A case of acquired phonological dyslexia with selective impairment of Kanji: analysis of reading impairment mechanism using cognitive neuropsychological models for reading.

We report a Japanese-speaking patient who showed acquired phonological dyslexia only in Kanji; difficulty in reading two-character Kanji nonwords despite her ability to read Kana nonwords, Kana words, and two-character Kanji inconsistent-atypical words; and inability to repeat reversal nonwords. We investigated the mechanism of nonword reading impairment using the dual-route cascaded model, it was likely that the reading deficit of Kanji nonwords with multiple pronunciations resulted from the dysfunction of the character-to-sound conversion rule system. The patient's reading performance on the dissociation of Kana and Kanji was considered to reflect the difference in the consistency of orthography-to-phonology mapping.

Does an impaired lexicon produce legitimate alternative reading of components (LARC) errors in reading Japanese Kanji? Evidence from two-Kanji compound word reading in a Japanese-speaking patient with aphasia.

Several studies have reported a strong association between semantic system impairment and LARC error production. However, our patient with a left temporal lobe contusion, including the fusiform gyrus, showed LARC errors even in two-Kanji compound words, the meanings of which the patient understood. Also, the poor results of lexical decision and picture naming suggested problems in orthographic and phonological retrieval. From these results, we concluded that at least some LARC errors are independent of semantic impairment, and other explanations are needed for this type of error.

A patient with aphasia using the nonsemantic lexical route for Kanji reading.

We report a patient with aphasia, caused by cerebral hemorrhage, who probably used the nonsemantic lexical route when reading words aloud. To investigate the mechanisms underlying her reading dysfunction, we analyzed her reading abilities using the Dual-Route Cascaded Model. Language tests resulted in low correct percentages for both reading comprehension and reading nonwords aloud, suggesting problems in the semantic system and the nonlexical route. Conversely, the patient showed high scores on the reading words aloud task. Although she failed to understand many inconsistent-atypical words in the reading comprehension test, she correctly read most words aloud, suggesting that she used the nonsemantic lexical route. In addition, the lexical reading route was analyzed in detail by using inconsistent-atypical Kanji words as stimuli. Finally, we analyzed her reading dysfunction compared with previous cases.

Cognitive neuropsychological analysis of differential reading and spelling disorder mechanisms in a patient with aphasia.

The purpose of this study was to determine if differential reading and spelling mechanisms were involved in a Japanese patient with aphasia. In our case, the patient scored low on all of the administered reading tasks, suggesting that both the reading lexical and non-lexical routes were impaired. In contrast, his writing-to-dictation score for Kana nonwords was high, suggesting that the spelling non-lexical route was intact. However, the patient scored low on a writing-to-dictation task comprised of high-familiarity Kanji words. The spelling lexical route was thought to be impaired. Therefore, the mechanism(s) involved in reading and spelling may differ in this case.

Cognitive Abilities Underlying Reading Accuracy, Fluency and Spelling Acquisition in Korean Hangul Learners from Grades 1 to 4: A Cross-Sectional Study.

The purpose of this cross-sectional study was to examine the cognitive abilities that predict reading and spelling performance in Korean children in Grades 1 to 4, depending on expertise and reading experience. As a result, visual cognition, phonological awareness, naming speed and receptive vocabulary significantly predicted reading accuracy in children in Grades 1 and 2, whereas visual cognition, phonological awareness and rapid naming speed did not predict reading accuracy in children in higher grades. For reading, fluency, phonological awareness, rapid naming speed and receptive vocabulary were crucial abilities in children in Grades 1 to 3, whereas phonological awareness was not a significant predictor in children in Grade 4. In spelling, reading ability and receptive vocabulary were the most important abilities for accurate Hangul spelling. The results suggested that the degree of cognitive abilities required for reading and spelling changed depending on expertise and reading experience.

Investigation of cognitive abilities related to reading and spelling in Korean: readers with high, average, and low skill levels.

In this study, we investigated the characteristics of cognitive abilities as predictors of Korean reading and spelling ability, and the characteristics of the cognition of reading difficulty in Korean. In 103 Korean third-grade children, we tested ability to read and spell, nonverbal intelligence, vocabulary size, phonological cognitive processing, visual cognitive processing, and naming speed. Our results indicated that receptive vocabulary, phoneme awareness, and naming speed served as factors for predicting reading test score; receptive vocabulary served as a factor for predicting spelling test score. We found that low reading-level groups had significantly slower performance on the naming speed task and lower scores on the receptive vocabulary test, as compared with the other groups (average and high reading-level groups). The present results have implications concerning useful tasks for screening for Korean poor readers.

