RESUMEN
Climate change mandates that we take steps to understand and mitigate the negative environmental consequences of the practice of health care, so that health care advances sustainably. In this article, the authors review and discuss a sample of technical and administrative advances required to align the practice of radiology with principles of environmental sustainability.
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Cambio Climático , Radiología , Atención a la SaludRESUMEN
The environmental, social, governance (ESG) movement has come to health care organizations, in part through the Biden administration's challenge to them to reduce greenhouse gas emissions by 50% by 2030 and achieve net zero emissions by 2050, in support of more robust environmental sustainability. Radiology practices should become knowledgeable about ESG concepts and look for opportunities that are meaningful and achievable to support their host organizations' ESG efforts. Examples of initiatives to support improved environmental sustainability include selecting the least energy intensive imaging method for a given diagnosis, shutting down equipment in standby mode, sourcing energy from renewable sources, and reducing waste through recycling. Optimizing imaging protocols can reduce radiation exposure to patients, energy used per examination, and the use of other resources such as iodinated contrast media, an environmental pollutant. Achieving socially equitable access to services for ethnic and racial minorities remains a challenge in the US health care system. Extending hours of operation for screening services to include nights and weekends can provide options for patients who otherwise must take time away from work with loss of income. With respect to governance, more transparency in leadership selection and greater opportunities for participation by women and racial/ethnic minorities in the leadership of professional organizations should be supported in radiology. To succeed in ESG initiatives, radiology practice leaders should consider appointing a lead person and a multifunctional team that includes broad representation from the radiology workplace. The team should work to identify opportunities that are realistic and achievable within their institutional contexts.
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Atención a la Salud , Radiología , Humanos , Femenino , Lugar de Trabajo , LiderazgoRESUMEN
BACKGROUND: Colon screening by optical colonoscopy (OC) or computed tomographic colonography (CTC) requires a laxative bowel preparation, which inhibits screening participation. OBJECTIVE: To assess the performance of detecting adenomas 6 mm or larger and patient experience of laxative-free, computer-aided CTC. DESIGN: Prospective test comparison of laxative-free CTC and OC. The CTC included electronic cleansing and computer-aided detection. Optical colonoscopy examinations were initially blinded to CTC results, which were subsequently revealed during colonoscope withdrawal; this method permitted reexamination to resolve discrepant findings. Unblinded OC served as a reference standard. (ClinicalTrials.gov registration number: NCT01200303) SETTING: Multicenter ambulatory imaging and endoscopy centers. PARTICIPANTS: 605 adults aged 50 to 85 years at average to moderate risk for colon cancer. MEASUREMENTS: Per-patient sensitivity and specificity of CTC and first-pass OC for detecting adenomas at thresholds of 10 mm or greater, 8 mm or greater, and 6 mm or greater; per-lesion sensitivity and survey data describing patient experience with preparations and examinations. RESULTS: For adenomas 10 mm or larger, per-patient sensitivity of CTC was 0.91 (95% CI, 0.71 to 0.99) and specificity was 0.85 (CI, 0.82 to 0.88); sensitivity of OC was 0.95 (CI, 0.77 to 1.00) and specificity was 0.89 (CI, 0.86 to 0.91). Sensitivity of CTC was 0.70 (CI, 0.53 to 0.83) for adenomas 8 mm or larger and 0.59 (CI, 0.47 to 0.70) for those 6 mm or larger; sensitivity of OC for adenomas 8 mm or larger was 0.88 (CI, 0.73 to 0.96) and 0.76 (CI, 0.64 to 0.85) for those 6 mm or larger. The specificity of OC at the threshold of 8 mm or larger was 0.91 and at 6 mm or larger was 0.94. Specificity for OC was greater than that for CTC, which was 0.86 at the threshold of 8 mm or larger and 0.88 at 6 mm or larger (P= 0.02). Reported participant experience for comfort and difficulty of examination preparation was better with CTC than OC. LIMITATIONS: There were 3 CTC readers. The survey instrument was not independently validated. CONCLUSION: Computed tomographic colonography was accurate in detecting adenomas 10 mm or larger but less so for smaller lesions. Patient experience was better with laxative-free CTC. These results suggest a possible role for laxative-free CTC as an alternate screening method.
