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As the architecture of logic devices is evolving towards gate-all-around (GAA) structure, research efforts on advanced transistors are increasingly desired. In order to rapidly perform accurate compact modeling for these ultra-scaled transistors with the capability to cover dimensional variations, neural networks are considered. In this paper, a compact model generation methodology based on artificial neural network (ANN) is developed for GAA nanosheet FETs (NSFETs) at advanced technology nodes. The DC and AC characteristics of GAA NSFETs with various physical gate lengths (Lg), nanosheet widths (Wsh) and thicknesses (Tsh), as well as different gate voltages (Vgs) and drain voltages (Vds) are obtained through TCAD simulations. Subsequently, a high-precision ANN model architecture is evaluated. A systematical study on the impacts of ANN size, activation function, learning rate, and epoch (the times of complete pass through the entire training dataset) on the accuracy of ANN models is conducted, and a shallow neural network configuration for generating optimal ANN models is proposed. The results clearly show that the optimized ANN model can reproduce the DC and AC characteristics of NSFETs very accurately with a fitting error (MSE) of 0.01.
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The synthesis of InVO4-CdS heterojunction photocatalysts has been achieved by a novel two-step approach, including a microwave-assisted technique, followed by a moderate hydrothermal method, marking the first successful instance of such a synthesis. X-ray diffraction, field-emission scanning electron microscopy, elemental color mapping, high-resolution transmission electron microscopy, UV-vis diffuse reflectance spectroscopy, Raman analysis, photoluminescence, X-ray photoelectron spectroscopy, and Brunauer-Emmett-Teller were employed to investigate the crystal structures, surface morphologies and particle sizes, chemical compositions, and optical characteristics of the as-synthesized materials. The research results indicated that the heterojunction InVO4-CdS, as synthesized, consisted of InVO4 microrods with an average size of around 15 nm and cadmium sulfide (CdS) microflowers with a diameter of 1.5 µm. Furthermore, all of the heterojunctions had favorable photoabsorption properties throughout the visible-light spectrum. The photocatalytic efficiency of the samples obtained was thoroughly assessed by the degradation of acid violet 7 (AV 7) under visible light irradiation with a wavelength greater than 420 nm. The photocatalytic efficiency for the decomposition of AV 7 was greatly enhanced in the InVO4-CdS (IVCS) heterojunctions when compared to prepared bare InVO4 and CdS. Additionally, it was observed that the composite material consisting of IVCS 3 wt % InVO4 combined with CdS exhibited the most significant enhancement in catalytic effectiveness for the photodegradation of AV 7 dye. Specifically, the catalytic performance of this composite material was found to be around 69.4 and 76.2 times greater than that of pure InVO4 and CdS, respectively. Furthermore, the experimental procedure including active species trapping provided evidence that h+ and â¢O2- radicals were the primary active species involved in the photocatalytic reaction process. Additionally, a potential explanation for the improved photocatalytic activity of the InVO4-CdS heterojunction was presented, taking into account the determination of band positions.
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Oat is considered as a moderately salt-tolerant crop that can be used to improve saline and alkaline soils. Previous studies have focused on short-term salt stress exposure, and the molecular mechanisms of salt tolerance in oat have not yet been elucidated. In this study, the salt-tolerant oat cultivar Vao-9 and the salt-sensitive oat cultivar Bai5 were treated with 6 days of 0 and 150 mmol L-1 salt stress (nNaCl:nNa2SO4 = 1:1). Label-Free technology was then used to analyze the differentially expressed proteins in leaves under 0 and 150 mmol L-1 salt stress. The obtained results indicated that total of 2,631 proteins were identified by mass spectrometry in the four samples. The salt-tolerant cultivar Vao-9 mainly enhances its carbohydrate and energy metabolism through the pentose and glucuronate interconversions, and carbon fixation pathways in prokaryotes, thereby reducing the damage caused by salt stress. In addition, the down-regulation of ribosomes expression and the up-regulated expression of HSPs and CRT are all through the regulation of protein synthesis in response to salt stress. However, GABA metabolism presents a different synthesis pattern in Bai5 and Vao-9. The main KEGG function of differential expressed protein (DEP) in Bai5 is classified into protein processing in the endoplasmic reticulum, estrogen signaling pathway, antigen processing and presentation, longevity regulating pathway-multiple species, arginine and proline metabolism, beta-alanine metabolism, vitamin B6 metabolism, salmonella infection, chloroalkane and chloroalkene degradation, and limonene and pinene degradation. Moreover, the main KEGG functions of DEP in Vao-9 are classified as ribosome and carbon fixation pathways in prokaryotes, pentose and glucuronate interconversions, GABA ergic synapse, and taurine and hypotaurine metabolism. The results obtained in this study provide an important basis for further research on the underlying mechanisms of salt response and tolerance in oat and other plant species.
