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1.
J Biol Regul Homeost Agents ; 33(2): 403-408, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30891999

RESUMEN

Coronary artery bypass grafting (CABG) is an effective scheme for treatment of myocardial ischemia. Hypoxemia is a common complication of CABG, which can affect surgical effect and prognosis and even induce multiple organ failure. To explore the clinical efficacy of bi-level positive airway pressure ventilation in the treatment of CABG-associated hypoxemia, 216 patients who were admitted to our hospital between August 2015 and April 2017 and developed CABG-associated hypoxemia were selected and randomly divided into 2 groups, an observation group (n=108) and a control group (n=108). Patients in the control group were given conventional treatment including continuous oxygen inhalation through nasal tube, anti-infection, bronchodilation, phlegm resolving, nutrition support, analgesia, cardiac function maintenance, coronary dilatation, anticoagulation and maintenance of stable internal environment, while patients in the observation group were given positive airway pressure ventilation via a breathing machine or nasal mask besides the conventional treatment.


Asunto(s)
Puente de Arteria Coronaria , Hipoxia/terapia , Respiración con Presión Positiva , Enfermedad de la Arteria Coronaria/cirugía , Humanos , Oxígeno , Resultado del Tratamiento
2.
Reprod Biomed Online ; 34(4): 354-360, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-28187961

RESUMEN

The aim of this retrospective study was to determine the clinical pregnancy rate in women undergoing letrozole ovarian stimulation and artificial insemination by donor (AID). Between 2012 and 2015, 130 natural cycles, 939 letrozole cycles and 130 letrozole plus gonadotrophin cycles were conducted. Letrozole cycles were divided into three groups according to LH concentration on the day of HCG administration (LH <10 mIU/ml and follicle size ≥18 cm; LH ≤10 to <20 mIU/ml; and LH ≥20 mIU/ml). Pregnancy rates were 17.3%, 22.4% and 26.8%, respectively (P = 0.012). In women given 10 mIU/ml LH or more, logistic regression identified oestradiol (OR 1.002, 95% CI, 1.000 to 1.004, P = 0.029) and leading follicle size (OR 0.861, 95% CI, 0.772 to 0.960, P = 0.007) as significant predictive factors of pregnancy rate; the higher the oestradiol and the smaller the follicles, the better the pregnancy rate. The pregnancy rate was significantly higher in the letrozole plus gonadotrophin group than the letrozole group (P = 0.04). Better pregnancy rates can be achieved if LH surge occurs before HCG administration, especially with higher oestradiol and lower follicle size; treatment with letrozole plus gonadotrophin was significantly more effective than letrozole alone in AID.


Asunto(s)
Inhibidores de la Aromatasa/uso terapéutico , Gonadotropinas/uso terapéutico , Inseminación Artificial Heteróloga , Nitrilos/uso terapéutico , Inducción de la Ovulación/métodos , Triazoles/uso terapéutico , Inhibidores de la Aromatasa/administración & dosificación , Inhibidores de la Aromatasa/efectos adversos , Estradiol/sangre , Femenino , Gonadotropinas/administración & dosificación , Gonadotropinas/efectos adversos , Humanos , Letrozol , Modelos Logísticos , Nitrilos/administración & dosificación , Nitrilos/efectos adversos , Folículo Ovárico/diagnóstico por imagen , Embarazo , Índice de Embarazo , Estudios Retrospectivos , Triazoles/administración & dosificación , Triazoles/efectos adversos
3.
Zhonghua Yi Xue Za Zhi ; 97(22): 1737-1739, 2017 Jun 13.
Artículo en Zh | MEDLINE | ID: mdl-28606285

RESUMEN

Objective: To explore the effect of implanting short stent in root of aorta for the treatment of Stanford type A aortic dissection. Methods: Clinical data of 39 patients with Stanford type A aortic dissection who underwent surgical procedure at the Department of Cardiovascular Surgery of Luoyang Central Hospital Affiliated to Zhengzhou University, between January 2013 and December 2015 were retrospectively analyzed. There were 31 males and 8 females aged 27 to 75 (49.3±10.3) years. All patients received short stent implanting in aortic root, total arch replacement and stented elephant trunk implantation were performed at the same time. Results: All the operations were successfully performed. Two patients died during hospitalization. Four patients underwent reexploration for postoperative bleeding. Postoperative mortality was 5.1%(2/39). Follow-up duration was 3 to 24 months, with a median time of 14 months. One patient died of lung infection, gastrointestinal bleeding and renal faliure during follow-up. Conclusion: Patients with aortic intimal tear located at higher root of aorta may be suitable for short stent implanting, and the procedure has satisfactory clinical outcomes.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/cirugía , Implantación de Prótesis Vascular , Stents , Adulto , Anciano , Aorta , Aorta Torácica , Aneurisma de la Aorta , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto Joven
4.
Genet Mol Res ; 13(4): 9403-11, 2014 Feb 14.
Artículo en Inglés | MEDLINE | ID: mdl-24615116

