Family caregivers' experiences and needs of transitional care during the transfer from intensive care unit to a general ward: A qualitative study.

AIM: To explore the family caregivers' experiences and needs of transitional care during the transfer from an intensive care unit to a general ward in China. BACKGROUND: The transfer of patients from the intensive care unit to the ward is a vulnerable time for patients and caregivers, exposing the risk of readmission and death. However, there are few qualitative studies on the family caregivers' views of transitional care for their loved ones in China. METHODS: With a qualitative research design, 15 interviews were conducted with 15 family caregivers of hospitalized patients transferred from the neurosurgery ICU to the general ward. Colaizzi's (1978) method of data analysis was performed using the NVivo 11.0 software. RESULTS: Based on data analysis, four themes were obtained: perception of transfer decision, the experience of transitional care, the obstacles to maintaining care efficiency and demand for transitional care. CONCLUSION: In order to enhance the continuity of care and improve patient safety during the transfer from an ICU to a general ward in China, priorities should be given to the implementation of effective strategies and methods, including providing psychological and emotional support, encouraging active participation of caregivers, and various communication and collaboration procedures. IMPLICATIONS FOR NURSING MANAGEMENT: The findings from this study can be used as a guide to better preparation and awareness among health care professionals to achieve the much-needed demands of family caregivers, as well as the increased quality of transitional care.

Cognition and practice on transitional care during the transfer from intensive care unit to a general ward among health care professionals: A qualitative study.

AIM: The aim of this study is to explore the cognition and practice on transitional care during the transfer from intensive care unit to a general ward among health care professionals in China. BACKGROUND: Due to the significant differences in the medical and humanistic environment at home and abroad, the safety of patients during the transmission from intensive care unit to the general ward is often ignored when their conditions become stable. There are few qualitative studies on the cognition and practice on transitional care during the transfer from intensive care unit to the ward among health care professionals in China. METHODS: With a qualitative research design, 20 medical and nursing staff in the neurosurgery intensive care unit and ward were interviewed from May 2021 to August 2021. NVivo 11.0 software was utilized for Colaizzi's (1978) method of data analysis. RESULTS: Based on data analysis, perceptions of transitional care, the influencing factors for transitional care and the recommendations for improving transitional care were obtained. CONCLUSION: To ensure the continuity of care and improve patient safety during the period from intensive care unit to a general ward in China, we should clarify the expectation for the content of intensive care unit transitional care services, establish the transitional nursing team, guide nursing work, standardize the handover mode and process from intensive care unit to the general ward, promote the communication and coordination of health care professionals and improve the transitional nursing security system from the perspective of institutional level. IMPLICATIONS FOR NURSING MANAGEMENT: This study can be used as a guide to help health care professionals provide a reference for the comprehensive development of transitional care services and the formulation of targeted intervention measures during the transfer from intensive care unit to a general ward in China.

Superior performance of oxygen vacancy-enriched Cu-Co3O4/urushiol-rGO/peroxymonosulfate for hypophosphite and phosphite removal by enhancing singlet oxygen.

The treatment of wastewater containing hypophosphite [P(I)] and phosphite [P(III)] is challenged by limitations of traditional Fenton oxidation such as low efficiency, secondary pollution and high costs. This study introduced a facile solvent-thermal method to synthesize Cu-Co3O4 nanoparticles uniformly loaded on graphene (Cu-Co3O4/U-rGO) through the reduction and coordination effects of urushiol (U). As prepared Cu-Co3O4/U-rGO exhibited excellent activity in activating peroxymonosulfate (PMS) for the oxidation of P(I)/P(III) to phosphate [P(V)] (0.229 min-1), along with high stability and reusability (91.5 % after 6 cycles), low metal leaching rate (Co: 0.2 mg/L, Cu: 0.05 mg/L), insensitivity to common anions in water and a wide pH range (3-11). The activation mechanism involved the synergistic effects from both urushiol and graphene, which promoted redox of Cu+/Cu2+ and Co2+/Co3+ and induced abundant oxygen vacancies for PMS activation to produce singlet oxygen. Furthermore, the Cu-Co3O4/U-rGO/PMS was also excellent in the oxidative removal of organic phosphorus. This study is expected to advance strategies for the treatment of P(I)/P(III)-rich wastewater and provide new insights for the development of low-cost, highly efficient heterogeneous catalysts with abundant oxygen vacancies.

[Retrospective analysis of 190 cases of hospitalized patients with psoriasis].

OBJECTIVE: To determine the basic characteristics and clinical manifestations of hospitalized patients with psoriasis in Hunan, and to provide reasonable reference for the etiology and treatment of psoriasis. METHODS: Totally 190 patients with psoriasis from January 1, 2012 to December 31, 2012 treated in the Department of Dermatology, the Second Affiliated Hospital of Central South University were retrospectively analyzed. The data were analyzed by SPSS17.0. RESULTS: The ratio of male to female inpatient numbers was 3.13:1, aged was between 40 and 70 years. The most common subtype of psoriasis was psoriasis vulgaris (64.73%), followed by psoriatic erythroderma (18.42%). The distribution of the subtype of psoriasis did not differ by gender. Nineteen patients recalled clearly the cause of proriasis, 5 of which were caused by medicine, and 4 by drinking. Totally 96 cases accompanied with other diseases, 24.21% of which accompanied with cardiovascular system disease. CONCLUSION: There is no season difference in the hospitalization of patients with psoriasis. there are more male than female inpatients. Treatment of psoriasis should consider clinical classification, drug adverse reactions, and individual factors for individual treatment.

Phosphonium-Based Porous Ionic Polymer with Hydroxyl Groups: A Bifunctional and Robust Catalyst for Cycloaddition of CO2 into Cyclic Carbonates.

