1.
Antimicrob Agents Chemother
; 68(7): e0160123, 2024 Jul 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38829050
RESUMEN
We examined the correlation between three different methods of Mycobacterium tuberculosis quantification: time to positivity (TTP), log10 CFU, and an assay to detect differentially detectable M. tuberculosis (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb (P < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.