Detalles de la búsqueda
1.
Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers.
Crit Rev Biochem Mol Biol
; 54(1): 41-60, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30773935
2.
Asymmetric Library Synthesis of P-Chiral t-Butyl-Substituted Secondary and Tertiary Phosphine Oxides.
J Org Chem
; 84(11): 7291-7302, 2019 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31099249
3.
P-Chiral, N-phosphoryl sulfonamide Brønsted acids with an intramolecular hydrogen bond interaction that modulates organocatalysis.
Org Biomol Chem
; 17(38): 8690-8694, 2019 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31535120
4.
Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle.
Bioorg Med Chem
; 26(8): 1713-1726, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29478802
5.
Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration.
Bioorg Med Chem
; 26(20): 5547-5554, 2018 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30309670
6.
A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.
Chembiochem
; 17(9): 843-51, 2016 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-26792008
7.
Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg Med Chem Lett
; 25(5): 1117-23, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25630225
8.
Solvent-Switchable Remote C-H Activation via 1,4-Palladium Migration Enables Site-Selective C-P Bond Formation: A Tool for the Synthesis of P-Chiral Phosphinyl Imidazoles.
Org Lett
; 26(20): 4200-4204, 2024 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38739265
9.
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.
Bioorg Med Chem
; 21(8): 2229-2240, 2013 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23477945
10.
Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer.
J Med Chem
; 66(23): 15776-15800, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37982711
11.
Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
BMC Struct Biol
; 12: 32, 2012 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23234314
12.
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.
Bioorg Med Chem
; 20(18): 5583-91, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22884353
13.
Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.
J Med Chem
; 65(3): 2471-2496, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35077178
14.
Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.
Bioorg Med Chem Lett
; 21(12): 3664-70, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21592789
15.
Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
J Am Chem Soc
; 132(43): 15204-12, 2010 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-20942454
16.
Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.
Bioorg Med Chem Lett
; 20(19): 5781-6, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20801032
17.
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Nature
; 426(6963): 186-9, 2003 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-14578911
18.
Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus.
Acc Chem Res
; 41(10): 1252-63, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18681464
19.
Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J Med Chem
; 62(21): 9691-9702, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31577901
20.
Isoprenoids and tau pathology in sporadic Alzheimer's disease.
Neurobiol Aging
; 65: 132-139, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29476987