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Pólipos Adenomatosos/diagnóstico por imagen , Pólipos del Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada/métodos , Pólipos Adenomatosos/patología , Anciano , Anciano de 80 o más Años , Enfermedades Asintomáticas , Pólipos del Colon/patología , Colonografía Tomográfica Computarizada/efectos adversos , Colonoscopía/efectos adversos , Colonoscopía/métodos , Femenino , Humanos , Laxativos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios ProspectivosRESUMEN
Computed tomographic (CT) colonography performed after tagging of fecal matter but without a cathartic agent, or noncathartic CT colonography (also known as laxative-free CT colonography), is regarded as a promising next-generation technique for reducing or eliminating the discomfort associated with cathartic bowel preparation, which is the major barrier to undergoing colon cancer screening. Electronic cleansing is an emerging technique for the removal of tagged fecal materials from CT colonographic images. Three major electronic cleansing artifacts--soft-tissue degradation, pseudo-soft-tissue structures, and incomplete cleansing--severely impair the quality of electronically cleansed noncathartic CT colonographic images and limit the diagnostic utility of this modality. A structure-analysis electronic cleansing scheme was developed that makes use of local morphologic information to identify submerged colonic soft-tissue structures while removing the tagged material. Combined with other cutting-edge image processing techniques, including local roughness analysis, mosaic decomposition, and level set segmentation, structure-analysis cleansing helps eliminate the aforementioned artifacts, providing diagnostic-quality cleansed CT colonographic images for the detection of colon cancer. Noncathartic CT colonography with the application of structure-analysis cleansing is expected to help promote CT colonography as a patient-friendly method of colorectal cancer screening.
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Colonografía Tomográfica Computarizada/métodos , Medios de Contraste/administración & dosificación , Medios de Contraste/química , Heces/química , Intensificación de Imagen Radiográfica/métodos , Catárticos , HumanosRESUMEN
Radiologists make many diagnoses, but only sporadically get feedback on the subsequent clinical courses of their patients. We have created a web-based application that empowers radiologists to create and maintain personal databases of cases of interest. This tool integrates with existing information systems to minimize manual input such that radiologists can quickly flag cases for further follow-up without interrupting their clinical work. We have integrated this case-tracking system with an electronic medical record aggregation and search tool. As a result, radiologists can learn the outcomes of their patients with much less effort. We intend this tool to aid radiologists in their own personal quality improvement and to increase the efficiency of both teaching and research. We also hope to develop the system into a platform for systematic, continuous, quantitative monitoring of performance in radiology.
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Registros Electrónicos de Salud , Radiología/métodos , Humanos , Radiología/instrumentación , Sistemas de Información Radiológica/instrumentaciónRESUMEN
Electronic cleansing (EC) is an emerging method for segmentation of fecal material in CT colonography (CTC) that is used for reducing or eliminating the requirement for cathartic bowel preparation and hence for improving patients' adherence to recommendations for colon cancer screening. In EC, feces tagged by an x-ray-opaque oral contrast agent are removed from the CTC images, effectively cleansing the colon after image acquisition. Existing EC approaches tend to suffer from the following cleansing artifacts: degradation of soft-tissue structures because of pseudo-enhancement caused by the surrounding tagged fecal materials, and pseudo soft-tissue structures and false fistulas caused by partial volume effects at the boundary between the air lumen and the tagged regions, called the air-tagging boundary (AT boundary). In this study, we developed a novel EC method, called structure-analysis cleansing, which effectively avoids these cleansing artifacts. In our method, submerged soft-tissue structures are recognized by their local morphologic signatures that are characterized based on the eigenvalues of a three-dimensional Hessian matrix. A structure-enhancement function is formulated for enhancing of the soft-tissue structures. In addition, thin folds sandwiched between the air lumen and tagged regions are enhanced by analysis of the local roughness based on multi-scale volumetric curvedness. Both values of the structure-enhancement function and the local roughness are integrated into the speed function of a level set method for delineating the tagged fecal materials. Thus, submerged soft-tissue structures as well as soft-tissue structures adhering to the tagged regions are preserved, whereas the tagged regions are removed along with the associated AT boundaries from CTC images. Evaluation of the quality of the cleansing based on polyps and folds in a colon phantom, as well as on polyps in clinical cathartic and noncathartic CTC cases with fluid and stool tagging, showed that our structure-analysis cleansing method is significantly superior to that of our previous thresholding-based EC method. It provides a cleansed colon with substantially reduced subtraction artifacts.
