1.
J Med Chem
; 44(13): 2061-4, 2001 Jun 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11405642
RESUMEN
Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.