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1.
Environ Geochem Health ; 45(3): 961-980, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-35391708

RESUMEN

This study investigated the concentration of heavy metals in rainwater (RW) at a semi-arid region of the Indo-Gangetic basin to understand the influence of local, regional, or long-range transport of air pollutants during the monsoon and non-monsoonal rain. The concentration of heavy metals in RW was determined using Atomic Absorption Spectrophotometer with Graphite Furnace, the scavenging ratio was estimated, and source interpretation was carried out using Principle Component Analysis (PCA) and HYSPLIT model. Ca was the highest contributor in RW followed by Na, Fe, Mg, and Al whereas Ba, Cr, Cu, Mn, Ni, Pb, and Zn were found in trace quantity. During the non-monsoon period, the crustal component (Ca) was the highest; however, during the monsoon, sea salt components (Na and Fe) were found higher. The scavenging ratio for metals was estimated and was found many times higher than those reported over European sites. The moderate concentration of heavy metal in RW was found with higher wind from South (S), South-West (SW), and North-West (NW) directions. Air mass back trajectory shows a significant contribution of metals from the Arabian Sea (South-Westerly wind) during active monsoon, whereas, in the non-monsoon season, the air masses mainly originated from the north-west indicating a contribution from wind-blown dust. The correlation analysis has shown the positive correlations between Ca and Mg, Mg and Na, Na and Cu, Al and Zn, Zn and Ba, Ba and Cr, and Cr and Zn. Principal Component Analysis (PCA) indicated loading of Ca, Na, Mg, Cu, Mn, and Ni in the first factor suggesting their crustal origin, whereas the second factor showed high loading of Al, Ba, Zn, Cr, and Ni indicating vehicular exhaust and industrial emission as their major sources, and loading for Ba and Mg in the third factor indicates the mixed contribution from both natural and anthropogenic sources in rainwater during the monsoon and non-monsoon periods. The data of this study can be used in the air pollution transport model. This study will help in source interpretation over the Indo-Gangetic basin and will help in planning for National Clean Air Program (NCAP) and deriving critical load.


Asunto(s)
Contaminantes Atmosféricos , Metales Pesados , Monitoreo del Ambiente , Metales Pesados/análisis , Contaminantes Atmosféricos/análisis , Lluvia , Aerosoles/análisis
2.
Environ Geochem Health ; 40(1): 145-161, 2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27807676

RESUMEN

USEPA's UNMIX, positive matrix factorization (PMF) and effective variance-chemical mass balance (EV-CMB) receptor models were applied to chemically speciated profiles of 125 indoor PM2.5 measurements, sampled longitudinally during 2012-2013 in low-income group households of Central India which uses solid fuels for cooking practices. Three step source apportionment studies were carried out to generate more confident source characterization. Firstly, UNMIX6.0 extracted initial number of source factors, which were used to execute PMF5.0 to extract source-factor profiles in second step. Finally, factor analog locally derived source profiles were supplemented to EV-CMB8.2 with indoor receptor PM2.5 chemical profile to evaluate source contribution estimates (SCEs). The results of combined use of three receptor models clearly describe that UNMIX and PMF are useful tool to extract types of source categories within small receptor dataset and EV-CMB can pick those locally derived source profiles for source apportionment which are analog to PMF-extracted source categories. The source apportionment results have also shown three fold higher relative contribution of solid fuel burning emissions to indoor PM2.5 compared to those measurements reported for normal households with LPG stoves. The previously reported influential source marker species were found to be comparatively similar to those extracted from PMF fingerprint plots. The comparison between PMF and CMB SCEs results were also found to be qualitatively similar. The performance fit measures of all three receptor models were cross-verified and validated and support each other to gain confidence in source apportionment results.