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Catárticos/uso terapéutico , Colon/patología , Colonografía Tomográfica Computarizada/instrumentación , Colonografía Tomográfica Computarizada/métodos , Algoritmos , Colon/diagnóstico por imagen , Pólipos del Colon/diagnóstico , Pólipos del Colon/patología , Colonoscopía/métodos , Medios de Contraste/farmacología , Heces , Humanos , Imagenología Tridimensional , Modelos Estadísticos , Distribución Normal , Fantasmas de Imagen , Tomografía Computarizada por Rayos X/métodos , Rayos XRESUMEN
We describe a method to perform postacquisition processing of computed tomography colonography (virtual colonoscopy) datasets that results in electronic removal of opacified, ingested bowel contents while reconstructing natural appearing boundaries of colon lumen and thereby permitting three-dimensional visual analyses of the resulting colon models.
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Inteligencia Artificial , Colonografía Tomográfica Computarizada/métodos , Imagenología Tridimensional/métodos , Intensificación de Imagen Radiográfica/métodos , Interpretación de Imagen Radiográfica Asistida por Computador/métodos , Técnica de Sustracción , Anciano , Algoritmos , Medios de Contraste , Femenino , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Modelos Biológicos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Procesamiento de Señales Asistido por ComputadorRESUMEN
Electronic cleansing (EC) is a method that segments fecal material tagged by an X-ray-opaque oral contrast agent in computed tomographic colonography (CTC) images, and effectively removes the material for digitally cleansing the colon. In this study, we developed a novel EC method, called mosaic decomposition (MD), for reduction of the artifacts due to incomplete cleansing of inhomogeneously tagged fecal material in CTC images, especially in noncathartic CTC images. In our approach, the entire colonic region, including the residual fecal regions, was first decomposed into a set of local homogeneous regions, called tiles, after application of a 3-D watershed transform to the CTC images. Each tile was then subjected to a single-class support vector machine (SVM) classifier for soft-tissue discrimination. The feature set of the soft-tissue SVM classifier was selected by a genetic algorithm (GA). A scalar index, called a soft-tissue likelihood, is formulated for differentiation of the soft-tissue tiles from those of other materials. Then, EC based on MD, called MD-cleansing, is performed by first initializing of the level-set front with the classified tagged regions; the front is then evolved by use of a speed function that was designed, based on the soft-tissue index, to reserve the submerged soft-tissue structures while suppressing the residual fecal regions. The performance of the MD-cleansing method was evaluated by use of a phantom and of clinical cases. In the phantom evaluation, our MD-cleansing was trained with the supine (prone) scan and tested on the prone (supine) scan, respectively. In both cases, the sensitivity and specificity of classification were 100%. The average cleansing ratio was 90.6%, and the soft-tissue preservation ratio was 97.6%. In the clinical evaluation, 10 noncathartic CTC cases (20 scans) were collected, and the ground truth of a total of 2095 tiles was established by manual assignment of a material class to each tile. Five cases were randomly selected for training GA/SVM, and the remaining five cases were used for testing. The overall sensitivity and specificity of the proposed classification scheme were 97.1% and 85.3%, respectively, and the accuracy was 94.6%. The area under the ROC curve (Az) was 0.96. Our results indicated that the use of MD-cleansing substantially improved the effectiveness of our EC method in the reduction of incomplete cleansing artifacts.
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Colon/diagnóstico por imagen , Heces , Imagenología Tridimensional/métodos , Reconocimiento de Normas Patrones Automatizadas/métodos , Intensificación de Imagen Radiográfica/métodos , Interpretación de Imagen Radiográfica Asistida por Computador/métodos , Tomografía Computarizada por Rayos X/métodos , Algoritmos , Inteligencia Artificial , Catárticos , Humanos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Técnica de SustracciónAsunto(s)
Colonografía Tomográfica Computarizada/normas , Neoplasias Colorrectales/diagnóstico por imagen , Documentación/normas , Guías de Práctica Clínica como Asunto , Sociedades Médicas/normas , Terminología como Asunto , Colonografía Tomográfica Computarizada/métodos , Neoplasias Colorrectales/clasificación , Neoplasias Colorrectales/patología , Medicina Basada en la Evidencia , Humanos , Sistemas de Información Radiológica/normas , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Estados UnidosRESUMEN
Colorectal polyps less than 6 mm in size pose a negligible risk to the development of colorectal carcinoma. The sensitivity and specificity for detection of diminutive lesions on all available examinations including CT colonography (CTC) and optical colonoscopy (OC) is relatively low. In the context of regular screening, the low clinical significance and slow to negligible growth of diminutive polyps, as well as the low detection performance of CTC and OC for these lesions, would contribute to wasted health care resource and excess morbidity if each diminutive polyp were referred for potential resection. Respect for patient safety, attention to proper use of resources, and appropriate focus on larger, clinically significant polyps lead the authors to the conclusion that colonic polyps of less than 6 mm should not be separately reported.
