[Study on Chemical Components of Tripterospermum chinense ( â ¡)].

Objective: To investigate the chemical components of Tripterospermum chinense. Methods: Various column chromatography were used in the isolation and purification,and physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. Results: A novel monoterpenoid and seven known compounds were isolated and identified as tripterospermum acid ester A( 1),strychnovoline( 2),p-hydroxybenzaldehyde( 3),isovitexin( 4),7-O-rhamnopyransoyl-isoorientin( 5),trifoliside( 6),2″-O-rhamnopyransoyl-trifoliside( 7) and sweroside( 8). Conclusion: Compound 1 is a new monoterpenoid,compounds 2,3 are isolated from this plant for the first time.

[Chemical Constituents from Roots and Rhizome of Trillium tschonoskii( â £)].

Objective: To investigate the chemical constituents from the roots and rhizome of Trillium tschonoskii. Methods: The85% methanol elution parts from the roots and rhizome of Trillium tschonoskii were separated and purified by polyamide,silica gel,RPC18,Sephadex LH-20 column chromatography and the preparation of high performance liquid. Chemical structures were identified by MS,1D and 2D-NMR experiment. Results: Ten steroidal saponins compounds were isolated and identified as diosgenin-3-O-α-L-rhamnopyranosyl-( 1→4)-α-L-rhamnopyranosyl-( 1→4)-[α-L-rhamnopyranosyl( 1 →2) ]-ß-D-glucopyranoside( 1),trikamsteroside E( 2),deoxytrikamsteroside E( 3),( 23 S,24S,25S)-spirostan-5-ene-1ß,3ß,21,23,24-pentahydroxy-1ß-O-α-L-rhamnopyranosyl-( 1 →2)-[O-ß-D-xylopyranosyl( 1→3) ]-O-α-L-pyranarabinoside( 4),trikamsteroside B( 5),27-hydroxy-trikamsteroside B( 6),3-acetyl-pennogenin( 7),dioscoreanoside I( 8),sileneoside G( 9) and intergristerone B( 10). Conclusion: Compounds 8 ~ 10 are isolated from this genus for the first time,compounds 1,3,4,6,7 are isolated from this plant for the first time.

[Chemical Constituents from Saururus chinensis].

OBJECTIVE: To investigate the chemical constituents of active components of Saururus chinensis on anti-nicotine withdrawal symptoms. METHODS: Various column chromatography were used in the isolation and purification, and physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. RESULTS: Six chemical compounds were isolated from the active part of anti-withdrawal symptoms, and were identified as 4'-hydroxyl-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan (1) ,3-(2-nitroethyl)-1-methoxyindole(2), elemicin (3), erythro-(7R, 8S) - (-) - (3,4,5-trimethoxy-7-hydroxy-1'-allyl-3', 5'-dimethoxy)-8-O-4'-neolignan (4), 3,4,5-trimethoxy-phenylacrylaldehyde (5) and dibutyl phthalate (6). CONCLUSION: Compound 1 is a novel lignan, compounds 2 - 6 are firstly isolated from this plant.

[Study on Phenylpropanoids of Gardenia jasminoides].

OBJECTIVE: To investigate the phenylpropanoids constituents of Gardenia jasminoides. METHODS: Various column chromatography were used in the isolation and purification, physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. RESULTS: Eight compounds were isolated from Gardenia jasminoides, including 4-hydroxy-cinnamic acid methylester (1), 3, 5-dimethoxy-4-hydroxy-cinnamic acid methylester (2), pisoninol II (3), 7-hydroxy-orebiusin A (4), (E) -3-(4'-hydroxyphenyl) -acrylic acid n-butyl ester (5), (E) -3-(4'-methoxyphenyl) -acrylic acid n-butyl ester (6), 4-methoxyl-phenylpropanol n-butyl ether (7) and cycloolivil (8). CONCLUSION: All compounds are firstly isolated from this plant.

Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes.

