assist the body to heal wounds and damaged tissues quickly and efficiently is of utmost importance. Tissue engineering technology helps to regenerate new tissue to replace the diseased or injured one. The technology uses biodegradable porous three-dimensional scaffolds for mimicking the structure and functions of the natural extracellular matrix. The material and design of scaffolds are critical areas of biomaterial research. Biomaterial-based three-dimensional structures have been the most promising material to serve as scaffolds for seeding cells, both in vivo and in vitro. One such material is polyhydroxyalkanoates (PHAs) which are thermoplastic biopolyesters that are highly suitable for this purpose due to their enhanced biocompatibility, biodegradability, thermo-processability, diverse mechanical properties, non-toxicity and natural origin. Moreover, they have tremendous possibilities of customization through biological physical and chemical modification as well as blending with other materials. They are being used for several tissue engineering applications such as bone graft substitute, cardiovascular patches, stents, for nerve repair and in implantology as valves and sutures. The present review overviews usage of a multitude of PHA-based biomaterials for a wide range of tissue engineering applications, based on their properties suitable for the specific applications.
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Polihidroxialcanoatos , Ingeniería de Tejidos , Materiales Biocompatibles/química , Polihidroxialcanoatos/química , Porosidad , Ingeniería de Tejidos/métodos , Andamios del Tejido/químicaRESUMEN
Fracture of the acromion process is an uncommon injury which is often diagnosed late. Though, usually managed conservatively, the indications for surgery in these fractures are very specific. A 52-year-old active man attended the out-patient department of our hospital following an injury to the right shoulder. An X-ray revealed a Type II, minimally displaced fracture of the base of the acromion process. Conservative management was attempted initially, which was converted to surgical stabilization after six weeks when it was noticed that the fracture had failed to unite and had progressed to become a displaced Type III fracture. Post-operative period was uneventful with a gradual return to the pre-injury level of function of the right shoulder, which was assessed by the Constant Score as well as the University of California Los Angeles (UCLA) shoulder score. The satisfaction with the final functional outcome was assessed by the UCLA shoulder score. Clinicians must look actively for acromion process fractures in all shoulder injuries. Minimally displaced fractures should be regularly followed up for displacement and sub-acromial space compromise. Although acromion fractures are usually treated conservatively, albeit a higher non-union rate, they should be treated surgically in the event of displacement or sub-acromial space reduction, in order to achieve good functional recovery.
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Cotton (Gossypium hirsutum L.), is an important fibre and oilseed crop of the world. India in particular has the largest area under cotton cultivation and around 60% proportion in the raw fibre textile industry is contributed by cotton alone. Cotton is affected by many diseases (bacterial blights, fungal leafspots, mildew) and pests (white flies, bollworms, aphids etc.). The bacterial blight disease caused by Xanthomonas axonopodis pv. malvacearum is considered as one of the most devastating one that cause huge losses in production every year. Due to systemic spread of this bacterial infection, combating this disease is slightly challenging. Spray of toxic chemicals like endosulfan, streptocycline and dimethoate is a common practice in fields but these chemicals are unable to control the disease spread substantially. Nanotechnology is a newly emerging technology that is being extensively exploited in the agriculture sector these days. Past studies have reported the antimicrobial effect of various metallic nanoparticles including zinc oxide nanoparticles which is known to possess antibacterial potential against both gram +ve and gram -ve bacteria. Based upon this, synthesis of ZnO nanoparticles was carried out using Morus alba plant leaf extract and the nanoparticles were characterised in detail using scanning electron microscopy, atomic force microscopy, X-ray diffraction analysis, electron dispersive X-ray spectroscopy study etc. The zinc oxide nanoparticles were found crystalline in nature and the size ranged between 10-50 nanometers. The efficacy of these nanoparticles was checked against Xanthomonas axonopodis pv. malvacearum under in vitro conditions and found to be very effective in controlling the bacterial spread in comparison to streptomycin that was used as control. Our results suggest that ZnO nanoparticles can be used as an effective antibacterial agent to control bacterial blight disease of cotton.
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Nanopartículas del Metal , Xanthomonas axonopodis , Xanthomonas , Óxido de Zinc , Antibacterianos/farmacología , Bacterias , Gossypium , Enfermedades de las Plantas , Óxido de Zinc/farmacologíaRESUMEN
SBA-16 is a mesoporous nanostructure with high surface area and cubic symmetry which make them an ideal carrier to carry different nanoparticles. Zinc peroxide (ZnO2) is a novel nanoparticle that inhibits the growth of microorganisms due to its antiseptic property. Thin film of SBA-16 and SBA-16/ZnO2 was deposited on glass slide by spin coating method. Anti-biofilm property of the thin films was examined against E. coli and S. aureus bacteria. Structural property was found out by wide angle X-ray diffraction (XRD), small angle X-ray scattering (SAXS) and High Resolution Transmission Electron Microscope (HRTEM). Fourier Transform Infrared Spectrophotometer (FTIR) was used to confirmation the presence of ZnO2 in Nano-composite and AFM utilized for surface topography of thin films. Fluorescent microscope image clearly revealed that SBA-16/ZnO2 nanocomposite thin film significantly inhibit the biofilm formation against both E. coli (gram negative bacteria) as well as S. aureus (gram positive bacteria) in comparision to SBA-16. The antimicrobial behavior of ZnO nanoparticle is due to formation of H2O2 as reactive oxygen species (ROS) to which the bacterial cells are permeable. H2O2 is a powerful oxidizing agents that oxidized the mycobacterial elements like DNA and proteins which results into the toxicity of the bacteria cell.