[Usefulness and limitations of rapid automatized naming to predict reading difficulties after school entry in preschool children].

We investigated the usability and limitations of Rapid Automatized Naming (RAN) results in 6-year-old Japanese preschool children to estimate whether reading difficulties will be encountered after school entry. We administered a RAN task to 1,001 preschool children. Then after they had entered school, we performed follow-up surveys yearly to assess their reading performance when these children were in the first, second, third and fourth grades. Also, we examined Hiragana non-words and Kanji words at each time point to detect the children who were having difficulty with reading Hiragana and Kanji. Results by Receiver Operating Characteristic analysis showed that the RAN result in 6-year-old preschool children was predictive of Kanji reading difficulty in the lower grades of elementary school, especially in the second grade with a probability of 0.86, and the area under the curve showed a probability of 0.84 in the third grade. These results suggested that the RAN task was useful as a screening tool.

Influence of cognitive abilities on literacy skills in a Korean-Japanese bilingual child with developmental dyslexia.

Some individuals with developmental dyslexia show dissociation in reading skills between languages. The occurrence of dissociation depends on differences in the orthographic characteristics and cognitive demands of languages. This article reports on a Korean-Japanese bilingual and biliterate boy, SJ, with developmental dyslexia (aged 11 years), who displayed dissociation between Korean and Japanese in reading and writing accuracy. This study aimed to discuss possible accounts for the profile of his literacy skills from orthographic and cognitive perspectives. To accomplish this aim, we measured SJ's literacy skills, receptive vocabulary, and cognitive abilities (i.e., phonological skills, naming speed, and visual skills) in both Korean and Japanese. Then, we compared his skills to those of monolingual and bilingual children. In terms of accuracy, his reading skills in Korean did not differ significantly from those of bilinguals, although they were lower than Korean monolinguals. His spelling skills were within the average range for Korean monolinguals and bilinguals. In contrast, his reading and writing accuracy levels in Japanese were low compared to both Japanese monolinguals and bilinguals. Moreover, his reading and writing deficits were more remarkable in Japanese kanji. However, his cognitive profile was similar between languages. Specifically, he showed deficits in phonological skills and naming speed in both languages, as well as deficits in visual skills. These results were explained by the facts that visual skills are one of the significant predictors of reading and writing accuracy in Japanese but not in Korean, and that visual skills are a key in learning kanji. Thus, our case, SJ, supports the cognitive account, namely, the idea that different cognitive demands on the development of literacy skills can cause dissociation in literacy skills (especially in terms of accuracy) in bilingual children.

The Influence of Orthographic Units Across Korean Children of Different Ages in Hangul Reading.

Using the dual-route reading model as a framework, this study investigated the following research questions on Hangul reading: Which orthographic units (e.g., letters, syllable blocks, and words) influence the reading performance of Korean-speaking children? In addition, do the influential units change as the children grow up? To answer these questions, we tested the effects of age, frequency, lexicality, and two types of length-the numbers of letters (letter length) and syllable blocks (syllable block length)-and the interactions of these factors in the reading performance of Korean-speaking preschool and primary school children from first to third grade. Regarding reading latencies, there was a significant three-way interaction of age × lexicality × length regardless of the type of length. This interaction indicated that, for words only, the interaction between age and length was significant. Accordingly, the length effect decreased as children's age increased. When reading latencies for words were analyzed with a mixed-effect model consisting of three factors-age, frequency, and length-neither a main effect of syllable block length nor an interaction of syllable block length with age was significant. In contrast, the interaction of age × letter length in word reading latencies remained significant. The length effect was smaller as children's age increased. In addition, the frequency effect was significant and interacted significantly with age. The frequency effect increased as children's age increased. In conclusion, significant frequency effects indicate that Korean-speaking children use the lexical process in addition to the non-lexical process when reading Hangul words. Importantly, as children grow up, a larger orthographic unit, that is, words, is more strongly related to reading performance, whereas the influence of the smaller orthographic unit, that is, letters, decreases.

