Changes in the epidemiology of hepatitis A: Clinical and preventive implications. / Cambios en la epidemiología de la hepatitis A: repercusiones clínicas y preventivas.

INTRODUCTION AND OBJECTIVES: Hepatitis A Virus Infection (HAI) has been related to the hygienic-sanitary situation of an area, the changes in the epidemiology of HAI in the province of Guadalajara between 1991 and 2017 are analyzed. MATERIALS AND METHODS: Cases of HAI declared between 1991 and 2017 in Guadalajara were included. The variables analyzed were age, sex, environment, risk factors for HAI and need for hospitalization. The incidence was compared in three periods: 1991-1999, 2000-2008 and 2009-2017. RESULTS: Two hundred and thirty-three cases of HAI were declared, the average incidence rate was 4.27 cases/100,000 inhabitants, highest between 1991 and 1999 (6.93) and lowest between 2009 and 2017 (1.92), with an increment in 2017 (5.5). The median age was 16 years (IR: 8.5-28.5 years), 58.4% were male, and the highest incidence occurred between 5 and 14 years in both sexes. The most frequent risk factors were family and non-family contact and trips to endemic areas (18.6%, 17.3% and 18.2%, respectively). The last risk factor increased after 2000 (P=.001), as did the incidence in urban areas. The MSM group showed an increase in the last period (P<.001). Hospital admissions increased progressively from the first to the third period studied (P=.001). CONCLUSIONS: HAI has a low incidence in our area. More cases related to travel or sexual practices are observed. This should be considered when establishing prevention policies, including vaccination of the most exposed people.

Ionizing diagnostic radiation exposure in patients with Crohn's disease: A retrospective study in a medium hospital and its predictive factors. / Exposición a radiación diagnóstica en pacientes con enfermedad de Crohn: estudio retrospectivo en un hospital medio y sus factores predictivos.

INTRODUCTION: It is estimated that diagnostic medical radiation exposure may be responsable for 0.5-2% of cancers worldwide. Because of the relapsing course of Crohn's disease (CD), these patients usually requiere multiple ionizing radiation test. OBJECTIVE: Stimating the total cumulative effective dose received by our CD patients and identifying the risk factors associated with the exposure to a cumulative effective dose due to the disease (CEED) > 50mSv. MATERIALS AND METHODS: Retrospective cohort study (2001-2014). POPULATION: patients with CD. Risk dose >50mSv. For calculating de cumulative effective dose and the CEED, all the ionizing test done were taken. For identifying predictive factors for receiving a CEDD >50mSv, an univariate and a multivariate logistic regression analyses were performed using a >50mSv dose as dependent variable. RESULTS: Of the 267 patients analyzed the 24.6% of them received a cumulative effective dose > 50mSv and the 15.2% a CEED>50mSv. In the multivariate analysis, the following variables were identified as independent predictors associated with a CEDD >50mSv: major surgery (OR= 2.1; IC95% [1.1-3.8]; p=.019) and severity (OR= 20.6; IC95% [4.5-94.8]; p<.01). CONCLUSIONS: Patients with CD are more at risk of receiving risk CEED, so it would be advisable to monitor the cumulative effective dose received to anticipate our intervention in order to avoid reaching that dose. The ultrasounds and abdominal resonance enterography are alternatives in these cases, although their accessibility is limited in some centers.

High Seroprevalence Against SARS-CoV-2 Among Faculty of Medicine and Health Sciences Personnel and Students of the University of Alcalá, Spain: Contributing Factors.

