Detalles de la búsqueda
1.
Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.
Pharmacol Res
; 190: 106724, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36907287
2.
Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein).
Pharmacol Res
; 146: 104297, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31175939
3.
P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
Int J Cancer
; 143(8): 2029-2038, 2018 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29744867
4.
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability.
Mol Pharm
; 15(11): 5124-5134, 2018 11 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30247919
5.
P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice.
Pharmacol Res
; 129: 414-423, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29155017
6.
Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1.
Toxicol Appl Pharmacol
; 329: 18-25, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28532671
7.
Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).
Mol Pharm
; 14(10): 3258-3268, 2017 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28880088
8.
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation.
Pharmacol Res
; 120: 43-50, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28288939
9.
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.
Int J Cancer
; 136(1): 225-33, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24825069
10.
Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.
Mol Pharm
; 12(12): 4259-69, 2015 Dec 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26474710
11.
P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.
Mol Pharm
; 12(10): 3714-23, 2015 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26317243
12.
Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).
Pharmacol Res
; 102: 200-7, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26361725
13.
Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).
Pharm Res
; 32(7): 2205-16, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25563977
14.
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).
Pharm Res
; 32(1): 37-46, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24962512
15.
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Mol Pharmacol
; 85(3): 520-30, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24334255
16.
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
Int J Cancer
; 134(6): 1484-94, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24037730
17.
In vivo disposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters.
Int J Cancer
; 135(7): 1700-10, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24554572
18.
Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.
Biomed Pharmacother
; 175: 116644, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38692057
19.
Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.
Mol Pharmacol
; 83(5): 919-29, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23429889
20.
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinib.
J Pharmacol Exp Ther
; 346(3): 486-94, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23843632