Altered visual character and object recognition in Japanese-speaking adolescents with developmental dyslexia.

Many studies have confirmed a brain dysfunction in people with developmental dyslexia (DD) in certain brain regions, including the left superior temporal gyrus and the left fusiform gyrus. However, the neurobiological substrates in Japanese-speaking people with dyslexia are not fully understood, mostly due to the uniqueness of the orthographic systems. Since a substantial part of the written Japanese includes the logographic Kanji as well as the phonographic Kana systems, the reading disability might be caused not only by a dysfunction in the phonological system, but also by a dysfunction in the visual recognition system. Previous studies reported altered hierarchical visual word form processing in the left occipitotemporal cortex; however, it remains unclear whether the altered hierarchical visual processing is language stimuli-specific. Therefore, we aimed to investigate whether (a) Japanese-speaking individuals with DD exhibit atypical hierarchical visual processing, and if so, (b) whether the altered hierarchical visual processing is language stimuli-specific or not. The present study investigated the brain activation pattern for the hierarchical component of the Kanji characters and object stimuli in typically developing (TD) adolescents and adolescents with DD using functional magnetic resonance imaging. For the Kanji characters, adolescents with DD showed a greater activation in the left occipital gyrus and right occipital fusiform gyrus, and this hyperactivity was also found for pseudo and artificial Kanji characters. These results imply reliance on an early visual system in Kanji reading in Japanese-speaking adolescents with DD. Additionally, we also investigated the brain activity for object stimuli, and adolescents with DD showed a greater activation in the bilateral occipital gyri compared with the TD adolescents. These results imply an altered hierarchical visual processing characterized by overactivation in the early visual areas, which is a not restricted to language stimulus only.

Left Amygdala Regulates the Cerebral Reading Network During Fast Emotion Word Processing.

Emotion words constitute a special class of verbal stimuli which can quickly activate the limbic system outside the left-hemisphere language network. Such fast response to emotion words may arise independently of the left occipitotemporal area involved in visual word-form analysis and rely on a distinct amygdala-dependent emotion circuit involved in fearful face processing. Using a hemifield priming paradigm with fMRI, we explored how the left and right amygdala systems interact with the reading network during emotion word processing. On each trial, participants viewed a centrally presented target which was preceded by a masked prime flashed either to the left or right visual field. Primes and targets, each denoting negative or positive nouns, could be either affectively congruent or incongruent with each other. We observed that affective congruency produced parallel changes in neural priming between the left frontal and parietotemporal regions and the bilateral amygdala. However, we also found that the left, but not right, amygdala exhibited significant change in functional connectivity with the neural components of reading as a function of affective congruency. Collectively, these results suggest that emotion words activate the bilateral amygdala during early stages of emotion word processing, whereas only the left amygdala exerts a long-distance regulatory influence over the reading network via its strong within-hemisphere connectivity.

Association Between Resting-State Functional Connectivity and Reading in Two Writing Systems in Japanese Children With and Without Developmental Dyslexia.

Introduction: Japanese is unique, as it features two distinct writing systems that share the same sound and meaning: syllabic Hiragana and logographic Kanji scripts. Acquired reading difficulties in Hiragana and Kanji have been examined in older patients with brain lesions. However, the precise mechanisms underlying deficits in developmental dyslexia (DD) remain unclear. Materials and Methods: The neural signatures of Japanese children with DD were examined by using resting-state functional magnetic resonance imaging. We examined 22 dyslexic and 46 typically developing (TD) children, aged 7-14 years. Results: Reading performance in each writing system was correlated with neural connectivity in TD children. In contrast, in children with DD, weak associations between neural connectivity and reading performance were observed. In TD children, Hiragana-reading fluency was positively correlated with the left fusiform gyrus network. No significant correlations between Hiragana fluency and neural connectivity were observed in children with DD. Correspondingly, there were fewer correlations between Kanji accuracy and strength of reading-related connectivity in children with DD, whereas positive correlations with the bilateral fronto-parietal network and negative correlations with the left fusiform network were found in TD children. Discussion: These data suggest that positive and negative coupling with neural connectivity is associated with developing Japanese reading skills. Further, different neural connectivity correlations between Hiragana fluency and Kanji accuracy were detected in TD children but less in children with DD. Conclusion: The two writing systems may exert differential effects and deficits on reading in healthy children and in children with DD, respectively.