Asunto(s)
Contaminación del Aire Interior/análisis , Culinaria , Monitoreo del Ambiente/métodos , Composición Familiar , Incendios , Modelos Químicos , Material Particulado/análisis , Conjuntos de Datos como Asunto , India , Estudios Longitudinales , Reproducibilidad de los Resultados , Población Urbana
3.
Environ Geochem Health ; 40(5): 2205-2222, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-29603086

RESUMEN

This study describes spatiotemporal patterns from October 2015 to September 2016 for PM2.5 mass and carbon measurements in rural (Kosmarra), urban (Raipur), and industrial (Bhilai) environments, in Chhattisgarh, Central India. Twenty-four-hour samples were acquired once every other week at the rural and industrial sites. Twelve-hour daytime and nighttime samples were acquired either a once a week or once every other week at the urban site. Each site was equipped with two portable, battery-powered, miniVol air samplers with PM2.5 inlets. Annual average PM2.5 mass concentrations were 71.8 ± 27 µg m-3 at the rural site, 133 ± 51 µg m-3 at the urban site, and 244.5 ± 63.3 µg m-3 at the industrial site, ~ 2-6 times higher than the Indian Annual National Ambient Air Quality Standard of 40 µg m-3. Average monthly nighttime PM2.5 and carbon concentrations at the urban site were consistently higher than those of daytime from November 2015 to April 2016, when temperatures were low. Annual average total carbon (TC = OC + EC) at the urban (46.8 ± 23.8 µg m-3) and industrial (98.0 ± 17.2 µg m-3) sites also exceeded the Indian PM2.5 NAAQS. TC accounted for 30-40% of PM2.5 mass. Annual average OC ranged from 17.8 ± 6.1 µg m-3 at the rural site to 64 ± 9.4 µg m-3 at the industrial site, with EC ranging from 4.51 ± 2.2 to 34.01 ± 7.8 µg m-3. The average OC/EC ratio at the industrial site (1.88) was 18% lower than that at the urban site and 52% lower than that at the rural site. OC was attributed to 43.0% of secondary organic carbon (SOC) at the rural site, twice that estimated for the urban and industrial sites. Mortality burden estimates for PM2.5 EC are 4416 and 6196 excess deaths at the urban and industrial sites, respectively, during 2015-2016.


Asunto(s)
Contaminantes Atmosféricos/análisis , Carbono/análisis , Monitoreo del Ambiente/métodos , Material Particulado/análisis , Bahías , India , Tamaño de la Partícula , Estaciones del Año , Temperatura
4.
Environ Geochem Health ; 39(5): 1045-1058, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27614876

RESUMEN

PM2.5 concentrations were measured in residential indoor environment in slums of central India during 2012-2013. In addition, a suite of chemical components including metals (Al, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Pb, Mo, Se, Sb, Na, Mg, K and Hg), ions (Na+, Mg2+, K+, Ca2+, F-, Cl-, NH4+, NO3- and SO42-) and carbon (OC and EC) were analyzed for all samples. Indoor PM2.5 concentrations were found to be several folds higher than the 24-h national ambient air quality standard (60 µg/m3) for PM2.5 in India, and the concentrations were found to vary from season to season. Mass closure was attempted for PM2.5 data, and close to 100 % mass was accounted for by organic matter, crustal material, secondary organic and inorganic aerosols and elemental carbon. Additionally, carcinogenic and non-carcinogenic health risks associated with exposure to indoor PM2.5 (inhalation, dermal and ingestion) were estimated and while exposures associated with dermal contact and ingestion were found to be within the acceptable limits, risk associated with inhalation exposure was found to be high for children and adults. Elements including Al, Cd, Co, Cr, Mn, Ni, As and Pb were present in high concentrations and contributed to carcinogenic and non-carcinogenic risks for residents' health. Results from this study highlight the need for efforts to reduce air pollution exposure in slum areas.


