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1.
A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function.
J Cell Sci
; 126(Pt 14): 3159-69, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23687373
2.
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem
; 65(1): 633-664, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34928601
3.
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Bioorg Med Chem Lett
; 21(10): 3037-40, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21482467
4.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34232650
5.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33662213
6.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34255512
7.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
ACS Med Chem Lett
; 11(8): 1581-1587, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32832027
8.
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
J Med Chem
; 63(17): 9020-9044, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787145
9.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.
J Med Chem
; 63(17): 9093-9126, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32702236
10.
Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 19(1): 158-62, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19019676
11.
A Perspective on Water Site Prediction Methods for Structure Based Drug Design.
Curr Top Med Chem
; 17(23): 2599-2616, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28460610
12.
A critical assessment of docking programs and scoring functions.
J Med Chem
; 49(20): 5912-31, 2006 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17004707
13.
Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
J Med Chem
; 46(21): 4428-49, 2003 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14521407
14.
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.
J Med Chem
; 45(1): 1-18, 2002 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-11754575
15.
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
ACS Med Chem Lett
; 4(10): 948-52, 2013 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900590
16.
Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.
J Med Chem
; 55(2): 576-86, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22136404
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