PURPOSE: Seroprevalence against SARS-CoV-2 within university systems is poorly studied, making evidence-based discussions of educational system reopening difficult. Moreover, few studies evaluate how antibodies against SARS-CoV-2 are maintained over time. We assessed serological response against the SARS-CoV-2 virus among our university students and staff. PATIENTS AND METHODS: In this prospective cohort study, seroprevalence was determined in 705 randomly selected volunteers, members of the Faculty of Medicine and Health Sciences of the University of Alcalá, using a chemiluminescent Siemens' SARS-CoV-2 immunoassay for total antibodies. Positive samples were tested for IgG and IgM/IgA using VIRCLIA® MONOTEST (Vircell). A first analysis took place during June 2020, and in those testing positive, a determination of secondary outcomes was performed in November 2020. RESULTS: A total of 130 subjects showed anti-SARS-CoV-2 antibodies (18.5%, 95% CI, 15.8-21.5%). Of these, IgM/IgA was positive in 27 and indeterminate in 19; IgG was positive in 118, indeterminate in 1. After 23 weeks, among 102 volunteers remeasured, IgG became undetectable in 6. Presence of antibodies was associated, in multivariable logistic regression, with exposure to infected patients (31.3%) [OR 1.84, 95% CI, 1.14-2.96; P = 0.012], presence of COVID-19 symptoms (52.4%) [OR 6.88, 95% CI, 4.28-11.06; P < 0.001], and confirmed earlier infection (82.9%) [OR 11.87, 95% CI, 4.26-33.07; P < 0.001]. CONCLUSIONS: The faculty of medicine and health sciences personnel and students of our university showed a high infection rate for SARS-CoV-2 during 2020 associated with providing clinical care to infected patients. This emphasizes the importance of the performance of continuous surveillance methods of the most exposed health personnel, including health science students.

Eficacia de la práctica de yoga y del ejercicio aeróbico frente al standard of care en pacientes con fibromialgia. Estudio FIB-YOGA-EA-SOC / Efficacy of Yoga Practice and Aerobic Exercise compared to Standard of Care in Patients with Fibromyalgia. FIB-YOGA-EA-SOC Study

Objetivo: evaluar los efectos de una intervención integral de yoga y de ejercicio aeróbico (EA) frente al ejercicio de la práctica habitual o standard of care (SOC) sobre el impacto general y la gravedad de la fibromialgia (FM). Métodos: ensayo clínico aleatorizado de tres brazos en mujeres diagnosticadas de FM (grupos: YOGA, serie de asanas de Satyananda Saraswasi (n= 31); EA, 7.000 pasos diarios (n= 31); SOC (n= 61)). Variables e instrumentos: datos antropométricos, sociodemográficos y clínicos; Fibromyalgia Impact Questionnaire (FIQ); dolor (Widespread pain Index -WPI-); gravedad de los síntomas (Symptom Severity Score -SSS-); calidad de vida (índice combinado de afectación en pacientes con FM -ICAF-); capacidad funcional (Fibromyalgia Health Assessment Questionnaire -FHAQ-). Para la comparación entre los grupos se utilizó la prueba t de Student . Resultados: se estudiaron 96 mujeres con FM. Con respecto al grupo SOC, se han observado mejorías estadísticamente significativas (p< 0,05), y a nivel clínico con las intervenciones YOGA y EA en el índice de dolor (WPI), impacto general y gravedad de la FM (FIQ), gravedad de los síntomas (SSS) y calidad de vida (ICAF). Sin embargo, no se observó una mejoría en la capacidad funcional (FHAQ). Comparando ambas intervenciones, YOGA versus EA, se vieron diferencias estadísticamente significativas en los síntomas específicos (SSS) y la calidad de vida (ICAF). Conclusiones: los profesionales de la salud se enfrentan a numerosos desafíos en el tratamiento de estos pacientes. Los hallazgos de este ensayo son prometedores respecto a los efectos beneficiosos del YOGA y EA para disminuir el dolor, el impacto general y gravedad, y gravedad de los síntomas, así como en mejorar la calidad de vida en pacientes con FM.(AU)