Asunto(s)
Contaminantes Atmosféricos/efectos adversos , Culinaria , Monitoreo del Ambiente , Exposición por Inhalación/efectos adversos , Material Particulado/efectos adversos , Contaminantes Atmosféricos/análisis , Contaminación del Aire Interior/efectos adversos , Contaminación del Aire Interior/análisis , Indicadores de Salud , Humanos , India , Tamaño de la Partícula , Material Particulado/análisis , Medición de Riesgo
5.
Talanta ; 275: 126113, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38669958

RESUMEN

We are reporting the two curcumin derivatives, ferrocenyl curcumin (Fc-cur) and 4-nitro-benzylidene curcumin (NBC), as a probe through dual modalities, i.e., fluorescence and electrochemical methods, for the detection of nitro-analytes, such as picric acid (PA). The probes exhibited aggregation-induced enhanced emission (AIEE), and the addition of picric acid (PA) demonstrated good and specific fluorimetric identification of PA in the aggregated state. By using density functional theory (DFT), the mechanism of picric acid's (PA) interactions with the probes was further investigated. DFT studies shows evidence of charge transfer from curcumin derivatives probe to picric acid resulting into the formation of an adduct. The reduction of trinitrophenol (PA) to 2, 4, 6-trinitrosophenol was investigated utilizing a probe-modified glassy carbon electrode (GCE) with a good detection limit of 9.63 ± 0.001 pM and 41.01 ± 0.002 pM, respectively, for Fc-cur@GCE and NBC@GCE, taking into account the redox behavior of the probe. The applicability of the designed sensor has been utilized for real-time application in the estimation of picric acid in several water samples collected from the different source.

6.
Trop Anim Health Prod ; 44(3): 665-74, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-21853412

RESUMEN

The present study was conducted to study the antibiotic resistance pattern among nontyphoidal Salmonella isolated from human, animal and meat. A total of 37 Salmonella strains isolated from clinical cases (human and animal) and meat during 2008-2009 belonging to 12 serovars were screened for their antimicrobial resistance pattern using 25 antimicrobial agents falling under 12 different antibiotic classes. All the Salmonella isolates tested showed multiple drug resistance varying from 5.40% to 100% with 16 of the 25 antibiotics tested. None of the isolates were sensitive to erythromycin and metronidazole. Resistance was also observed against clindamycin (94.59%), ampicillin (86.49%), co-trimoxazole (48.65%), colistin (45.94%), nalidixic acid (35.10%), amoxyclave (18.90%), cephalexin, meropenem, tobramycin, nitrofurantoin, tetracycline, amoxicillin (8.10% each), sparfloxacin and streptomycin (5.40% each). Isolates from clinical cases of animals were resistant to as many as 16 antibiotics, whereas isolates from human clinical cases and meat were resistant to 9 and 14 antibiotics, respectively. Overall, 19 resistotypes were recorded. Analysis of multiple antibiotic resistance index (MARI) indicated that clinical isolates from animals had higher MARI (0.25) as compared to isolates from food (0.22) and human (0.21). Among the different serotypes studied for antibiogram, Paratyhi B isolates, showed resistance to three to 13 antibiotics, whereas Typhimurium strains were resistant to four to seven antibiotics. Widespread multidrug resistance among the isolates from human, animal and meat was observed. Some of the uncommon serotypes exhibited higher resistance rate. Considerable changes in the resistance pattern were also noted. An interesting finding was the reemergence of sensitivity to some of the old antibiotics (chloromphenicol, tetracycline).


Asunto(s)
Antiinfecciosos/farmacología , Farmacorresistencia Bacteriana Múltiple , Carne/microbiología , Salmonelosis Animal/microbiología , Infecciones por Salmonella/microbiología , Salmonella/efectos de los fármacos , Animales , Búfalos , Bovinos , Enfermedades de los Bovinos/epidemiología , Enfermedades de los Bovinos/microbiología , Microbiología de Alimentos , Enfermedades de las Cabras/epidemiología , Enfermedades de las Cabras/microbiología , Cabras , Humanos , India/epidemiología , Pruebas de Sensibilidad Microbiana/veterinaria , Prevalencia , Salmonella/clasificación , Salmonella/aislamiento & purificación , Infecciones por Salmonella/epidemiología , Salmonelosis Animal/epidemiología , Especificidad de la Especie
7.
Ren Fail ; 33(4): 411-7, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21529270

