[Dongbai Tonglin Mixture for the treatment of chronic prostatitis].

OBJECTIVE: To evaluate the efficacy of Dongbai Tonglin Mixture (DTM) in the treatment of chronic prostatitis (CP) with the damp-heat downward diffusion syndrome. METHODS: We randomly selected 76 cases of CP with the damp-heat downward diffusion syndrome, equally divided them into a DTM and a control group, and treated them by oral administration of DTM and Qianlie Tai Tablets, respectively, both for 8 weeks. We obtained the NIH-CPSI and TCM Syndrome Scores of the patients, recorded the counts of white blood cells (WBC) and small particles of lecithin (SPL) in the prostate fluid, and compared them between the two groups before and after treatment. RESULTS: Compared with the baseline, the total NIH-CPSI scores were significantly reduced in both groups after treatment (P<0.05), particularly the scores on urination symptoms, pain / discomfort and quality of life (P<0.05), even more significantly in the DTM than in the control group (P<0.05), and so were the TCM Syndrome Scores (P<0.05), especially the scores on urinary incontinence, abdominal pain, perineal pain, and scrotal dampness (P<0.05), even more significantly in the former than in the latter group (P<0.05). The count of WBC in the prostate fluid was remarkably decreased (P<0.05), while that of SPL markedly increased in both groups after treatment (P<0.05), with an even more significant improvement in the DTM than in the control group (P<0.05), and the overall effectiveness rate of treatment was significantly higher in the former group than in the latter (88.89% vs 70.27%, P<0.05). CONCLUSION: Dongbai Tonglin Mixture is effective for the treatment of CP with the damp-heat downward diffusion syndrome.

MCIBI++: Soft Mining Contextual Information Beyond Image for Semantic Segmentation.

Co-occurrent visual pattern makes context aggregation become an essential paradigm for semantic segmentation. The existing studies focus on modeling the contexts within image while neglecting the valuable semantics of the corresponding category beyond image. To this end, we propose a novel soft mining contextual information beyond image paradigm named MCIBI++ to further boost the pixel-level representations. Specifically, we first set up a dynamically updated memory module to store the dataset-level distribution information of various categories and then leverage the information to yield the dataset-level category representations during network forward. After that, we generate a class probability distribution for each pixel representation and conduct the dataset-level context aggregation with the class probability distribution as weights. Finally, the original pixel representations are augmented with the aggregated dataset-level and the conventional image-level contextual information. Moreover, in the inference phase, we additionally design a coarse-to-fine iterative inference strategy to further boost the segmentation results. MCIBI++ can be effortlessly incorporated into the existing segmentation frameworks and bring consistent performance improvements. Also, MCIBI++ can be extended into the video semantic segmentation framework with considerable improvements over the baseline. Equipped with MCIBI++, we achieved the state-of-the-art performance on seven challenging image or video semantic segmentation benchmarks.

DMRNet++: Learning Discriminative Features With Decoupled Networks and Enriched Pairs for One-Step Person Search.

Person search aims at localizing and recognizing query persons from raw video frames, which is a combination of two sub-tasks, i.e., pedestrian detection and person re-identification. The dominant fashion is termed as the one-step person search that jointly optimizes detection and identification in a unified network, exhibiting higher efficiency. However, there remain major challenges: (i) conflicting objectives of multiple sub-tasks under the shared feature space, (ii) inconsistent memory bank caused by the limited batch size, (iii) underutilized unlabeled identities during the identification learning. To address these issues, we develop an enhanced decoupled and memory-reinforced network (DMRNet++). First, we simplify the standard tightly coupled pipelines and establish a task-decoupled framework (TDF). Second, we build a memory-reinforced mechanism (MRM), with a slow-moving average of the network to better encode the consistency of the memorized features. Third, considering the potential of unlabeled samples, we model the recognition process as semi-supervised learning. An unlabeled-aided contrastive loss (UCL) is developed to boost the identification feature learning by exploiting the aggregation of unlabeled identities. Experimentally, the proposed DMRNet++ obtains the mAP of 94.5% and 52.1% on CUHK-SYSU and PRW datasets, which exceeds most existing methods.

Sparse R-CNN: An End-to-End Framework for Object Detection.

Object detection serves as one of most fundamental computer vision tasks. Existing works on object detection heavily rely on dense object candidates, such as k anchor boxes pre-defined on all grids of an image feature map of size H×W. In this paper, we present Sparse R-CNN, a very simple and sparse method for object detection in images. In our method, a fixed sparse set of learned object proposals ( N in total) are provided to the object recognition head to perform classification and localization. By replacing HWk (up to hundreds of thousands) hand-designed object candidates with N (e.g., 100) learnable proposals, Sparse R-CNN makes all efforts related to object candidates design and one-to-many label assignment completely obsolete. More importantly, Sparse R-CNN directly outputs predictions without the non-maximum suppression (NMS) post-processing procedure. Thus, it establishes an end-to-end object detection framework. Sparse R-CNN demonstrates highly competitive accuracy, run-time and training convergence performance with the well-established detector baselines on the challenging COCO dataset and CrowdHuman dataset. We hope that our work can inspire re-thinking the convention of dense prior in object detectors and designing new high-performance detectors.