Objective: to assess the effects of a comprehensive yoga and aerobic exercise (AE) intervention versus standard of care (SOC) exercise on the overall impact and severity of fibromyalgia (FM). Methods: three-arm randomised clinical trial in women diagnosed with FM (groups: YOGA, Satyananda Saraswasi asana series (n=31); AE, 7,000 steps per day (n= 31); SOC (n= 61)). Variables and instruments: anthropometric, sociodemographic and clinical data; Fibromyalgia Health Assessment Questionnaire (FIQ); pain (Widespread pain Index (WPI)); symptom severity (Symptom Severity Score (SSS); quality of life (Combined Index of Severity of Fibromyalgia (CISF)); functional capacity (Fibromyalgia Health Assessment Questionnaire (FHAQ)). For comparison between groups, Student's t-test was used. Results: ininety-six women with FM were studied. With respect to the SOC group, statistically significant (p<0.05), and clinically significant improvements were observed with the YOGA and AE interventions in pain index (WPI), overall impact and severity of FM (FIQ), symptom severity (SSS) and quality of life (CISF). However, no improvement in functional capacity (FHAQ) was observed. Comparing both interventions, yoga versus AE, statistically significant differences were seen in specific symptoms (SSS) and quality of life (CISF). Conclusions: healthcare professionals face numerous challenges in the management of these patients. The findings of this trial are promising regarding the beneficial effects of YOGA and AE in decreasing pain, global impact and severity, and symptom severity, as well as improving quality of life in patients with FM.(AU)

Results of an anaemia treatment protocol complementary to blood transfusion in elderly patients with hip fracture.

BACKGROUND: Anaemia is a very common condition in elderly patients with hip fracture. The side effects of blood transfusions are well known, and further research on potential alternative therapies is needed. OBJECTIVES AND DESIGN: A non-controlled descriptive study, conducted on 138 patients admitted for hip fracture, aimed at analysing the effects of an anaemia treatment protocol adjunctive to transfusion, based on the use of supra-physiological doses of intravenous iron and erythropoietin (IS/EPOS). The variables collected were, medical history, physical and cognitive status prior to fracture, as well as the need of blood products, medical complications during admission and their functional outcome at three and six months after the fracture were evaluated. Transfusion rates were compared with a historical control group when the only treatment for acute anaemia was transfusion (2011). RESULTS: Almost half (63, 48%) of the patients received blood transfusion, with (91,70%) IS/EPOD. Intravenous iron did not reduce the percentage of transfused patients (56% vs. 44%), but it did reduce the number of blood units required (0.7 units less in IS/EPO group). Patients who required transfusion had a longer hospital stay, (1.7 days; 13.2 vs. 11.5; p<0.005). Patients who received IS had better functional recovery assessed with Barthel index and the Functional Ambulation Categories (FAC scale) at 3 and 6 months after the fracture. Patients with malnutrition or subtrochanteric fracture needed more tabletransfusions (p<0.005). Functional recovery at 3 and 6 months after fracture was better in patients who received intravenous iron. Neither blood transfusions nor intravenous iron were associated with infectious complications or increased mortality. The patient series of this study was compared with a group of patients with hip fracture and similar characteristics seen in 2011, before intravenous iron was available, revealing a 17% reduction in blood transfusion needs (p<0.005). CONCLUSION: The use of intravenous iron in elderly patients with hip fracture may help to reduce the number of blood units needed for the treatment of anaemia, although a causal relationship cannot be established due to not having a control group. Transfusions were associated with longer hospital stay in elderly patients with hip fracture.

[Geriatric intervention in elderly hip fracture patients admitted to University Hospital of Guadalajara: Clincal, healthcare and economical repercussions]. / Intervención geriátrica en el anciano ingresado por fractura de cadera en el Hospital Universitario de Guadalajara: repercusión clínica, asistencial y económica.

