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Dual-wavelength fiber lasers operating with a wide spectral separation are of considerable importance for many applications. In this study, we propose and experimentally explore an all-fiberized dual-wavelength random fiber laser with bi-directional laser output operating at 1064 and 1550â nm, respectively. A specially designed Er/Yb co-doped fiber, by optimizing the concentrations of the co-doped Er, Yb, Al and P, was developed for simultaneously providing Er ions gain and Yb ions gain for RFL. Two spans of single mode passive fibers are employed to providing random feedback for 1064 and 1550â nm random lasing, respectively. The RFL generates 5.35 W at 1064â nm and 6.61 W at 1550â nm random lasers. Two power amplifiers (PA) enhance the seed laser to 50 W at 1064â nm with a 3â dB bandwidth of 0.31â nm and 20 W at 1550â nm with a 3â dB bandwidth of 1.18â nm. Both the short- and long-term time domain stabilities are crucial for practical applications. The output lasers of 1064 and 1550â nm PAs are in the single transverse mode operating with a nearly Gaussian profile. To the best of our knowledge, this is the first demonstration of a dual-wavelength RFL, with a spectral separation as far as about 500â nm in an all-fiber configuration.
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We proposed spectrally temporally cascaded optical parametric amplification (STOPA) using pump energy recycling to simultaneously increase spectral bandwidth and conversion efficiency in optical parametric amplification (OPA). Using BiB3O6 and KTiOAsO4 nonlinear crystals, near-single-cycle mid-infrared (MIR) pulses with maximum energy conversion efficiencies exceeding 25% were obtained in simulations. We successfully demonstrated sub-two-cycle, CEP-stable pulse generation at 1.8â µm using a four-step STOPA system in the experiment. This method provides a solution to solve the limitations of the gain bandwidth of nonlinear crystals and the low conversion efficiency in broadband OPA systems, which is helpful for intense attosecond pulse generation and strong laser field physics studies.
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In the past few years, annular structured beams have been extensively studied due to their unique "doughnut" structure and characteristics such as phase and polarization vortices. Especially in the 2â µm wavelength range, they have shown promising applications in fields such as novel laser communication, optical processing, and quantum information processing. In this Letter, we observed basis vector patterns with orthogonality and completeness by finely cavity-mode tailoring with end-mirror space position in a Tm:CaYAlO4 laser. Multiple annular structured beams including azimuthally, linearly, and radially polarized beams (APB, LPB, and RPB) operated at a Q-switched mode-locking (QML) state with a typical output power of â¼18â mW around 1962â nm. Further numerical simulation proved that the multiple annular structured beams are the coherent superposition of different Hermitian Gaussian modes. Using a self-made M-Z interferometer, we have demonstrated that the obtained multiple annular beams have a vortex phase with orbital angular momentum (OAM) of l = ±1. To the best of our knowledge, this is the first observation of vector and scalar annular vortex beams in the 2â µm solid-state laser.
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Recently, it has become imperative to develop high energy density as well as high safety lithium-ion batteries (LIBS) to meet the growing energy demand. Among the anode materials used in LIBs, the currently used commercial graphite has low capacity and is a safety hazard due to the formation of lithium dendrites during the reaction. Among the transition metal oxide (TMO) anode materials, TMO based on the intercalation reaction mechanism has a more stable structure and is less prone to volume expansion than TMO based on the conversion reaction mechanism, especially the niobium-based oxide in it has attracted much attention. Niobium-based oxides have a high operating potential to inhibit the formation of lithium dendrites and lithium deposits to ensure safety, and have stable and fast lithium ion transport channels with excellent multiplicative performance. This review summarizes the recent developments of niobium-based oxides as anode materials for lithium-ion batteries, discusses the special structure and electrochemical reaction mechanism of the materials, the synthesis methods and morphology of nanostructures, deficiencies and improvement strategies, and looks into the future developments and challenges of niobium-based oxide anode materials.
