1.
J Org Chem
; 85(12): 7916-7924, 2020 Jun 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32427486
RESUMEN
The highly enantioselective copper/chiral phosphine-catalyzed hydro-, bora-, and carbo-metalations of difluorocyclopropenes with PHMS [H-Si], H-BPin, (BPin)2, and (CH3)2Zn [Zn-Me] are shown to regiodivergently afford highly enantioenriched and functionalized difluorocyclopropanes. These examples can be viewed as the first successful syntheses of "chiral" gem-dimethyl and tert-butyl analogues.