OBJECTIVE: To evaluate the healthcare outcomes and economic impact of geriatric intervention in patients over 75 years old with hip fracture in acute phase. MATERIAL AND METHODS: Retrospective study of patients admitted to the University Hospital of Guadalajara (HUGU) due to hip fracture. An analysis was made of the number of cases per year, preoperative period, hospital stay, and mortality of all the patients over 75 years admitted to the HUGU due to hip fracture between 2002 and 2013. RESULTS: A total of 2942 patients were included. Comparing the activity of 2013 to that of 2006, the mean hospital stay fell from 18.5 to 11.2 days (-39.2%), and mortality from 8.9% to 6.8% (-23%). In contrast, the mean preoperative stay remained at a mean of 2.7 days versus 2.4 in previous years in the early post-intervention period. Hospital stay decreased, despite a progressive annual increase in the daily cost of hospitalisation due to hip fracture surgery, the reduced stay led to a reduction of the total cost by more than 900,000 euros each year. Geriatric intervention has gradually reduced mean hospital stay and mortality, although with a tendency to increase mean preoperative stay. CONCLUSIONS: Geriatric intervention in patients with hip fracture reduces mortality and length of hospital stay, and decreasing costs.

Exposición a radiación diagnóstica en pacientes con enfermedad de Crohn: estudio retrospectivo en un hospital medio y sus factores predictivos / Ionizing diagnostic radiation exposure in patients with Crohn's disease: a retrospective study in a medium hospital and its predictive factors

Introducción. La exposición a radiación ionizante procedente de pruebas médicas puede ser responsable del 0,5-2% de los cánceres a nivel mundial. Debido al curso crónico en brotes y al comienzo temprano de la enfermedad de Crohn (EC), estos pacientes requieren múltiples exploraciones radiológicas ionizantes. Objetivo. Estimar la cantidad de radiación ionizante que reciben nuestros pacientes con EC así como identificar aquellos factores de riesgo asociados a recibir una dosis de radiación debida a su enfermedad (DEED)>50mSv. Material y métodos. Estudio de cohorte retrospectivo (2001-2014). Población: pacientes con EC. Dosis de riesgo >50mSv. Para el cálculo de dosis efectiva total y DEED se recogieron las exploraciones radiológicas a las que fueron sometidos. Para la identificación de factores predictivos asociados a recibir una DEED > 50mSv se realizó mediante regresión logística uni- y multivariante utilizando la dosis >50mSv como variable dependiente. Resultados. De los 267 pacientes con EC analizados, el 24,6% recibieron una dosis efectiva total >50mSv y el 15,2% una DEED >50mSv. En el análisis multivariante las variables que de forma independiente se asociaron a recibir una DEED >50mSv fueron la cirugía mayor (OR= 2,1; IC95% [1,1-3,8]; p=0,019) y la gravedad (OR=20,1; IC95% [2,7-148,4]; p<0,001). Conclusiones. Los pacientes con EC están más expuestos a recibir una DEED de riesgo, por lo que sería conveniente monitorizar la DE recibida para anticipar nuestra actuación con el fin de evitar llegar a dicha dosis. La ecografía y la entero-RNM son alternativas a considerar en estos casos, aunque su accesibilidad está limitada en algunos centros (AU)

Introduction. It is estimated that diagnostic medical radiation exposure may be responsable for 0.5-2% of cancers worldwide. Because of the relapsing course of Crohn's disease (CD), these patients usually requiere multiple ionizing radiation test. Objective. Stimating the total cumulative effective dose received by our CD patients and identifying the risk factors associated with the exposure to a cumulative effective dose due to the disease (CEED) > 50mSv. Materials and methods. Retrospective cohort study (2001-2014). Population: patients with CD. Risk dose >50mSv. For calculating de cumulative effective dose and the CEED, all the ionizing test done were taken. For identifying predictive factors for receiving a CEDD >50mSv, an univariate and a multivariate logistic regression analyses were performed using a >50mSv dose as dependent variable. Results. Of the 267 patients analyzed the 24.6% of them received a cumulative effective dose > 50mSv and the 15.2% a CEED>50mSv. In the multivariate analysis, the following variables were identified as independent predictors associated with a CEDD >50mSv: major surgery (OR= 2.1; IC95% [1.1-3.8]; p=.019) and severity (OR= 20.6; IC95% [4.5-94.8]; p<.01). Conclusions. Patients with CD are more at risk of receiving risk CEED, so it would be advisable to monitor the cumulative effective dose received to anticipate our intervention in order to avoid reaching that dose. The ultrasounds and abdominal resonance enterography are alternatives in these cases, although their accessibility is limited in some centers (AU)