Exploring the mechanism of Xiaoqinglong decoction in the treatment of infantile asthma based on network pharmacology and molecular docking.

To explore the mechanism of Xiaoqinglong decoction (XQLD) in the treatment of infantile asthma (IA) based on network pharmacology and molecular docking. The active ingredients of fdrugs in XQLD were retrieved from Traditional Chinese Medicine Systems Pharmacology database and then the targets of drug ingredients were screened. The disease targets of IA were obtained from OMIM and Gencards databases, and the intersection targets of XQLD in the treatment of IA were obtained by Venny 2.1 mapping of ingredient targets and disease targets. Cytoscape software was used to construct active ingredient-intersection target network. The potential targets of XQLD in the treatment of IA were analyzed by protein-protein interaction network using STRING platform, and the Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were obtained by R Studio software. AutoDock was used to perform molecular docking for verification. In this study, 150 active ingredients of XQLD were obtained, including quercetin, kaempferol, ß-sitosterol, luteolin, stigmasterol, and so on. And 92 intersection targets of drugs and diseases were obtained, including interleukin 6 (IL6), cystatin 3, estrogen receptor 1, hypoxia inducible factor 1A, HSP90AA1, epidermal growth factor receptor and so on. There were 127 items of Gene Ontology enrichment analysis and 125 Kyoto Encyclopedia of Genes and Genomes enrichment results, showing that apoptosis, IL-17 signaling pathway, tumor necrosis factor signaling pathway, P13K-Akt signaling pathway and other pathways may play a key role in the treatment of IA by XQLD. The results of molecular docking showed that the key active ingredients including quercetin, kaempferol, ß-sitosterol, luteolin, stigmasterol, and the core targets including IL6, cystatin 3, estrogen receptor 1, hypoxia inducible factor 1A, HSP90AA1, and epidermal growth factor receptor had good binding activity. Through network pharmacology and molecular docking, the potential targets and modern biological mechanisms of XQLD in the treatment of IA were preliminarily revealed in the study, which will provide reference for subsequent animal experiments and clinical trials.

Birds of a Feather Flock Together: Category-Divergence Guidance for Domain Adaptive Segmentation.

Unsupervised domain adaptation (UDA) aims to enhance the generalization capability of a certain model from a source domain to a target domain. Present UDA models focus on alleviating the domain shift by minimizing the feature discrepancy between the source domain and the target domain but usually ignore the class confusion problem. In this work, we propose an Inter-class Separation and Intra-class Aggregation (ISIA) mechanism. It encourages the cross-domain representative consistency between the same categories and differentiation among diverse categories. In this way, the features belonging to the same categories are aligned together and the confusable categories are separated. By measuring the align complexity of each category, we design an Adaptive-weighted Instance Matching (AIM) strategy to further optimize the instance-level adaptation. Based on our proposed methods, we also raise a hierarchical unsupervised domain adaptation framework for cross-domain semantic segmentation task. Through performing the image-level, feature-level, category-level and instance-level alignment, our method achieves a stronger generalization performance of the model from the source domain to the target domain. In two typical cross-domain semantic segmentation tasks, i.e., GTA 5→ Cityscapes and SYNTHIA → Cityscapes, our method achieves the state-of-the-art segmentation accuracy. We also build two cross-domain semantic segmentation datasets based on the publicly available data, i.e., remote sensing building segmentation and road segmentation, for domain adaptive segmentation. Our code, models and datasets are available at https://github.com/HibiscusYB/BAFFT.

Conditional Hyper-Network for Blind Super-Resolution With Multiple Degradations.

Although the single-image super-resolution (SISR) methods have achieved great success on the single degradation, they still suffer performance drop with multiple degrading effects in real scenarios. Recently, some blind and non-blind models for multiple degradations have been explored. However, these methods usually degrade significantly for distribution shifts between the training and test data. Towards this end, we propose a novel conditional hyper-network framework for super-resolution with multiple degradations (named CMDSR), which helps the SR framework learn how to adapt to changes in the degradation distribution of input. We extract degradation prior at the task-level with the proposed ConditionNet, which will be used to adapt the parameters of the basic SR network (BaseNet). Specifically, the ConditionNet of our framework first learns the degradation prior from a support set, which is composed of a series of degraded image patches from the same task. Then the adaptive BaseNet rapidly shifts its parameters according to the conditional features. Moreover, in order to better extract degradation prior, we propose a task contrastive loss to shorten the inner-task distance and enlarge the cross-task distance between task-level features. Without predefining degradation maps, our blind framework can conduct one single parameter update to yield considerable improvement in SR results. Extensive experiments demonstrate the effectiveness of CMDSR over various blind, and even several non-blind methods. The flexible BaseNet structure also reveals that CMDSR can be a general framework for a large series of SISR models. Our code is available at https://github.com/guanghaoyin/CMDSR.