Young people's experiences with mental health medication: A narrative review of the qualitative literature.

BACKGROUND: With the growing prevalence of mental illness in young people, healthcare professionals require an understanding of the social and psychological implications of medication use in this population. AIM: To characterize the qualitative literature regarding the perceptions and experiences of young people taking medication for mental illness. METHODS: A narrative review of qualitative studies involving young people (13-24 years) taking any medication as treatment for a mental illness. The Medication Experience Model guided analysis of quotes related to medication use. RESULTS: Of the 27 included studies, the majority involved participants with depression and utilized interviews. Young people reported a wide range of mental health medication experiences, both negative and positive, which could influence medication acceptance. Lack of autonomy and the influence of family members were challenges faced by this population. CONCLUSIONS: Young people reported that medications had affected them in various ways across multiple dimensions. Lack of involvement in decision-making and a loss of autonomy were of particular relevance to young people, issues which should also be of interest to healthcare professionals.

The price of good welfare: Does informing consumers about what on-package labels mean for animal welfare influence their purchase intentions?

Public concern for farm animal welfare is growing. However, high welfare purchases require consumers to make sense of often confusing labels. This study aims to investigate consumers' preferences for higher welfare products with on-package animal welfare labels and to explore whether providing consumers with detailed information about the welfare conditions behind on-package animal welfare labels could have a positive influence on farm animal welfare. The survey was conducted online and involved participants (N = 1612) being randomly assigned into one of two-treatment groups: (1) an animal welfare label and (2) an animal welfare label with details about the welfare standards signified by that label. Participants were asked their intentions to purchase products with varying animal welfare labels. Participants were also surveyed with an adapted version of the Animal Attitude Scale that measured pro-welfare attitudes, resulting in an Animal Empathy Score (AES), a series of demographics questions, and to rate the welfare of pigs, chickens and laying hens in Australian food production. The results revealed that the provision of additional information significantly increased intention to purchase higher than conventional welfare products. The empathy measures revealed that younger participants, females and those with lower household incomes all had significantly higher AES. Moreover, AES was associated with intent to purchase higher welfare products. No interaction terms were significant, suggesting that the positive influence of information on purchase intentions is not dependent on participants' pro-welfare attitudes. Given animal welfare is market-driven in countries such as Australia, the findings suggest that providing farm animal welfare information at the point-of-purchase could boost appreciation and demand for higher than conventional welfare products.

Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.

Recombinant tau protein is widely used to study the biochemical, cellular and pathological aspects of tauopathies, including Alzheimer's disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTPD-17). Pure tau in high yield is a requirement for in vitro evaluation of the protein's physiological and toxic functions. However, the preparation of recombinant tau is complicated by the protein's propensity to aggregate and form truncation products, necessitating the use of multiple, time-consuming purification methods. In this study, we investigated parameters that influence the expression of wild type and FTPD-17 pathogenic tau, in an attempt to identify ways to maximise expression yield. Here, we report on the influence of the choice of host strain, induction temperature, duration of induction, and media supplementation with glucose on tau expression in Escherichia coli. We also describe a straightforward process to purify the expressed tau proteins using immobilised metal affinity chromatography, with favourable yields over previous reports. An advantage of the described method is that it enables high yield production of functional oligomeric and monomeric tau, both of which can be used to study the biochemical, physiological and toxic properties of the protein.

Reported Agonistic Behaviours in Domestic Horses Cluster According to Context.