The selective incorporation of a deuterium atom into small molecules with high selectivity is highly valuable for medical and chemical research. Unfortunately, this remains challenging due to the complete deuteration caused by commonly used hydrogen isotope exchange strategies. We report the development of a photocatalytic selective monodeuteration protocol utilizing C-C bond as the unconventional functional handle. The synergistic combination of radical-mediated C-C bond scission and deuterium atom transfer processes enables the effective constructions of benzylic CDH moieties with high selectivity for monodeuteration. The combinational use of a bisphosphonium photocatalyst, thiol catalyst, and CH3OD deuteration agent provides operationally simple conditions for photocatalytic monodeuteration. Moreover, the photoinduced electron transfer process of the bisphosphonium photocatalyst is elucidated through a series of spectroscopy experiments, identifying a peculiar back electron transfer process that can be regulated by subsequent nucleophilic additions.

How Does Person-Environment Fit Relate to Career Calling? The Role of Psychological Contracts and Organizational Career Management.

Purpose: The formation of one's career calling involves endowing work with meaning and realizing oneself in work, and it has become a focus of organizational behavior research in the past decade. Although there are many studies on the outcome variables of career calling, research on the antecedents of career calling formation is relatively scarce, and its mechanisms are unclear. Based on fit theory and social exchange theory, we analyzed the data of 373 employees and explored the relationship between person-environment fit (focusing on person-organization fit and person-job fit), psychological contract, career calling and organizational career management. Methods: We adopted a multi-timepoint data collection method to analyze data from 373 employees from an internet technology company. A mediated moderation model and hypotheses were tested using Mplus 8.3 software. Results: The results showed that person-organization fit and person-job fit were positively related to career calling, and the psychological contract played a partial mediating role. The moderating effect of organizational career management on person-organization fit, person-job fit and the psychological contract was also confirmed. Moreover, the mediating effect of the psychological contract was stronger when organizational career management was higher. Conclusion: We examined the important influence of individual-level and organizational-level factors on the formation of career calling. The findings highlight the important role and mechanism of person-environment fit in the formation of career calling through psychological factors, which has managerial implications for how to develop employees' career calling.

Selective oxidation of benzylic alcohols via synergistic bisphosphonium and cobalt catalysis.

A synergistic photocatalytic system using a bisphosphonium catalyst and a cobalt catalyst has been developed, enabling the selective oxidation of benzylic alcohols under oxidant-free and environmentally benign conditions. High efficiencies have been obtained for a variety of alcohol substrates, and exclusive selectivity for aldehyde products has been achieved across the board. Furthermore, this photocatalytic system proved to be efficient when performed under continuous-flow conditions, even using a simple and easily assembled continuous-flow setup.

Electrophysiological evidence for women superiority on unfamiliar face processing.

Previous research has reported that women superiority on face recognition tasks, taking sex difference in accuracy rates as major evidence. By appropriately modifying experimental tasks and examining reaction time as behavioral measure, it was possible to explore which stage of face processing contributes to womens' superiority. We used a modified delayed matching-to-sample task to investigate the time course characteristics of face recognition by ERP, for both men and women. In each trial, participants matched successively presented faces to samples (target faces) by key pressing. It was revealed that women were more accurate and faster than men on the task. ERP results showed that compared to men, women had shorter peak latencies of early components P100 and N170, as well as larger mean amplitude of the late positive component P300. Correlations between P300 mean amplitudes and RTs were found for both sexes. Besides, reaction times of women but not men were positively correlated with N170 latencies. In general, we provided further evidence for women superiority on face recognition in both behavioral and neural aspects.

Germline cytotoxic lymphocytes defective mutations in Chinese patients with lymphoma.

Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the development of lymphoma in Chinese patients are limited to date. In the present study, 90 patients with lymphoma were analyzed for UNC13D, PRF1, STXBP2, STX11, SH2D1A and X-linked inhibitor of apoptosis. Mutations were observed in 24 (26.67%) patients; 16 patients exhibited mutations in UNC13D, 7 exhibited PRF1 mutations, and 1 exhibited monoallelic mutation in STX11. UNC13D c.2588G>A/p.G863D mutation was detected in 9 patients (10.00%) and in 4/210 controls (1.90%). This mutation was predicted to be pathogenic and it predominantly existed in the Chinese population. These findings suggest that impaired cytotoxic machinery may represent a predisposing factor for the development of lymphoma. Furthermore, these data describe a distinct mutation spectrum in Chinese patients with lymphoma, whereby UNC13D is the most frequently mutated gene. In addition, these findings suggest UNC13D c.2588G>A mutation is a founder mutation in Chinese patients.