RESUMEN
OBJECTIVE: To analyze the Z values of true and false positive cases by non-invasive prenatal testing (NIPT) in order to improve its accuracy in clinical practice. METHODS: Results of 24 384 NIPT tests were reviewed. For cases with high risks for trisomies 21, 18 and 13, the range of Z values in true and false positive cases was analyzed and discussed. RESULTS: A total of 335 high-risk cases were identified by NIPT, among which 256 had elected prenatal diagnosis, 153 (59.77%) were verified as true positives, and 103 (40.23%) were false positives, and the area under the curve (AUC) was 0.9994. For NIPT screening, the positive predictive value (PPV) for trisomy 21 was 100% when Z>13, regardless if the pregnant woman was over 35. When 3Asunto(s)
Trastornos de los Cromosomas
, Síndrome de Down
, Femenino
, Embarazo
, Humanos
, Síndrome de la Trisomía 13/diagnóstico
, Síndrome de la Trisomía 13/genética
, Trisomía/diagnóstico
, Trisomía/genética
, Síndrome de Down/diagnóstico
, Síndrome de Down/genética
, Trastornos de los Cromosomas/genética
, Síndrome de la Trisomía 18/diagnóstico
, Diagnóstico Prenatal/métodos