Agonistic behaviours are often directed at other animals for self-defence or to increase distance from valued resources, such as food. Examples include aggression and counter-predator behaviours. Contemporary diets may boost the value of food as a resource and create unanticipated associations with the humans who deliver it. At the same time the domestic horse is asked to carry the weight of riders and perform manoeuvres that, ethologically, are out-of-context and may be associated with instances of pain, confusion, or fear. Agonistic responses can endanger personnel and conspecifics. They are traditionally grouped along with so-called vices as being undesirable and worthy of punishment; a response that can often make horses more dangerous. The current study used data from the validated online Equine Behavioural and Research Questionnaire (E-BARQ) to explore the agonistic behaviours (as reported by the owners) of 2734 horses. With a focus on ridden horses, the behaviours of interest in the current study ranged from biting and bite threats and kicking and kick threats to tail swishing as an accompaniment to signs of escalating irritation when horses are approached, prepared for ridden work, ridden, and hosed down (e.g., after work). Analysis of the responses according to the context in which they arise included a dendrographic analysis that identified five clusters of agonistic behaviours among certain groups of horses and a principal component analysis that revealed six components, strongly related to the five clusters. Taken together, these results highlight the prospect that the motivation to show these responses differs with context. The clusters with common characteristics were those observed in the context of: locomotion under saddle; saddling; reactions in a familiar environment, inter-specific threats, and intra-specific threats. These findings highlight the potential roles of fear and pain in such unwelcome responses and challenge the simplistic view that the problems lie with the nature of the horses themselves rather than historic or current management practices. Improved understanding of agonistic responses in horses will reduce the inclination of owners to label horses that show such context-specific responses as being generally aggressive.

Animal models for dystonia.

Symptomatic animal models have clinical features consistent with human disorders and are often used to identify the anatomical and physiological processes involved in the expression of symptoms and to experimentally demonstrate causality where it would be infeasible in the patient population. Rodent and primate models of dystonia have identified basal ganglia abnormalities, including alterations in striatal GABAergic (ie, transmitting or secreting γ-aminobutyric acid) and dopaminergic transmission. Symptomatic animal models have also established the critical role of the cerebellum in dystonia, particularly abnormal glutamate signaling and aberrant Purkinje cell activity. Further, experiments suggest that the basal ganglia and cerebellum are nodes in an integrated network that is dysfunctional in dystonia. The knowledge gained from experiments in symptomatic animal models may serve as the foundation for the development of novel therapeutic interventions to treat dystonia. © 2013 Movement Disorder Society.

Effect of sacroiliac fusion on gait, standing balance, and pelvic mobility for unilateral sacroiliac joint dysfunction.

Background: Sacroiliac joint fusion (SIF) has been shown to effectively alleviate pain and improve functional deficits associated with sacroiliac joint dysfunction (SIJD). Previous studies have demonstrated significant improvements in gait function, however, none have reported both over-ground walking and quiescent standing, and additionally, none have included analysis of pelvic kinematics which may contain important information regarding pain avoidant compensatory behaviors. The purpose of this study was to identify objective functional differences between symptomatic and asymptomatic sides of unilateral sacroiliac joint dysfunction (SIJD) patients and to demonstrate the effectiveness of unilateral sacroiliac fusion (SIF) to improve gait and balance function compared to matched controls. Methods: Thirteen unilateral SIJD patients were evaluated before and 6 months after SIF and were compared to matched asymptomatic controls. Pain and disability were assessed using visual analog scales and the Oswestry disability index respectively. Over ground walking and standing balance were assessed using 3D joint kinematics and kinetic ground reaction force analyses. Results: Preoperatively, SIJD patients reported high levels of pain and disability and exhibited significant deficits in gait including elevated step width, reduced hip flexion/extension, and elevated pelvic motion as well as elevated center of pressure sway characteristics during standing. After unilateral SIF, patients reported significant reductions in pain and demonstrated significant improvements in gait including normalization of step width between sides and improved hip motion however elevated pelvic obliquity and rotation motion remained. Improvements in standing balance included reduced coronal sway characteristics and normalization of loading symmetry between sides. Conclusion: Unilateral SIF resulted in significant improvements in both gait and balance function among SIJD patients to levels comparable to matched controls, however elevated pelvic motion remained. These findings help inform surgeons on the effectiveness of SIF for unilateral SIJD and provide important information regarding interpretation of functional outcomes.

The Fibre Requirements of Horses and the Consequences and Causes of Failure to Meet Them.