Cognitive neuropsychological and regional cerebral blood flow study of a Japanese-English bilingual girl with specific language impairment (SLI).

We report here on an investigation into the possible factors which might have contributed to language impairment (LI) in EM, a 14-year-old Japanese-English bilingual girl. EM was born in the UK to Japanese parents with no other siblings, and used English to communicate with all other people except for her parents. A delay in her English language development was identified at primary school in the UK, which was attributed to her bilingualism. The deficiency in her English language skills persisted into her adolescence despite more than adequate educational opportunities (including additional language support). At the start of her secondary education, language ability/literacy attainment tests were conducted in both English and Japanese, and the results suggested specific language impairment (SLI) in both languages. Further, her brain Single Photon Emission Computed Tomography (SPECT) revealed significantly lower Regional Cerebral Blood Flow(rCBF) in the left temporo-parietal area, which is also similar to the area of dysfunction often found among Japanese individuals with SLI.

The effect of the position of atypical character-to-sound correspondences on reading kanji words aloud: Evidence for a sublexical serially operating kanji reading process.

In English, the size of the regularity effect on word reading-aloud latency decreases across position of irregularity. This has been explained by a sublexical serially operating reading mechanism. It is unclear whether sublexical serial processing occurs in reading two-character kanji words aloud. To investigate this issue, we studied how the position of atypical character-to-sound correspondences influenced reading performance. When participants read inconsistent-atypical words aloud mixed randomly with nonwords, reading latencies of words with an inconsistent-atypical correspondence in the initial position were significantly longer than words with an inconsistent-atypical correspondence in the second position. The significant difference of reading latencies for inconsistent-atypical words disappeared when inconsistent-atypical words were presented without nonwords. Moreover, reading latencies for words with an inconsistent-atypical correspondence in the first position were shorter than for words with a typical correspondence in the first position. This typicality effect was absent when the atypicality was in the second position. These position-of-atypicality effects suggest that sublexical processing of kanji occurs serially and that the phonology of two-character kanji words is generated from both a lexical parallel process and a sublexical serial process.

Relationship between the change of language symptoms and the change of regional cerebral blood flow in the recovery process of two children with acquired aphasia.

OBJECTIVE: This study aimed to investigate the relationship between the change of language symptoms and the change of regional cerebral blood flow (rCBF) in the recovery process of two children with acquired aphasia caused by infarctions from Moyamoya disease with an onset age of 8years. METHODS: We compared the results for the Standard Language Test of Aphasia (SLTA) with rCBF changes in 7 language regions in the left hemisphere and their homologous regions in the right hemisphere at 4 time points from 3weeks for up to 5years after the onset of aphasia, while controlling for the effect of age. RESULTS: In both cases, strong correlations were seen within a hemisphere between adjacent regions or regions that are connected by neuronal fibers, and between some language regions in the left hemisphere and their homologous regions in the right hemisphere. Conversely, there were differences between the two cases in the time course of rCBF changes during their recovery process. CONCLUSION: Consistent with previous studies, the current study suggested that both hemispheres were involved in the long-term recovery of language symptoms in children with acquired aphasia. We suggest that the differences between both cases during their recovery process might be influenced by the brain states before aphasia, by which hemisphere was affected, and by the timing of the surgical revascularization procedure. However, the changes were observed in the data obtained for rCBF with strong correlations with the changes in language performance, so it is possible that rCBF could be used as a biomarker for language symptom changes.

An objective estimation of the removability of three home reliners.

The purpose of this study was to investigate methods for evaluating objectively the removability of three commercially available home reliners (Cushion Correct, Tafugurippu Pink A and Liodent Pink). After immersing each of the reliners in distilled water at 37ºC for 24 h, we compared their removability using the peel test with a finger, which was evaluated based on a visual analogue scale and the percentage of the residual area. An experimental rake-up test was also undertaken to quantify removability, evaluated based on the total amount of work required to remove it. The Tafugurippu Pink A product was easier to remove with a finger than the other two home reliner products, and required the least total amount of work to be removed in the experimental rake-up test. Furthermore, the rake-up test performed could possibly be used for objective evaluation of the removability of home reliner.

