Effects of Respiratory Function Exercise and Psychological Nursing on COPD Patients: A Comprehensive Study.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a prevalent and impactful respiratory condition, necessitating effective interventions for improved patient outcomes. This retrospective analysis aimed to explore the efficacy of respiratory function exercise combined with psychological nursing on cardiopulmonary function index, exercise tolerance, and quality of life in patients with stable COPD. Methods: The data of 100 patients with stable COPD admitted to Cangzhou Central Hospital from June 2019 to June 2021 were retrospectively analyzed. Patients were assigned to the experimental group (n=50) and the control group (n=50) alphabetically by their initials. Patients in both groups were treated with conventional care combined with respiratory function exercise, and the experimental group additionally received psychological care intervention. Pulmonary function indicators, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), one-second rate (FEV1/FVC), 6-min walking test (6MWT) results, quality of life (physical health and role emotional), anxiety and depression self-rating scale scores, nursing satisfaction, and clinical efficacy were compared between the two groups before and after treatment. Results: The two groups presented no significant differences in baseline data (P > .05). The experimental group outperformed the control group in terms of pulmonary function index, quality of life, and nursing satisfaction (P < .001). The observation group obtained lower negative emotion scores than the control group after nursing intervention (P < .001). After nursing, the FEV1/FVC in the experimental group was significantly higher than that in the control group [(58.63 ± 5.64) vs (46.36 ± 5.23)]. The 6MWT results in the experimental group were significantly better than those in the control group [(398.35 ± 28.65) m vs (348.97 ± 26.98) m] (all P < .001). Conclusion: The results revealed that this combined approach effectively improves lung function, mitigates negative emotions, enhances nursing satisfaction, and significantly boosts the quality of life in patients with stable COPD. These findings underscore the potential clinical relevance of implementing such interventions for better COPD management and patient well-being.

Sequential administration of pemetrexed and cisplatin reprograms tumor immune microenvironment and potentiates PD-1/PD-L1 treatment in a lung cancer model.

This article aimed to investigate the effects of the administration method of pemetrexed and cisplatin on the efficacy and safety of treating non-small cell lung cancer (NSCLC) and the intrinsic molecular mechanism. Subcutaneous injection of A549 cells into BALB/C nude mice was used to explore the efficacy of different administration methods of pemetrexed and cisplatin in vivo. Immunogenic cell death (ICD) was evaluated by ATP secretion, ecto-CALR expression, and high mobility group protein 1 release. Western blot, qRT-PCR, and immunohistochemical staining were applied to detect the expression of apoptosis, cell cycle, and stimulator of interferon genes (STING) pathway-related markers. Immune microenvironment was evaluated by secretion of cytokines, infiltration of CD8+ T cells, and expression of programmed death molecular ligand-1 (PD-L1). Sequential treatment with pemetrexed and cisplatin inhibited A549 cell-driven tumor formation in nude mice and regulated the expression of apoptosis and cell cycle-related genes. STING pathway and ICD were further activated by sequential treatment with pemetrexed and cisplatin. This sequential administration method increased the levels of interferon ß, tumor necrosis factor α, interleukin 12, and C-X-C motif chemokine ligand 10, enhanced the infiltration of CD8+ T cells, and upregulated the expression of PD-L1. Sequential administration of pemetrexed and cisplatin in the treatment of mouse NSCLC model may have a better effect than combination of drugs, providing theoretical basis and potential guidance for clinical medication.

Effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life of stable COPD patients.