Intervención geriátrica en el anciano ingresado por fractura de cadera en el Hospital Universitario de Guadalajara: repercusión clínica, asistencial y económica / Geriatric intervention in elderly hip fracture patients admitted to University Hospital of Guadalajara: clincal, healthcare and economical repercussions

Objetivo. Evaluar los resultados asistenciales y la repercusión económica de la intervención geriátrica en pacientes mayores de 75 años con fractura de cadera en fase aguda. Material y métodos. Estudio retrospectivo de los pacientes ingresados por fractura de cadera en el Hospital Universitario de Guadalajara (HUGU). Se evaluaron parámetros asistenciales del total de los pacientes ingresados por fractura de cadera en el HUGU entre los años 2002 y 2013 (n=2.942), tales como número anual de casos, la estancia preoperatoria, la estancia global y la mortalidad. Evaluación del efecto de la intervención geriátrica protocolizada iniciada en 2006 mediante la comparación de datos entre las etapas previa y posterior a su puesta en marcha. Resultados. La intervención geriátrica ha supuesto una reducción progresiva de estancia media y la mortalidad, aunque con una tendencia aumentar la estancia prequirúrgica. Comparando la actividad del 2013 con la del 2006, la estancia media se redujo del 18,5 al 11,2 días (-39,2%) y la mortalidad desde el 8,9 hasta el 6,8% (-23%). Por el contrario, la estancia preoperatoria media se mantuvo en 2,7 días de media en los años postintervención, frente a 2,4 en los años previos. A pesar del incremento anual del precio diario de la hospitalización por factura de cadera, el descenso de la estancia implica una reducción del coste del proceso que supera los 900.000 euros anuales. Conclusiones. La intervención geriátrica contribuye a la reducción observada de la mortalidad y la estancia hospitalaria por fractura de cadera, disminuyendo el coste de la hospitalización (AU)

Objective. To evaluate the healthcare outcomes and economic impact of geriatric intervention in patients over 75 years old with hip fracture in acute phase. Material and methods. Retrospective study of patients admitted to the University Hospital of Guadalajara (HUGU) due to hip fracture. An analysis was made of the number of cases per year, preoperative period, hospital stay, and mortality of all the patients over 75 years admitted to the HUGU due to hip fracture between 2002 and 2013. Results. A total of 2942 patients were included. Comparing the activity of 2013 to that of 2006, the mean hospital stay fell from 18.5 to 11.2 days (-39.2%), and mortality from 8.9% to 6.8% (-23%). In contrast, the mean preoperative stay remained at a mean of 2.7 days versus 2.4 in previous years in the early post-intervention period. Hospital stay decreased, despite a progressive annual increase in the daily cost of hospitalisation due to hip fracture surgery, the reduced stay led to a reduction of the total cost by more than 900,000 euros each year. Geriatric intervention has gradually reduced mean hospital stay and mortality, although with a tendency to increase mean preoperative stay. Conclusions. Geriatric intervention in patients with hip fracture reduces mortality and length of hospital stay, and decreasing costs (AU)

Evaluación de la implantación de un protocolo de recuperación intensificada en cirugía electiva de colon y recto: un estudio cuasiexperimental / No disponible