RESUMEN

This study aimed to disclose the potential causality of low bilirubin in patients with nephrotic syndrome (NS). Correlation analysis was carried out on total bilirubin (TBIL) to serum albumin (ALB), urine protein (Upr), and urinary microalbumin/creatinine (Umalb/cr) for three groups in a case-control study. P < 0.001 was observed for TBIL, ALB, Umalb/cr, and Upr between the NS and chronic nephritis (CN) groups, and P values of 0.0001, 1.000, 0.0001, and 0.0001 were observed for TBIL, ALB, Umalb/cr, and Upr, respectively, between the postoperative gastroparesis (PGS) and CN groups. The values of r and P in correlation to TBIL were 0.549 and 0.000 for ALB, -0.405 and 0.000 for Umalb/cr, and -0.448 and 0.000 for Upr in the NS group; -0.007 and 0.959 for ALB, 0.213 and 0.091 for Umalb/cr, and -0.082 and 0.519 for Upr in the PGS group; and 0.509 and 0.000 for ALB, -0.431 and 0.000 for Umalb/cr, and -0.362 and 0.002 for Upr in the CN group. A probable causality is implied between the low level of blood bilirubin and its loss in urine in NS patients. This conclusion may provide a theoretical basis for the feasibility of therapies against oxidative stress in NS patients.


Asunto(s)
Bilirrubina/sangre , Gastroparesia/sangre , Síndrome Nefrótico/sangre , Complicaciones Posoperatorias/etiología , Albúmina Sérica/metabolismo , Adulto , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Proteinuria/sangre
5.
Artículo en Zh | MEDLINE | ID: mdl-38246756

RESUMEN

Objective: To observe the feelings of listening to music and the importance of music in the daily life of post-lingual deaf adults with cochlear implants, and to explore the relevant influencing factors. Methods: This was a cross-sectional survey study. From January 2021 to August 2021,the Music-Related Quality of Life Scale was used to evaluate the music needs and music experiences of 63 post-lingual deaf adults who met the inclusion criteria, including 27 males and 36 females, aged (40.7±12.3) years, at the time of surgery (36.8±13.1) years, and with a preoperative hearing aid ineffective time of (3.9±5.8) years. Indicators analyzed included age, duration of ineffective preoperative hearing aid wear, preoperative music preference, duration of postoperative cochlear implant use, current hearing aid modality, and auditory rehabilitation outcomes. Whether the six factors mentioned above constituted an influence on the subjects' music listening was investigated using SPSS 25.0 statistical software. Results: All of the observations in the scale were correlated with a single factor. The two sub-dimensions of music experience section were related to the effect of auditory rehabilitation. In the importance section, the effect of auditory rehabilitation was the influential factor of the dimension of "participation importance", and the preoperative enjoyment of music was the relevant influential factor of the dimension of "perceived importance". There was a significant difference between the groups when they were grouped by the above factors (P value<0.05), while there was no statistically significance between the groups when they were grouped by other factors (P value>0.05). Conclusions: Post-lingual deaf adults show the need and attempt to listen to music after cochlear implantation. The effectiveness of auditory rehabilitation and the degree of music preference preoperatively are two important factors that influence music listening in implant recipients. Once the level of auditory communication has been restored to a certain degree, it is important to pay more attention to the needs of music for implant recipients and train them in time, especially for those with music preferences preoperatively.


