RESUMEN
We report a case of pigmented villonodular synovitis of the elbow in a 55-year-old woman. Its radiological feature, the fenestrated fossa, may be characteristic of the advanced stage of this disorder.
Asunto(s)
Articulación del Codo , Sinovitis Pigmentada Vellonodular/diagnóstico por imagen , Sinovitis Pigmentada Vellonodular/patología , Femenino , Humanos , Persona de Mediana Edad , Radiografía , Sinovitis Pigmentada Vellonodular/cirugíaRESUMEN
The effects of vitamin D3 deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor in the duodenum, kidney and cerebellum of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of the fetal 28 kDa CaBP (CaBP-D28k) in the cerebellum, kidney and duodenum, and the 9 kDa CaBP (CaBP-D9k) in the intestine and kidney. Vitamin D receptor was undetectable in all fetal tissues, regardless of maternal vitamin D status, at all stages of gestation examined. Thus it appears that maternal vitamin D status does not affect the ontogeny of CaBP-D9k or CaBP-D28k in the mouse fetus. The factors that influence the appearance of calbindins in the fetus are unclear.
Asunto(s)
Cerebelo/embriología , Colecalciferol/deficiencia , Duodeno/embriología , Riñón/embriología , Preñez , Proteína G de Unión al Calcio S100/metabolismo , Deficiencia de Vitamina D/metabolismo , Animales , Cerebelo/metabolismo , Colecalciferol/administración & dosificación , Dieta , Duodeno/metabolismo , Femenino , Inmunohistoquímica , Riñón/metabolismo , Mesonefro/metabolismo , Ratones , Ratones Endogámicos , Estado Nutricional , Embarazo , Receptores de Calcitriol/análisis , Proteína G de Unión al Calcio S100/análisisRESUMEN
The effects of vitamin D deficiency on the ontogeny of calcium-binding proteins (CaBPs) and the vitamin D receptor (VDR) in the placenta and yolk sac of the mouse were examined. Maternal vitamin D status did not affect the time of appearance of CaBP-D9k (9 kDa) in the yolk sac endoderm or trophoblastic giant cells (TGCs) of the placenta. VDRs were undetectable in TGCs and yolk sac endoderm, but were present in the intraplacental yolk sac. Since yolk sac endoderm and TGCs contain CaBP but not VDR, it is unlikely that CaBP synthesis and/or activity in these cells is controlled by vitamin D. The TGCs, therefore, may be involved in vitamin D-independent transplacental transfer of calcium.
Asunto(s)
Receptores de Calcitriol/metabolismo , Proteína G de Unión al Calcio S100/metabolismo , Trofoblastos/metabolismo , Deficiencia de Vitamina D/metabolismo , Animales , Calbindinas , Endodermo/química , Endodermo/metabolismo , Femenino , Inmunohistoquímica , Ratones , Ratones Endogámicos , Embarazo , Receptores de Calcitriol/análisis , Proteína G de Unión al Calcio S100/análisis , Trofoblastos/química , Trofoblastos/citología , Saco Vitelino/química , Saco Vitelino/metabolismoRESUMEN
Whether an occupation can cause carpal tunnel syndrome requiring carpal tunnel decompression (CTD) is contentious. We compared the demographics and incidence rates in lamb-freezing workers with the general population who had CTD. In the general population there were 1002 (63%) females and 583 (37%) males, mean age 48 years, and the rate of CTD was 1.36/1000 per annum. In lamb-freezing workers there were 225 males (mean age 38.4 years) and 60 females (mean age 44.6 years); most workers required CTD in their first three seasons. Compared with the general population, the incidence rate ratios in all freezing workers was 16.8; boners, 51.6; meat packers, 22.8; and slaughtermen, 5.4. All groups had a greater rate of CTD than the general population. This study suggests that carpal tunnel syndrome can be directly caused by an occupation.
Asunto(s)
Mataderos , Síndrome del Túnel Carpiano/epidemiología , Congelación/efectos adversos , Enfermedades Profesionales/epidemiología , Exposición Profesional/efectos adversos , Adulto , Factores de Edad , Anciano , Síndrome del Túnel Carpiano/diagnóstico , Estudios de Cohortes , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Nueva Zelanda , Enfermedades Profesionales/diagnóstico , Factores de Riesgo , Factores Sexuales , Adulto JovenAsunto(s)
Cementos para Huesos , Fémur/cirugía , Prótesis de Cadera , Fémur/diagnóstico por imagen , Humanos , RadiografíaRESUMEN
Carpal tunnel syndrome is common at the largest lamb processing plant in the world, especially in new lamb boners. The purpose of this study was to establish the incidence and whether expeditious return to work following open carpal tunnel decompression was possible. Two hundred patients with a neurophysiologically confirmed diagnosis underwent surgery between 2002 and 2006. One hundred and eighty-seven patients were assessed retrospectively and 13 prospectively. The incidence in new lamb boners was 10% in their first season. On average, workers commenced rehabilitation at 11 days post-operatively and full duties at 29 days post-operatively with minimal further time off taken. Ninety percent returned to their previous role. By 8 weeks in the prospective group visual analogue pain scores had improved from 8.75 to 2.0 (P<0.01) and Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores had improved from 140 points to 68 (P<0.01). Grip/pinch testing, static two-point discrimination scores and complication rates were comparable with previous studies. This study provides good evidence that coordinated, early rehabilitation and return to work is effective in a high-demand population.