INTRODUCCIÓN: Los protocolos de recuperación intensificada (PRI) en cirugía de colon y recto disminuyen la estancia hospitalaria y las complicaciones, pero son pocos los estudios acerca de si son coste-efectivos. MÉTODOS: Comparamos un grupo de 121 pacientes (grupo RICA) operados de forma consecutiva de cirugía electiva de colon y recto según un PRI, con una cohorte histórica de 135 pacientes (grupo preRICA) operados antes de la implantación del PRI de forma tradicional. Se realizó un análisis univariante para comparar los datos de estancia, complicaciones, reingresos y coste efectividad, y un análisis multivariante para comprobar si la realización de cirugía laparoscópica, el PRI, las complicaciones, el sexo y la edad influían de forma independiente en la estancia hospitalaria, los reingresos y los costes. RESULTADOS: Los dos grupos fueron homogéneos, realizándose más cirugía laparoscópica en el grupo RICA (27 (20%) vs 45 (37,2%), p = 0,006). En el grupo RICA se objetivó una disminución de la estancia hospitalaria de 1,2 días (11 ± 3,8 vs 9,8 ± 3,7, p = 0,018), sin aumentar la tasa de complicaciones (49 (36,3%) vs 38 (31,4%), p = 0,49), de reingresos a los 30 días tras el alta hospitalaria (15 (11,1%) vs 12 (9,9%), p = 0,756), la mortalidad (1 (0,7%) vs 2 (1,7%), p = 0,498) ni el gasto sanitario (1618,8 € ± 830,5 ± 1578,6 ± 491,1, p = 0,634). La laparoscopia redujo de forma independiente la estancia hospitalaria y la tasa de reingresos, mientras que la presencia de complicaciones severas lo aumentó. CONCLUSIONES: La aplicación de un PRI en cirugía electiva de colon y recto es coste-efectiva, pues mejora los resultados obtenidos sin incrementar el gasto sanitario

INTRODUCTION: ERAS (Enhanced Recovery After Surgery) protocols in colorectal surgery reduce hospital stay and com-plications, but there are few studies on whether they are cost-effective. METHODS: We compared a group of 121 patients (ERAS group) consecutively operated on elective colorectal surgery according to an ERAS protocol, with a historical cohort of 135 patients (preERAS group) operated prior to the implantation of the protocol in a traditional manner. A univariate analysis was performed to compare the data of stay, complications, readmissions and cost effectiveness, and a multivariate analysis to check whether laparoscopic surgery, the ERAS protocol, complications, sex and age had an independent influence hospital stay, readmissions rate and costs. RESULTS: The two groups were homogeneous, with more laparoscopic surgery performed in the ERAS group (27 (20%) vs 45 (37.2%), p = 0.006). In the ERAS group, a decrease in hospital stay was observed in 1,2 days (11 ± 3.8 vs 9.8 ± 3.7, p = 0.018), without increasing the complication rate (49 (36.3%) vs 38 (31.4%), p = 0.49), readmissions at 30 days after hospital discharge (15 (11.1%) vs 12 (9.9%), p = 0.756), mortality (1 (0.7%) vs 2 (1.7%), p = 0.498) and healthcare costs (1618.8 € ± 830.5 vs 1578.6 € ± 491.1, p = 0.634). Laparoscopic surgery independently reduced the hospital stay and the rate of readmissions, while the presence of severe complications increased them. CONCLUSIONS: The application of an ERAS protocol in elective colorectal surgery surgery is cost-effective, since it improves the results obtained without increasing healthcare costs

Tratamiento con pembrolizumab en paciente con infección por virus de la inmunodeficiencia humana y leucoencefalopatía multifocal progresiva / Pembrolizumab treatment for progressive multifocal leukoencephalopathy in a patient with Human Immunodeficiency Virus infection

No disponible

Results of an anaemia treatment protocol complementary to blood transfusion in elderly patients with hip fracture / Resultados de un protocolo de tratamiento de anaemia con terapias complementarias a transfusión en anciano con fractura de cadera