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The genetic control and signaling pathways of vascular development are not comprehensively understood. Transcription factors Islet2 (Isl2) and nr2f1b are critical for vascular growth in zebrafish, and further transcriptome analysis has revealed potential targets regulated by isl2/nr2f1b. In this study, we focused on the potential activation gene signal-transducing adaptor protein 2b (stap2b) and revealed a novel role of stap2b in vascular development. stap2b mRNA was expressed in developing vessels, suggesting stap2b plays a role in vascularization. Knocking down stap2b expression by morpholino injection or Crispr-Cas9-generated stap2b mutants caused vascular defects, suggesting a role played by stap2b in controlling the patterning of intersegmental vessels (ISVs) and the caudal vein plexus (CVP). The vessel abnormalities associated with stap2b deficiency were found to be due to dysregulated cell migration and proliferation. The decreased expression of vascular-specific markers in stap2b morphants was consistent with the vascular defects observed. In contrast, overexpression of stap2b enhanced the growth of ISVs and reversed the vessel defects in stap2b morphants. These data suggest that stap2b is necessary and sufficient to promote vascular development. Finally, we examined the interaction between stap2b and multiple signaling. We showed that stap2b regulated ISV growth through the JAK-STAT pathway. Moreover, we found that stap2b was regulated by Notch signaling to control ISV growth, and stap2b interacted with bone morphogenetic protein signaling to contribute to CVP formation. Altogether, we demonstrated that stap2b acts downstream of the isl2/nr2f1b pathway to play a pivotal role in vascular development via interaction with multiple signaling pathways.
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Proteínas de Pez Cebra , Pez Cebra , Animales , Proteínas Adaptadoras Transductoras de Señales/metabolismo , Quinasas Janus/metabolismo , Neovascularización Fisiológica/genética , Transducción de Señal/fisiología , Factores de Transcripción STAT/metabolismo , Pez Cebra/genética , Pez Cebra/metabolismo , Proteínas de Pez Cebra/metabolismoRESUMEN
Carbon microspheres have indeed shown great promise as effective materials for absorbing electromagnetic waves, particularly in microwave applications. Their unique properties, such as high surface area, porosity, and electronic characteristics, make them ideal candidates for addressing the growing concerns around electromagnetic pollution from electronic devices. By leveraging the properties of these materials, we can work toward creating more efficient and sustainable electromagnetic wave absorption technologies. Recent efforts have focused on synthesizing and investigating carbon microsphere-based electromagnetic wave-absorbing nanomaterials with the ambition of achieving the desired attributes of being thin, light, wide, and robust. This Review first delves into the detailed mechanism of electromagnetic wave absorption, followed by an elucidation of the preparation methods for carbon microsphere-based nanomaterials. Furthermore, it systematically outlines the common methods and strategies employed to improve the microwave absorption capabilities of carbon microspheres, including chemical vapor deposition, emulsion polymerization, hydrothermal methods, and template methods. Lastly, it outlines the challenges encountered by carbon microsphere-based electromagnetic wave absorption nanomaterials and outlines their prospects, mainly morphology change, component hybridization, and elemental doping. This Review aims to provide valuable insights into the creation of carbon microsphere nanomaterials with excellent electromagnetic wave absorption properties.
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The stannic oxide (SnO2) anode expands in volume during cycling causing a decrease in reversible capacity. In this work, we generated a spherical SnO2/Sn heterojunction with core-shell structure composites encapsulated by graphene (SnO2/Sn/G) in situ using a simple one-step hydrothermal and subsequent annealing process. SnO2/Sn heterojunction nanospheres dispersed in a porous graphene framework accelerate the diffusion kinetics of electrons and ions. In addition, the structure plays a key role in mitigating large volume changes and nanostructure agglomeration. As a result, SnO2/Sn/G exhibits excellent performance as an anode material for lithium-ion batteries (LIBs), maintaining a reversible specific capacity of 720.6 mA h g-1 even after 600 cycles at a current density of 0.5 A g-1.
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Currently, it remains a challenge to make comprehensive improvements to overcome the disadvantages of volume expansion, Li2O irreversibility and low conductivity of SnO2. Heterostructure construction has been investigated as an effective strategy to promote electron transfer and surface reaction kinetics, leading to high electrochemical performance. Herein, NiO/SnO2 heterojunction modified nitrogen doped graphene (NiO/SnO2@NG) anode materials were prepared using hydrothermal and carbonization techniques. Based on the excellent structural advantages, sufficiently small NiO/SnO2 heterojunction nanoparticles increase the interfacial density to promote Li2O decomposition, and the built-in electric field accelerates the charge transport rate to improve the conductivity. The three-dimensional porous graphene framework effectively mitigates volume expansion during cycling and stabilizes the reactive interface of electrode materials. The results show that the NiO/SnO2@NG mixture has high reversible specific capacity (938.8 mA h g-1 after 450 cycles at 0.1 A g-1), superior multiplicity performance (374.5 mA h g-1 at 3.0 A g-1) and long cycle life (685.3 mA h g-1 after 1000 cycles at 0.5 A g-1). Thus, this design of introducing NiO to form heterostructures with SnO2 is directly related to enhancing the electrochemical performance of lithium-ion batteries (LIBs).
