[Prevalence of mammary alterations in women assisted in a municipality in the state of Paraná]. / Prevalência de alterações mamárias em mulheres atendidas em um município do estado do Paraná.

The purpose of this quantitative and retrospective study was to analyze the prevalence of mammary alterations from 1304 women in the city of Francisco Beltrão-Paraná (PR), Brazil, registered in the SISMAMA system, from a Regional Health Center in Paraná State. Between 2009 and 2012, data was collected in May and June 2013 and statistically analyzed. The results showed that 694 (53.2%) of women were under 49 years old, 1126 (86.3%) had no increased risk for developing breast cancer, and 1205 (92.5%) underwent mammography screening. Color and tracking information were omitted in most entries.The BI-RADS category 0 (inconclusive result) was the most prominent. Categories with higher chances of malignancy (BI-RADS 4 and 5) prevailed in the left breast in women older than 50. Diagnosis of radial sclerosing lesions associated with infiltrating ductal carcinoma was predominant in 53.0% (n = 9) of the histopathological exams. We conclude that these findings are partially supported by the literature.

The role of nucleus accumbens and dorsolateral striatal D2 receptors in active avoidance conditioning.

The role of dopamine (DA) in rewarding motivated actions is well established but its role in learning how to avoid aversive events is still controversial. Here we tested the role of D2-like DA receptors in the nucleus accumbens (NAc) and the dorsolateral striatum (DLS) of rats in the learning and performance of conditioned avoidance responses (CAR). Adult male Wistar rats received systemic, intra-NAc or intra-DLS (pre- or post-training) administration of a D2-like receptor agonist (quinpirole) or antagonist ((-)sulpiride) and were given two sessions in the two-way active avoidance task. The main effects observed were: (i) sulpiride and lower (likely pre-synaptic) doses of quinpirole decreased the number of CARs and increased the number of escape failures; (ii) higher doses of quinpirole (likely post-synaptic) increased inter-trial crossings and failures; (iii) pre-training administration of sulpiride decreased the number of CARs in both training and test sessions when infused into the NAc, but this effect was observed only in the test session when it was infused into the DLS; (iv) post-training administration of sulpiride decreased CARs in the test session when infused into the NAc but not DLS. These findings suggest that activation of D2 receptors in the NAc is critical for fast adaptation to responding to unconditioned and conditioned aversive stimuli while activation of these receptors in the DLS is needed for a slower learning of how to respond to the same stimuli based on previous experiences.

Non-motor function of the midbrain dopaminergic neurons.

The roles of the nigrostriatal pathway are far beyond the simple control of motor functions. The tonic release of dopamine in the dorsal and ventral striatum controls the choice of proper actions toward a given environmental situation. In the striatum, a specific action is triggered by a specific stimulus associated with it. When the subject faces a novel and salient stimulus, the phasic release of dopamine allows synaptic plasticity in the cortico-striatal synapses. Neurons of different regions of cortical areas make synapses that converge to the same medium spine neurons of the striatum. The convergent associations form functional units encoding body parts, objects, locations, and symbolic representations of the subject's world. Such units emerge in the striatum in a repetitive manner, like a mosaic of broken mirrors. The phasic release of dopamine allows the association of units to encode an action of the subject directed to an object or location with the outcome of this action. Reinforced stimulus-action-outcome associations will affect future decision making when the same stimulus (object, location, idea) is presented to the subject in the future. In the absence of a minimal amount of striatal dopamine, no action is initiated as seen in Parkinson's disease subjects. The abnormal and improper association of these units leads to the initiation of unpurposeful and sometimes repetitive actions, as those observed in dyskinetic patients. The association of an excessive reinforcement of some actions, like drug consumption, leads to drug addiction. Improper associations of ideas and unpleasant outcomes may be related to traumatic and depressive symptoms common in many diseases, including Parkinson's disease. The same can be said about the learning and memory impairments observed in demented and nondemented Parkinson's disease patients.

Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission.

Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. The aim of the present study was to propose a model to explain how critical factors determine the direction of these turns. Unilateral lesion of the SNpc was induced with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Separate analysis showed that neither the type of neurotoxin nor the site of lesion along the nigrostriatal pathway was able to predict the direction of the turns these rats made after they were challenged with apomorphine. However, the combination of these two factors determined the magnitude of the lesion estimated by tyrosine-hydroxylase immunohistochemistry and HPLC-ED measurement of striatal dopamine. Very small lesions did not cause turns, medium-size lesions caused ipsiversive turns, and large lesions caused contraversive turns. Large-size SNpc lesions resulted in an increased binding of [(3)H]raclopride to D2 receptors, while medium-size lesions reduced the binding of [(3)H]SCH-23390 D1 receptors in the ipsilateral striatum. These results are coherent with the model proposing that after challenged with a dopamine receptor agonist, unilaterally SNpc-lesioned rats rotate toward the side with the weaker activation of dopamine receptors. This activation is weaker on the lesioned side in animals with small SNpc lesions due to the loss of dopamine, but stronger in animals with large lesions due to dopamine receptor supersensitivity.

Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze.

The multiple memory systems theory proposes that the hippocampus and the dorsolateral striatum are the core structures of the spatial/relational and stimulus-response (S-R) memory systems, respectively. This theory is supported by double dissociation studies showing that the spatial and cue (S-R) versions of the Morris water maze are impaired by lesions in the dorsal hippocampus and dorsal striatum, respectively. In the present study we further investigated whether adult male Wistar rats bearing double and bilateral electrolytic lesions in the dorsal hippocampus and dorsolateral striatum were as impaired as rats bearing single lesions in just one of these structures in learning both versions of the water maze. Such a prediction, based on the multiple memory systems theory, was not confirmed. Compared to the controls, the animals with double lesions exhibited no improvement at all in the spatial version and learned the cued version very slowly. These results suggest that, instead of independent systems competing for holding control over navigational behaviour, the hippocampus and dorsal striatum both play critical roles in navigation based on spatial or cue-based strategies.

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses.

RATIONALE: Aversively motivated learning is more poorly understood than appetitively motivated learning in many aspects, including the role of dopamine receptors in different regions of the striatum. OBJECTIVES: The present study investigated the roles of the D1-like DA receptors in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) on learning and performance of conditioned avoidance responses (CARs). METHODS: Adult male Wistar rats received intraperitoneal (i.p.), intra-NAc, or intra-DLS injections of the D1 dopamine receptor agonist SKF 81297 or the D1 receptor antagonist SCH 23390 20 min before or immediately after a training session in the CAR task two-way active avoidance, carried out 24 h before a test session. RESULTS: Pre-training administration of SCH 23390, but not SKF 81297, caused a significant decrease in the number of CARs in the test, but not in the training session, when injected into the DLS, or in either session when injected into the NAc. It also caused a significant increase in the number of escape failures in the training session when injected into the NAc. Systemic administration caused a combination of these effects. Post-training administrations of these drugs caused no significant effect. CONCLUSIONS: The results suggest that the D1-like receptors in the NAc and DLS play important, though different, roles in learning and performance of CAR.

Efeito da suplementação aguda com cafeína na resposta bioquímica durante exercício de endurance em ratos / Effect of acute caffeine supplementation in biochemical response during endurance exercise in rats / Efecto de la suplementación aguda con cafeína en la respuesta bioquímica durante ejercicio de endurance en ratones

RESUMOIntrodução:A cafeína é atualmente a substância mais consumida no mundo, e associada ao exercício físico, vem trazendo importantes ganhos no desempenho.Objetivo:Investigar efeitos bioquímicos da suple-mentação aguda de cafeína após um exercício de endurance em ratos Wistar.Métodos:Foram utilizados 27 ratos Wistar machos, pesando 357 ± 73 g, distribuídos de forma aleatória em três grupos: 1) Controle (sem suplementação e exercício); 2) Salina (salina + exercício); 3) Cafeína (6 mg/Kg de cafeína + exercício). As suple-mentações foram administradas com antecedência de 50 minutos da natação com duração de 60 minutos. Logo após a natação, os animais foram sacrificados para coleta de sangue e biópsia de tecido hepático e muscular. Foram analisados os níveis de glicose sanguínea, triglicerídeos, lactato sérico e concentrações de glicogênio hepático e muscular. Todos os resultados foram representados como média ± EPM. Para a análise estatística foi usado o teste ANOVA one way, sendo considerada diferença estatística somente para P<0,05.Resultados:O glicogênio muscular e o lactato não diferiram entre os grupos. A cafeína preservou os níveis de glicose sanguínea e glicogênio hepático (P<0,05). A cafeína elevou os níveis de glicerol plasmático em 31,2% (P<0,05) quando comparado ao grupo exercitado sem suplementação.Conclusão:O estudo reporta que o uso da cafeína pré-exercício promove alterações bioquímicas que podem melhorar a eficiência metabólica durante o exercício de endurance.

