RESUMEN
The nonlinearity of magnons plays an important role in the study of an optomagnonical system. Here in this paper, we focus on the high-order sideband and frequency comb generation characteristics in the atom coupled optomagnonical resonator. We find that the atom-cavity coupling strength is related to the nonlinear coefficients, and the efficiency of sidebands generation could be reinforced by tuning the polarization of magnons. Besides, we show that the generation of the sidebands could be suppressed under the large dissipation condition. This study provides a novel way to engineer the low-threshold high-order sidebands in hybrid optical microcavities.
RESUMEN
Cellular FLICE-like inhibitory protein (c-FLIPL) is a key inhibitory protein in the extrinsic apoptotic pathway. Recent studies showed that c-FLIPL could translocate into the nucleus and might be involved in the Wnt signaling pathway. The nuclear function of c-FLIPL was still unclear. Here we found a novel c-FLIPL-associated protein TIP49, which is a nuclear protein identified as a cofactor in the transcriptional regulation of ß-catenin. They had co-localization in the nucleus and the DED domain of c-FLIPL was required for the association with TIP49. By performing ChIP experiments, C-FLIPL was detected in the ITF-2 locus and facilitated TIP49 accumulation in the formation of complexes at the T-cell-specific transcription factor site of human ITF-2 promoter. When TIP49 knockdown, c-FLIPL-driven Wnt activation, and cell proliferation were inhibited, suggesting that a role of nuclear c-FLIPL involved in modulation of the Wnt pathway was in a TIP49-dependent manner. Elevated expression of c-FLIPL and TIP49 that coincided in human lung cancers were analyzed in silico using the Oncomine database. Their high expressions were reconfirmed in six lung cancer cell lines and correlated with cell growth. The association of c-FLIPL and TIP49 provided an additional mechanism involved in c-FLIPL-mediated functions, including Wnt activation.
Asunto(s)
Proteína Reguladora de Apoptosis Similar a CASP8 y FADD/metabolismo , Proteínas Portadoras/metabolismo , ADN Helicasas/metabolismo , Proteínas Wnt/metabolismo , beta Catenina/metabolismo , ATPasas Asociadas con Actividades Celulares Diversas , Animales , Proteínas Portadoras/genética , División Celular , Línea Celular Tumoral , Núcleo Celular/metabolismo , ADN Helicasas/genética , Técnicas de Silenciamiento del Gen , Células HEK293 , Humanos , Ratones , Unión Proteica , Técnicas del Sistema de Dos HíbridosRESUMEN
Optomagnonics supports optical modes with high-quality optical factors and strong photon-magnon interaction on the scale of micrometers. These novel features provide an effective way to modulate the electromagnetic field in optical microcavities. Here in this work, we studied the magnon-induced chaos in an optomagnonical cavity under the condition of parity-time symmetry, and the chaotic behaviors of electromagnetic field could be observed under ultralow thresholds. Even more, the existence optomagnetic interaction makes this chaotic phenomenon controllable through modulating the external field. This research will enrich the study of light matter interaction in the microcavity and provide a theoretical guidance for random number state generation and the realization of the chaotic encryption of information on chips.