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An assay that integrates histidine-rich peptides (HisRPs) with high-affinity aptamers was developed enabling the specific and sensitive determination of the target lysozyme. The enzyme-like activity of HisRP is inhibited by its interaction with a target recognized by an aptamer. In the presence of the target, lysozyme molecules progressively assemble on the surface of HisRP in a concentration-dependent manner, resulting in the gradual suppression of enzyme-like activity. This inhibition of HisRP's enzyme-like activity can be visually observed through color changes in the reaction product or quantified using UV-visible absorption spectroscopy. Under optimal conditions, the proposed colorimetric assay for lysozyme had a detection limit as low as 1 nM and exhibited excellent selectivity against other nonspecific interferents. Furthermore, subsequent research validated the practical applicability of the developed colorimetric approach to saliva samples, indicating that the assay holds significant potential for the detection of lysozymes in samples derived from humans.
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Colorimetría , Muramidasa , Saliva , Muramidasa/análisis , Muramidasa/química , Muramidasa/metabolismo , Colorimetría/métodos , Humanos , Saliva/química , Saliva/enzimología , Límite de Detección , Péptidos/química , Aptámeros de Nucleótidos/química , Proteínas/análisis , Técnicas Biosensibles/métodos , Histidina/análisis , Histidina/químicaRESUMEN
Improper disposal of waste oils containing hazardous components damages the environment and the ecosystem, posing a significant threat to human life and health. Here, we present a method of discharge-assisted laser-induced breakdown spectroscopy combined with filter paper sampling (DA-LIBS-FPS) to detect hazardous components and trace the source of polluting elements. DA-LIBS-FPS significantly enhances spectral intensity by 1-2 orders of magnitude due to the discharge energy deposition into the laser-induced plasma and the highly efficient laser-sample interaction on the filter paper, when compared to single-pulse LIBS with silica wafer sampling (SP-LIBS-SWS). Additionally, the signal-to-noise ratio and the signal-to-background ratio are both significantly increased. Resultantly, indiscernible lines, such as CN and Cr I, are well distinguished. In contrast with DA-LIBS combined with silica wafer sampling (DA-LIBS-SWS), the spectral signal fluctuations in DA-LIBS-FPS are reduced by up to 33%, because of the homogeneous distribution of the oil layer on the filter paper in FPS. Further examination indicates that the limit of detection for Ba is reduced from a several parts per million level in SP-LIBS-SWS to a dozens of parts per billion level in DA-LIBS-FPS, i.e., nearly 2 orders of magnitude enhancement in analysis sensitivity. This improvement is attributed to the extended plasma lifespan in DA-LIBS and the increasing electron density and plasma temperature in FPS. DA-LIBS-FPS provides a low-cost, handy, rapid, and highly sensitive avenue to analyze the hazardous components in waste oils with great potential in environmental and ecological monitoring.
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The utilization of mid-infrared (mid-IR) light spanning the 3-5â µm range presents notable merits over the 1.5â µm band when operating in adverse atmospheric conditions. Consequently, it emerges as a promising prospect for serving as optical carriers in free-space communication (FSO) through atmospheric channels. However, due to the insufficient performance level of devices in the mid-IR band, the capability of mid-IR communication is hindered in terms of transmission capacity and signal format. In this study, we conduct experimental investigations on the transmission of time-domain multiplexed ultra-short optical pulse streams, with a pulse width of 1.8 ps and a data rate of up to 40 Gbps at 3.6â µm, based on the difference frequency generation (DFG) effect. The mid-IR transmitter realizes an effective wavelength conversion of optical time division multiplexing (OTDM) signals from 1.5â µm to 3.6â µm, and the obtained power of the 40 Gbps mid-IR OTDM signal at the optimum temperature of 54.8â °C is 7.4 dBm. The mid-IR receiver successfully achieves the regeneration of the 40 Gbps 1.5â µm OTDM signal, and the corresponding regenerated power at the optimum temperature of 51.5â °C is -30.56â dBm. Detailed results pertaining to the demodulation of regeneration 1.5â µm OTDM signal have been acquired, encompassing parameters such as pulse waveform diagram, bit error rate (BER), and Q factor. The estimated power penalty of the 40 Gbps mid-IR OTDM transmission is 2.4â dB at a BER of 1E-6, compared with the back-to-back (BTB) transmission. Moreover, it is feasible by using chirped PPLN crystals with wider bandwidth to increase the data rate to the order of one hundred gigabits.