Failure to meet the minimum forage requirement of 1.5% of the horse's bodyweight and the opportunity for foraging for a minimum of 8 h a day (not going without this opportunity longer than four to five consecutive hours) can have both physiological and behavioural consequences. To provide an energy source for horses, rations often include starch rather than fibre. This can result in health issues related to the gastrointestinal tract (GIT) in the horse. In the stomach, the main concern is equine gastric ulcer syndrome (EGUS) and, more specifically, equine squamous gastric disease (ESGD). Ulcerations are caused either by increasing acidity in the stomach (from starch ingestion and reduced saliva production) or splashing of acidic juices caused by a lack of a forage barrier prior to exercise or prolonged periods without fibrous feed intake, which allows the stomach to collapse and spread acidic gastric fluids into the upper squamous regions of the stomach. In the hindgut, starch that has escaped digestion in the small intestine causes microbial instability and increased production of volatile fatty acids (VFA) and lactic acid. This puts horses at great risk for acidosis and subsequent laminitis. Shifts in the hindgut microbiota will also affect a horse's behaviour via the gut-brain axis, as well as potentially compromise immune function. Reduced fluid intake caused by reduced saliva production can result in colic. Choosing a fibrous alternative for starch in a high-energy diet greatly reduces the risk of EGUS and acidosis and improves digestion, GIT pH, body condition, behaviour, immune functions, and performance. Providing hay can reduce crib-biting, wood-chewing, coprophagia, the consumption of bedding, aggression, and stress, and subsequently increase social bonding and affiliation with conspecifics. Adequate fibre intake is related to reduced clinical signs of EGUS, reduced reactivity, and better adaptation to weaning. Lignophagia (wood chewing) has also been observed in horses that are foraging, and this is thought to reflect low fibre content in the available forage (for example, early vegetative, lush pasture).

Defining the Characteristics of Successful Biosecurity Scent Detection Dogs.

To perform their role effectively, scent detection dogs require certain characteristics. Identifying these characteristics will inform the selection of prospective dogs and preferred approaches to their training. The current study drew upon the perspectives of industry stakeholders to identify the behavioural traits considered relevant for detection dogs in biosecurity screening roles. Dog handlers, trainers, and supervisors (n = 25) in Australian biosecurity operations participated in focus group interviews to determine the perceived characteristics that, in their experience, influence detection performance. Their descriptions were used to create a questionnaire which was then administered to handlers to assess the working behaviours of current biosecurity dogs. Responses were collected for 88% of the operational dogs (n = 36). An exploratory factor analysis revealed seven tentative dimensions: search motivation, emotional stability, search arousal, food motivation, play motivation, search independence, and search focus. Search motivation and search arousal were both positively associated with handler ratings of detection performance (p ≤ 0.006). In general, biosecurity dogs were scored consistently high in ratings of search motivation, emotional stability, and food motivation. Our approach has advanced our understanding of the working behaviours and characteristic profile of biosecurity detector dogs and will be used to inform candidate selection processes.

Investigating the Market Value of Brumbies (Equus caballus) in the Australian Riding Horse Market.

Feral horses, also known as brumbies, are widely distributed across Australia with some populations being managed largely by human intervention. Rehoming of suitable feral horses following passive trapping has wide community acceptance as a management tool. However, there is little information about the number and relative economic value of feral horses compared with cohorts in the riding horse market. We examined 15,404 advertisements of horses for sale in 53 editions of Horse Deals, published from February 2017 to July 2022. Despite the considerable media attention and public scrutiny surrounding feral horse management, rehomed feral horses represented only a tiny fraction of the horse market in the current study. Of the 15,404 advertisements examined, only 128 (0.0083%) were for feral horses. We recorded phrases used to describe behavioural characteristics and other variables. The following variables were found to be not independent: Ridden Status, Height, Age, Sex, Colour, and Warning terms/more work. Using descriptive statistics to describe basic features of the data, the average price for feral horses ($1408) was lower than that for domestic horses ($1790) with the maximum price for a domestic horse being nearly twice the maximum for a feral horse. Univariate analysis showed feral horses were over-represented among "Unbroken" horses and underrepresented among "Ridden", "Broodmare" and "Harness" horses compared with domestic bred horses (p < 0.001). Feral horses appeared over-represented at shorter heights, among younger age groups (3 years or younger and 3.1 to 6 years) (p < 0.001) and in the dilute colour category (p = 0.008). The multivariable mixed model on price revealed that for domestic horses, the highest estimated marginal mean price averaged across the colour categories was for ridden horses aged 6.1-10-year-old at $1657.04 (95% CI $1320.56-$2074.66). In contrast, for feral horses, the multivariable mixed model demonstrated the similar highest estimated marginal mean averaged was for green broken 3-6-year-old horses that have undergone foundation training under saddle at $2526.97 (95% CI $1505.63-$4208.27). Australian feral horses were valued differently tfromsimilar domestic horses in the recreational riding horse market and further research is warranted to determine appropriate target markets and boost the sustainability of rehoming as a feral horse management tool.