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Pólipos del Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada/métodos , Adenoma/diagnóstico , Adenoma/epidemiología , Adenoma/etiología , Pólipos del Colon/complicaciones , Pólipos del Colon/patología , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/etiología , Humanos , Tamizaje Masivo/métodos , Lesiones Precancerosas , Prevalencia , Índice de Severidad de la Enfermedad , Estados Unidos/epidemiologíaRESUMEN
RATIONALE AND OBJECTIVES: The purpose of this evaluation was to compare the tagging quality of a barium-based regimen with that of iodine-based regimens for computed tomographic (CT) colonography. MATERIALS AND METHODS: Tagging quality was assessed retrospectively in three different types of fecal-tagging CT colonographic cases: 24 barium-based cases, 22 nonionic iodine-based cases, and 24 ionic iodine-based cases. For the purpose of evaluation, the large intestine was divided into six segments, and the tagging homogeneity of a total of 420 segments (70 patients) was graded by three blinded readers from 0 (heterogeneous) to 4 (homogeneous). RESULTS: For barium-based cases, the average score for the three readers was 2.4, whereas it was 3.4 for nonionic iodine and 3.6 for ionic iodine. The percentages of segments that were assigned scores of 4 (excellent tagging [100%]) were 11.6%, 61.9%, and 72.9% for the barium-based, nonionic iodine-based, and ionic iodine-based regimens, respectively. The homogeneity scores of iodine-based fecal-tagging regimens were significantly higher than those of the barium-based fecal-tagging regimen (P < .001). The CT attenuation values of tagging in the cases were also assessed: the minimum and maximum values were significantly higher for the iodine-based regimens than for the barium-based regimen (P < .001). CONCLUSIONS: The iodine-based fecal-tagging regimens provide significantly greater homogeneity in oral-tagging fecal material than the barium-based fecal-tagging regimen. Iodine-based fecal-tagging regimens can provide an appropriate method for use in nonlaxative or minimum-laxative CT colonography.
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Sulfato de Bario , Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada/métodos , Diatrizoato de Meglumina , Heces , Yohexol , Administración Oral , Adulto , Anciano , Anciano de 80 o más Años , Sulfato de Bario/administración & dosificación , Medios de Contraste/administración & dosificación , Diatrizoato de Meglumina/administración & dosificación , Femenino , Humanos , Yohexol/administración & dosificación , Masculino , Persona de Mediana Edad , Intensificación de Imagen Radiográfica/métodos , Reproducibilidad de los Resultados , Estudios Retrospectivos , Sensibilidad y Especificidad , Método Simple CiegoRESUMEN
PURPOSE: To prospectively compare the homogeneity, adequacy, and patient acceptance of nonionic iodine-based regimens with those of a barium-based regimen for computed tomographic (CT) colonography with electronic subtraction cleansing. MATERIALS AND METHODS: After institutional review board approval and informed consent were obtained, 68 subjects (41 men (60%) men, 27 (40%) women; mean age, 60 years +/- 6 [standard deviation]) with average or moderate risk factors for development of colorectal carcinoma were recruited and placed into three study groups. Group 1 (n = 25) ingested 150-mL aliquots of 2% barium sulfate suspension with meals and snacks for 48 hours prior to imaging, without other diet modification or a cathartic. Group 2 (n = 21) ingested 10-mL aliquots of nonionic iodinated contrast material (iopromide) with a concentration of 300 mg per milliliter with meals and snacks for 2 days before imaging, without diet modification or a cathartic. Group 3 (n = 22) ingested nonionic iodinated contrast material (iohexol) with a concentration of 300 mg per milliliter with meals and snacks for 2 days before imaging and ingested 34 g of magnesium citrate the evening prior to imaging. CT colonography was also performed on 10 control subjects who ingested polyethylene glycol electrolyte solution prior to imaging. Subjective and numerical measures of bowel preparation quality, homogeneity, and patient comfort among the noncathartic and cathartic cohorts were compared with nonparametric analysis of variance, the Fisher exact test, and the F test, as appropriate. The study was HIPAA compliant. RESULTS: Study subjects who received tagging preparations reported significantly improved discomfort scores when compared with those of the control subjects (P < .05, each comparison). There was no significant difference in discomfort scores among groups 1, 2, and 3. For each reader, scores of subtracted image readability were highest for group 3. Dichotomized rates of preparation "success" were also greatest for group 3. CONCLUSION: In this series, the patient discomfort scores were significantly improved with tagging preparations for CT colonography. Nonionic iodinated contrast material in conjunction with a hyperosmotic laxative (magnesium citrate) was associated with the best subjective and numerical indices of readability.