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Ultrafast fiber lasers combining high peak power and excellent beam quality in the 1-µm wavelength range have been explored to applications in industry, medicine and fundamental science. Here, we report generation of a high-energy sub 300 fs polarization maintaining fiber chirped pulse amplification (CPA) system by using a Yb-doped large mode area tapered polarization maintaining (PM) optical fiber with the core/cladding diameters of 35/250 µm at the thin end and 56/400 µm at the thick end. The taper fiber design features a confined core for selective gain amplification and multi-layer cladding for enhanced suppression of higher order modes. In this regime, we have demonstrated 266 fs pulse amplification with peak power of up to 132 MW at a repetition rate of 2 MHz and high beam quality with measured M2 value of 1.1â¼1.3. To the best of our knowledge, it is the highest peak power reported in such tapered Yb-doped fiber (T-YDF) amplifier in the femtosecond regime. This work indicates the great potential of the T-YDF to realize further power scaling, high laser efficiency, and excellent beam quality in high-power femtosecond fiber lasers.
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Different from the traditional ideal column symmetry cavities, we directly generated the cylindrical vector pulsed beams in the folded six-mirror cavity by employing a c-cut Tm:CaYAlO4 (Tm:CYA) crystal and SESAM. By adjusting the distance between the curved cavity mirror (M4) and the SESAM, both the radially polarized beam and azimuthally polarized beam are generated around 1962 nm and the two vectorial modes can be freely switched in the resonator. Further increased the pump power to 7 W, the stable radially polarized Q-switched mode-locked (QML) cylindrical vector beams were also obtained with an output power of 55â mW, the sub-pulse repetition rate of 120.42â MHz, pulse duration of â¼0.5â ns and the beam quality factor M2 of â¼2.9. To our knowledge, this is the first report of radially and azimuthally polarized beams in the 2â µm wavelength solid-state resonator.
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We propose a simple and robust all-optical pulse sampling method to characterize the temporal profiles of ultrashort laser pulses. The method is based on a third-harmonic generation (THG) process with perturbation in ambient air, which requires no retrieval algorithm and can be potentially applied to electric field measurement. The method has been successfully used to characterize multi-cycle and few-cycle pulses with a spectral range from 800â nm to 2200â nm. Considering the broad phase-matching bandwidth of THG and extremely low dispersion of air, this method is suitable for ultrashort pulse characterization even for single-cycle pulses in the near- to mid-infrared range. Thus, the method provides a reliable and highly accessible approach for pulse measurement in ultrafast optics research.
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This communication investigated the dust effect on microelectromechanical system (MEMS) thermal wind sensors, with an aim to evaluate performance in practical applications. An equivalent circuit was established to analyze the temperature gradient influenced by dust accumulation on the sensor's surface. The finite element method (FEM) simulation was carried out to verify the proposed model using COMSOL Multiphysics software. In experiments, dust was accumulated on the sensor's surface by two different methods. The measured results indicated that the output voltage for the sensor with dust on its surface was a little smaller than that of the sensor without dust at the same wind speed, which can degrade the measurement sensitivity and accuracy. Compared to the sensor without dust, the average voltage was reduced by about 1.91% and 3.75% when the dustiness was 0.04 g/mL and 0.12 g/mL, respectively. The results can provide a reference for the actual application of thermal wind sensors in harsh environments.
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Polvo , Sistemas Microelectromecánicos , Polvo/análisis , Viento , Temperatura , Programas InformáticosRESUMEN
The carbon emissions growth in the construction industry hinders the achievement of global carbon-neutral target, especially in China. Studies suggest that developing low-carbon technologies is an effective means of achieving the low-carbon transition (LCT) in the construction industry. However, these studies ignore the fact that the LCT is a complex and systemic issue that needs to consider the interaction of technical and non-technical factors. Thus, based on the socio-technical system transition theory, this study identified the influencing factors and constructs a dynamics model to simulate the dynamic changes of the LCT in China's construction industry under different scenarios. The results showed that multi-level factors coordinated to drive the LCT of the construction industry. Environmental factors played a weak role and the effectiveness of government intervention decreased with the transition process. On the contrary, technological and market factors were indispensable drivers and especially played a dominant role during the later stages of the transition. Finally, the LCT pathway of China's construction industry was proposed based on the results. These findings expand the boundary of theoretical research on industrial transition and provide a decision-making reference for the advancement of international carbon-neutral work.