Improving the standardisation, timeliness and efficiency of the occupational therapy admission process in an older adult inpatient service.

Occupational therapists (OTs) are at the forefront of providing recovery-oriented care for older people through timely assessments of patient's engagement in daily living activities among many other interventions. This aids a timely, safe and successful discharge from hospital.This project built on the foundations of previous work while considering the context and requirements of two older adult wards, the rates of admission and staff retention. The specific aim agreed was for 90% of patients admitted to the older adults' inpatient units to be assessed by the occupational therapy (OTY) team within days of admission by December 2022.The OTs worked in collaboration to initiate two tests of change with a total of five PDSA cycles.Our tests of change resulted in an increase of patients engaging in OTY initial assessments within seven days of admission from 47.65% (May to November 2021) to 78% (December 2021 to December 2022).Our team embarked on a quality improvement project to improve standardisation, efficiency and timeliness of the OTY process in an older adult inpatient service by using a pragmatic measure and tests of change evidenced in a previous study. This evidenced the generalisability of the findings of this study. While we were able to improve the timeliness of OTY initial assessments, we concluded that the overall impact on outcomes such as timely discharge was also dependent on other clinical and social factors.

Resolution of extensive leptomeningeal metastasis and clinical spinal cord compression from breast cancer using weekly docetaxel chemotherapy.

Metastatic breast cancer to the leptomeninges is a late event in the disease course and is associated with significant morbidity and a grave prognosis. Treatment typically involves direct intrathecal injection of chemotherapy into the cerebrospinal fluid compartment since systemic chemotherapy penetrates poorly to the central nervous system. Here we report an interesting clinical observation involving a patient presenting with leptomeningeal spread of breast cancer causing extensive spinal cord compression with obliteration of the subarachnoid space, thus precluding the use of direct intrathecal chemotherapy. We administered systemic chemotherapy using weekly docetaxel with complete radiographic resolution of her disease and recovery from clinical spinal cord compression. While this is a single clinical observation, weekly administration of docetaxel in this circumstance may have been associated with improved drug "escape" into the central nervous system and better antitumor effect. Because leptomeningeal disease is typically a late event in metastatic breast cancer, resistance to therapeutic intervention may reflect intrinsically resistant disease in the setting of extensive prior therapy rather than a routine problem with systemic drug delivery to the CNS. Studying patterns of disease relapse in patients who had received adjuvant weekly taxanes may provide insights into this hypothesis.

Empowering international canine inherited disorder management.

The mapping of the canine genome and the study of canine breed genomic architecture has revolutionized the discovery of genetic tests for inherited disorders in dogs. As the genetics underlying complex disorders are revealed, canine breeders and their registering organisations will be required to understand genetics in a much more sophisticated way. To facilitate the management of genetic disorders in the era of new complex information, we consider how best to apply the results of new research and analytical techniques to benefit the wider canine breeding community with the aims of improving canine health and maintaining benevolent genetic diversity. If this is not done, there is a serious risk that expensive and valuable genetic research will remain unused or be misused to the detriment of breeds. In this review, we make a case for the formation of an international organisation that will exist as a central repository for breed-based genetic analysis and information sharing. This organisation ("Inter-Dog") could be modelled on a similar organisation that is monitoring genetic improvement of dairy cattle. The formation of such an organisation will require the collaboration of international kennel management organisations, researchers, and agencies offering genetic testing services.

Valued personality traits in livestock herding Kelpies-Development and application of a livestock herding dog assessment form.