RESUMEN

AIM: Oxidative stress (OS) and endothelial dysfunction are implicated in accelerated atherosclerosis in chronic kidney disease (CKD). We assessed endothelial function, OS, and carotid intimal medial thickness (CIMT) and their correlates in 44 CKD stage 5 patients (group III) before and after hemodialysis (HD), 40 patients of CKD stages 3 and 4 (group II), and 25 matched controls (group I). METHODS: OS was measured by serum concentration of antioxidants; vitamin C and fractional reducing ability of plasma (FRAP) and pro-oxidant; thiobarbituric acid reactive substances (TBARS). Ultrasonography of carotid artery for CIMT and of brachial artery for flow-mediated dilatation (endothelium-dependent dilatation, EDD) was done. RESULTS: TBARS increased significantly with severity of CKD. Antioxidants FRAP and vitamin C were significantly lower in CKD patients as compared with controls, but there was no significant difference between groups II and III. EDD decreased significantly with severity of CKD, whereas CIMT though higher in CKD patients as compared with controls was not significantly different between groups II and III. After a session of HD as compared with predialysis, levels of TBARS decreased, whereas those of FRAP, vitamin C, and EDD increased. On multivariate analysis, there was negative correlation of TBARS with glomerular filtration rate (GFR), serum albumin, hemoglobin, and EDD. Vitamin C had positive correlations with GFR, serum albumin, hemoglobin, and EDD. EDD had direct correlation with GFR, whereas CIMT correlated negatively with EDD. CONCLUSIONS: Endothelial dysfunction and OS occur early in CKD, are closely related to each other and structural atherosclerosis, and are proportional to decline in GFR.


Asunto(s)
Endotelio Vascular/fisiopatología , Estrés Oxidativo , Insuficiencia Renal Crónica/metabolismo , Adulto , Antioxidantes/metabolismo , Arterias Carótidas/diagnóstico por imagen , Endotelio Vascular/diagnóstico por imagen , Femenino , Tasa de Filtración Glomerular , Humanos , Masculino , Oxidantes/sangre , Diálisis Renal , Insuficiencia Renal Crónica/diagnóstico por imagen , Insuficiencia Renal Crónica/fisiopatología , Insuficiencia Renal Crónica/terapia , Ultrasonografía , Vasodilatación
8.
J Assoc Physicians India ; 59: 38-41, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21751663

RESUMEN

Rapidly progressive renal failure (RPRF) is an initial clinical diagnosis in patients who present with progressive renal impairment of short duration. The underlying etiology may be a primary renal disease or a systemic disorder. Important differential diagnoses include vasculitis (systemic or renal-limited), systemic lupus erythematosus, multiple myeloma, thrombotic microangiopathy and acute interstitial nephritis. Good history taking, clinical examination and relevant investigations including serology and ultimately kidney biopsy are helpful in clinching the diagnosis. Early definitive diagnosis of RPRF is essential to reverse the otherwise relentless progression to end-stage kidney disease.


Asunto(s)
Riñón/patología , Insuficiencia Renal/diagnóstico , Insuficiencia Renal/etiología , Biopsia , Diagnóstico Diferencial , Progresión de la Enfermedad , Humanos , Factores de Riesgo
9.
Sci Total Environ ; 770: 145324, 2021 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-33736388

