RESUMEN
The Affordable Care Act has served as a catalyst for the changes currently underway in the U.S. health care system and accelerated change underway over the past two decades. Employers are striving to make sense of an evolving health environment while meeting the needs of an increasingly diverse workforce. The health care landscape has shifted from the "Era of the Health Plan" to the "Era of the Person," where employers must pay heed to the distinct needs of each discrete population. To achieve optimal business performance, employers must adopt differentiated solutions that make health care local, personal and specific.
Asunto(s)
Planes de Asistencia Médica para Empleados/economía , Cobertura del Seguro/economía , Financiación Personal/tendencias , Humanos , Patient Protection and Affordable Care Act , Estados UnidosRESUMEN
With Supreme Court and election uncertainty now resolved over the Patient Protection and Affordable Care Act (ACA), employers are recognizing the need for immediate action and reassessing the role they play in promoting and insuring the health of their population. Centered on a consistent need to have a workforce that is healthy, present and high-performing, employers face four possible strategic paths. This article discusses those paths along with their attendant risks and opportunities.
Asunto(s)
Planes de Asistencia Médica para Empleados/organización & administración , Toma de Decisiones en la Organización , Planes de Asistencia Médica para Empleados/economía , Humanos , Motivación , Salud Laboral , Patient Protection and Affordable Care Act , Estados UnidosRESUMEN
Successfully having employees take personal responsibility for their benefits plans requires going beyond the rapid rollout of new benefit plan designs; it requires employers to invest in understanding the complexity of their workforce. This article reviews the evolution of benefit plans and what has arisen as the current state of employee benefits. It then discusses steps employers can take to build a successful total benefit strategy that recognizes the importance of the emerging workforce's racial, ethnic and cultural diversity.
Asunto(s)
Comportamiento del Consumidor/economía , Planes de Asistencia Médica para Empleados/economía , Actitud Frente a la Salud , Toma de Decisiones , Costos de la Atención en Salud/tendencias , Humanos , Ahorros Médicos , Cultura Organizacional , Administración de Personal , Jubilación/economía , Responsabilidad Social , Estados UnidosRESUMEN
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Asunto(s)
Inhibidores Enzimáticos/síntesis química , Imidazoles/química , Imidazoles/farmacología , Plasmacitoma/tratamiento farmacológico , Receptor TIE-2/antagonistas & inhibidores , Receptor TIE-2/química , Animales , Línea Celular Tumoral , Diseño de Fármacos , Inhibidores Enzimáticos/farmacología , Humanos , Concentración 50 Inhibidora , Ratones , Modelos Químicos , Modelos Moleculares , Trasplante de Neoplasias , Piridinas/farmacología , Proteínas Quinasas p38 Activadas por Mitógenos/metabolismoRESUMEN
In an effort to understand the effect of N-alkylation of triarylimidazoles on Tie2 inhibition, ortho-substituted C-2 aryl analogs were synthesized to investigate the effect of different torsion angles on potency. This exercise resulted in the identification of a potent and selective tetrasubstituted imidazole that was efficacious in an animal model of angiogenesis.