The integration of synergic hydrogen bond donors and nucleophilic anions that facilitates the ring-opening of epoxide is an effective way to develop an active catalyst for the cycloaddition of CO2 with epoxides. In this work, a new heterogeneous catalyst for the cycloaddition of epoxides and CO2 into cyclic carbonates based on dual hydroxyls-functionalized polymeric phosphonium bromide (PQPBr-2OH) was presented. Physicochemical characterizations suggested that PQPBr-2OH possessed large surface area, hierarchical pore structure, functional hydroxyl groups, and high density of active sites. Consequently, it behaved as an efficient, recyclable, and metal-free catalyst for the additive and solvent free cycloaddition of epoxides with CO2. Comparing the activity of PQPBr-2OH with that of the reference catalysts based on mono and non-hydroxyl functionalized polymeric phosphonium bromides suggested that hydroxyl functionalities in PQPBr-2OH showed a critical promotion effect on its catalytic activity for CO2 conversion. Moreover, PQPBr-2OH proved to be quite robust and recyclable. It could be reused at least ten times with only a slight decrease of its initial activity.

The reactivity of phenancyl bromide under ß-cyclodextrin as supramolecular catalyst: a computational survey.

Phenacyl bromide as one starting material in multicomponent reactions (MCRs) with ß-cyclodextrin (ß-CD) as catalyst can get an excellent yield in short reaction times. The interaction of ß-CD with phenacyl bromide plays an important role in this process. This paper studies the complex of ß-CD with phenacyl bromide using density functional theory (DFT) method. Energy is investigated to find out the lowest energy of two possible complexation models. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis. The relative position between phenacyl bromide and ß-CD is confirmed by (1)H nuclear magnetic resonance ((1)HNMR). The results of frontier molecular orbitals and charge distribution reveal that ß-CD catalyst improves the reactivity and electrophilicity of phenacyl bromide, meanwhile, the carbonyl group of phenacyl bromide more easily gives a carbocationic intermediate in the presence of ß-CD as catalyst. The reactivity of phenancyl bromide under ß-CD as supramolecular catalysis is improved.

DFT study of the per-6-amino-ß-cyclodextrin as catalyst in synthesis of 2-aryl-2,3-dihydro-4-quinolones.

The synthesis of 2-aryl-2,3-dihydro-4-quinolones in the presence of per-6-amino-ß-cyclodextrin (per-6-ABCD) as catalyst can improve selectivity and yield. The interaction between per-6-ABCD and benzaldehyde or o-aminoacetophenone plays an important role in this reaction. This paper studies the complexes of per-6-ABCD with benzaldehyde and o-aminoacetophenone using density functional theory (DFT) method. The reaction process is investigated by studying the energy of the reactants and the product. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis, the results propose the donor-acceptor interactions of complex. The Mulliken charge and frontier orbital are employed for revealing the charge distribution. In addition, (13)C nuclear magnetic resonance ((13)CNMR) spectroscopy shows that the carbon atom on the aldehyde group for benzaldehyde, carbonyl group and the carbon atom connected with carbonyl group for o-aminoacetophenone are apparently activated in the cavity of per-6-ABCD. The probable catalytic mechanism of per-6-ABCD is discussed in terms of the calculated parameters.

Interaction of ß-cyclodextrin as catalyst with acetophenone in asymmetric reaction: a theoretical survey.

The asymmetric reduction of acetophenone with sodium borohydride in the presence of ß-cyclodextrin (ß-CD) as catalyst can improve selectivity and yield. The interaction between acetophenone and ß-CD plays an important role for the reduction of acetophenone. This work studies the reaction of acetophenone in the presence of ß-CD using density functional theory (DFT) method. Energy is investigated to find out the lowest energy of two possible complexation models. The geometrical structure confirms that acetophenone inserts into the cavity mainly from the secondary hydroxyl side. Hydrogen bonds are researched on the basis of natural bonding orbital (NBO) analysis, the results confirm the donor-acceptor interactions of complex. Mülliken charge and frontier orbital are employed for revealing the electronic transfer. In addition, (13)C nuclear magnetic resonance ((13)CNMR) spectroscopy shows that the active site concentrates on the carbon atom of carbonyl group. The probable catalytic mechanism of ß-CD is discussed in terms of the calculated parameters.

Osteopontin promotes the progression of gastric cancer through the NF-κB pathway regulated by the MAPK and PI3K.

To elucidate the biological functions of osteopontin (OPN) in gastric tumors and to better understand the molecular events of OPN responsible for the malignancy, the present studies were performed. Growth curve, apoptosis assay, invasion assay and migration assay revealed that OPN status significantly affected proliferation, apoptosis, invasion and migration in gastric cancer cell lines. In mouse xenograft models of human gastric cancer, OPN silencing significantly inhibited tumor growth and the incidence of metastasis compared with non-silenced control. Mechanistic investigations revealed that OPN silencing inhibited the mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase (NF-κB) pathways, and OPN-mediated NF-κB activity was reduced in the presence of MAPK or PI3K inhibitor. Our findings also indicated that OPN through the NF-κB pathway promotes the expression of matrix metalloproteinase 2 (MMP-2), MMP-9 and urokinase-type plasminogen activator (uPA), the activation of MMP-2 and MMP-9, and the inhibition of caspase-3. Taken together, our results reveal that OPN promotes the progression of gastric cancer through the NF-κB pathway, which is regulated by the MAPK and PI3K pathways and leads to MMP-2, MMP-9 and uPA activation and caspase-3 inhibition. These findings identify OPN as a novel oncogene in gastric cancer and suggest that OPN is an attractive therapeutic target for this aggressive malignancy.

Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.

Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.