RESUMEN

National Capital Region (NCR) encompassing New Delhi is one of the most polluted urban metropolitan areas in the world. Real-time chemical characterization of fine particulate matter (PM1 and PM2.5) was carried out using three aerosol mass spectrometers, two aethalometers, and one single particle soot photometer (SP2) at two sites in Delhi (urban) and one site located ~40 km downwind of Delhi, during January-March 2018. The campaign mean PM2.5 (NR-PM2.5 + BC) concentrations at the two urban sites were 153.8 ± 109.4 µg.m-3 and 127.8 ± 83.2 µg.m-3, respectively, whereas PM1 (NR-PM1 + BC) was 72.3 ± 44.0 µg.m-3 at the downwind site. PM2.5 particles were composed mostly of organics (43-44)% followed by chloride (14-17)%, ammonium (9-11)%, nitrate (9%), sulfate (8-10)%, and black carbon (11-16)%, whereas PM1 particles were composed of 47% organics, 13% sulfate as well as ammonium, 11% nitrate as well as chloride, and 5% black carbon. Organic aerosol (OA) source apportionment was done using positive matrix factorization (PMF), solved using an advanced multi-linear engine (ME-2) model. Highly mass-resolved OA mass spectra at one urban and downwind site were factorized into three primary organic aerosol (POA) factors including one traffic-related and two solid-fuel combustion (SFC), and three oxidized OA (OOA) factors. Whereas unit mass resolution OA at the other urban site was factorized into two POA factors related to traffic and SFC, and one OOA factor. OOA constituted a majority of the total OA mass (45-55)% with maximum contribution during afternoon hours ~(70-80)%. Significant differences in the absolute OOA concentration between the two urban sites indicated the influence of local emissions on the oxidized OA formation. Similar PM chemical composition, diurnal and temporal variations at the three sites suggest similar type of sources affecting the particulate pollution in Delhi and adjoining cities, but variability in mass concentration suggest more local influence than regional.

10.
Clin Exp Nephrol ; 14(3): 268-71, 2010 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-20016924

RESUMEN

Renal involvement in leprosy has been reported rarely in the literature. Acute kidney injury in patients with leprosy is uncommon and may occur due to acute tubular necrosis, drug-induced interstitial nephritis and rarely crescentic glomerulonephritis. The latter with histologic confirmation of the diagnosis has been reported in very few cases of leprosy. A 25-year-old male, on therapy for multibacillary leprosy, was found to have deranged renal functions on evaluation for a history of nausea, vomiting, swelling and episode of haematuria. Kidney biopsy was performed twice over a period of 2 weeks, showing progression from diffuse proliferative glomerulonephritis to crescentic glomerulonephritis, pauci-immune in nature. The patient was treated aggressively with intravenous steroids, following which his renal functions stabilized. Crescentic glomerulonephritis, an extremely rare phenomenon in leprosy, should be considered in these patients presenting with features of acute kidney injury. Timely performed renal biopsy assists in accurate diagnosis and appropriate management of the patient, hence preserving renal parenchyma. Rapid progression from diffuse proliferative glomerulonephritis to crescentic glomerulonephritis in a patient with leprosy is described herein for the first time in the literature.


Asunto(s)
Glomerulonefritis/etiología , Lepra Multibacilar/complicaciones , Lesión Renal Aguda/diagnóstico , Lesión Renal Aguda/patología , Adulto , Biopsia , Progresión de la Enfermedad , Glomerulonefritis/diagnóstico , Glomerulonefritis/patología , Humanos , Riñón/patología , Masculino
11.
Sci Total Environ ; 745: 140924, 2020 Nov 25.
Artículo en Inglés | MEDLINE | ID: mdl-32738681

RESUMEN

Delhi is one of the most polluted cities worldwide and a comprehensive understanding and deeper insight into the air pollution and its sources is of high importance. We report 5 months of highly time-resolved measurements of non-refractory PM2.5 and black carbon (BC). Additionally, source apportionment based on positive matrix factorization (PMF) of the organic aerosol (OA) fraction is presented. The highest pollution levels are observed during winter in December/January. During that time, also uniquely high chloride concentrations are measured, which are sometimes even the most dominant NR-species in the morning hours. With increasing temperature, the total PM2.5 concentration decreases steadily, whereas the chloride concentrations decrease sharply. The concentrations measured in May are roughly 6 times lower than in December/January. PMF analysis resolves two primary factors, namely hydrocarbon-like (traffic-related) OA (HOA) and solid fuel combustion OA (SFC-OA), and one or two secondary factors depending on the season. The uncertainties of the PMF analysis are assessed by combining the random a-value approach and the bootstrap resampling technique of the PMF input. The uncertainties for the resolved factors range from ±18% to ±19% for HOA, ±7% to ±19% for SFC-OA and ±6 % to ±11% for the OOAs. The average correlation of HOA with equivalent black carbon from traffic (eBCtr) is R2 = 0.40, while SFC-OA has a correlation of R2 = 0.78 with equivalent black carbon from solid fuel combustion (eBCsf). Anthracene (m/z 178) and pyrene (m/z 202) (PAHs) are mostly explained by SFC-OA and follow its diurnal trend (R2 = 0.98 and R2 = 0.97). The secondary oxygenated aerosols are dominant during daytime. The average contribution during the afternoon hours (1 pm-5 pm) is 59% to the total OA mass, with contributions up to 96% in May. In contrast, the primary sources are more important during nighttime: the mean nightly contribution (22 pm-3 am) to the total OA mass is 48%, with contributions up to 88% during some episodes in April.