Asunto(s)
Implantación Coclear , Implantes Cocleares , Música , Adulto , Femenino , Masculino , Humanos , Calidad de Vida , Estudios Transversales
6.
Eur Rev Med Pharmacol Sci ; 27(16): 7590-7596, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37667936

RESUMEN

OBJECTIVE: To study the effects of early sequential enteral nutrition (ESEN) therapy and early non-sequential enteral nutrition (EN) therapy on the nutritional status, recovery, and quality of life of patients who undergo postoperative chemotherapy for esophageal cancer. PATIENTS AND METHODS: The data of 90 patients who underwent postoperative chemotherapy for esophageal cancer in Gansu Provincial Cancer Hospital from January 2018 to June 2020 were analyzed retrospectively. Patients were divided the Test group and the Control group (n=45 each) based on the method of nutritional support. Patients in the Control group were treated with non-sequential early enteral nutrition and the Test group treated with sequential early enteral nutrition until the discharge. Nutritional status, recovery, and quality of life of the chemotherapy patients in the two groups were compared. RESULTS: After the intervention, the pre-protein, albumin and hemoglobin levels were higher in the Test group than in the control group (p<0.05). Postoperative exhaustion, incision healing and length of hospital stay were significantly lower in the Test group than in the Control group (p<0.05), while the scores on all dimensions of the short-form 36 health survey scale (SF-36) and the total score were higher than in the Control group (p<0.05). CONCLUSIONS: Sequential early enteral nutrition may be used for patients who undergo chemotherapy after esophageal cancer surgery to promote their early recovery and improve their quality of life and nutritional status.


Asunto(s)
Neoplasias Esofágicas , Estado Nutricional , Humanos , Calidad de Vida , Nutrición Enteral , Estudios Retrospectivos , Neoplasias Esofágicas/terapia
7.
Eur Rev Med Pharmacol Sci ; 25(3): 1330-1338, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-33629303

RESUMEN

OBJECTIVE: To detect the expression of high-mobility group nucleosome-binding domain 5 (HMGN5) in colorectal cancer tissues, to explore the function of HMGN5 on the proliferation and metastasis of colorectal cancer cells, and to further study the molecular mechanism of HMGN5 in the malignant progression of colorectal cancer (CRC). PATIENTS AND METHODS: The cancer tissues and para-carcinoma tissues were harvested from 40 patients with CRC. The expression of HMGN5 was detected via quantitative real-time polymerase chain reaction (qRT-PCR), and the relation between HMGN5 and clinical indexes of CRC patients was further analyzed. The CRC HT29 and HCT116 cell lines with high expression levels of HMGN5 were selected, and the HMGN5 knockdown model was established. The functions of HMGN5 on CRC cells were stated by cell counting kit-8 (CCK-8) assay and transwell migration assay. Then, the association between HMGN5 and fibroblast growth factor 12 (FGF12) was further explored via Dual-Luciferase reporter assay and reverse assay. RESULTS: The qRT-PCR showed that HMGN5 expression was significantly rising in cancer tissues compared to the control group. The incidence rate of lymph node metastasis and distant metastasis was higher in higher expression HMGN5 group than the lower expression HMGN5 group. The results of cell function experiments revealed that silence of HMGN5 could suppress the proliferation and migration of HT29 and HCT116. In addition, it was found using qRT-PCR that knockdown of HMGN5 could significantly down-regulate the expressions of FGF12, FGFR, PI3K and AKT in HT29 and HCT116 cells. The targeted binding relation between HMGN5 and FGF12 was also indicated by the dual-luciferase reporter assay. The consequence of qRT-PCR manifested that FGF12 expression markedly rose in CRC tissues, which had a positive correlation with HMGN5. Moreover, reverse assay indicated that the inhibitory effect of HMGN5 knockdown on the malignant progression of CRC could be reversed by recombinant FGF12, indicating once again that there is a mutual regulatory effect between HMGN5 and FGF12. CONCLUSIONS: HMGN5 can increase the proliferative and migrative capacity of CRC cells via targeted binding to FGF12. In addition, clinical data analyses demonstrate that HMGN5 is intimately related to the incidence rate of lymph node metastasis and distant metastasis in patients with CRC.


Asunto(s)
Neoplasias Colorrectales/metabolismo , Factores de Crecimiento de Fibroblastos/metabolismo , Proteínas HMGN/metabolismo , Receptores de Factores de Crecimiento de Fibroblastos/metabolismo , Transactivadores/metabolismo , Línea Celular , Movimiento Celular , Neoplasias Colorrectales/patología , Femenino , Factores de Crecimiento de Fibroblastos/genética , Proteínas HMGN/genética , Humanos , Masculino , Persona de Mediana Edad , Receptores de Factores de Crecimiento de Fibroblastos/genética , Transactivadores/genética
9.
Artículo en Zh | MEDLINE | ID: mdl-29871349

RESUMEN

Objective:To explore the mutation spectrum of SLC26A4 in Chinese patients with enlarged vestibular aqueduct syndrome.Method:Genomic DNA samples were extracted from peripheral blood of the cochlear implant recipients associated with enlarged vestibular aqueduct syndrome. The SLC26A4 mutations were analyzed by direct sequencing.Result:A novel missense mutation(347G>A) of SLC26A4 gene was found in a male patient,which led to a substitution of codon 116 from glycine to asparagic acid. This mutation was not observed among 60 normal controls.Conclusion:The 347G>A of SLC26A4 gene was a novel pathologic mutation,contributing to the mutation spectrum of SLC26A4 of enlarged vestibular aqueduct syndrome.


