Evaluation of eSie VVI Technology on Left Ventricular Systolic Function Changes in Uremic Patients Undergoing Dialysis.

To analyze the longitudinal peak systolic strain of left ventricular myocardium in three layers before and after hemodialysis in uremic patients, and to explore the value of eSie VVI (Velocity Vector Imaging) technology in evaluating the changes of left ventricular myocardial systolic function in uremic patients in a short time after hemodialysis, the longitudinal peak systolic laminar strain and global full-thickness strain of 17 segments of the left ventricle are obtained by eSie VVI software analysis, and the results are deduced in Excel form. Statistical analysis is made on the results of longitudinal peak systolic stratified strain of left ventricular inner, middle and outer layers and whole myocardium in uremic patients before and after hemodialysis. The results show that eSie VVI technology can more sensitively and accurately evaluate the changes of left ventricular myocardial systolic function after hemodialysis in uremic patients, and has certain clinical value.

Correlation between serum inflammatory factors TNF-α, IL-8, IL-10 and Henoch-Schonlein purpura with renal function impairment.

The changes of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10) in the serum of Henoch-Schonlein purpura nephritis (HSPN) patients were analyzed to explore the correlation between the above inflammatory factors and progression of the disease. The present study used the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) method to detect the serum levels of TNF-α, IL-8, IL-10 and urine protein in 112 cases of patients with Henoch-Schonlein purpura (HSP), including 54 cases of HSP combined with renal function impairment (group HSPN), and 58 cases not combined with renal function impairment (NHSPN), as well as 50 healthy patients who were selected as the control group. The concentration of TNF-α, IL-8, and IL-10 in the serum of HSP patients were higher than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the levels of IL-10, and IL-8 between the HSPN group and the NHSPN group (P>0.05), but the level of TNF-α in the serum of HSPN group was significantly higher than that of NHSPN group (P<0.05). TNF-α, IL-8 and IL-10 levels of the acute nephritis, chronic nephritis and nephrotic syndrome groups were all higher than the simple proteinuria group. In addition, the levels of the three factors of the acute nephritis group were all higher than those of the chronic nephritis and nephrotic syndrome groups (P<0.05). IL-8, IL-10, and TNF-α were positively correlated with the urinary protein levels. The results indicated that the levels of serum TNF-α, IL-8 and IL-10 are correlated with HSPN, and serum TNF-α concentration can be used as an indicator of the severity of HSPN.