Livestock herding dogs contribute greatly to the rural economy of Australia. However, their selection currently lacks a cohesive or methodical approach. For example, there is no accessible tool for assessing Australian livestock herding dogs' suitability for work. The purpose of the current study was to devise a herding dog assessment form, the Herding Dog Assessment Form-Personality (HDAF-P), to facilitate collection of data on relevant behavioural phenotypes of large numbers of working Kelpies and to apply the HDAF-P to identify personality traits needed for herding dog performance. The focus was on creating a succinct form that was salient and accessible to livestock herding dog owners. Wherever practical, terms and methods from published personality questionnaires were integrated. Seventeen terms were included as behavioural descriptors in the HDAF-P which was then used by 95 owners to assess a sample of 228 of their working Kelpies. Owners were also asked to rate the overall ability of their dog(s). Of these dogs, 210 (all twelve months or older) were fully described and their data were used in the analysis. Thus, the study was designed to reveal which personality traits are most critical to the overall ability of the herding dogs and to undertake an exploratory analysis of the patterns of dog behaviour revealed by the HDAF-P in non-juvenile dogs. The traits that showed the strongest correlations (using Kendall's Tau correlation analysis) with overall ability were initiative (T = 0.41, p < 0.001), persistence (T = 0.36, p < 0.001), intelligence (T = 0.32, p < 0.001), confidence (T = 0.36, p < 0.001) and nervousness (T = -0.30, p < 0.001). An exploratory principal component analysis of trait scores revealed that 64.5% of the variance could be explained by four components that share several similarities with those reported by previous dog personality studies. These findings confirm that the HDAF-P has potential for the practical assessment of livestock herding dog personality and can elucidate traits that should be considered for prioritisation in training and breeding to optimise herding dog ability.

Influences on Infrared Thermography of the Canine Eye in Relation to the Stress and Arousal of Racing Greyhounds.

Infrared thermography (IRT) can be used to identify stressors associated with greyhound racing procedures. However, factors unrelated to stress may influence measurements. Validation of an eye side (right or left) and a reference point on the eye is required if IRT is to be standardised for industry use. Infrared images of greyhound heads (n = 465) were taken pre-racing and post-racing at three racetracks. Average temperature was recorded at seven different locations on each eye. A multivariate analysis model determined how several factors influenced eye temperature (ET) pre-racing and post-racing. As expected, ET increased after racing, which may be attributed to physical exertion, stress and arousal. The right eye and lacrimal caruncle had the highest sensitivity to temperature changes and could be considered reference points for future studies. Additionally, dogs that raced later had higher ET, and Richmond racetrack had the lowest pre-race ET, but the highest post-race ET. This may suggest that arousal increases as the race meet progresses and certain track attributes could increase stress. Furthermore, ET increased as humidity increased, and higher post-race ET was associated with light-coloured, young and low-performing dogs. Environmental and biological factors need to be considered if IRT is to become accurate in the detection of canine stress and monitoring of greyhound welfare.

The race that segments a nation: Findings from a convenience poll of attitudes toward the Melbourne Cup Thoroughbred horse race, gambling and animal cruelty.

The annual Melbourne Cup Thoroughbred horse race has iconic status among many Australians but sits in the context of increasing criticism of the welfare of Thoroughbred racing horses and the ethics of gambling. Despite heated debates and protests playing out in the public domain, there is scant empirical research to document Australian attitudes to the Melbourne Cup, or horse racing more generally. Specifically, little is known about how support for or against the Melbourne Cup correlate with age, gender, income and level of education. To provide a more nuanced understanding of attitudes towards the cup beyond the rudimentary binaries of those who are 'for' or 'against' gambling and horse racing, the purpose of the study was to identify clusters of people with particular views. An opportunistic survey collected data on respondents' gender, age, place of residence, weekly income, employment status and highest level of education, and sought their level of agreement with six statements about the Melbourne Cup, gambling and animal cruelty. Ordinal logistic regression and Chi-square analysis were used to evaluate the age and gender of respondents in clusters respectively. Agreement with the statements revealed some significant associations. Male respondents were at greater odds for agreement with the statement: I regularly bet on horse races (OR = 2.39; 95% CI = 1.78-3.22) as were respondents aged 18-19 years (OR = 2.88; 95% CI = 1.13-7.35) and 20-24 years (OR = 1.90; 95% CI 1.00-3.62) compared with the median 35-40 years age bracket. Agreement with the statement: I will watch the Melbourne Cup but will not place a bet was more likely among the full-time employed (OR = 1.60; 95% CI = 1.10-2.32), for those aged 20-24 years (OR = 1.85; 95% CI = 1.16-2.95). The odds of increasing agreement with the statement: I have never been interested in the Melbourne Cup were multiplied by 0.87 (95% CI = 0.82-0.92) with each successive five-year age bracket. The most useful of the predictor variables for agreement was level of education. The odds of increasing with the statement: I have become less interested in the Melbourne Cup over recent years because of my concerns with gambling were multiplied by 1.09 (95% CI = 1.02-1.15) for each increased level of education. Agreement with the statement: I have become less interested in the Melbourne Cup because of my concerns about animal cruelty was weaker amongst male respondents (OR = 0.62; 95% CI = 0.48-0.80), and those in increasing age brackets (OR = 0.88; 95% CI = 0.83-0.93). A series of six clusters were identified that show how certain attributes of respondents characterise their responses. The authors labelled these clusters "Devotees" (n = 313; 30.4% of respondents), "Flaneurs" (n = 244; 21.8% of respondents), "Disapprovers" (n = 163; 15.9% of respondents), "Casuals" (n = 148; 14.4% of respondents), "Gamblers" (n = 126; 12.3% of respondents) and "Paradoxical-voters" (n = 54; 5.3% of respondents). The implications for support of the Melbourne Cup are explored.

