RESUMEN
One natural p-terphenyl glycoside, gliocladinin C, and two furano-polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine. The absolute configurations of these compounds were elucidated by HR-ESI-MS, NMR, the DP4+ probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep-2 and HepG-2).
Asunto(s)
Antineoplásicos/química , Chaetomium/metabolismo , Compuestos de Terfenilo/química , Antineoplásicos/farmacología , Línea Celular Tumoral , Supervivencia Celular/efectos de los fármacos , Chaetomium/química , Dicroismo Circular , Humanos , Espectroscopía de Resonancia Magnética , Conformación Molecular , Compuestos de Terfenilo/farmacologíaRESUMEN
The STRICTA checklist is the guideline for reporting clinical trials undertaken using acupuncture intervention. As an extension of the CONSORT checklist, the STRICTA checklist facilitates the reporting quality of acupuncture clinical trials. The clinical research paradigm changes along with the development of science and technology. It is crucial to ensure whether or not the existing STRICTA checklist guides the reporting clinical trials of acupuncture now and in the future as well. This paper introduces the development and the updating procedure of the STRICTA checklist, analyzes the characteristics of utility and the limitation, and proposes several suggestions on the difficulties and challenges encountered in the implementation of the STRICTA checklist of current version so as to advance the further update and improvement.
Asunto(s)
Terapia por Acupuntura , Lista de Verificación , Humanos , Terapia por Acupuntura/normas , Ensayos Clínicos como Asunto/normas , Proyectos de Investigación/normasRESUMEN
The differences in the objective, starting point, disease spectrum and interventions of acupuncture-moxibustion clinical trials at home and abroad are collected. By taking two articles of acupuncture-moxibustion clinical trials in foreign countries accepted by JAMA as example, the reasons are analyzed on the dual character of negative and positive results obtained in acupuncture-moxibustion trials of foreign countries. The therapeutic regimens in acupuncture-moxibustion clinical trials in foreign countries are lack of TCM thinking, the manipulation of interventions have not displayed the basic principle of TCM in treatment of diseases, which is separated the theory from the practice in treatment with Chinese herbal medicine and acupuncture-moxibustion. Besides, the advantages in therapeutic effect of acupuncture-moxibustion have not been truly reflected. Regarding the dual character of negative and positive results in acupuncture-moxibustion clinical trials of foreign countries, it is suggested that acupuncture-moxibustion has not been thoroughly understood in foreign countries and its research content have not been in compliance with the theory of traditional acupuncture-moxibustion.