12.
Clin Exp Nephrol ; 13(4): 389-391, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19142576
13.
Clin Exp Nephrol ; 13(5): 531-532, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19437094

RESUMEN

Noonan syndrome is characterised by short stature, typical facial dysmorphology and congenital heart defects. Urogenital abnormalities are reported in 10% of the cases. We present a 14-year-old girl with characteristic features of Noonan syndrome and nephrotic-range proteinuria. She had crossed fused ectopic kidneys. Renal biopsy showed focal segmental glomerulosclerosis. Oral steroids were instituted and she responded well. The case highlights this novel renal presentation of Noonan syndrome.


Asunto(s)
Glomeruloesclerosis Focal y Segmentaria/patología , Riñón/anomalías , Síndrome de Noonan/patología , Adolescente , Femenino , Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico , Humanos , Síndrome de Noonan/tratamiento farmacológico , Esteroides/uso terapéutico
14.
Clin Exp Nephrol ; 13(6): 667-70, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19652903

RESUMEN

Ankylosing spondylitis is a chronic inflammatory disease of the vertebral joints and soft tissues. Renal involvement, apart from amyloidosis, is rare in this disorder. Of the various glomerulonephritides reported in association with ankylosing spondylitis, IgA nephropathy is the most common. Membranous glomerulonephritis occurs very rarely in patients with ankylosing spondylitis, and only four such cases have been reported in the available English literature. Due to the rarity of this association, membranous glomerulonephritis may not initially be considered in patients with ankylosing spondylitis and proteinuria. We report the case of a 29-year-old man with ankylosing spondylitis who presented with pedal edema and was detected to have nephrotic syndrome. A percutaneous renal biopsy showed features of membranous glomerulonephritis with capillary wall granular deposits of IgG and C3 on immunofluorescence and subepithelial immune complex deposits on electron microscopy. No other secondary cause of membranous glomerulopathy was found on extensive investigations. Membranous glomerulonephritis is extremely rare in association with ankylosing spondylitis, the present case being the fifth such report. The exact relationship of these two entities (etiological or coincidental) still needs to be elucidated. The occurrence of this rare association needs to be recognized and differentiated from other more common causes of renal involvement in ankylosing spondylitis.


Asunto(s)
Glomerulonefritis Membranosa/complicaciones , Espondilitis Anquilosante/complicaciones , Adulto , Técnica del Anticuerpo Fluorescente , Humanos , Masculino , Síndrome Nefrótico/complicaciones
15.
Clin Exp Nephrol ; 13(4): 373-377, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19169768

RESUMEN

The hepatitis B virus (HBV) is estimated to have infected about 350 million people worldwide, making it one of the most common human pathogens. Renal involvement is among its most common extra hepatic manifestations and usually manifests in the form of immune complex mediated glomerulopathy, such as membranous glomerulonephritis (MGN), membranoproliferative glomerulonephritis (MPGN), mesangioproliferative glomerulonephritis and immunoglobulin A (IgA) nephropathy. Occurrence of focal and segmental glomerular sclerosis (FSGS) with HBV infection is rare and only five cases have been reported earlier. We report two cases of hepatitis B associated FSGS. In both the cases, HBsAg was demonstrated in the renal tissue and both the cases showed response to treatment with lamivudine, thus indicating a possible causal association between the viral infection and occurrence of nephrotic syndrome.