Mortality Resulting from Undesirable Behaviours in Dogs Aged Three Years and under Attending Primary-Care Veterinary Practices in Australia.

There is increasing evidence that undesirable behaviours (UBs) in dogs can compromise the welfare of both canine companions and their carers. Veterinarians are regularly consulted about affected animals and may be asked to euthanase the more severely affected individuals. A recent study of veterinary records showed that UBs were the predominant cause of mortality in young dogs in the UK. This companion study from Australia reports the proportion of mortality due to UBs among dogs aged three years and under that attended veterinary practices from 2013 to 2018. Deidentified patient records were extracted from the VetCompass Australia database and manually assessed to reveal the prevalence and type of UBs reported. The results reveal that 29.7% of the 4341 dogs that died at three years of age or under had deaths ascribed to at least one UB, and that the most commonly reported UB was aggression. Neutered dogs had 2.5× the odds of death due to an UB compared to intact dogs, and crossbred dogs were found to have 1.43× the odds of a UB related death compared to purebred dogs. The breeds at highest risk were Australian cattle dogs (odds ratio (OR) 4.77) and American Staffordshire terriers (OR 4.69). The attending veterinarian referred behaviour cases to a behaviourist or dog trainer in 11.0% of all UB cases, and attempted pharmacological therapy in 5.9% of cases. The results reveal how often UBs affect dogs and their owners in Australia, and infer the beneficial impact that educating dog owners and veterinary professionals in modifying and managing UBs may have.

The Impact of the Sex of Handlers and Riders on the Reported Social Confidence, Compliance and Touch Sensitivity of Horses in Their Care.

Current evidence of how human sex-related differences in riders and handlers may influence horse behaviour is limited. The Equine Behaviour Assessment and Research Questionnaire (E-BARQ) was used to collect demographic data on riders and handlers (n = 1420) and behavioural data on their horses. It includes demographic items about the sex of the respondent and how frequently the horse has been ridden or handled by male and female humans. The questionnaire then gathers observations on the horse's behaviour on the ground and under saddle or when driven. Using E-BARQ's battery of 97 questions, the current study showed differences in ridden and non-ridden horse behaviour that were related to the sex of the rider or handler. Data were evaluated using multivariate analysis and revealed that horses handled by male humans were significantly more difficult to catch (t-value = -3.11; p = 0.002) and significantly more defensive when approached (t-value = -2.104; p = 0.035), but significantly less likely to pull on the reins/brace the neck or toss their head (t-value 1.980; p = 0.048) than horses handled more frequently by female humans. The differences found between male and female horse handlers suggest that sex is an important factor to consider when understanding equine behaviour. Our study explored reported differences in confidence, handling and working compliance and touch sensitivity among horses ridden and handled by male and female humans and suggested further research into how these differences are gendered.

Understanding Cognitive Communication Needs in Pediatric Traumatic Brain Injury: Issues Identified at the 2020 International Cognitive-Communication Disorders Conference.