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Industria de la Construcción , Carbono/análisis , China , Dióxido de Carbono/análisis , Desarrollo EconómicoRESUMEN
Many regulators controlling arterial identity are well described; however, transcription factors that promote vein identity and vascular patterning have remained largely unknown. We previously identified the transcription factors Islet2 (Isl2) and Nr2f1b required for specification of the vein and tip cell identity mediated by notch pathway in zebrafish. However, the interaction between Isl2 and Nr2f1b is not known. In this study, we report that Nr2f2 plays minor roles on vein and intersegmental vessels (ISV) growth and dissect the genetic interactions among the three transcription factors Isl2, Nr2f1b, and Nr2f2 using a combinatorial knockdown strategy. The double knockdown of isl2/nr2f1b, isl2/nr2f2, and nr2f1b/nr2f2 showed the enhanced defects in vasculature including less completed ISV, reduced veins, and ISV cells. We further tested the genetic relationship among these three transcription factors. We found isl2 can regulate the expression of nr2f1b and nr2f2, suggesting a model where Isl2 functions upstream of Nr2f1b and Nr2f2. We hypothsized that Isl2 and Nr2f1b can function together through cis-regulatory binding motifs. In-vitro luciferase assay results, we showed that Isl2 and Nr2f1b can cooperatively enhance gene expression. Moreover, co-immunoprecipitation results indicated that Isl2 and Nr2f1b interact physically. Together, we showed that the interaction of the Nr2f1b and Nr2f2 transcription factors in combination with the Islet2 play coordinated roles in the vascular development of zebrafish.
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Arterias , Proteínas con Homeodominio LIM , Factores de Transcripción , Proteínas de Pez Cebra , Pez Cebra , Animales , Arterias/crecimiento & desarrollo , Proteínas con Homeodominio LIM/genética , Proteínas con Homeodominio LIM/metabolismo , Factores de Transcripción/genética , Factores de Transcripción/metabolismo , Venas , Pez Cebra/genética , Pez Cebra/crecimiento & desarrollo , Proteínas de Pez Cebra/genética , Proteínas de Pez Cebra/metabolismoRESUMEN
For positioning Talbot encoder and Talbot lithography, etc., properties manipulation of Talbot imaging is highly expected. In this work, an investigation on the distance and depth modulation of Talbot imaging, which employs a specially designed grating structure, is presented. Compared with the current grating structure, the proposed grating structure is characterized by having the phase layers with uneven thicknesses. Such a specific structural design can cause the offset of Talbot image from its nominal position, which in turn generates the spatial distance modulation of self-imaging and imaging depth expansion. Theoretical analysis is performed to explain its operating principle, and simulations and experiments are carried out to demonstrate its effectiveness.
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We propose and demonstrate an all-optical pulse sampling technique based on the transient grating (TG) procedure with perturbation, which provides a simple and robust manner to characterize an ultrashort laser pulse without employing a retrieval algorithm. In our approach, a two-orders weaker perturbation pulse perturbs the diffracted pulse from the TG, which is generated by another strong fundamental pulse. The modulation of the diffracted pulse energy directly represents the temporal profile of the perturbation pulse. We have successfully characterized few-cycle and multi-cycle pulses, which is consistent with the results verified by the widely employed frequency-resolved optical gating (FROG) method. Our method provides a potential way to characterize ultrashort laser waveform from the deep-UV to far-infrared region.
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BACKGROUND: Stomatitis is inflammation of the oral mucosa. Angiopoietin-like protein 4 (ANGPTL4) has pleiotropic functions both anti-inflammatory and pro-inflammatory properties. In the present study, we tested whether there is a correlation between increased ANGPTL4 expression and inflammation in stomatitis mice and the mechanisms involved. METHODS AND RESULTS: In this study, the oral mucosa of mice was burned with 90% phenol and intraperitoneal injection of 5-fluorouracil to establish the model of stomatitis mice. The pathological changes of stomatitis mice were observed by H&E staining of paraffin section. The expressions of cytokines and ANGPTL4 were detected by fluorescence quantitative PCR, and the protein levels of ANGPTL4 were detected by western blot. Compared with control group, the oral mucosal structure of model mice was damaged. The expression of ANGPTL4 were significantly increased concomitantly with elevated production of anti-inflammatory cytokine (peroxisome proliferator-activated receptor alpha) and pro-inflammatory cytokines [nuclear transcription factor-kappa B, interleukin-6 (IL-6), IL-1ß, and tumor necrosis factor-α] in mice with stomatitis. CONCLUSIONS: This study suggests that ANGPTL4 may be a double-edged sword in multiple inflammatory responses in stomatitis mice.