Asunto(s)
Pérdida Auditiva Sensorineural/genética , Proteínas de Transporte de Membrana/genética , Mutación , Acueducto Vestibular/anomalías , Humanos , Masculino , Transportadores de Sulfato
10.
J Clin Densitom ; 9(3): 351-7, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16931355

RESUMEN

Calcaneus quantitative ultrasound (QUS) assessment is a safe and reliable method for evaluating skeletal status. Until now, considerable data have been accumulated on the distribution of QUS in Caucasian populations, whereas such data are still insufficient in Asian populations, especially in Chinese mainland. The present study aimed to obtain the distribution characteristic of calcaneus QUS in healthy Chinese women, and to further investigate the distribution of low bone mass by QUS stiffness index (SI). This study included 2,498 healthy Chinese females aged 10-87 yr. The QUS exhibited a characteristic mild rise and then fall pattern with increasing age. Age, body height, and weight were significant influencing factors on SI, especially age and weight. The prevalence of osteoporosis detected using instrument-derived T-score or internal T-score was different from that calculated according to calcaneus bone mass density (BMD) previously reported. Furthermore, between instrument-derived T-scores and internal T-scores, there were also significant differences. We concluded that the World Health Organization criteria from BMD may not be appropriate for QUS, and the instrument-derived T-score may also not be appropriate for the studied population. The results will be useful for predicting fracture risk of Chinese women and determining diagnostic criteria of osteoporosis by QUS.


Asunto(s)
Calcáneo/diagnóstico por imagen , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Pueblo Asiatico , Densidad Ósea , Niño , China , Femenino , Humanos , Persona de Mediana Edad , Osteoporosis/diagnóstico por imagen , Ultrasonografía
11.
World J Gastroenterol ; 7(6): 841-5, 2001 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11854913

RESUMEN

AIM: To clone the cDNA of UGT1A9 from a Chinese human liver and establish the Chinese hamster lung (CHL) cell line expressing human UGT1A9. METHODS: cDNA of UGT1 A9 was transcripted from mRNA by reverse transcriptase-ploymerase chain reaction, and was cloned into the pGEM-T vector which was amplified in the host bacteric E.Coli DH5(alpha). The inserted fragment, verified by DNA sequencing, was subcloned into the Hind III /Not I site of a mammalian expression vector pREP9 to construct the plasmid termed pREP9-UGT1A9. CHL cells were transfected with the resultant recombinants, pREP9-UGT1A9, and selected by G418 (400 mg x L(-1)) for one month. The surviving clone (CHL-UGT1A9) was harvested as a pool and sub-cultured in medium containing G418 to obtain samples forUGT1A9 assays. The enzyme activity of CHL-UGT1A9 towards propranolol in S9 protein of the cell was determined by HPLC. RESULTS: The sequence of the cDNA segment cloned, which was 1666 bp in length, was identical to that released by Gene Bank (GenBank accession number: AF056188) in coding region. The recombinant constructed, pREP9-UGT1A9, contains the entire coding region, along with 18 bp of the 5' and 55 bp of the 3' untranslated region of theUGT1A9 cDNA, respectively. The cell lines established expressed the protein of UGT1A9, and the enzyme activity towards propranolol in S9 protein was found to be 101+/- 24 pmol x min(-1) x mg(-1) protein (n=3), but was not detectable in parental CHL cells. CONCLUSION: The cDNA of UGT1A9 was successfully cloned from a Chinese human liver and transfected into CHL cells. The CHL-UGT1 A9 cell lines established efficiently expressed the protein ofUGT1A9 for the further enzyme study of drug glucuronidation.