Purpose In early 2020, the second International Cognitive-Communication Disorders Conference was held to provide an opportunity for researchers and clinician-scientists to discuss the most recent advances and pressing issues in the care of individuals with cognitive-communication disorders (CCDs). Presentations and discussions resulted in the identification of four areas in need of attention: (a) terminology, (b) training, (c) interdisciplinary teams, and (d) pediatrics. We will explore the four themes identified at ICCDC, specifically expanding on how terminology, training, and teams intersect in pediatric traumatic brain injury care. Additionally, we will provide two case studies to highlight the integration of these themes and suggest ways to advance clinical service provision across medical and educational settings for persons with CCDs through the lens of pediatrics. Conclusion While speech-language pathology has come a long way since the original discussion of CCD over 30 years ago, clinicians and researchers have ongoing opportunities to help advance the ways in which speech-language pathologists offer support to persons, specifically children, with CCDs and to continue to advance the profession.

The Reported Use of Tongue-Ties and Nosebands in Thoroughbred and Standardbred Horse Racing-A Pilot Study.

This article reports on the results of a survey of racehorse trainers (n = 112) outlining the reasons for tongue-tie (TT) and noseband (NB) use by Thoroughbred trainers (TBTs) (n = 72) and Standardbred trainers (SBTs) (n = 40). The study also investigated the reported effectiveness of TTs and possible complications arising from their use. Tongue-tie use was reported by 62.5% (n = 70) of racehorse trainers. The reasons for TT use varied between TBTs and SBTs. For TBTs, the most common reason for TT use was to prevent or reduce airway obstruction (72.3%, n = 34), followed closely by to prevent or reduce airway noise (55.3%, n = 16). Standardbred trainers assigned equal importance for TT use [to prevent or reduce airway obstruction (69.6%, n = 16) and to prevent the horse from moving its tongue over the bit (69.6%, n = 16)]. Tongue-ties were considered significantly less effective at improving performance than at reducing airway obstruction and preventing the tongue from moving over the bit (t = -2.700, p = 0.0007). For respondents who used both TTs and NBs, there was a mild to moderate positive association between the reasons for using TTs and NBs. Of the 70 TT-using respondents, 51.4% (n = 36) recorded having encountered either a physical or behavioural complication due to TT use, with redness/bruising of the tongue (20.0%, n = 14) being the most common physical complication reported. Duration of use influenced the risk of observing complications. The likelihood of a respondent reporting a behavioural complication due to TT use increased with every minute of reported application and a nine-minute increment in application period doubled the odds of a respondent reporting a complication. Tightness was a risk factor for physical complications: Checking TT tightness by noting the tongue as not moving was associated with increased reporting of physical complications (OR = 6.59; CI 1.1-67.5). This pilot study provides some insight into how and why TTs are applied by some racehorse trainers, and the potential risks associated with their use. A further study of a larger cohort is recommended because these results are valid for only the 112 trainers who responded and cannot be generalized to the equine industry.

Inbreeding levels in an open-registry pedigreed dog breed: The Australian working kelpie.

The depletion in genetic diversity of closed-pedigree dog breeds can be a contentious topic and can lead to calls for open-registry. However, strong evidence in support of proposed open-registry solutions is lacking, with the reproductive isolation of these breeds unlikely to be the sole cause of elevated inbreeding levels. Human-induced limitations, such as popular sire effects, are unlikely to be confined to closed-registry breeds and conceivably play an important role in maintaining genetic diversity within all breeds. Consequently, the aim of the current study was to explore inbreeding levels in an open-registry breed and determine the impact open-registry has on genetic diversity. Complete pedigree records on all Australian working kelpies (AWKs) were provided by the Working Kelpie Council with the cleaned pedigree consisting of 86,671 individuals with a median pedigree depth of 6.6 generations. The average inbreeding coefficient in the AWK population was 0.049 with an increase in inbreeding coefficient of 0.0016/year. This demonstrates that opening a breed registry can have a beneficial impact on the level of inbreeding within a population over the longer-term. However, allowing for a generation length of 5.1 years yielded an effective population size of 61 for AWKs and demonstrated a pattern consistent with closed-registry dog populations of comparable size.