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Colonografía Tomográfica Computarizada/métodos , Anciano , Sulfato de Bario , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Técnica de SustracciónRESUMEN
PURPOSE: To retrospectively determine if three-dimensional (3D) viewing improves radiologists' accuracy in classifying true-positive (TP) and false-positive (FP) polyp candidates identified with computer-aided detection (CAD) and to determine candidate polyp features that are associated with classification accuracy, with known polyps serving as the reference standard. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained; this study was HIPAA compliant. Forty-seven computed tomographic (CT) colonography data sets were obtained in 26 men and 10 women (age range, 42-76 years). Four radiologists classified 705 polyp candidates (53 TP candidates, 652 FP candidates) identified with CAD; initially, only two-dimensional images were used, but these were later supplemented with 3D rendering. Another radiologist unblinded to colonoscopy findings characterized the features of each candidate, assessed colon distention and preparation, and defined the true nature of FP candidates. Receiver operating characteristic curves were used to compare readers' performance, and repeated-measures analysis of variance was used to test features that affect interpretation. RESULTS: Use of 3D viewing improved classification accuracy for three readers and increased the area under the receiver operating characteristic curve to 0.96-0.97 (P<.001). For TP candidates, maximum polyp width (P=.038), polyp height (P=.019), and preparation (P=.004) significantly affected accuracy. For FP candidates, colonic segment (P=.007), attenuation (P<.001), surface smoothness (P<.001), distention (P=.034), preparation (P<.001), and true nature of candidate lesions (P<.001) significantly affected accuracy. CONCLUSION: Use of 3D viewing increases reader accuracy in the classification of polyp candidates identified with CAD. Polyp size and examination quality are significantly associated with accuracy.
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Pólipos del Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Imagenología Tridimensional/métodos , Interpretación de Imagen Radiográfica Asistida por Computador/métodos , Adulto , Anciano , Colonografía Tomográfica Computarizada/estadística & datos numéricos , Diagnóstico por Computador , Reacciones Falso Positivas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estándares de Referencia , Estudios RetrospectivosRESUMEN
BACKGROUND: CT colonography (CTC) is utilized as a diagnostic tool in the detection of colon polyps and early colorectal cancer in adults. Large studies in the literature, although focused on adult populations, have shown CTC to be a safe, accurate, non-invasive technique. OBJECTIVE: We evaluated the technical feasibility of CTC in children using a low-dose technique. MATERIALS AND METHODS: From November 2001 to April 2004 we evaluated eight patients (3-17 years) with non-contrast CTC. Seven of the patients had CTC, followed by standard colonoscopy (SC) the same day; in one patient, CTC followed a failed SC. CTC results were compared to results of SC. The estimated effective dose from each CTC was calculated and compared to that of standard barium enema. RESULTS: CTC results were consistent with those of SC. Sensitivity for polyps 5-10 mm was 100%, and sensitivity for polyps 10 mm and larger was 66.7%. The estimated mean effective dose was 2.17 mSv for CTC, compared to the 5-6 mSv for a standard air-contrast barium enema in a small child. CONCLUSION: Our initial experience shows CTC in children is well-tolerated, safe, and useful. The procedure can be performed successfully with a low radiation dose, and preliminary results compare well with SC.