Asunto(s)
Clonación Molecular , ADN Complementario/genética , ADN Complementario/metabolismo , Expresión Génica , Glucuronosiltransferasa/genética , Hígado/metabolismo , Animales , Línea Celular , Cricetinae , Cricetulus , Humanos , Datos de Secuencia Molecular , UDP Glucuronosiltransferasa 1A9
12.
Chin Med J (Engl) ; 102(11): 879-84, 1989 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-2517730

RESUMEN

In this study, we observed the endotoxin induced platelet aggregation, 5-HT and beta-g releases, cellular cAMP decrease, and also the changes of morphology and membrane fluidity of platelet. These changes play an important role in septic shock, especially in disseminated intravascular coagulation (DIC) and respiratory distress syndrome (RDS). After anisodamine (654) intervention all the parameters mentioned above were improved to a certain extent. This preliminary study of the inhibiting mechanism of 654 on rabbit platelets activated by ET supports the clinical possibility of using 654 for relieving DIC and RDS.


Asunto(s)
Escherichia coli , Inhibidores de Agregación Plaquetaria , Agregación Plaquetaria/efectos de los fármacos , Alcaloides Solanáceos/farmacología , Animales , Plaquetas/efectos de los fármacos , Endotoxinas/antagonistas & inhibidores , Femenino , Masculino , Fluidez de la Membrana/efectos de los fármacos , Conejos
13.
Zhonghua Zhong Liu Za Zhi ; 9(3): 221-3, 1987 May.
Artículo en Zh | MEDLINE | ID: mdl-3447866

RESUMEN

From July 1984 to December 1985, hemihepatectomy was done in 20 liver cancer patients under normothermic interruption of porta hepatis. There were 19 primary and 1 secondary liver carcinomas. Of the former, 17 (89%) were associated with mild or moderate cirrhosis. The peak age ranged 36-60 years. Right hemihepatectomy was performed in 18 and left hemihepatectomy in 2 with an operative mortality of 0%. Hepatic failure or secondary bleeding was not found. In the specimens resected, the largest weight was 2,500 gm. The normothermic interruption of porta hepatis usually lasted 15-25 minutes, a time long enough for hemihepatectomy. This procedure, being simple in manipulation and less detrimental to physiologic and biochemical balance in the human body, is relatively practical and beneficial to hepatectomy.


Asunto(s)
Hepatectomía/métodos , Neoplasias Hepáticas/cirugía , Adulto , Temperatura Corporal , Humanos , Cirrosis Hepática/complicaciones , Neoplasias Hepáticas/complicaciones , Neoplasias Hepáticas/secundario , Masculino , Persona de Mediana Edad
14.
Zhonghua Nei Ke Za Zhi ; 30(12): 743-5, 789, 1991 Dec.
Artículo en Zh | MEDLINE | ID: mdl-1815876

RESUMEN

Dynamic change of serum tissue-type plasminogen, activator (t-PA) and PAI activity was studied in 22 cases with acute myocardial infarction (AMI) 11 cases with unstable angina (UA) and 24 healthy persons. The group of AMI was divided into two subgroups, one with severe complications, AMI-A subgroup and the other without complication, AMI-B subgroup. The results revealed: t-PA activity was decreased in AMI group, especially in AMI-A subgroup; PAI activity was markedly increased in AMI-A subgroup in first three days after onset; there was a marked decrease of active type in AMI-A subgroup. The study confirms that the function of fibrinolytic system is abnormal in patients with AMI and UA. The change of activity of t-PA and PAI is closely related with the severity of AMI. It is important to augment the activity of the fibrinolytic system in the treatment of AMI.


Asunto(s)
Infarto del Miocardio/sangre , Inactivadores Plasminogénicos/sangre , Activador de Tejido Plasminógeno/sangre , Adulto , Anciano , Angina Inestable/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad
15.
Zhonghua Yi Xue Za Zhi ; 74(4): 203-5, 253, 1994 Apr.
Artículo en Zh | MEDLINE | ID: mdl-7922757

RESUMEN

Transcervical cannulation of the proximal oviduct was performed with a tube catheter and flexible guidewire under hysteroscopic guidance to evaluate and treat intramural fallopian tube obstruction in 37 patients. Hysteroscopic cannulation with direct visualization by laparoscopy was successful in 69.2% of the obstructed tubes, 77.4% of the cases. 74% of the obstructed tubes diagnosed by HSG and/or laparoscopy was patent after hydrotubation and cannulation by hysteroscopy. Transcervical cannulation of the proximal oviduct is an effective method for evaluation and treatment of cornual obstruction.


Asunto(s)
Cateterismo/métodos , Enfermedades de las Trompas Uterinas/diagnóstico , Enfermedades de las Trompas Uterinas/cirugía , Histeroscopía , Adulto , Constricción Patológica , Pruebas de Obstrucción de las Trompas Uterinas , Femenino , Humanos , Infertilidad Femenina/cirugía , Laparoscopía/métodos
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