Asunto(s)
Glomeruloesclerosis Focal y Segmentaria/virología , Antígenos de la Hepatitis B/análisis , Virus de la Hepatitis B/inmunología , Hepatitis B/complicaciones , Riñón/virología , Síndrome Nefrótico/virología , Adolescente , Biopsia , ADN Viral/sangre , Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico , Hepatitis B/diagnóstico , Hepatitis B/tratamiento farmacológico , Antígenos del Núcleo de la Hepatitis B/análisis , Antígenos de Superficie de la Hepatitis B/análisis , Virus de la Hepatitis B/genética , Humanos , Inmunohistoquímica , Lamivudine/uso terapéutico , Masculino , Síndrome Nefrótico/tratamiento farmacológico , Proteinuria/virología , Resultado del Tratamiento
16.
BMC Health Serv Res ; 9: 97, 2009 Jun 09.
Artículo en Inglés | MEDLINE | ID: mdl-19508710

RESUMEN

BACKGROUND: Nepal's Safe Delivery Incentive Programme (SDIP) was introduced nationwide in 2005 with the intention of increasing utilisation of professional care at childbirth. It provided cash to women giving birth in a health facility and an incentive to the health provider for each delivery attended, either at home or in the facility. We explored early implementation of the programme at the district-level to understand the factors that have contributed to its low uptake. METHODS: We conducted in ten study districts a series of key informant interviews and focus group discussions with staff from health facilities and the district health office and other stakeholders involved in implementation. Manual content analysis was used to categorise data under emerging themes. RESULTS: Problems at the central level imposed severe constraints on the ability of district-level actors to implement the programme. These included bureaucratic delays in the disbursement of funds, difficulties in communicating the policy, both to implementers and the wider public and the complexity of the programme's design. However, some district implementers were able to cope with these problems, providing reasons for why uptake of the programme varied considerably between districts. Actions appeared to be influenced by the pressure to meet local needs, as well individual perceptions and acceptance of the programme. The experience also sheds light on some of the adverse effects of the programme on the wider health system. CONCLUSION: The success of conditional cash transfer programmes in Latin America has led to a wave of enthusiasm for their adoption in other parts of the world. However, context matters and proponents of similar programmes in south Asia should give due attention to the challenges to implementation when capacity is weak and health services inadequate.


Asunto(s)
Financiación Personal/economía , Promoción de la Salud/economía , Servicios de Salud Materna/economía , Femenino , Grupos Focales , Investigación sobre Servicios de Salud , Humanos , Entrevistas como Asunto , Motivación , Nepal , Cooperación del Paciente , Embarazo
17.
J Assoc Physicians India ; 57: 595-6, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20209722

RESUMEN

Sternum is resistant to infections and thus infrequent site of osteomyelitis. Involvement of sternum by Mycobacterium tuberculosis is rare. We report case of 37-year-old male with isolated tuberculosis of the sternum, a 14-year-old girl with tuberculosis of the sternum and Potts spine and a 55-year-old male with tubercular sinus of the sternum, three different presentations of the same disease.


Asunto(s)
Esternón , Tuberculosis Osteoarticular/diagnóstico , Adulto , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad
18.
Environ Sci Pollut Res Int ; 26(4): 3771-3794, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30539401

RESUMEN

Urban areas in developing countries are major sources of carbonaceous aerosols and air pollutants, pointing out the need for a detailed assessment of their levels and origin close to the source. A multi-instrument research campaign was performed in Delhi during December 2015-February 2016 aimed at exploring the pollution levels and the contribution of various sources to particulate matter (PM) concentrations, black carbon (BC) aerosols, and trace gases. The weak winds (< 5-6 m s-1) along with the shallow boundary layer favoured the formation of thick and persistent fog conditions, which along with the high BC (24.4 ± 12.2 µg m-3) concentrations lead to the formation of smog. Very high pollution levels were recorded during the campaign, with mean PM10, PM2.5, CO, NO, and O3 concentrations of 245.5 ± 109.8 µg m-3, 145.5 ± 69.5 µg m-3, 1.7 ± 0.5 ppm, 7.9 ± 2.3 ppb, and 31.3 ± 18.4 ppb, respectively. This study focuses on examining the daily/diurnal cycles of the aerosol optical properties (extinction, scattering, absorption coefficients, single scattering albedo), as well as of PM and other pollutant concentrations, along with changes in meteorology (mixing-layer height and wind speed). In addition, the hot-spot pollution sources in the greater Delhi area were determined via bivariate plots and conditional bivariate probability function (CBPF), while the distant sources were examined via the concentration weighted trajectory (CWT) analysis. The results show that the highest aerosol absorption and scattering coefficients, PM, and trace gas concentrations are detected for weak winds (< 2 m s-1) with a preference for eastern directions, revealing high contribution from local sources and accumulation of pollutants within urban Delhi.


