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Bioorg Med Chem Lett
; 20(8): 2542-5, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20299216
RESUMEN
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improved the overall general profile of these prolinate derivatives.