1.
Methods Enzymol
; 346: 649-60, 2002.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11883097
Asunto(s)
Terapia Genética , Vectores Genéticos , Herpesvirus Humano 4/genética , Plásmidos , Northern Blotting , Humanos , Fenotipo , Transgenes
2.
Stat Med
; 21(23): 3571-82, 2002 Dec 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12436456
RESUMEN
The paper considers the statistical problem of estimating the origin of DNA replication within the human ribosomal DNA (rDNA) locus and the issue of assessing the standard error of the estimate. Based on mapping the cumulative replication index (CRI), two different modelling schemes are suggested and investigated. The statistical problem of constructing a confidence interval for the origin of DNA replication is related to Fieller's problem of obtaining a confidence interval for the ratio of two normal means. Standard normal theory, the delta and bootstrap methods are used to estimate the standard error of the estimate of the origin of DNA replication, as well as the variation of the replication rate.