ABSTRACTIntroduction:Caffeine is presently the most consumed substance in the world and, associated with physical exercise, brings important achievements in performance.Objective:To investigate the biochemical effects of acute caffeine supplementation after endurance exercise in Wistar rats.Methods:Twenty-seven male Wistar rats have been used, weighing 357 ± 73 g, randomly distributed in three groups: 1) Control (without supplementa-tion and exercise), 2) Saline (saline+ exercise), 3) Caffeine (6 mg/kg caffeine + exercise). Supplements have been administered 50 minutes before the 60-minute swimming test. Immediately after swimming, the animals have been sacrificed for blood sampling and biopsy of liver and muscle tissue. The levels of blood glucose, triglycerides, serum lactate and concentrations of glycogen in liver and muscle have been analyzed. All results were expressed as mean ± SEM. The statistical analysis used was the ANOVA one way test, being considered statistically signi-ficant only P<0.05.Results:Muscle glycogen and lactate did not differ between groups. Caffeine has preserved the levels of blood glucose and liver glycogen (P<0.05). Caffeine has elevated the levels of plasma glycerol in 31.2% (P<0.05), when compared to the group exercised without supplementation.Conclusion:The study reports that the use of pre-exercise caffeine promotes biochemical alterations that can improve metabolic efficiency during the endurance exercise.

RESUMENIntroducción:La cafeína es actualmente la sustancia de mayor consumo en el mundo, y combinado con el ejercicio físico, ha traído beneficios importantes en el rendimiento durante el ejercicio.Objetivo:Investigar los efec-tos bioquímicos da la suplementación aguda de cafeína después de un ejercicio de endurance en ratones Wistar.Métodos:Fueron utilizados 27 ratones Wistar machos, con 357 ± 73 g de peso corporal, distribuidos de forma alea-toria en tres grupos: 1) Control (sin suplementación y ejercicio); 2) Salina (salina + ejercicio); 3) Cafeína (6 mg/Kg de cafeína + ejercicio). Las suplementaciones les fueran administradas 50 minutos antes de la natación con duración de 60 minutos. Después de la natación, los animales fueron sacrificados para la extracción de sangre y biopsia de tejido hepático y muscular. Fueron analizados los niveles de glucosa sanguínea, triglicéridos, lactato sérico y concentraciones de glucógeno hepático y muscular. Todos los resultados fueron representados como media ± EPM. Para la análisis estadística se aplicó la prueba ANOVA one way, siendo considerada diferencia estadística sólo para P<0,05.Resultados:Lo glucógeno muscular y el lactato no difirieron entre los grupos. La cafeína preservo los niveles de glucosa sanguínea y glucógeno hepático (P<0,05). La cafeína elevo los niveles de glicerol plasmático en 31,2% (P<0,05) en comparación con el grupo ejercitado sin suplementación.Conclusión:El estudio reporta que el uso de la cafeína antes del ejercicio promueve alteraciones bioquímicas que pueden mejorar la eficiencia metabólica durante el ejercicio de endurance.

Avaliação dos níveis de estresse e depressão em professores da rede pública do município de Francisco Beltrão - PR / Evaluation of stress and depression levels in teachers of public schools in the city of Francisco Beltrão - PR

As elevadas mudanças nas estruturas sociais e familiares, cada vez mais complexas, bem como a necessidade de novas práticas de inclusão social e de integração escolar vêm exigindo cada vez mais do professor. Essa realidade pode desenvolver estresse, ansiedade e até mesmo depressão nos docentes. É necessário alertar os educadores sobre os perigos que essas enfermidades podem apresentar, tanto na vida profissional quanto na vida pessoal, pois muitos desses profissionais são afastados justamente devido a essas doenças. Suspeita-se que indivíduos estressados estão mais propensos a desenvolver quadros depressivos, então este estudo verificou esta hipótese em professores da rede pública do sudoeste do Paraná. Foi realizado um estudo prospectivo, experimental e longitudinal, com o objetivo de detectar a percentagem de professores da rede pública que apresentam altos níveis de estresse e depressão e alertá-los sobre os problemas decorrentes destas patologias. Foram utilizados dois questionários validados de autopreenchimento para verificar a severidade de distúrbios psiquiátricos não psicóticos, relacionados ao estresse e depressão. Os escores obtidos a partir da somatória das questões respondidas pelos professores no questionário GHQ-12 e no Inventário de Beck foram analisados através dos testes de Kruskal-Wallis e quando possível por ANOVA de uma via, e foram considerados significantes quando o p ≤ 0,05. Dos 106 professores participantes da pesquisa, 46,2% deles sofrem de algum nível de estresse psicossomático e 21,7% possuem características de depressão. Esses números demonstram a necessidade de uma maior visibilidade da questão e o auxílio a esses profissionais, procurando melhorar a qualidade de vida dessa categoria profissional.

