Measurements of the gravitational constant using two independent methods.

The Newtonian gravitational constant, G, is one of the most fundamental constants of nature, but we still do not have an accurate value for it. Despite two centuries of experimental effort, the value of G remains the least precisely known of the fundamental constants. A discrepancy of up to 0.05 per cent in recent determinations of G suggests that there may be undiscovered systematic errors in the various existing methods. One way to resolve this issue is to measure G using a number of methods that are unlikely to involve the same systematic effects. Here we report two independent determinations of G using torsion pendulum experiments with the time-of-swing method and the angular-acceleration-feedback method. We obtain G values of 6.674184 × 10-11 and 6.674484 × 10-11 cubic metres per kilogram per second squared, with relative standard uncertainties of 11.64 and 11.61 parts per million, respectively. These values have the smallest uncertainties reported until now, and both agree with the latest recommended value within two standard deviations.

Amelioration of Lung Fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration.

Idiopathic Pulmonary Fibrosis (IPF) is identifiable by the excessive increase of mesenchyme paired with the loss of epithelium. Total flavonoids of Astragalus (TFA), the main biologically active ingredient of the traditional Chinese medicine, Astragalus membranaceus (Huangqi), shows outstanding effects on treating pulmonary disorders, including COVID-19-associated pulmonary dysfunctions. This study was designed to evaluate the efficacy of TFA on treating pulmonary fibrosis and the possible mechanisms behind these effects. A549 cells were treated with TGF-[Formula: see text]1 and TFA to observe the potential effects of TFA on regulating alveolar epithelial cell proliferation, TGF-[Formula: see text]1-induced EMT, and the underlying mechanisms in vitro. Then, mouse pulmonary fibrosis was induced with a single intra-tracheal injection of bleomycin, and TFA was administrated by i.p. injection. Lung fibrosis was evaluated through histological and molecular analyses, and the possible mechanisms were explored using immunological methods. The results demonstrated that TFA could promote cell proliferation but inhibit TGF-[Formula: see text]1-induced EMT on A549 cells. TFA attenuated BLM-induced pulmonary fibrosis in mice by modulating inflammatory infiltration and M2 macrophage polarization; it furthermore modulated EMT through regulating the TGF-[Formula: see text]1/Smad pathway. In addition, TFA augmented the expression of the Wnt7b protein, which plays an important role in alveolar epithelium reparation. In conclusion, TFA alleviated bleomycin-induced mouse lung fibrosis by preventing the fibrotic response and increasing epithelium regeneration.

Precision measurement of the Newtonian gravitational constant.

The Newtonian gravitational constant G, which is one of the most important fundamental physical constants in nature, plays a significant role in the fields of theoretical physics, geophysics, astrophysics and astronomy. Although G was the first physical constant to be introduced in the history of science, it is considered to be one of the most difficult to measure accurately so far. Over the past two decades, eleven precision measurements of the gravitational constant have been performed, and the latest recommended value for G published by the Committee on Data for Science and Technology (CODATA) is (6.674 08 ± 0.000 31) × 10-11 m3 kg-1 s-2 with a relative uncertainty of 47 parts per million. This uncertainty is the smallest compared with previous CODATA recommended values of G; however, it remains a relatively large uncertainty among other fundamental physical constants. In this paper we briefly review the history of the G measurement, and introduce eleven values of G adopted in CODATA 2014 after 2000 and our latest two values published in 2018 using two independent methods.

Research on supporting mounts of spheres in measurement of gravitational constant G.

The ongoing precision measurement of the gravitational constant G at our group is performed by using two different kinds of methods: time-of-swing method (ToS) and angular acceleration feedback method. In the two methods, the stainless steel spheres are employed as source masses, and the position stability of the spheres is an important parameter, which make suitable mounts for supporting the spheres needed extremely. In this paper, an upgraded three-point mount is introduced and tested in detail. Experimental results show that, for the sphere supported by the three-point mount used in the ToS method, the repeatability, the temperature influence, and the vibration influence are all less than 0.1 µm (about 2 ppm for the value of G). For the sphere supported by the three-point mount used in the AAF method, similar results are obtained, the largest change of the sphere's position is about 0.6 µm, introduced by a temperature change of 1 °C, which also results in an uncertainty of 2 ppm for the value of G.

Influence of tungsten fiber's slow drift on the measurement of G with angular acceleration method.

In the measurement of the gravitational constant G with angular acceleration method, the equilibrium position of torsion pendulum with tungsten fiber undergoes a linear slow drift, which results in a quadratic slow drift on the angular velocity of the torsion balance turntable under feedback control unit. The accurate amplitude determination of the useful angular acceleration signal with known frequency is biased by the linear slow drift and the coupling effect of the drifting equilibrium position and the room fixed gravitational background signal. We calculate the influences of the linear slow drift and the complex coupling effect on the value of G, respectively. The result shows that the bias of the linear slow drift on G is 7 ppm, and the influence of the coupling effect is less than 1 ppm.

Preliminary determination of Newtonian gravitational constant with angular acceleration feedback method.

This paper describes the preliminary measurement of the Newtonian gravitational constant G with the angular acceleration feedback method at HUST. The apparatus has been built, and preliminary measurement performed, to test all aspects of the experimental design, particularly the feedback function, which was recently discussed in detail by Quan et al. The experimental results show that the residual twist angle of the torsion pendulum at the signal frequency introduces 0.4 ppm to the value of G. The relative uncertainty of the angular acceleration of the turntable is approximately 100 ppm, which is mainly limited by the stability of the apparatus. Therefore, the experiment has been modified with three features: (i) the height of the apparatus is reduced almost by half, (ii) the aluminium shelves were replaced with shelves made from ultra-low expansion material and (iii) a perfect compensation of the laboratory-fixed gravitational background will be carried out. With these improvements, the angular acceleration is expected to be determined with an uncertainty of better than 10 ppm, and a reliable value of G with 20 ppm or below will be obtained in the near future.