Audiovisual phonological mismatch produces early negativity in auditory cortex.

During silent reading, visual information provided by letters is converted to auditory information in the mind. The purpose of this study was to identify the primary locus for auditory verbal imagery in the brain. Neuromagnetic recording was obtained from 10 right-handed study participants, who were instructed to identify infrequently occurring phonological mismatches between a random-ordered sequence of syllable sounds and a visually presented syllabogram sequence. The activity difference in early latency, calculated by subtracting the averaged responses to matched syllables from the averaged responses to mismatched syllables, showed a spatiotemporal profile strikingly similar to that of mismatch negativity. Auditory imagery of forthcoming verbal sounds may establish a memory trace as a template for imagery-based mismatch negativity generation in the auditory cortex.

Auditory imagery mismatch negativity elicited in musicians.

A mismatch between auditory sensation and expectant imagery of syllables elicited a possible equivalent of mismatch negativity in a previous study. The purpose of this study was to verify whether auditory imagery from musical notation could also mediate such imagery-based mismatch negativity. Neuromagnetic recording was obtained from eight musicians, who were instructed to identify unpredictably occurring pitch mismatches between a random tone sequence and a visually presented musical score. The difference between incongruent and congruent responses showed a magnetic distribution consistent with two frontal-negative current dipoles bilaterally located in the vicinity of Heschl's gyrus, peaking at approximately 150 ms in latency. This imagery-based mismatch negativity may represent an early neural process of deviance detection between the sensory input and expectant imagery.

Investigation of basic cognitive predictors of reading and spelling abilities in Tunisian third-grade primary school children.

BACKGROUND: This study investigated first the main cognitive abilities; phonological processing, visual cognition, automatization and receptive vocabulary in predicting reading and spelling abilities in Arabic. Second, we compared good/poor readers and spellers to detect the characteristics of cognitive predictors which contribute to identifying reading and spelling difficulties in Arabic speaking children. METHODS: A sample of 116 Tunisian third-grade children was tested on their abilities to read and spell, phonological processing, visual cognition, automatization and receptive vocabulary. RESULTS: For reading, phonological processing and automatization uniquely predicted Arabic word reading and paragraph reading abilities. Automatization uniquely predicted Arabic non-word reading ability. For spelling, phonological processing was a unique predictor for Arabic word spelling ability. Furthermore, poor readers had significantly lower scores on the phonological processing test and slower reading times on the automatization test as compared with good readers. Additionally, poor spellers showed lower scores on the phonological processing test as compared with good spellers. Visual cognitive processing and receptive vocabulary were not significant cognitive predictors of Arabic reading and spelling abilities for Tunisian third grade children in this study. CONCLUSIONS: Our results are consistent with previous studies in alphabetic orthographies and demonstrate that phonological processing and automatization are the best cognitive predictors in detecting early literacy problems. We suggest including phonological processing and automatization tasks in screening tests and in intervention programs may help Tunisian children with poor literacy skills overcome reading and spelling difficulties in Arabic.

Neural basis of hierarchical visual form processing of Japanese Kanji characters.

INTRODUCTION: We investigated the neural processing of reading Japanese Kanji characters, which involves unique hierarchical visual processing, including the recognition of visual components specific to Kanji, such as "radicals." METHODS: We performed functional MRI to measure brain activity in response to hierarchical visual stimuli containing (1) real Kanji characters (complete structure with semantic information), (2) pseudo Kanji characters (subcomponents without complete character structure), (3) artificial characters (character fragments), and (4) checkerboard (simple photic stimuli). RESULTS: As we expected, the peaks of the activation in response to different stimulus types were aligned within the left occipitotemporal visual region along the posterior-anterior axis in order of the structural complexity of the stimuli, from fragments (3) to complete characters (1). Moreover, only the real Kanji characters produced functional connectivity between the left inferotemporal area and the language area (left inferior frontal triangularis), while pseudo Kanji characters induced connectivity between the left inferotemporal area and the bilateral cerebellum and left putamen. CONCLUSIONS: Visual processing of Japanese Kanji takes place in the left occipitotemporal cortex, with a clear hierarchy within the region such that the neural activation differentiates the elements in Kanji characters' fragments, subcomponents, and semantics, with different patterns of connectivity to remote regions among the elements.