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OBJECTIVE: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis. METHODS: A total of 122 subjects with coronary heart disease who underwent interventional therapy in our hospital from January 2017 to January 2019 were chosen as the observation group, and 122 healthy people during the same period were chosen as the control group. We retrospectively analyzed the levels of serum miR-221, miR-222, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Pearson correlation analysis was used to reveal the relationship between serum levels of miR-221, miR-222 and CRP, TNF-α and IL-6, N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction (LVEF%) in the observation group. The levels of serum miR-221, miR-222, TNF-α, CRP and IL-6 before and after treatment were compared in the observation group. After a follow-up of 6 months, the observation group was divided into a poor-prognosis group (26 cases) and a good-prognosis group (96 cases) according to whether there was an adverse cardiovascular event or not. The levels of serum miR-221 and miR-222 before and after intervention treatment were compared between the two groups. And the clinical values of miR-221 and miR-222 levels before and after intervention treatment in the observation group were analyzed by the ROC curve. RESULTS: The levels of serum miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were markedly higher than those of the control group. And levels of serum miR-221, miR-222 were negatively correlated with LVEF% while positively correlated with CRP, TNF-α, IL-6 and NT-proBNP (P<0.05). After treatment, the levels of miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were significantly reduced (all P<0.05). Compared with the good prognosis group, the levels of miR-221 and miR-222 before and after treatment were markedly higher in the poor prognosis group (all P<0.05). Both before and after treatment, the levels of miR-221 and miR-222 have certain clinical value in evaluating the prognosis (all AUC>0.800). CONCLUSION: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. The levels of miR-221 and miR-222 before and after treatment have certain clinical value in evaluating the prognosis of patients.
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Soil salinity is among the crucial factors that impact on crop productivity, including oat (Avena sativa L.). Herein, we used two distinct oat cultivars with varied salt tolerance levels to unravel adaptive responses to salt stress by metabolomic and transcriptomic characterization. Metabolomic profiling revealed 201 metabolites, including saccharides, amino acids, organic acids, and secondary metabolites. The levels of most saccharides and amino acids were elevated in Baiyan 2 (BY2) as well as in Baiyan 5 (BY5) exposed to salt stress. In the tolerant cultivar BY2 exposed to 150 mM NaCl, concentrations of most of the metabolites increased significantly, with sucrose increased by 38.34-fold, Sophorose increased by 314.15-fold and Isomaltose 2 increased by 25.76-fold. In the sensitive cultivar BY5, the concentrations of most metabolites increased after the plant was exposed to 150 mM NaCl but decreased after the plant was exposed to 300 mM NaCl. Transcriptomic analysis revealed that gene expressions in BY5 were significantly affected under exposure to 300 mM NaCl (34040 genes up-regulated and 14757 genes down-regulated). Assessment of metabolic pathways as well as KEGG enrichment revealed that salt stress interferes with the biosynthesis of two oat cultivars, including capacity expenditure and sugar metabolism. Most of the BY2 genes enhanced energy consumption (for example, glycolysis) and biosynthesis (for instance, starch and sugar metabolism) under salt stress. In contrast, genes in BY5 were found to be down-regulated, leading to the inhibition of energy consumption and biosynthesis, which may also be attributed to salt sensitivity in BY5. In addition, the modified Na+/K+ transporter genes expression is associated with the predominant ionic responses in BY2, which leads low concentration of Na+ and high K+ when exposed to high salt situations. These findings suggest that the varied defensive capacities of these two oat cultivars in response to salt stress are due to their variations in energy-expenditure strategy, synthesis of energy substances and ion transport in roots. Our present study offers a crucial reference for oat cultivation under saline soil.
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Avena , Metaboloma , Tolerancia a la Sal , Transcriptoma , Avena/genética , Avena/fisiología , Regulación de la Expresión Génica de las Plantas , SalinidadRESUMEN
As a new member of carbon dots (CDs), Polymer dots (PDs) prepared by hydrothermal treatment of polymers, usually consist of the carbon core and the connected partially degraded polymer chains. This type of CDs might possess aqueous solubility, non-toxicity, excellent stability against photo-bleaching and high visible light activity. In this research, PDs were prepared by a moderate hydrothermal treatment of polyvinyl alcohol, and PDs grafted TiO2 (PDs-TiO2) nanohybrids with TiOC bonds were prepared by a facile in-situ hydrothermal treatment of PDs and Ti (SO4)2. Under visible light irradiation, the PDs-TiO2 demonstrate excellent photocatalytic activity for methyl orange degradation, and the photocatalytic rate constant of PDs-TiO2 is 3.6 and 9.5 times higher than that of pure TiO2 and commercial P25, respectively. In addition, the PDs-TiO2 exhibit good recycle stability under UV-Vis light irradiation. The interfacial TiOC bonds and the π-conjugated structures in PDs-TiO2 can act as the pathways to quickly transfer the excited electrons between PDs and TiO2, therefore contribute to the excellent photocatalytic activity.