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Colonografía Tomográfica Computarizada/métodos , Poliposis Adenomatosa del Colon/diagnóstico por imagen , Adolescente , Sulfato de Bario , Niño , Preescolar , Pólipos del Colon/diagnóstico por imagen , Colonoscopía , Medios de Contraste , Enema , Estudios de Factibilidad , Femenino , Hemorragia Gastrointestinal/diagnóstico por imagen , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Masculino , Dosis de Radiación , Recto , Seguridad , Sensibilidad y EspecificidadRESUMEN
PURPOSE: To evaluate the effect of various bowel contrast material concentrations and subtraction software on size measurements of well-defined polyp lesions in a colon phantom at CT colonography. MATERIALS AND METHODS: Repeated scanning and a precise reference standard required the use of a colon phantom in which 21 polyps were randomly distributed. Two readers who had each reviewed computed tomographic (CT) colonographic images from more than 100 cases evaluated polyp size on images obtained when the phantom was partially filled with varying concentrations of contrast material, scanned by using CT colonography, and subjected to electronic subtraction cleansing. The single largest dimension was recorded for each reader for a randomized series of polyps. These measurements were compared with a reference standard that was based on a combination of the manufacturer's polyp size specifications and the subsequent verification of these sizes by an independent consensus panel. Six weeks after initial observations, readers evaluated images of the phantom scanned without the presence of contrast material. Polyp size estimations for the two readers for each series were compared with the reference standard to obtain a mean absolute measurement error for each reader for each series. Data for each reader were compared by using a nonparametric Kruskal-Wallis analysis of variance test. A pair-wise comparison of the experimental and control series was then performed by using the Dunn post hoc test. RESULTS: Contrast material dilutions resulting in an average attenuation of less than 500 HU resulted in complete subtraction and the absence of streak artifacts. There was no statistically significant difference between the average measurement error for contrast attenuations between 300 and 500 HU when compared with that of control. Streak artifact was noticeable for the highest dilution (mean, 840 HU). No statistically significant differences were observed for series in which cleansing software was used in the absence of bowel contrast material. CONCLUSION: The combination of electronic cleansing and bowel contrast enhancement in the range of 300-500 HU results in no substantial change in readers' estimations of polyp size at CT colonography.
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Pólipos del Colon/diagnóstico por imagen , Colonografía Tomográfica Computarizada , Yohexol/análogos & derivados , Intensificación de Imagen Radiográfica/métodos , Análisis de Varianza , Medios de Contraste , Humanos , Variaciones Dependientes del Observador , Fantasmas de Imagen , Programas Informáticos , Técnica de SustracciónRESUMEN
BACKGROUND AND AIMS: There has been much speculation about the potential impact on the use of conventional colonoscopy if "virtual" computed tomographic colonography (CTC) became a widely accepted modality for colorectal cancer (CRC) screening. However, no formal analysis of the impact of CTC on colonoscopy demand has been reported. METHODS: A mathematical model to predict colonoscopy demand based on several relevant input parameters was constructed. Current national colonoscopy practice, estimated using various published reports, was used as the foundation to project colonoscopy demand if CTC were implemented as the primary CRC screening modality. RESULTS: In the base-case analysis, if CTC were used as the primary modality for CRC screening, 1.78 million colonoscopies could be eliminated from the total 6.47 million in 2003. Depending on the polyp size threshold used to define a CTC study as positive (6 or 10 mm), this loss would be partially offset by 1.21 million (6 mm) or .34 million (10 mm) follow-up colonoscopies for CTC examinations with positive findings, resulting in a net loss of .57 million (8.8% decrease) (6 mm) or 1.44 million (22.3% decrease) (10 mm). Extensive sensitivity analyses showed that the findings of this model were robust and insensitive to most parameters tested but were sensitive to a few parameters, including the percentage of CTC examinations with positive findings. CONCLUSIONS: Wide-scale implementation of CTC for CRC screening would likely lead to a decrease in use of conventional colonoscopy. The percentage of CTC studies with positive findings seemed to be a pivotal variable, which would be determined in large part by the polyp size ultimately established to define a positive finding.
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Colonografía Tomográfica Computarizada/métodos , Colonoscopía/métodos , Colonografía Tomográfica Computarizada/mortalidad , Colonografía Tomográfica Computarizada/estadística & datos numéricos , Colonoscopía/estadística & datos numéricos , Humanos , Modelos Teóricos , Cooperación del Paciente , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Estados UnidosRESUMEN
The authors evaluated a computed tomography (CT) colonographic technique with a combination of preexamination orally ingested positive contrast material and postacquisition image processing to subtract out the ingested opacified bowel contents. With this technique, rigorous physical purging of the bowel was not necessary before structural examination of the colon. With images obtained in 20 patients, two readers were able to correctly identify the majority of polyps confirmed at colonoscopy. Their performance for detection of lesions larger than 1 cm was similar to that with conventional CT colonography.