Background: Anaemia is a very common condition in elderly patients with hip fracture. The side effects of blood transfusions are well known, and further research on potential alternative therapies is needed. Objectives and design: A non-controlled descriptive study, conducted on 138 patients admitted for hip fracture, aimed at analysing the effects of an anaemia treatment protocol adjunctive to transfusion, based on the use of supra-physiological doses of intravenous iron and erythropoietin (IS/EPOS). The variables collected were, medical history, physical and cognitive status prior to fracture, as well as the need of blood products, medical complications during admission and their functional outcome at three and six months after the fracture were evaluated. Transfusion rates were compared with a historical control group when the only treatment for acute anaemia was transfusion (2011). Results: Almost half (63, 48%) of the patients received blood transfusion, with (91,70%) IS/EPOD. Intravenous iron did not reduce the percentage of transfused patients (56% vs. 44%), but it did reduce the number of blood units required (0.7 units less in IS/EPO group). Patients who required transfusion had a longer hospital stay, (1.7 days; 13.2 vs. 11.5; p<0.005). Patients who received IS had better functional recovery assessed with Barthel index and the Functional Ambulation Categories (FAC scale) at 3 and 6 months after the fracture. Patients with malnutrition or subtrochanteric fracture needed more tabletransfusions (p<0.005). Functional recovery at 3 and 6 months after fracture was better in patients who received intravenous iron. Neither blood transfusions nor intravenous iron were associated with infectious complications or increased mortality. The patient series of this study was compared with a group of patients with hip fracture and similar characteristics seen in 2011, before intravenous iron was available, revealing a 17% reduction in blood transfusion needs (p<0.005). Conclusion: The use of intravenous iron in elderly patients with hip fracture may help to reduce the number of blood units needed for the treatment of anaemia, although a causal relationship cannot be established due to not having a control group. Transfusions were associated with longer hospital stay in elderly patients with hip fracture

Introducción: El síndrome anémico es muy frecuente en el anciano ingresado por fractura de cadera. Los documentados efectos secundarios de la transfusión de hemoderivados hacen necesario investigar otras posibles alternativas terapéuticas. Material y métodos: Estudio descriptivo de 138 pacientes ingresados por fractura de cadera que evalúa el efecto de un protocolo de tratamiento de anemia perioperatoria complementario a transfusión, basado en el empleo de dosis suprafisiológicas de hierro intravenoso y eritropoyetina (FE/EPO). Se trata de un estudio descriptivo sin grupo control. Se evaluaron los antecedentes médicos de los pacientes, y su situación mental y física previas al ingreso, la necesidad de hemoderivados, las complicaciones en el ingreso y su evolución funcional en los 6 meses posteriores a la fractura. Los ratios de transfusión fueron comparados con los de una muestra histórica de similares características sin tratamiento con ferroterapia intravenosa (2011). Resultados: Recibieron transfusión el 48% de los pacientes (63) y ferroterapia parenteral con eritropoyetina (FE/EPO) el 70% (91). La administración de FE/EPO no disminuyó el porcentaje de pacientes hemotransfundidos (56 vs. 44%) de forma significativa, pero sí redujo el número de unidades de sangre requeridas (0,7 unidades menos en grupo de FE/EPO). Los pacientes que recibieron ferroterapia intravenosa tuvieron una estancia hospitalaria de 1,7 días inferior que los transfundidos (11,5 vs. 13,2; p<0,005). La administración de hierro parenteral se relacionó con tendencia a una mejor recuperación de capacidad de autocuidados y deambulación medidos mediante el índice de Barthel (IB) y la escala de deambulación de Holden (FAC) a los 3 y 6 meses de la fractura. La anemia y la malnutrición al ingreso, así como el tipo de fracturas subtrocantérea se relacionaron de forma independiente a mayor necesidad de transfusión (p<0,005). Ni las transfusiones ni el tratamiento con ferroterapia parenteral se asociaron a más complicaciones infecciosas ni a mayor mortalidad. Al comparar la muestra actual con un control histórico de pacientes con fractura de cadera sin disponibilidad de tratamiento con hierro intravenoso, se observa reducción actual del porcentaje de pacientes transfundidos en un 17% (p<0,005). Conclusión: El empleo de ferroterapia intravenosa en pacientes con fractura de cadera puede reducir el número de unidades de hemoderivados necesarias, sí bien no se puede establecerse una relación causal al no ser un estudio controlado. La transfusión se asocia con una prolongación de la estancia hospitalaria en el anciano ingresado por fractura de cadera