The increased changes in the social and familiar structures, more and more complex, as well as the need of new social inclusion and school integration practices, have been demanding even more of the teacher. This reality can develop stress, anxiety and even depression on the lecturer. It is necessary to alert the educators about the risk that these diseases can offer, both for their professional and personal life, since many of these professionals are off work precisely due to these diseases. There is a suspicion that stressed people are more likely to develop depression, so this research evaluated this hypothesis on the public education system in Paraná. A prospective, experimental and longitudinal study was developed, which had the objective of detecting the percentage of teachers from the public education system that demonstrates high stress and depression levels, and warn them about the problems deriving from these pathologies. Two validated self-answering questionnaires were used to verify the severity of the non-psychotic psychiatric disorders, related to psychological stress and depression. The scores obtained from the total sum of answered questions by teachers in the GHQ-12 questionnaire and Beck's Inventory were analyzed through Kuskal-Wallis tests, and, when possible, by one-way ANOVA, and were considered significant when p ≤ 0.05. From 106 research participants, 46.2% suffer from some level of psychosomatic stress and 21.7% presented characteristics of depression. These numbers show the necessity of a greater visibility of the problem and the assistance to these professionals, seeking to improve their quality of life.

Microdialysis study of striatal dopamine in MPTP-hemilesioned rats challenged with apomorphine and amphetamine.

Motor impairments of Parkinson's disease (PD) appear only after the loss of more than 70% of the DAergic neurons of the substantia nigra pars compacta (SNc). An earlier phase of this disease can be modeled in rats that received a unilateral infusion of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) into the SNc. Though these animals do not present gross motor impairments, they rotate towards the lesioned side when challenged with DAergic drugs, like amphetamine and apomorphine. The present study aimed to test whether these effects occur because the drugs disrupt compensatory mechanisms that keep extracellular levels of dopamine in the striatum (DA(E)) unchanged. This hypothesis was tested by an in vivo microdialysis study in awake rats with two probes implanted in the right and left striatum. Undrugged rats did not present turning behaviour and their basal DA(E) did not differ between the lesioned and sham-lesioned sides. However, after apomorphine treatment, DA(E) decreased in both sides, but to a larger extent in the lesioned side at the time the animals started ipsiversive turning behaviour. After amphetamine challenge, DA(E) increased in both sides, becoming significantly higher in the non-lesioned side at the time the animals started ipsiversive turning behaviour. These results are in agreement with the hypothesis that absence of gross motor impairments in this rat model of early phase PD depends on maintenance of extracellular DA by mechanisms that may be disrupted by events demanding its alteration to higher or lower levels.

Learning processing in the basal ganglia: a mosaic of broken mirrors.

In the present review we propose a model to explain the role of the basal ganglia in sensorimotor and cognitive functions based on a growing body of behavioural, anatomical, physiological, and neurochemical evidence accumulated over the last decades. This model proposes that the body and its surrounding environment are represented in the striatum in a fragmented and repeated way, like a mosaic consisting of the fragmented images of broken mirrors. Each fragment forms a functional unit representing articulated parts of the body with motion properties, objects of the environment which the subject can approach or manipulate, and locations the subject can move to. These units integrate the sensory properties and movements related to them. The repeated and widespread distribution of such units amplifies the combinatorial power of the associations among them. These associations depend on the phasic release of dopamine in the striatum triggered by the saliency of stimuli and will be reinforced by the rewarding consequences of the actions related to them. Dopamine permits synaptic plasticity in the corticostriatal synapses. The striatal units encoding the same stimulus/action send convergent projections to the internal segment of the globus pallidus (GPi) and to the substantia nigra pars reticulata (SNr) that stimulate or hold the action through a thalamus-frontal cortex pathway. According to this model, this is how the basal ganglia select actions based on environmental stimuli and store adaptive associations as nondeclarative memories such as motor skills, habits, and memories formed by Pavlovian and instrumental conditioning.