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Nanocompuestos , Óxido de Zinc , Antibacterianos/farmacología , Biopelículas , Escherichia coli , Peróxido de Hidrógeno/farmacología , Dispersión del Ángulo Pequeño , Dióxido de Silicio , Espectroscopía Infrarroja por Transformada de Fourier , Staphylococcus aureus , Difracción de Rayos X , Óxido de Zinc/farmacologíaRESUMEN
BACKGROUND: There is emerging interest and increasing amount of evidence that support the interrelationship between periodontitis and systemic conditions. Epidemiological and microbiological-immunological studies have lent credence to the concept that periodontal disease may be a separate risk factor for cardiovascular disease, cerebrovascular disease, and respiratory disease, as well as preterm delivery of low-birth-weight infants. AIM: The aim of this study was to evaluate the influence of periodontal infection as a possible risk factor for preterm low birth weight (LBW) based on age, literacy, and hemoglobin level of mother. MATERIALS AND METHODS: The observational study was conducted on 200 subjects, which were selected from the free labor ward, District Hospital, Saifai, Etawah, UP, India. Periodontal examinations were performed using the World Health Organization criteria. The periodontal status of the mother was recorded using Community Periodontal Index. RESULTS: For this study, chi-square test was performed to know the effect of variables and to find out the statistical significance of the study. Age of mother shows statistical insignificant association with periodontal disease, whereas literacy of mothers showed statistical significant association with periodontal disease, and periodontal status and hemoglobin levels of the mothers also showed a significant association. CONCLUSION: The prevalence of LBW infants was considerably less in mothers with a healthy periodontium and increased with progressive periodontal disease.
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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.
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Benign fibrous histiocytoma (FH) is a benign soft-tissue tumor that can present as a fibrous tissue mass anywhere in the body. The involvement of the paranasal sinuses is extremely rare, and very few cases have been reported in literature till date. We here report a case of benign FH localized in the maxillary sinus. The clinical and histological features of the lesion are discussed with a brief literature review of this pathology in the paranasal sinuses.
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Thymol is a natural bioactive agent which possesses various medicinal properties like antimicrobial, antifungal, anti-inflammatory, anticancer etc. and has been widely used in traditional medicine and food industries. It is eco-friendly, cheap, nontoxic and has been granted generally recognized as safe (GRAS) notation by USFDA. Its use is somewhat muted due to drawbacks like lesser bioavailability, comparatively poor solubility and low susceptibility to oxidation. In the present work, nanoformulation of thymol was prepared by ionic complexation of tragacanth gum and chitosan. Chitosan of different concentrations was used to obtain desired particle size and encapsulation efficiency. It was noted that a ratio of 1:2 (tragacanth gum:chitosan) yielded a minimum particle size along with higher encapsulation efficiency. Morphology of these optimized nanoparticles was found to be spherical using TEM. These particles were found in the size range of 150-200â¯nm. Further comparative study of the prepared nanoformulation and thymol for antioxidant and anti-inflammatory efficacy was done using DPPH method and HRBC (Human red blood cell) stabilization method. The results suggested an increase in both anti-inflammatory and antioxidant activity of thymol nanoformulation. This study will open up new avenues for application in the field of food and pharmaceutical industries.
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Antiinflamatorios/farmacología , Antioxidantes/farmacología , Quitosano/química , Preparaciones de Acción Retardada/farmacología , Nanopartículas/química , Timol/farmacología , Tragacanto/química , Antiinflamatorios/química , Antioxidantes/química , Compuestos de Bifenilo/antagonistas & inhibidores , Preparaciones de Acción Retardada/química , Diclofenaco/farmacología , Portadores de Fármacos , Composición de Medicamentos/métodos , Liberación de Fármacos , Eritrocitos/efectos de los fármacos , Humanos , Cinética , Nanopartículas/ultraestructura , Tamaño de la Partícula , Picratos/antagonistas & inhibidores , Timol/químicaRESUMEN
BACKGROUND: Arsenic is a well-documented human carcinogen widely distributed in the environment. Chronic exposure of humans to inorganic arsenicals causes many adverse health effects. The present work was conducted to evaluate the protective effect of Syzygium cumini seed extract (SCE) on arsenic-induced genotoxicity and hepatotoxicity in Wistar albino rats. METHODS: Rats were randomly divided into five groups of six animals each. Group 1 served as normal control, Group 2 received SCE, 200 mg/kg daily, and Group 3 received arsenic, 100 ppm in drinking water. Groups 4 and 5 received SCE, 200 mg/kg and 400 mg/kg, respectively, daily, simultaneously with 100 ppm arsenic in drinking water. After 60 days, blood samples were collected and comet assay was performed using isolated lymphocytes. Activities of serum marker enzymes were assayed and lipid peroxidation (LPO) levels were estimated. Serum catalase (CAT) and superoxide dismutase (SOD) activities, and blood reduced glutathione (GSH) were measured. RESULTS: Exposure to arsenic caused a significant increase in serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and bilirubin, accompanied by a decrease in total protein levels as well as CAT and SOD activities, and GSH. Enhanced LPO and lymphocyte DNA damage was also observed in arsenic-administered rats. The arsenic-induced toxicity was significantly reversed by the simultaneous administration of SCE at both the lower and higher dosages. CONCLUSION: This investigation offers strong evidence for the hepato-protective and antioxidative effects of SCE against arsenic-induced oxidative stress.