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1.
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension.
Diabetologia
; 63(4): 733-743, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31858186
2.
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.
J Pharmacol Exp Ther
; 344(1): 196-206, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23090647
3.
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.
J Pharmacol Exp Ther
; 336(2): 423-30, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20966038
4.
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Pharmacol Res Perspect
; 8(2): e00579, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32314550
5.
Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial.
Clin J Am Soc Nephrol
; 16(1): 59-69, 2020 12 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-33328269
6.
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.
Front Pharmacol
; 11: 419, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32322204
7.
A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects.
Clin Pharmacol Drug Dev
; 8(5): 564-575, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30422390
8.
Metabolism and disposition of MM-433593, a selective FAAH-1 inhibitor, in monkeys.
Pharmacol Res Perspect
; 2(5): e00059, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25505606
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