Prevalence of mammary alterations in women assisted in a municipality in the state of Paraná / Prevalencia de alteraciones de mama en las mujeres atendidas en una ciudad del estado de Paraná / Prevalência de alterações mamárias em mulheres atendidas em um município do estado do Paraná

The purpose of this quantitative and retrospective study was to analyze the prevalence of mammary alterations from 1304 women in the city of Francisco Beltrão- Paraná (PR), Brazil, registered in theSISMAMA system, froma Regional Health Center in Paraná State. Between 2009 and 2012, data was collected in May and June 2013 and statistically analyzed. The results showed that 694 (53.2%)of women were under 49 years old, 1126 (86.3%) had no increased risk for developing breast cancer, and 1205 (92.5%) underwentmammography screening. Color and tracking information were omitted in most entries. The BI-RADS (r) category 0 (inconclusive result) was the most prominent.Categories with higher chances of malignancy (BI-RADS (r) 4 and 5) prevailed in the left breast in women older than 50. Diagnosis of radial sclerosing lesions associated with infiltrating ductal carcinoma was predominant in 53.0% (n = 9) of the histopathological exams. We conclude that these findings are partially supported by the literature.

Este estudio cuantitativo y retrospectivo tuvo como objetivo analizar la prevalencia de las alteraciones mamarias en 1.304 mujeres del municipio de Francisco Beltrão- Paraná (PR), Brasil, inscrito en el SISMAMA de la Regional de Salud del Estado de Paraná, entre 2009 y 2012, los datos fueron recolectados en mayo y junio de 2013 y se analizaron estadísticamente. Los resultados mostraron que 694 (53,2%) mujeres tenían hasta 49 años 1126 (86,3%) no tenían mayor riesgo para el cáncer de mama, 1205 (92,5%) fueron sometidos a la mamografía de rastreo. La información de color y el seguimiento se omite en la mayoría de las entradas. Predominan la categoría BI-RADS(r) 0 (examen inconcluyente). Categorías con mayores posibilidades de malignidad (BI-RADS(r) 4 y 5) fueron superiores para el seno izquierdo en mujeres mayores de 50 años. Diagnóstico de las lesiones esclerosantes radiales asociados con carcinoma ductal infiltrante fue predominante en 53,0% (n=9) de la histopatología. Llegamos a la conclusión de que estos resultados son parcialmente compatibles con la literatura.

Este estudo quantitativo e retrospectivo teve como objetivo analisar a prevalência de alterações mamárias de 1304 mulheres do município de Francisco Beltrão - Paraná (PR), Brasil, cadastradas no SISMAMA de uma Regional de Saúde do Estado do Paraná, entre 2009 e 2012. Os dados foram coletados em maio e junho de 2013 e analisados estatisticamente. Os resultados apontaram que 694 (53,2%) mulheres tinham idade até 49 anos, 1126 (86,3%) não possuíam risco aumentado para desenvolver câncer de mama, 1205 (92,5%) realizaram mamografia de rastreamento. Cor e seguimento foram informações omitidas na maioria dos cadastros. Predominou a categoria (BI-RADS(r) 0) exame inconclusivo). Categorias com maiores chances de malignidade (BI-RADS(r) 4 e 5) prevaleceram na mama esquerda de mulheres acima de 50 anos. Diagnóstico de lesão esclerosante radial associada ao carcinoma ductalinfiltrante predominou em 53,0% (n=9) dos exames histopatológicos. Conclui-se que estes dados são parcialmente corroborados pela literatura.

Avaliação antibacteriana do extrato de melaleuca (Melaleuca alternifolia) frente à cepa de Staphylococcus aureus / Antibacterial evaluation of melaleuca (Melaleuca alternifolia) extract in face of Staphylococcus aureus strain

O uso de óleos essenciais para o tratamento de patologias de pele vem crescendo a cada dia, são facilmente comercializados para diferentes fins. Este trabalho visou a comparação e comprovação do efeito antimicrobiano do óleo essencial comercial de Melaleuca alternifolia e do óleo extraído direto da planta frente a cepa de Staphylococcus aureus (ATCC-25923). Para os testes foram escolhidos dois óleos comerciais tratados neste estudo como A e B e a extração do óleo da planta nas diferentes sazonalidades. A técnica utilizada para os testes foi a do poço por Pour Plate. A cultura bacteriana foi inoculada em placas de meio Ágar Mueller Hinton (MHA). A inoculação se deu com uma suspensão de colônias seguindo a escala de McFarland em salina estéril com concentração de 0,9 %. A cada placa contendo o meio de cultura adicionou-se 1ml dessa suspensão do inoculo, em seguida foram realizados os poços com adição de 20 µl de óleo, estes conservados em estufa a 37°C por 24 horas. Como controle positivo foi utilizado discos do antibiótico Eritromicina comercial. Todos os testes foram realizados e analisados em duplicata. Para a análise foram medidos o diâmetro dos halos de todas as amostras, os quais apresentaram uma discreta inibição. Conclui-se que o óleo essencial extraído em junho obteve maior inibição, sendo mais efetivo em Staphylococcus aureus do que os óleos comerciais A e B.