OBJECTIVE: To investigate the effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life (QOL) of patients with stable chronic obstructive pulmonary disease (COPD). METHODS: This randomized trial was conducted on 84 subjects with stable COPD recruited in our hospital from March 2018 to December 2019 and they were divied into the observation group (n=42) and the control group (n=42) based on nursing methods. The control group adopted conventional nursing, and the observation group received cardiopulmonary rehabilitation nursing in addition to conventional method. The exercise endurance, cardiopulmonary function, psychological state, QOL and nursing satisfaction were compared at pre- and post-nursing care. RESULTS: Before nursing, no notable difference was observed in 6 min walking distance (6MWD), deep inspiratory volume (IC), left ventricular ejection fraction (LVEF), forced vital capacity (FVC), Forced expiratory volume in one second (FEV1), FEV1/FVC, Self-Rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) score, QOL, scores of symptoms, activities and impact in these two groups (P>0.05). After nursing, 6MWD and IC of observation group were remarkably higher (P<0.05); LVEF, FVC, FEV1 and FEV1/FVC in the observation group were remarkably higher (P<0.05); SAS and SDS scores of two groups decreased, and the observation group was notably lower (P<0.05); the QOL scores of symptoms, activities and effects of two groups were notably reduced, and the observation group was remarkably lower (P<0.05). The nursing satisfaction of the observation group was considerably higher than the control group (95.23% vs 76.19%) (P<0.05). CONCLUSION: Cardiopulmonary rehabilitation nursing has a remarkable effect on COPD patients in stable stage, which can enhance patients' exercise endurance and lung function, reduce adverse emotions, and improve patients' QOL and nursing satisfaction.

[Significance of the changes of platelet activation and fibrinolytic activity in patients with obstructive sleep apnea-hypopnea syndrome].

OBJECTIVE: To investigate the changes of platelet activation, coagulability, and fibrinolytic activation in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after the institution of nasal continuous positive airway pressure (nCPAP). METHODS: Fifty-eight cases of OSAHS confirmed by polysomnography (PSG) were selected as the trial group, 20 subjects without OSAHS were recruited as the control group. Eleven patients with severe OSAHS were treated by nCPAP. Plasma GMP-140, GPIIb/IIIa and D-dimer were measured by ELISA. RESULTS: Plasma levels of GMP-140, GPIIb/IIIa and D-dimer were significantly higher in patients with moderate to severe OSAHS than those in the control group, P < 0.05, and nCPAP therapy decreased their levels significantly, P < 0.001. GMP-140, GPIIb/IIIa and D-dimer were correlated positively with AHI, and negatively with minimal oxygen saturation, P < 0.001. CONCLUSIONS: Our findings suggest that activation of platelet and coagulation system with fibrinolytic activation may be associated with the high prevalence of cerebrovascular and cardiovascular events in patients with OSAHS. nCPAP therapy is effective in correcting these coagulatory and fibrinolytic abnormalities.

[Detection of thromboxane B2, 6-keto-prostaglandin F1alpha and anticardiolipin antibody in patients with obstructive sleep apnea-hypopnea syndrome].

OBJECTIVE: To observe the changes of thromboxane B(2) (TXB(2)), 6-keto-prostaglandin F1alpha (6-K-PGF1alpha) and anticardiolipin antibody (ACA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after institution of nasal continuous positive airway pressure (nCPAP). METHODS: Sixty cases of OSAHS confirmed by polysomnography (PSG) were selected as the trial group, and 20 normal donors without OSAHS were recruited as the control group. Nineteen patients with severe OSAHS were treated by nCPAP. Plasma levels of TXB(2), 6-K-PGF1alpha were detected by enzyme-linked immunosorbent assay (ELISA). RESULTS: Plasma (serum) level of TXB(2) (ACA) was significantly higher in patients with moderate to severe OSAHS than that in control group (P < 0.01), and nCPAP therapy decreased its level significantly (P < 0.01). Plasma level of 6-K-PGF1alpha was significantly lower than that in the control group (P < 0.01), and nCPAP therapy increased its level significantly (P < 0.01). TXB(2) and ACA were correlated positively with AHI, and negatively with minimal oxygen saturation (P < 0.01). 6-K-PGF1alpha was correlated negatively with AHI, and positively with minimal oxygen saturation (P < 0.01). CONCLUSIONS: The results indicate that patients with OSAHS are susceptible to thromboembolism disease. TXB(2), 6-K-PGF1alpha, ACA may be associated with the high prevalence of thromboembolism in patients with OSAHS. nCPAP therapy is effective in correcting TXB(2), 6-K-PGF1alpha, ACA.