Dysregulated microRNAs and long non-coding RNAs associated with extracellular matrix stiffness.

Extracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and affects both physiological and pathological processes. A variety of studies have demonstrated that mRNAs, such as Piezo1, integrin ß1, and Yes-associated protein (YAP)/tafazzin (TAZ), can sense the mechanical signals induced by ECM stiffness and transmit them from the extracellular space into the cytoplasm. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been reported to play important roles in various cellular processes. Therefore, the interactions between ncRNAs and ECM stiffness, as well as the underlying molecular mechanisms, have become intriguing. In this review, we summarize recent findings on miRNAs and lncRNAs that interact with ECM stiffness. Several miRNAs and lncRNAs are involved in the progression of liver cancer, breast cancer, osteosarcoma, and cardiovascular diseases under the regulation of ECM stiffness. Through these ncRNAs, cellular behaviors including cell differentiation, proliferation, adhesion, migration, invasion, and epithelial-mesenchymal transition (EMT) are affected by ECM stiffness. We also integrate the ncRNA signaling pathways associated with ECM stiffness, in which typical signaling pathways like integrin ß1/TGFß1, phosphatidylinositol-3 kinase (PI3K)/AKT, and EMT are involved. Although our understanding of the relationships between ncRNAs and ECM stiffness is still limited, further investigations may provide new insights for disease treatment. ECM-associated ncRNAs may serve as disease biomarkers or be targeted by drugs.

Nanoencapsulated MgBu2@ZIF-67 to Construct High Loading Mg-Co@C Nanocomposites: Breaking Through the Barrier of Room Temperature Onset Dehydrogenation.

The synergies of nanoconfinement and catalysis is an effective strategy to improve the kinetic and thermodynamic properties of Mg-based materials. However, obtaining Mg-based materials with high loading, anti-aggregation, and containing nanocatalysts to achieve dehydrogenation at room temperature remains a huge challenge. Herein, a novel and universal preparation strategy for Mg-Co@C nanocomposites with 9.5 nm Mg nanoparticles and 9.4 nm Co nanocatalysts embedded in carbon scaffold is reported. The 9.3 nm MgBu2 nanosheets precipitated by solvent displacement are encapsulated in ZIF-67 to prepare MgBu2@ZIF-67 precursors, then removing excess MgBu2 on the precursor surface and pyrolysis to obtain Mg-Co@C. It is worth noting that the Mg loading rate of Mg-Co@C is as high as rare 69.7%. Excitingly, the Mg-Co@C begins to dehydrogenate at room temperature with saturate capacity of 5.1 wt.%. Meanwhile, its dehydrogenation activation energy (Ea(des) = 68.8 kJ mol-1) and enthalpy (ΔH(des) = 61.6 kJ mol-1) significantly decrease compared to bulk Mg. First principles calculations indicate that the hydrogen adsorption energy on the Mg2CoH5 surface is only -0.681 eV. This work provides a universally applicable novel method for the preparation of nanoscale Mg-based materials with various nanocatalysts added, and provides new ideas for Mg-based materials to achieve room temperature hydrogen storage.

Is there an intergenerational discrepancy in the comprehension and aesthetic preference regarding emoji usage? Evidence from WeChat.

Emojis are widely used on social media, blogs, and instant messaging to express users' feelings. However, in everyday interactions, the same emoji often has different interpretations and aesthetic preferences among different age groups. This can lead to communication barriers and misunderstandings. Based on social identity theory, this study uses WeChat, a social platform popular in China, to analyze intergenerational differences in emoji understanding and preferences through a questionnaire survey. The results indicate: (1) There are significant intergenerational differences in the usage habits, interpretation, and aesthetic preferences of emojis. (2) Middle-aged and elderly tend to interpret goodbye emoji symbols as simple emotional expressions, such as "goodbye" or "see you later," while younger-age groups lean towards more complex emotions and social intentions, such as "speechlessness" and "end of friendship." (3) Younger-age groups use emojis frequently and with a wide variety, whereas middle-aged and elderly groups use emojis less frequently and with limited variety. Younger individuals' aesthetic preferences for emojis lean towards humor, conflict, and narrative, whereas middle-aged and elderly groups prefer emojis with bright colors and everyday greetings typical of their generation. Based on research findings, we believe that social identity theory provides a framework for understanding how individuals establish their identities through interactions with specific social groups. This study is beneficial for identifying the comprehension and aesthetic biases in emoji usage across generations, sheds light on the broader implications of social identity theory in digital communication contexts, and promotes friendly social interactions in real-time communication applications.

Construction of multifunctional interface engineering on Cu-SSZ-13@Ce-MnOx/Mesoporous-silica catalyst for boosting activity, SO2 tolerance and hydrothermal stability.

Although small pore Cu-SSZ-13 catalysts have been successful as commercial catalysts for controlling NOx emissions from mobile sources, the challenges of high light-off temperature, SO2 tolerance and hydrothermal stability still need to be addressed. Here, we synthesized a multifunctional core-shell catalyst with Cu-SSZ-13 as the core phase and Ce-MnOx supported Mesoporous-silica (Meso-SiO2) as the shell phase via self-assembly and impregnation. The core-shell catalyst exhibited excellent low-temperature activity, SO2 tolerance and hydrothermal stability compared to the Cu-SSZ-13. The Ce-MnOx species dispersed in the shell are found to enhance both the acidic and oxidative properties of the core-shell catalyst. More critically, these species can rapidly activate NO and oxidize it to NO2, which allows the NH3-SCR reaction on the core-shell catalyst to be initiated in the shell phase. Meanwhile, Ce-MnOx species can react preferentially with SO2 as sacrifice components, effectively avoiding the sulfur inactivation of the copper active sites. Furthermore, the hydrophobic Meso-SiO2 shell provides an important barrier for the core phase, which reduces the loss of active species, acid sites and framework Al of the aged core-shell catalyst and mitigates the collapse of the zeolite framework. This work provides a new strategy for the design of novel and efficient NH3-SCR catalysts.