Asunto(s)
Aerosoles/análisis , Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , Monitoreo del Ambiente/métodos , India , Material Particulado/análisis , Estaciones del Año , Hollín/análisis , Viento
19.
Sci Adv ; 5(1): eaau8066, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30729159

RESUMEN

Light-absorbing organic aerosols, known as brown carbon (BrC), counteract the overall cooling effect of aerosols on Earth's climate. The spatial and temporal dynamics of their light-absorbing properties are poorly constrained and unaccounted for in climate models, because of limited ambient observations. We combine carbon isotope forensics (δ13C) with measurements of light absorption in a conceptual aging model to constrain the loss of light absorptivity (i.e., bleaching) of water-soluble BrC (WS-BrC) aerosols in one of the world's largest BrC emission regions-South Asia. On this regional scale, we find that atmospheric photochemical oxidation reduces the light absorption of WS-BrC by ~84% during transport over 6000 km in the Indo-Gangetic Plain, with an ambient first-order bleaching rate of 0.20 ± 0.05 day-1 during over-ocean transit across Bay of Bengal to an Indian Ocean receptor site. This study facilitates dynamic parameterization of WS-BrC absorption properties, thereby constraining BrC climate impact over South Asia.

20.
Sci Total Environ ; 654: 493-504, 2019 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-30447588

RESUMEN

Emission factors (EFs) of PM2.5, carbon fractions, major ionic (K+, Ca2+, NH4+, SO42-, NO3- and Cl-) and elemental (Al, Cr, Cu and Fe) species from combustion of commonly used household solid fuel were determined in 10 different states in India during cooking practices. The study involved sampling during actual household cooking involving use of a variety of fuels including coal balls (CB), fuel wood (FW), dung cakes (DC), crop residues (CR), mixed fuels (MF: dung cakes + fuel woods). Species-wise highest EFs (g·kg-1) were: 34.16 ±â€¯10.1 for PM2.5 (CB), 14.18 ±â€¯5.8 for OC (CB), 2.33 ±â€¯1.4 for EC (DC), 1.03 ±â€¯0.2 for K+ (CR), 2.21 ±â€¯0.6 NH4+ (DC), 0.61 ±â€¯0.2 for NO3- (CB), 0.59 ±â€¯0.1 for SO42- (CB), 0.69 ±â€¯0.1 for Cl- (CR) among the fuels. Higher OC EFs for CB could be attributed to higher moisture content (>13%) in coal-powder that is used to handmade coal balls. It is observed that, in general, OC3 and EC1 were the dominant thermally evolved carbon mass fractions. The study averaged MCE values were in the range 0.93-0.98, which could be attributed to higher variability in flaming and smoldering episodes during the combustion of selected fuels. Sum of ionic EFs for emissions from DC, CR and MF were found to be higher than those observed for FW and CB. The K+/EC and Cl-/EC (~1) ratios could be better indicators of CR fuels to differentiate it from FW, whereas NH4+/EC (~1) is suitable to indicate DC. Average annual emission estimates of PM2.5 (2.00 ±â€¯0.53 Tg·yr-1), OC (0.86 ±â€¯0.23 Tg·yr-1) and EC (0.11 ±â€¯0.02 Tg·yr-1) for tested fuels are evaluated to be contributing 27, 15 and 4% of total PM2.5, OC and EC, respectively, toward annual emission budget from different anthropogenic activities in India.

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