The use of essential oils for the treatment of skin diseases is growing. They are easily marketed for different purposes. This study sought to compare and prove the antimicrobial effect of the commercial essential oil of Melaleuca alternifolia and oil directly extracted from the plant with the strain of Staphylococcus aureus (ATCC 25923). For the tests, two commercial oils were chosen, treated in this study as A and B, and the oil extracted from the plant in the different seasonalities. The technique used for the tests was the Pour Plate well. The bacterial culture was inoculated onto plates with Mueller Hinton Agar (MHA). Inoculation took place with the suspension of colonies following the McFarland scale in 0.9% sterile saline solution. A total of 1 ml of this inoculum suspension was added to each plate containing the culture medium, then the wells were used with the addition of 20 µl of oil. These were stored at 37 °C for 24 hours. Antibiotic erythromycin commercial discs were used as positive control. All tests were performed and analyzed in duplicate. For the analysis, the diameters of all samples were measured, which showed a slight inhibition. It can be concluded that the essential oil extracted in June presented higher inhibition, being more efficient against Staphylococcus aureus than commercial oils A and B.

Prevalência de compulsão alimentar periódica em indivíduos do sudoeste do Paraná / Prevalence of periodic binge eating disorder in the population in the southwest of Paraná

Devido o transtorno de compulsão alimentar periódico estar aumentando significativamente e pela inexistência de estudos na região sudoeste objetivou-se verificar a prevalência deste transtorno em indivíduos do sudoeste do Paraná, por meio da aplicação da Escala de Compulsão Alimentar Periódica (ECAP) validada para o português. Trata-se de um estudo quantitativo realizado por meio de aplicação de um questionário de coleta de dados autoaplicável em dois postos de saúde do sudoeste do Paraná. A pesquisa foi aprovada pelo Comitê de Ética, depois de submetido na Plataforma Brasil, de acordo com a resolução 466/2012 do Conselho Nacional de Saúde. A amostra em estudo foi constituída por 120 (100%) participantes do sexo feminino em estado nutricional de eutrofia, sobrepeso e obesidade, com idade mínima de 20 e máxima de 59 anos (média ± EPM de 35,25 ± 0,95 anos), observamos que 80% da amostra não apresentam compulsão alimentar periódica, 15% apresentaram compulsão alimentar periódica moderado e 5% apresentaram compulsão alimentar periódica severa com média de 32,83 pontos. Ao analisar a faixa etária de maior risco, observa-se que os indivíduos entre 20-29 anos e 30-39 anos apresentam pontuações mais elevadas (F(3,116) =2,47; p ≤ 0.05). Os indivíduos obesos da faixa etária de 30-39 anos apresentaram escores mais elevados sendo significantes em relação aos indivíduos eutróficos da mesma faixa etária (p ≤ 0,05). Assim conclui-se que o IMC mais elevado é fator de risco para desenvolvimento de TCAP, assim como em indivíduos com menor faixa etária na idade adulta.

Binge eating disorder (BED) is significantly increasing, and the lack of studies in the southwestern region, the aim of this study was to determine the prevalence of BED in subjects in southwestern Paraná by applying the Binge Eating Scale (BES) validated for Portuguese. This is a quantitative study conducted through a self-administered data collection questionnaire applied in two health centers in southwestern Paraná. The study was approved by the Ethics Committee, after undergoing Platform Brazil, according to Resolution 466/2012 from the National Health Council (CNES). The study sample consisted of 120 (100%) female participants in the nutritional status of normal weight, overweight and obesity, with a minimum age of 20 and maximum of 59 years (mean ± SEM of 35.25 ± 0.95 years). It was observed that 80% of the sample did not have BED, while 15% presented moderate BED and 5% had severe BED, averaging 32.83 points. When analyzing the age group presenting the greatest risk, it could be observed that individuals between 20-29 years old and 30-39 years old have the highest scores (F (3.116) = 2.47, p ≤ 0.05). Obese individuals in the age group of 30-39 years old had higher scores, being significant when compared to normal individuals in the same age group (p ≤ 0.05). Thus, it can be concluded that higher body mass index is a risk factor for developing BED, as well as in individuals with lower age in adulthood.